Ethyl diphenylglycolate

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  • Identifiers

    CAS number
    52182-15-7

    Molecular formula
    C16H16O3

    SMILES
    CCOC(=O)C(C1=CC=CC=C1)(C2=CC=CC=C2)O

    Safety labels

    Corrosive
    Corrosive

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Sweet 59.07%
    Balsamic 54.15%
    Honey 47.49%
    Fruity 47.09%
    Floral 46.28%
    Rose 37.83%
    Powdery 35.99%
    Spicy 33.82%
    Vanilla 33.5%
    Green 30.81%

     

    Flavor
    Bitter 46.4%
    Sweet 43.61%
    Fruity 40.33%
    Balsam 37.45%
    Rose 29.79%
    Floral 29.48%
    Honey 27.91%
    Mild 26.48%
    Peach 23.97%
    Odorless 23.9%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    3.0

    pKa est.
    6.82 (neutral)

    Molecular weight
    256.3 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    336°C

    Flash point

    • 162.8 ˚C est.

  • Synonyms

    • Ethyl benzilate
    • 52182-15-7
    • Benzilic Acid Ethyl Ester
    • ethyl 2-hydroxy-2,2-diphenylacetate
    • Ethyl diphenylglycolate
    • Ethyl benzillate
    • EINECS 257-713-7
    • DTXSID10200211
    • NSC 62707
    • NSC-62707
    • Benzeneacetic acid, .alpha.-hydroxy-.alpha.-phenyl-, ethyl ester
    • Benzilsaureethylester
    • MFCD00016850
    • 7CFR9ZJ7RE
    • Benzilic acid, ethyl ester
    • SCHEMBL2763579
    • Ethyl hydroxy(diphenyl)acetate #
    • Diphenylglycolic Acid Ethyl Ester
    • DTXCID10122702
    • NSC62707
    • AKOS024287625
    • FE71296
    • AS-62244
    • DB-052086
    • CS-0314004
    • E0747
    • NS00032443
    • D90561
    • Benzeneacetic acid, alpha-hydroxy-alpha-phenyl-, ethyl ester
    • 257-713-7

  • Applications

    Ethyl diphenylglycolate (CAS 52182-15-7) is primarily used in perfumery as a fragrance fixative to extend and stabilize aroma notes. It is commonly employed as a fragrance ingredient in cosmetics and personal care formulations, contributing to scent retention in lotions, creams, and fragrances. In household products, it can function as a fragrance component in air fresheners, cleaners, and laundry products. In the polymer and plastics sector, it may be evaluated as a plasticizer or processing aid and can serve as an intermediate in the synthesis of other fragrance-related compounds. Its exact use is subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 91.74
    methanol 89.39
    isopropanol 60.97
    water 0.11
    ethyl acetate 150.17
    n-propanol 90.91
    acetone 347.82
    n-butanol 79.05
    acetonitrile 149.34
    DMF 780.6
    toluene 141.21
    isobutanol 65.09
    1,4-dioxane 321.53
    methyl acetate 225.93
    THF 455.06
    2-butanone 302.09
    n-pentanol 62.64
    sec-butanol 74.58
    n-hexane 9.29
    ethylene glycol 18.3
    NMP 539.38
    cyclohexane 41.23
    DMSO 240.97
    n-butyl acetate 114.78
    n-octanol 63.9
    chloroform 628.04
    n-propyl acetate 97.97
    acetic acid 116.35
    dichloromethane 583.94
    cyclohexanone 551.4
    propylene glycol 22.0
    isopropyl acetate 96.06
    DMAc 566.88
    2-ethoxyethanol 87.67
    isopentanol 64.62
    n-heptane 11.45
    ethyl formate 141.58
    1,2-dichloroethane 565.93
    n-hexanol 85.67
    2-methoxyethanol 162.73
    isobutyl acetate 66.09
    tetrachloromethane 54.47
    n-pentyl acetate 111.24
    transcutol 168.03
    n-heptanol 71.5
    ethylbenzene 75.3
    MIBK 98.51
    2-propoxyethanol 115.36
    tert-butanol 78.24
    MTBE 90.55
    2-butoxyethanol 102.32
    propionic acid 111.59
    o-xylene 85.18
    formic acid 32.9
    diethyl ether 131.95
    m-xylene 70.09
    p-xylene 89.88
    chlorobenzene 311.37
    dimethyl carbonate 135.36
    n-octane 10.59
    formamide 106.39
    cyclopentanone 585.63
    2-pentanone 208.18
    anisole 134.28
    cyclopentyl methyl ether 154.25
    gamma-butyrolactone 489.95
    1-methoxy-2-propanol 108.68
    pyridine 542.9
    3-pentanone 201.87
    furfural 403.49
    n-dodecane 8.66
    diethylene glycol 75.65
    diisopropyl ether 31.85
    tert-amyl alcohol 82.48
    acetylacetone 222.77
    n-hexadecane 10.16
    acetophenone 164.55
    methyl propionate 178.8
    isopentyl acetate 98.51
    trichloroethylene 999.09
    n-nonanol 59.97
    cyclohexanol 120.5
    benzyl alcohol 120.34
    2-ethylhexanol 54.8
    isooctanol 53.4
    dipropyl ether 60.02
    1,2-dichlorobenzene 260.68
    ethyl lactate 51.69
    propylene carbonate 244.86
    n-methylformamide 243.57
    2-pentanol 50.28
    n-pentane 10.13
    1-propoxy-2-propanol 76.58
    1-methoxy-2-propyl acetate 100.15
    2-(2-methoxypropoxy) propanol 72.5
    mesitylene 45.08
    ε-caprolactone 324.32
    p-cymene 42.21
    epichlorohydrin 549.52
    1,1,1-trichloroethane 306.2
    2-aminoethanol 42.77
    morpholine-4-carbaldehyde 364.68
    sulfolane 449.1
    2,2,4-trimethylpentane 7.68
    2-methyltetrahydrofuran 234.66
    n-hexyl acetate 134.72
    isooctane 5.03
    2-(2-butoxyethoxy)ethanol 96.95
    sec-butyl acetate 65.55
    tert-butyl acetate 90.24
    decalin 17.28
    glycerin 37.72
    diglyme 220.15
    acrylic acid 114.54
    isopropyl myristate 48.6
    n-butyric acid 142.6
    acetyl acetate 110.98
    di(2-ethylhexyl) phthalate 50.64
    ethyl propionate 91.69
    nitromethane 307.7
    1,2-diethoxyethane 100.65
    benzonitrile 184.57
    trioctyl phosphate 37.55
    1-bromopropane 190.31
    gamma-valerolactone 519.29
    n-decanol 43.94
    triethyl phosphate 47.61
    4-methyl-2-pentanol 32.42
    propionitrile 164.52
    vinylene carbonate 259.22
    1,1,2-trichlorotrifluoroethane 261.96
    DMS 119.8
    cumene 46.71
    2-octanol 56.82
    2-hexanone 128.43
    octyl acetate 63.69
    limonene 57.09
    1,2-dimethoxyethane 230.72
    ethyl orthosilicate 42.8
    tributyl phosphate 39.02
    diacetone alcohol 109.77
    N,N-dimethylaniline 84.96
    acrylonitrile 247.46
    aniline 152.85
    1,3-propanediol 67.82
    bromobenzene 290.77
    dibromomethane 384.44
    1,1,2,2-tetrachloroethane 719.91
    2-methyl-cyclohexyl acetate 75.58
    tetrabutyl urea 66.82
    diisobutyl methanol 30.52
    2-phenylethanol 110.4
    styrene 104.38
    dioctyl adipate 70.32
    dimethyl sulfate 178.61
    ethyl butyrate 78.36
    methyl lactate 84.17
    butyl lactate 74.65
    diethyl carbonate 62.11
    propanediol butyl ether 70.35
    triethyl orthoformate 58.85
    p-tert-butyltoluene 38.96
    methyl 4-tert-butylbenzoate 111.43
    morpholine 334.57
    tert-butylamine 47.23
    n-dodecanol 33.57
    dimethoxymethane 273.3
    ethylene carbonate 211.09
    cyrene 108.6
    2-ethoxyethyl acetate 118.62
    2-ethylhexyl acetate 83.73
    1,2,4-trichlorobenzene 260.69
    4-methylpyridine 376.99
    dibutyl ether 68.5
    2,6-dimethyl-4-heptanol 30.52
    DEF 294.64
    dimethyl isosorbide 136.82
    tetrachloroethylene 441.58
    eugenol 103.67
    triacetin 96.56
    span 80 67.32
    1,4-butanediol 28.02
    1,1-dichloroethane 369.28
    2-methyl-1-pentanol 63.79
    methyl formate 202.42
    2-methyl-1-butanol 73.36
    n-decane 14.75
    butyronitrile 146.53
    3,7-dimethyl-1-octanol 44.8
    1-chlorooctane 57.34
    1-chlorotetradecane 23.78
    n-nonane 13.3
    undecane 10.92
    tert-butylcyclohexane 12.78
    cyclooctane 11.78
    cyclopentanol 126.95
    tetrahydropyran 312.18
    tert-amyl methyl ether 79.64
    2,5,8-trioxanonane 140.82
    1-hexene 42.67
    2-isopropoxyethanol 64.76
    2,2,2-trifluoroethanol 49.87
    methyl butyrate 140.37

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction