Ethyl Glycolate

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  • Identifiers

    CAS number
    623-50-7

    Molecular formula
    C4H8O3

    SMILES
    CCOC(=O)CO

    Safety labels

    Irritant
    Irritant

  • Odor profile

    Fruity 66.86%
    Caramellic 64.88%
    Ethereal 59.91%
    Winey 49.85%
    Sweet 46.65%
    Rummy 41.5%
    Buttery 40.16%
    Fermented 36.19%
    Burnt 31.75%
    Sharp 30.92%

    Scent© AI

  • Properties

    XLogP3-AA
    -0.2

    Molecular weight
    104.1 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Very fast

    Boiling point est.
    152°C

    Flash point est.
    62.9 ˚C

  • Synonyms

    • Ethyl glycolate
    • 623-50-7
    • ethyl 2-hydroxyacetate
    • Ethyl hydroxyacetate
    • Acetic acid, hydroxy-, ethyl ester
    • Ethyl glycollate
    • GLYCOLIC ACID, ETHYL ESTER
    • Hydroxyacetic acid ethyl ester
    • MFCD00021970
    • Acetic acid, 2-hydroxy-, ethyl ester
    • NSC 8835
    • EINECS 210-798-4
    • BRN 1743766
    • C306E91WFK
    • AI3-03541
    • NSC-8835
    • 4-03-00-00580 (Beilstein Handbook Reference)
    • Glycolic Acid Ethyl Ester
    • UNII-C306E91WFK
    • ethyl-hydroxyacetate
    • Ethyl 2-Hydroxyacetate; Ethyl Hydroxyacetate; Glycolic Acid Ethyl Ester; 2-Hydroxyacetic Acid Ethyl Ester; NSC 8835
    • Ethyl glycolate, 98%
    • HOCH2COOC2H5
    • SCHEMBL5075
    • hydroxyacetic acid ethylester
    • WLN: Q1VO2
    • hydroxy acetic acid ethyl ester
    • hydroxy-acetic acid ethyl ester
    • DTXSID5060772
    • ZANNOFHADGWOLI-UHFFFAOYSA-
    • NSC8835
    • 2-hydroxy-acetic acid ethyl ester
    • Acetic acid, hydroxy, ethyl ester
    • Acetic acid, 2hydroxy, ethyl ester
    • AKOS009157950
    • CS-W019892
    • AS-17295
    • BP-21252
    • SY002762
    • DB-001024
    • G0242
    • NS00022536
    • EN300-42326
    • Q27275115
    • F0001-1672
    • Z385458066
    • InChI=1/C4H8O3/c1-2-7-4(6)3-5/h5H,2-3H2,1H3

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 328.4
    methanol 789.16
    isopropanol 196.29
    water 90.53
    ethyl acetate 189.05
    n-propanol 222.96
    acetone 478.12
    n-butanol 169.75
    acetonitrile 577.07
    DMF 1293.88
    toluene 31.59
    isobutanol 133.29
    1,4-dioxane 461.19
    methyl acetate 252.56
    THF 378.98
    2-butanone 233.97
    n-pentanol 128.18
    sec-butanol 147.25
    n-hexane 11.97
    ethylene glycol 358.54
    NMP 806.03
    cyclohexane 13.9
    DMSO 1912.96
    n-butyl acetate 94.48
    n-octanol 63.16
    chloroform 181.58
    n-propyl acetate 107.6
    acetic acid 657.26
    dichloromethane 352.57
    cyclohexanone 252.97
    propylene glycol 174.7
    isopropyl acetate 89.63
    DMAc 696.15
    2-ethoxyethanol 388.96
    isopentanol 116.88
    n-heptane 9.76
    ethyl formate 262.89
    1,2-dichloroethane 309.82
    n-hexanol 86.97
    2-methoxyethanol 716.74
    isobutyl acetate 48.12
    tetrachloromethane 34.98
    n-pentyl acetate 71.31
    transcutol 499.97
    n-heptanol 45.63
    ethylbenzene 27.24
    MIBK 90.45
    2-propoxyethanol 232.84
    tert-butanol 239.32
    MTBE 139.58
    2-butoxyethanol 117.26
    propionic acid 296.87
    o-xylene 38.93
    formic acid 797.86
    diethyl ether 162.3
    m-xylene 29.96
    p-xylene 37.91
    chlorobenzene 89.51
    dimethyl carbonate 100.7
    n-octane 5.96
    formamide 822.21
    cyclopentanone 355.12
    2-pentanone 167.56
    anisole 107.15
    cyclopentyl methyl ether 130.25
    gamma-butyrolactone 516.4
    1-methoxy-2-propanol 342.78
    pyridine 216.37
    3-pentanone 133.57
    furfural 585.03
    n-dodecane 6.05
    diethylene glycol 316.12
    diisopropyl ether 34.63
    tert-amyl alcohol 180.39
    acetylacetone 224.67
    n-hexadecane 6.58
    acetophenone 112.65
    methyl propionate 187.07
    isopentyl acetate 74.28
    trichloroethylene 351.31
    n-nonanol 53.13
    cyclohexanol 118.76
    benzyl alcohol 120.32
    2-ethylhexanol 52.7
    isooctanol 38.76
    dipropyl ether 56.52
    1,2-dichlorobenzene 104.73
    ethyl lactate 90.08
    propylene carbonate 211.36
    n-methylformamide 696.58
    2-pentanol 95.14
    n-pentane 12.98
    1-propoxy-2-propanol 129.65
    1-methoxy-2-propyl acetate 104.21
    2-(2-methoxypropoxy) propanol 135.35
    mesitylene 24.46
    ε-caprolactone 245.51
    p-cymene 26.02
    epichlorohydrin 472.99
    1,1,1-trichloroethane 114.87
    2-aminoethanol 340.27
    morpholine-4-carbaldehyde 682.2
    sulfolane 784.49
    2,2,4-trimethylpentane 9.93
    2-methyltetrahydrofuran 226.21
    n-hexyl acetate 103.04
    isooctane 6.36
    2-(2-butoxyethoxy)ethanol 184.18
    sec-butyl acetate 53.64
    tert-butyl acetate 98.4
    decalin 10.85
    glycerin 352.89
    diglyme 352.52
    acrylic acid 355.93
    isopropyl myristate 38.9
    n-butyric acid 260.93
    acetyl acetate 119.71
    di(2-ethylhexyl) phthalate 51.28
    ethyl propionate 101.77
    nitromethane 1205.07
    1,2-diethoxyethane 144.92
    benzonitrile 176.21
    trioctyl phosphate 38.42
    1-bromopropane 105.7
    gamma-valerolactone 553.61
    n-decanol 40.79
    triethyl phosphate 53.75
    4-methyl-2-pentanol 51.61
    propionitrile 274.87
    vinylene carbonate 241.55
    1,1,2-trichlorotrifluoroethane 388.85
    DMS 107.15
    cumene 25.79
    2-octanol 37.92
    2-hexanone 110.95
    octyl acetate 54.55
    limonene 39.77
    1,2-dimethoxyethane 521.4
    ethyl orthosilicate 48.16
    tributyl phosphate 50.81
    diacetone alcohol 158.52
    N,N-dimethylaniline 85.65
    acrylonitrile 439.26
    aniline 95.31
    1,3-propanediol 351.13
    bromobenzene 70.82
    dibromomethane 188.27
    1,1,2,2-tetrachloroethane 280.58
    2-methyl-cyclohexyl acetate 58.7
    tetrabutyl urea 75.34
    diisobutyl methanol 35.67
    2-phenylethanol 80.51
    styrene 39.44
    dioctyl adipate 70.39
    dimethyl sulfate 256.73
    ethyl butyrate 78.45
    methyl lactate 164.27
    butyl lactate 72.6
    diethyl carbonate 59.69
    propanediol butyl ether 129.3
    triethyl orthoformate 58.8
    p-tert-butyltoluene 25.39
    methyl 4-tert-butylbenzoate 102.58
    morpholine 455.46
    tert-butylamine 121.16
    n-dodecanol 32.66
    dimethoxymethane 407.38
    ethylene carbonate 191.74
    cyrene 150.44
    2-ethoxyethyl acetate 110.88
    2-ethylhexyl acetate 55.85
    1,2,4-trichlorobenzene 117.52
    4-methylpyridine 203.05
    dibutyl ether 55.74
    2,6-dimethyl-4-heptanol 35.67
    DEF 315.76
    dimethyl isosorbide 209.86
    tetrachloroethylene 197.37
    eugenol 121.85
    triacetin 113.06
    span 80 109.04
    1,4-butanediol 188.81
    1,1-dichloroethane 163.81
    2-methyl-1-pentanol 102.96
    methyl formate 527.39
    2-methyl-1-butanol 120.53
    n-decane 8.95
    butyronitrile 225.17
    3,7-dimethyl-1-octanol 57.43
    1-chlorooctane 32.36
    1-chlorotetradecane 15.9
    n-nonane 8.75
    undecane 7.01
    tert-butylcyclohexane 10.68
    cyclooctane 6.58
    cyclopentanol 159.27
    tetrahydropyran 203.34
    tert-amyl methyl ether 109.87
    2,5,8-trioxanonane 271.99
    1-hexene 38.7
    2-isopropoxyethanol 189.41
    2,2,2-trifluoroethanol 277.85
    methyl butyrate 161.86

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction