Ethyl Dihydrogen Phosphate

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  • Identifiers

    CAS number
    1623-14-9

    Molecular formula
    C2H7O4P

    SMILES
    CCOP(=O)(O)O

  • Odor profile

    Fragrance
    Odorless 60.0%
    Fresh 23.71%
    Sour 23.21%
    Fruity 23.04%
    Ethereal 21.62%
    Sharp 20.97%
    Green 20.44%
    Pungent 18.17%
    Alcoholic 16.87%
    Winey 16.65%

     

    Flavor
    Odorless 54.41%
    Sour 40.08%
    Pungent 33.95%
    Sharp 33.24%
    Rancid 31.11%
    Vinegar 31.09%
    Acidic 30.4%
    Cheese 26.05%
    Sweat 23.81%
    Soy 23.5%

     

    Odor impact est.
    Medium

  • Properties

    XLogP3-AA
    -1.2

    pKa est.
    8.78 (weak base)

    Molecular weight
    126.05 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    268°C

    Melting point expt.

    • -56.4 °C

    Flash point

    • 127.57 ˚C est.

  • Synonyms

    • Ethyl dihydrogen phosphate
    • Monoethyl phosphate
    • 1623-14-9
    • Monoethyl acid phosphate
    • O-Ethyl dihydrogen phosphate
    • PHOSPHORIC ACID, MONOETHYL ESTER
    • Phosphoric acid monoethyl ester
    • Ethyl phosphate, mono-
    • EINECS 216-603-9
    • BMH1WT204A
    • ethoxyphosphonic acid
    • BRN 1702252
    • CHEBI:42383
    • AI3-15046
    • Ethyl phosphate ((eto)(ho)2po)
    • DTXSID70862718
    • Ethyl Dihydrogen Phosphate;
    • EFS
    • UNII-BMH1WT204A
    • ethanol-phosphate
    • EP, organic acid
    • mono-ethyl phosphate
    • ethyl dihydrogenphosphate
    • Epitope ID:143619
    • SCHEMBL40792
    • DTXCID70197719
    • MFCD00045735
    • AKOS006230103
    • DB03822
    • FE152839
    • NS00069984
    • EN300-7577245
    • Q23994379
    • 216-603-9
    • ATJ

  • Applications

    Ethyl Dihydrogen Phosphate (CAS 1623-14-9) is a phosphorus-containing ester used primarily as an intermediate in the synthesis of phosphate esters. In industry, it acts as a phosphorylation reagent to convert alcohols to phosphate esters and serves as a building block for phosphate-containing polymers and crosslinking agents used in coatings, inks, and adhesives. It can function as an acid source or buffering component in various industrial formulations. It may be used as a precursor to derivative phosphate esters for specialty polymers and ceramics after processing.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 183.98
    methanol 313.34
    isopropanol 114.98
    water 397.18
    ethyl acetate 22.85
    n-propanol 99.81
    acetone 116.01
    n-butanol 80.92
    acetonitrile 28.36
    DMF 420.03
    toluene 9.99
    isobutanol 53.11
    1,4-dioxane 82.15
    methyl acetate 23.39
    THF 206.07
    2-butanone 43.12
    n-pentanol 52.02
    sec-butanol 64.48
    n-hexane 3.92
    ethylene glycol 203.05
    NMP 305.18
    cyclohexane 4.74
    DMSO 629.02
    n-butyl acetate 16.37
    n-octanol 26.77
    chloroform 6.5
    n-propyl acetate 15.19
    acetic acid 115.29
    dichloromethane 13.3
    cyclohexanone 66.7
    propylene glycol 147.54
    isopropyl acetate 20.57
    DMAc 186.14
    2-ethoxyethanol 189.51
    isopentanol 53.71
    n-heptane 4.34
    ethyl formate 42.81
    1,2-dichloroethane 18.79
    n-hexanol 40.87
    2-methoxyethanol 386.96
    isobutyl acetate 6.42
    tetrachloromethane 2.81
    n-pentyl acetate 20.05
    transcutol 148.12
    n-heptanol 32.32
    ethylbenzene 5.04
    MIBK 32.74
    2-propoxyethanol 144.09
    tert-butanol 127.61
    MTBE 29.77
    2-butoxyethanol 81.36
    propionic acid 54.15
    o-xylene 12.14
    formic acid 249.51
    diethyl ether 39.32
    m-xylene 11.67
    p-xylene 5.46
    chlorobenzene 7.38
    dimethyl carbonate 25.39
    n-octane 2.19
    formamide 349.44
    cyclopentanone 125.03
    2-pentanone 54.49
    anisole 18.13
    cyclopentyl methyl ether 66.55
    gamma-butyrolactone 128.39
    1-methoxy-2-propanol 254.59
    pyridine 34.01
    3-pentanone 27.19
    furfural 148.1
    n-dodecane 1.62
    diethylene glycol 202.56
    diisopropyl ether 12.15
    tert-amyl alcohol 71.58
    acetylacetone 64.48
    n-hexadecane 1.75
    acetophenone 22.25
    methyl propionate 30.81
    isopentyl acetate 13.36
    trichloroethylene 16.32
    n-nonanol 23.97
    cyclohexanol 53.38
    benzyl alcohol 32.58
    2-ethylhexanol 16.39
    isooctanol 22.09
    dipropyl ether 20.11
    1,2-dichlorobenzene 7.97
    ethyl lactate 28.63
    propylene carbonate 45.7
    n-methylformamide 207.95
    2-pentanol 51.6
    n-pentane 6.15
    1-propoxy-2-propanol 78.54
    1-methoxy-2-propyl acetate 30.48
    2-(2-methoxypropoxy) propanol 57.1
    mesitylene 10.52
    ε-caprolactone 54.14
    p-cymene 6.1
    epichlorohydrin 93.16
    1,1,1-trichloroethane 5.92
    2-aminoethanol 225.48
    morpholine-4-carbaldehyde 239.1
    sulfolane 247.68
    2,2,4-trimethylpentane 2.26
    2-methyltetrahydrofuran 79.21
    n-hexyl acetate 23.17
    isooctane 2.15
    2-(2-butoxyethoxy)ethanol 87.29
    sec-butyl acetate 9.54
    tert-butyl acetate 29.0
    decalin 2.06
    glycerin 289.45
    diglyme 126.28
    acrylic acid 63.45
    isopropyl myristate 10.78
    n-butyric acid 56.23
    acetyl acetate 14.0
    di(2-ethylhexyl) phthalate 16.31
    ethyl propionate 15.37
    nitromethane 146.48
    1,2-diethoxyethane 29.54
    benzonitrile 15.98
    trioctyl phosphate 13.59
    1-bromopropane 9.63
    gamma-valerolactone 188.54
    n-decanol 18.15
    triethyl phosphate 10.41
    4-methyl-2-pentanol 27.16
    propionitrile 17.0
    vinylene carbonate 36.75
    1,1,2-trichlorotrifluoroethane 84.77
    DMS 15.17
    cumene 5.21
    2-octanol 21.25
    2-hexanone 22.08
    octyl acetate 15.89
    limonene 9.19
    1,2-dimethoxyethane 153.79
    ethyl orthosilicate 9.86
    tributyl phosphate 12.58
    diacetone alcohol 80.55
    N,N-dimethylaniline 21.73
    acrylonitrile 25.38
    aniline 32.19
    1,3-propanediol 215.52
    bromobenzene 4.74
    dibromomethane 9.15
    1,1,2,2-tetrachloroethane 17.56
    2-methyl-cyclohexyl acetate 13.96
    tetrabutyl urea 23.79
    diisobutyl methanol 13.1
    2-phenylethanol 27.23
    styrene 5.32
    dioctyl adipate 16.99
    dimethyl sulfate 72.31
    ethyl butyrate 14.77
    methyl lactate 65.13
    butyl lactate 28.35
    diethyl carbonate 8.75
    propanediol butyl ether 79.11
    triethyl orthoformate 12.9
    p-tert-butyltoluene 6.6
    methyl 4-tert-butylbenzoate 41.66
    morpholine 132.7
    tert-butylamine 53.32
    n-dodecanol 13.33
    dimethoxymethane 182.35
    ethylene carbonate 30.3
    cyrene 67.08
    2-ethoxyethyl acetate 26.89
    2-ethylhexyl acetate 9.56
    1,2,4-trichlorobenzene 8.98
    4-methylpyridine 36.04
    dibutyl ether 12.36
    2,6-dimethyl-4-heptanol 13.1
    DEF 75.69
    dimethyl isosorbide 79.92
    tetrachloroethylene 14.15
    eugenol 49.58
    triacetin 23.81
    span 80 50.7
    1,4-butanediol 101.31
    1,1-dichloroethane 8.43
    2-methyl-1-pentanol 30.74
    methyl formate 133.44
    2-methyl-1-butanol 44.88
    n-decane 2.6
    butyronitrile 23.55
    3,7-dimethyl-1-octanol 18.03
    1-chlorooctane 7.12
    1-chlorotetradecane 3.58
    n-nonane 2.53
    undecane 2.01
    tert-butylcyclohexane 1.94
    cyclooctane 2.88
    cyclopentanol 89.6
    tetrahydropyran 46.35
    tert-amyl methyl ether 28.97
    2,5,8-trioxanonane 101.91
    1-hexene 7.32
    2-isopropoxyethanol 89.55
    2,2,2-trifluoroethanol 60.01
    methyl butyrate 22.71

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction