Ethyl phthalyl ethyl glycolate

Overview IFRA Request a quote

  • Identifiers

    CAS number
    84-72-0

    Molecular formula
    C14H16O6

    SMILES
    CCOC(=O)COC(=O)C1=CC=CC=C1C(=O)OCC

    Safety labels

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Odorless 53.32%
    Winey 41.38%
    Fruity 33.84%
    Herbal 30.14%
    Caramellic 29.66%
    Floral 29.43%
    Balsamic 27.69%
    Burnt 25.12%
    Grape 24.48%
    Honey 23.01%

     

    Flavor
    Bitter 61.93%
    Fruity 35.09%
    Mild 32.41%
    Odorless 32.03%
    Grape 26.38%
    Wine 23.91%
    Bland 23.38%
    Aniseed 23.21%
    Tarragon 22.55%
    Faint 22.39%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    2.4

    pKa est.
    4.4 (weak acid)

    Molecular weight
    280.27 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    346°C

    Flash point

    • 172.01 ˚C est.

  • Synonyms

    • Ethyl phthalyl ethyl glycolate
    • 84-72-0
    • Ethoxycarbonylmethyl ethyl phthalate
    • UNII-C591YI5BTG
    • EINECS 201-555-3
    • C591YI5BTG
    • BRN 1389422
    • DTXSID3024100
    • AI3-01794
    • DTXCID604100
    • 1,2-Benzenedicarboxylic acid, 2-ethoxy-2-oxoethyl-, ethyl ester
    • 4-09-00-03256 (Beilstein Handbook Reference)
    • 1,2-Benzenedicarboxylic acid, 1-(2-ethoxy-2-oxoethyl) 2-ethyl ester
    • RefChem:139044
    • 1,2-Benzenedicarboxylic acid, 2-ethoxy-2-oxoethyl-, ethyl ester (9CI)
    • 201-555-3
    • PZBLUWVMZMXIKZ-UHFFFAOYSA-N
    • Santicizer E-15
    • Diethyl o-carboxybenzoyloxyacetate
    • ETHYL CARBETHOXYMETHYL PHTHALATE
    • Carbethoxymethyl ethyl phthalate
    • ETHYLPHTHALYLETHYLGLYCOLATE
    • 2-O-(2-ethoxy-2-oxoethyl) 1-O-ethyl benzene-1,2-dicarboxylate
    • MFCD00059377
    • 1,2-Benzenedicarboxylic acid, 2-ethoxy-2-oxoethyl ethyl ester
    • Phthalic acid, ethyl ester, ester with ethyl glycolate
    • 2-ethoxy-2-oxoethyl ethyl phthalate
    • ethyl 2-[2-(ethoxycarbonyl)phenylcarbonyloxy]acetate
    • ethyl 2-[(2-ethoxy-2-oxoethoxy)carbonyl]benzoate
    • Ethyl phthalyl ethyl glycolat
    • SCHEMBL1639856
    • CHEMBL3187049
    • MSK1167
    • Tox21_301488
    • SBB059637
    • AKOS015889357
    • CAS-84-72-0
    • NCGC00255284-01
    • LS-14296
    • SY053891
    • 1-(2-Ethoxy-2-oxoethyl) 2-ethyl phthalate
    • CS-0326308
    • E0164
    • NS00015591
    • Phthalic acid, ethyl ester-(ethyl glycolate)
    • ST51044559
    • Phthalic Acid Ethoxycarbonylmethyl Ethyl Ester
    • 1-(2-Ethoxy-2-oxoethyl) 2-ethyl phthalate #
    • E78910
    • phthalic acid ethoxycarbonylmethyl ester ethyl ester
    • 2-Ethoxy-2-oxoethyl ethyl benzene-1,2-dicarboxylate
    • Q27275211
    • O2-(2-ethoxy-2-oxo-ethyl) O1-ethyl benzene-1,2-dicarboxylate
    • 84-72-0

  • Applications

    Ethyl phthalyl ethyl glycolate, CAS 84-72-0, is used as a fragrance-related intermediate and processing aid across multiple industries; in perfumery it may be used as a fragrance fixative or carrier to help extend aroma longevity; in cosmetics and personal care formulations it may serve as a solvent or carrier for fragrance components; in coatings and inks it may be employed as a solvent or plasticizer to modify film formation and flexibility; in polymers and plastics manufacturing it may act as a specialty plasticizer or reactive intermediate for resin formulations; and in industrial manufacturing it is commonly evaluated as an intermediate for the synthesis of fragrance ingredients and related polymeric materials.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 66.01
    methanol 118.45
    isopropanol 38.58
    water 0.47
    ethyl acetate 275.36
    n-propanol 46.2
    acetone 453.14
    n-butanol 40.52
    acetonitrile 353.27
    DMF 877.93
    toluene 174.27
    isobutanol 33.49
    1,4-dioxane 285.56
    methyl acetate 344.92
    THF 363.21
    2-butanone 300.57
    n-pentanol 41.98
    sec-butanol 48.92
    n-hexane 5.09
    ethylene glycol 17.81
    NMP 971.77
    cyclohexane 9.16
    DMSO 1009.98
    n-butyl acetate 116.23
    n-octanol 15.21
    chloroform 531.0
    n-propyl acetate 132.31
    acetic acid 211.14
    dichloromethane 969.53
    cyclohexanone 348.15
    propylene glycol 12.15
    isopropyl acetate 118.77
    DMAc 1116.86
    2-ethoxyethanol 155.42
    isopentanol 42.76
    n-heptane 3.06
    ethyl formate 121.25
    1,2-dichloroethane 697.1
    n-hexanol 28.28
    2-methoxyethanol 213.47
    isobutyl acetate 55.34
    tetrachloromethane 41.34
    n-pentyl acetate 57.98
    transcutol 268.34
    n-heptanol 16.53
    ethylbenzene 81.31
    MIBK 80.67
    2-propoxyethanol 103.02
    tert-butanol 75.97
    MTBE 98.93
    2-butoxyethanol 57.17
    propionic acid 106.31
    o-xylene 107.64
    formic acid 114.51
    diethyl ether 125.85
    m-xylene 72.68
    p-xylene 100.86
    chlorobenzene 225.91
    dimethyl carbonate 184.9
    n-octane 1.97
    formamide 387.9
    cyclopentanone 488.41
    2-pentanone 177.53
    anisole 190.48
    cyclopentyl methyl ether 164.84
    gamma-butyrolactone 692.18
    1-methoxy-2-propanol 114.45
    pyridine 511.49
    3-pentanone 202.62
    furfural 577.54
    n-dodecane 1.8
    diethylene glycol 94.8
    diisopropyl ether 27.2
    tert-amyl alcohol 79.19
    acetylacetone 311.61
    n-hexadecane 2.15
    acetophenone 217.31
    methyl propionate 277.61
    isopentyl acetate 95.77
    trichloroethylene 1167.38
    n-nonanol 16.06
    cyclohexanol 63.96
    benzyl alcohol 137.67
    2-ethylhexanol 24.11
    isooctanol 15.6
    dipropyl ether 43.21
    1,2-dichlorobenzene 209.93
    ethyl lactate 57.14
    propylene carbonate 245.11
    n-methylformamide 317.93
    2-pentanol 31.01
    n-pentane 3.94
    1-propoxy-2-propanol 63.87
    1-methoxy-2-propyl acetate 120.77
    2-(2-methoxypropoxy) propanol 88.01
    mesitylene 36.13
    ε-caprolactone 288.11
    p-cymene 29.53
    epichlorohydrin 746.27
    1,1,1-trichloroethane 318.69
    2-aminoethanol 32.3
    morpholine-4-carbaldehyde 549.83
    sulfolane 819.59
    2,2,4-trimethylpentane 3.58
    2-methyltetrahydrofuran 268.66
    n-hexyl acetate 70.16
    isooctane 1.54
    2-(2-butoxyethoxy)ethanol 87.79
    sec-butyl acetate 83.87
    tert-butyl acetate 120.42
    decalin 9.03
    glycerin 35.04
    diglyme 242.3
    acrylic acid 144.54
    isopropyl myristate 29.6
    n-butyric acid 111.45
    acetyl acetate 177.47
    di(2-ethylhexyl) phthalate 37.74
    ethyl propionate 136.91
    nitromethane 823.05
    1,2-diethoxyethane 112.79
    benzonitrile 171.36
    trioctyl phosphate 21.38
    1-bromopropane 161.93
    gamma-valerolactone 586.41
    n-decanol 12.73
    triethyl phosphate 61.26
    4-methyl-2-pentanol 19.0
    propionitrile 160.99
    vinylene carbonate 244.62
    1,1,2-trichlorotrifluoroethane 346.75
    DMS 150.06
    cumene 40.62
    2-octanol 12.66
    2-hexanone 116.46
    octyl acetate 39.55
    limonene 37.62
    1,2-dimethoxyethane 319.06
    ethyl orthosilicate 52.97
    tributyl phosphate 33.45
    diacetone alcohol 116.29
    N,N-dimethylaniline 119.37
    acrylonitrile 283.45
    aniline 178.62
    1,3-propanediol 52.14
    bromobenzene 249.48
    dibromomethane 469.5
    1,1,2,2-tetrachloroethane 722.3
    2-methyl-cyclohexyl acetate 78.11
    tetrabutyl urea 51.33
    diisobutyl methanol 17.45
    2-phenylethanol 83.23
    styrene 121.42
    dioctyl adipate 56.35
    dimethyl sulfate 376.2
    ethyl butyrate 89.54
    methyl lactate 93.73
    butyl lactate 41.0
    diethyl carbonate 79.1
    propanediol butyl ether 37.01
    triethyl orthoformate 61.81
    p-tert-butyltoluene 25.33
    methyl 4-tert-butylbenzoate 105.27
    morpholine 306.67
    tert-butylamine 36.94
    n-dodecanol 10.48
    dimethoxymethane 345.82
    ethylene carbonate 186.82
    cyrene 129.35
    2-ethoxyethyl acetate 112.4
    2-ethylhexyl acetate 78.68
    1,2,4-trichlorobenzene 267.37
    4-methylpyridine 456.2
    dibutyl ether 34.44
    2,6-dimethyl-4-heptanol 17.45
    DEF 322.52
    dimethyl isosorbide 196.55
    tetrachloroethylene 428.06
    eugenol 92.53
    triacetin 115.33
    span 80 50.28
    1,4-butanediol 26.09
    1,1-dichloroethane 365.12
    2-methyl-1-pentanol 51.0
    methyl formate 271.04
    2-methyl-1-butanol 45.23
    n-decane 2.72
    butyronitrile 103.56
    3,7-dimethyl-1-octanol 20.09
    1-chlorooctane 16.45
    1-chlorotetradecane 8.32
    n-nonane 2.39
    undecane 2.15
    tert-butylcyclohexane 5.84
    cyclooctane 3.02
    cyclopentanol 74.98
    tetrahydropyran 185.79
    tert-amyl methyl ether 101.41
    2,5,8-trioxanonane 175.19
    1-hexene 28.73
    2-isopropoxyethanol 93.13
    2,2,2-trifluoroethanol 119.18
    methyl butyrate 165.81

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction