Ethyl glutamate

Overview IFRA Request a quote

  • Identifiers

    CAS number
    1119-33-1

    Molecular formula
    C7H13NO4

    SMILES
    CCOC(=O)CC[C@@H](C(=O)O)N

    Safety labels

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Fruity 50.96%
    Sweet 40.27%
    Odorless 38.41%
    Winey 32.86%
    Caramellic 31.53%
    Buttery 27.61%
    Grape 23.95%
    Savory 22.84%
    Milky 22.73%
    Ethereal 20.76%

     

    Flavor
    Odorless 51.54%
    Fruity 42.61%
    Mild 34.45%
    Very mild 28.54%
    Bland 24.79%
    Yeast 24.64%
    Sour 22.78%
    Sweet-like 22.38%
    Grape 22.14%
    Marshmallow 20.94%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    -3.0

    pKa est.
    5.83 (weak acid)

    Molecular weight
    175.18 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    306°C

    Flash point

    • 155.66 ˚C est.

  • Synonyms

    • 1119-33-1
    • L-Glutamic acid 5-ethyl ester
    • Ethyl glutamate
    • L-Glutamic acid gamma-ethyl ester
    • gamma-Ethylglutamate
    • ethyl l-glutamate
    • UNII-3EC85NWR4K
    • 3EC85NWR4K
    • .gamma.-Ethylglutamate
    • DTXSID901018766
    • EINECS 214-274-6
    • Ethyl .gamma.-L-glutamate
    • .GAMMA.-ETHYL GLUTAMATE
    • 5-ETHYL GLUTAMATE, L-
    • .GAMMA.-MONOETHYL GLUTAMATE
    • Glutamic acid, 5-O-ethyl (ester)
    • L-Glutamic acid .gamma.-ethyl ester
    • L-Glutamic acid-.gamma.-ethyl ester
    • NSC-16885
    • NSC-156977
    • L-GLUTAMIC ACID 5-ETHYL ESTER [MI]
    • L-GLUTAMIC ACID 5-ETHYL ESTER [WHO-DD]
    • Ethyl gamma-L-glutamate
    • gamma-ethyl glutamate
    • RefChem:138936
    • ETHYL GLUTAMATE [INCI]
    • GAMMA-MONOETHYL GLUTAMATE
    • L-Glutamic acid-gamma-ethyl ester
    • DTXCID001476789
    • 214-274-6
    • XMQUEQJCYRFIQS-YFKPBYRVSA-N
    • h-glu(oet)-oh
    • (2S)-2-amino-5-ethoxy-5-oxopentanoic acid
    • L-GLUTAMIC ACID, 5-ETHYL ESTER
    • 5-Ethyl-L-glutamate
    • 5-Ethyl L-Glutamate
    • MFCD00037217
    • Glutamic acid, 5-ethyl ester, L-
    • NSC 16885
    • .gamma.-Ethyl L-glutamate
    • NSC 156977
    • Glutamic acid gamma-ethyl ester
    • EGLU amino acid
    • (S)-2-Amino-5-ethoxy-5-oxopentanoic acid
    • alpha-ethylglutamic acid
    • gamma-Ethyl L-glutamate
    • Ethyl hydrogen L-glutamate
    • L-Glutamate-.gamma.-ethyl ester
    • Glutamic acid .gamma.-ethyl ester
    • L-Glutamate-gamma-ethyl ester
    • 25189-52-0
    • Pemetrexed Impurity 76
    • Poly(gamma-ethyl glutamate)
    • L-Glutamic acid-5-ethylester
    • SCHEMBL374739
    • Poly(gamma-ethyl L-glutamate)
    • L-glutamic acid-5-ethyl ester
    • orb1697267
    • CHEMBL4062406
    • CHEBI:234576
    • Glutamic acid gamma-monoethyl ester
    • L-Glutamic acid gamma -ethyl ester
    • NSC823863
    • AKOS006237182
    • FD21427
    • NSC-823863
    • Poly(L-glutamic acid gamma-ethyl ester)
    • AS-17275
    • SY015381
    • CS-0085963
    • E1155
    • L-Glutamic acid, 5-ethyl ester, homopolymer
    • NS00081363
    • (2S)-2-amino-5-ethoxy-5-oxo-pentanoic acid
    • EN300-187122
    • 119G331
    • F045347
    • Q27257110
    • 1119-33-1

  • Applications

    Ethyl glutamate is the ethyl ester of glutamic acid and is typically used as an intermediate in chemical and pharmaceutical manufacturing; it commonly serves as a chiral building block for amino acid derivatives and peptidomimetics; it also acts as a precursor to glutamate-derived compounds in the agricultural sector; it participates in polymer chemistry as a monomer or modifier for amino-acid–based polymers and biodegradable polyesters; and in research and development settings it is used as a reagent for protecting and transforming amino groups in synthetic sequences.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 6.23
    methanol 36.99
    isopropanol 2.7
    water 237.15
    ethyl acetate 2.33
    n-propanol 3.04
    acetone 5.73
    n-butanol 2.92
    acetonitrile 2.16
    DMF 245.67
    toluene 1.05
    isobutanol 3.06
    1,4-dioxane 6.62
    methyl acetate 2.42
    THF 11.46
    2-butanone 2.9
    n-pentanol 2.48
    sec-butanol 2.57
    n-hexane 0.37
    ethylene glycol 42.5
    NMP 300.4
    cyclohexane 0.34
    DMSO 476.31
    n-butyl acetate 2.15
    n-octanol 1.78
    chloroform 1.34
    n-propyl acetate 1.93
    acetic acid 84.97
    dichloromethane 2.59
    cyclohexanone 14.79
    propylene glycol 29.39
    isopropyl acetate 2.23
    DMAc 197.02
    2-ethoxyethanol 25.15
    isopentanol 4.12
    n-heptane 0.27
    ethyl formate 8.4
    1,2-dichloroethane 2.6
    n-hexanol 2.08
    2-methoxyethanol 53.18
    isobutyl acetate 1.18
    tetrachloromethane 0.59
    n-pentyl acetate 2.27
    transcutol 62.45
    n-heptanol 1.95
    ethylbenzene 1.15
    MIBK 3.45
    2-propoxyethanol 13.71
    tert-butanol 7.95
    MTBE 2.43
    2-butoxyethanol 8.93
    propionic acid 18.0
    o-xylene 2.66
    formic acid 314.63
    diethyl ether 0.8
    m-xylene 1.71
    p-xylene 1.7
    chlorobenzene 1.41
    dimethyl carbonate 7.3
    n-octane 0.16
    formamide 222.44
    cyclopentanone 22.27
    2-pentanone 3.12
    anisole 4.05
    cyclopentyl methyl ether 5.08
    gamma-butyrolactone 43.94
    1-methoxy-2-propanol 26.67
    pyridine 6.09
    3-pentanone 2.94
    furfural 72.16
    n-dodecane 0.1
    diethylene glycol 37.33
    diisopropyl ether 0.69
    tert-amyl alcohol 8.17
    acetylacetone 12.03
    n-hexadecane 0.12
    acetophenone 8.85
    methyl propionate 4.48
    isopentyl acetate 2.75
    trichloroethylene 5.1
    n-nonanol 1.81
    cyclohexanol 4.86
    benzyl alcohol 7.86
    2-ethylhexanol 1.76
    isooctanol 1.98
    dipropyl ether 1.23
    1,2-dichlorobenzene 2.65
    ethyl lactate 8.09
    propylene carbonate 21.03
    n-methylformamide 70.67
    2-pentanol 1.81
    n-pentane 0.22
    1-propoxy-2-propanol 8.21
    1-methoxy-2-propyl acetate 7.06
    2-(2-methoxypropoxy) propanol 20.67
    mesitylene 1.63
    ε-caprolactone 17.93
    p-cymene 1.18
    epichlorohydrin 15.19
    1,1,1-trichloroethane 1.08
    2-aminoethanol 39.38
    morpholine-4-carbaldehyde 125.95
    sulfolane 171.59
    2,2,4-trimethylpentane 0.3
    2-methyltetrahydrofuran 5.08
    n-hexyl acetate 3.3
    isooctane 0.16
    2-(2-butoxyethoxy)ethanol 22.36
    sec-butyl acetate 1.4
    tert-butyl acetate 4.2
    decalin 0.36
    glycerin 91.39
    diglyme 36.76
    acrylic acid 37.62
    isopropyl myristate 1.45
    n-butyric acid 14.33
    acetyl acetate 4.47
    di(2-ethylhexyl) phthalate 5.63
    ethyl propionate 2.52
    nitromethane 80.96
    1,2-diethoxyethane 3.71
    benzonitrile 4.62
    trioctyl phosphate 3.12
    1-bromopropane 0.61
    gamma-valerolactone 67.68
    n-decanol 1.39
    triethyl phosphate 3.92
    4-methyl-2-pentanol 2.01
    propionitrile 1.58
    vinylene carbonate 21.7
    1,1,2-trichlorotrifluoroethane 49.73
    DMS 6.65
    cumene 1.27
    2-octanol 1.2
    2-hexanone 2.28
    octyl acetate 2.13
    limonene 1.59
    1,2-dimethoxyethane 26.51
    ethyl orthosilicate 3.15
    tributyl phosphate 3.88
    diacetone alcohol 16.0
    N,N-dimethylaniline 6.54
    acrylonitrile 4.82
    aniline 4.12
    1,3-propanediol 28.1
    bromobenzene 1.08
    dibromomethane 1.25
    1,1,2,2-tetrachloroethane 4.94
    2-methyl-cyclohexyl acetate 3.99
    tetrabutyl urea 7.46
    diisobutyl methanol 1.59
    2-phenylethanol 4.59
    styrene 1.13
    dioctyl adipate 4.12
    dimethyl sulfate 39.04
    ethyl butyrate 2.41
    methyl lactate 20.39
    butyl lactate 7.31
    diethyl carbonate 2.35
    propanediol butyl ether 19.44
    triethyl orthoformate 3.04
    p-tert-butyltoluene 1.2
    methyl 4-tert-butylbenzoate 13.08
    morpholine 10.43
    tert-butylamine 2.91
    n-dodecanol 1.07
    dimethoxymethane 22.83
    ethylene carbonate 13.35
    cyrene 37.68
    2-ethoxyethyl acetate 5.58
    2-ethylhexyl acetate 2.04
    1,2,4-trichlorobenzene 3.87
    4-methylpyridine 7.29
    dibutyl ether 1.1
    2,6-dimethyl-4-heptanol 1.59
    DEF 19.77
    dimethyl isosorbide 30.63
    tetrachloroethylene 4.54
    eugenol 15.13
    triacetin 10.71
    span 80 16.1
    1,4-butanediol 15.73
    1,1-dichloroethane 0.83
    2-methyl-1-pentanol 3.59
    methyl formate 50.06
    2-methyl-1-butanol 4.23
    n-decane 0.17
    butyronitrile 1.79
    3,7-dimethyl-1-octanol 2.01
    1-chlorooctane 0.5
    1-chlorotetradecane 0.27
    n-nonane 0.16
    undecane 0.13
    tert-butylcyclohexane 0.31
    cyclooctane 0.24
    cyclopentanol 6.7
    tetrahydropyran 1.9
    tert-amyl methyl ether 3.27
    2,5,8-trioxanonane 35.09
    1-hexene 0.62
    2-isopropoxyethanol 10.73
    2,2,2-trifluoroethanol 41.93
    methyl butyrate 4.8

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction