Ethyl diethoxyacetate

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  • Identifiers

    CAS number
    6065-82-3

    Molecular formula
    C8H16O4

    SMILES
    CCOC(C(=O)OCC)OCC

    Safety labels

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Fruity 88.7%
    Ethereal 49.18%
    Caramellic 34.6%
    Apple 32.36%
    Sweet 31.53%
    Winey 31.38%
    Herbal 29.81%
    Buttery 29.59%
    Fresh 28.35%
    Rummy 25.71%

     

    Flavor
    Fruity 76.96%
    Green 42.64%
    Fruit 40.03%
    Fatty 39.81%
    Sweet 37.18%
    Creamy 34.45%
    Pineapple 32.88%
    Wine 32.87%
    Tropical 32.8%
    Waxy 31.4%

     

    Odor impact est.
    Medium

  • Properties

    XLogP3-AA
    1.1

    pKa est.
    6.57 (neutral)

    Molecular weight
    176.21 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Moderately fast

    Boiling point est.
    197°C

    Flash point

    • 63.81 ˚C est.

  • Synonyms

    • Ethyl diethoxyacetate
    • Acetic acid, diethoxy-, ethyl ester
    • Diethoxyacetic acid ethyl ester
    • EINECS 227-999-8
    • ACETIC ACID,DIETHOXY,ETHYL ESTER
    • Acetic acid, 2,2-diethoxy-, ethyl ester
    • DTXSID2064101
    • RefChem:138916
    • DTXCID2042854
    • 227-999-8
    • InChI=1/C8H16O4/c1-4-10-7(9)8(11-5-2)12-6-3/h8H,4-6H2,1-3H
    • XCLBIKIQSCTANZ-UHFFFAOYSA-N
    • 6065-82-3
    • ethyl 2,2-diethoxyacetate
    • MFCD00009231
    • Ethyldiethoxyacetate
    • ETHYL-2,2-DIETHOXYACETATE
    • Diethoxy-acetic acid ethyl ester
    • Glyoxylic acid ethyl ester diethyl acetal
    • ethyl bis(ethyloxy)acetate
    • Ethyl diethoxyacetate, 97%
    • SCHEMBL143815
    • Ethyl Glyoxylate Diethyl Acetal
    • orb2940175
    • SCHEMBL4852525
    • STR03318
    • SBB089170
    • AKOS009157532
    • DIETHOXY ACETIC ACID ETHYLESTER
    • CS-W001603
    • HY-W001603
    • SY009521
    • DB-002716
    • D1883
    • NS00034424
    • EN300-39039
    • F216413
    • F0001-1587
    • Z381787790
    • 6065-82-3

  • Applications

    Ethyl diethoxyacetate (CAS 6065-82-3) is an important organic synthesis intermediate, used as a building block for pharmaceuticals, agrochemicals, and other industrial chemicals. It also acts as a solvent or co-solvent in coatings, inks, and cleaning formulations. In polymer chemistry, it can serve as a precursor for plastics and polymer additives, and is commonly evaluated for fragrance applications as a solvent or carrier. Additionally, it is used as a component in adhesive formulations.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 510.77
    methanol 913.36
    isopropanol 326.48
    water 8.64
    ethyl acetate 321.24
    n-propanol 399.34
    acetone 503.06
    n-butanol 327.12
    acetonitrile 461.46
    DMF 1013.48
    toluene 240.59
    isobutanol 272.84
    1,4-dioxane 844.8
    methyl acetate 422.69
    THF 695.1
    2-butanone 354.28
    n-pentanol 282.65
    sec-butanol 329.65
    n-hexane 62.77
    ethylene glycol 269.09
    NMP 916.53
    cyclohexane 271.76
    DMSO 834.86
    n-butyl acetate 284.04
    n-octanol 176.33
    chloroform 2105.23
    n-propyl acetate 248.08
    acetic acid 1139.97
    dichloromethane 1992.48
    cyclohexanone 699.24
    propylene glycol 216.97
    isopropyl acetate 175.67
    DMAc 759.28
    2-ethoxyethanol 461.57
    isopentanol 213.27
    n-heptane 50.77
    ethyl formate 488.05
    1,2-dichloroethane 1012.44
    n-hexanol 243.65
    2-methoxyethanol 746.98
    isobutyl acetate 138.45
    tetrachloromethane 433.55
    n-pentyl acetate 227.59
    transcutol 567.16
    n-heptanol 150.69
    ethylbenzene 176.37
    MIBK 122.01
    2-propoxyethanol 392.64
    tert-butanol 337.19
    MTBE 218.9
    2-butoxyethanol 267.22
    propionic acid 519.36
    o-xylene 192.12
    formic acid 568.3
    diethyl ether 247.07
    m-xylene 126.32
    p-xylene 251.87
    chlorobenzene 624.63
    dimethyl carbonate 180.52
    n-octane 33.85
    formamide 640.53
    cyclopentanone 633.35
    2-pentanone 222.11
    anisole 294.9
    cyclopentyl methyl ether 281.5
    gamma-butyrolactone 863.58
    1-methoxy-2-propanol 376.87
    pyridine 974.63
    3-pentanone 223.77
    furfural 1120.59
    n-dodecane 29.62
    diethylene glycol 396.75
    diisopropyl ether 64.76
    tert-amyl alcohol 319.4
    acetylacetone 289.74
    n-hexadecane 33.69
    acetophenone 330.22
    methyl propionate 301.49
    isopentyl acetate 223.27
    trichloroethylene 2027.86
    n-nonanol 150.26
    cyclohexanol 485.96
    benzyl alcohol 403.85
    2-ethylhexanol 168.11
    isooctanol 111.67
    dipropyl ether 140.92
    1,2-dichlorobenzene 593.81
    ethyl lactate 186.12
    propylene carbonate 548.34
    n-methylformamide 619.17
    2-pentanol 177.43
    n-pentane 61.88
    1-propoxy-2-propanol 243.52
    1-methoxy-2-propyl acetate 201.32
    2-(2-methoxypropoxy) propanol 203.24
    mesitylene 90.15
    ε-caprolactone 648.04
    p-cymene 114.28
    epichlorohydrin 885.61
    1,1,1-trichloroethane 834.2
    2-aminoethanol 352.55
    morpholine-4-carbaldehyde 735.74
    sulfolane 952.31
    2,2,4-trimethylpentane 34.17
    2-methyltetrahydrofuran 464.88
    n-hexyl acetate 291.89
    isooctane 16.94
    2-(2-butoxyethoxy)ethanol 278.1
    sec-butyl acetate 140.63
    tert-butyl acetate 154.9
    decalin 82.68
    glycerin 351.41
    diglyme 577.98
    acrylic acid 605.14
    isopropyl myristate 111.24
    n-butyric acid 560.74
    acetyl acetate 277.66
    di(2-ethylhexyl) phthalate 143.29
    ethyl propionate 232.54
    nitromethane 1078.07
    1,2-diethoxyethane 254.16
    benzonitrile 538.09
    trioctyl phosphate 111.68
    1-bromopropane 437.57
    gamma-valerolactone 849.42
    n-decanol 106.9
    triethyl phosphate 157.63
    4-methyl-2-pentanol 88.83
    propionitrile 408.67
    vinylene carbonate 657.55
    1,1,2-trichlorotrifluoroethane 920.59
    DMS 252.28
    cumene 119.37
    2-octanol 125.22
    2-hexanone 202.4
    octyl acetate 155.38
    limonene 161.8
    1,2-dimethoxyethane 741.82
    ethyl orthosilicate 140.14
    tributyl phosphate 126.95
    diacetone alcohol 195.68
    N,N-dimethylaniline 222.34
    acrylonitrile 596.91
    aniline 396.86
    1,3-propanediol 430.49
    bromobenzene 626.0
    dibromomethane 1207.31
    1,1,2,2-tetrachloroethane 1615.48
    2-methyl-cyclohexyl acetate 197.96
    tetrabutyl urea 174.21
    diisobutyl methanol 85.82
    2-phenylethanol 291.58
    styrene 258.96
    dioctyl adipate 186.82
    dimethyl sulfate 289.76
    ethyl butyrate 221.5
    methyl lactate 233.48
    butyl lactate 194.6
    diethyl carbonate 203.95
    propanediol butyl ether 242.2
    triethyl orthoformate 185.15
    p-tert-butyltoluene 105.42
    methyl 4-tert-butylbenzoate 248.27
    morpholine 827.6
    tert-butylamine 212.29
    n-dodecanol 84.06
    dimethoxymethane 412.44
    ethylene carbonate 515.55
    cyrene 258.0
    2-ethoxyethyl acetate 244.77
    2-ethylhexyl acetate 198.09
    1,2,4-trichlorobenzene 681.41
    4-methylpyridine 682.16
    dibutyl ether 164.62
    2,6-dimethyl-4-heptanol 85.82
    DEF 415.88
    dimethyl isosorbide 329.26
    tetrachloroethylene 1397.81
    eugenol 272.66
    triacetin 247.26
    span 80 229.44
    1,4-butanediol 259.64
    1,1-dichloroethane 852.45
    2-methyl-1-pentanol 218.86
    methyl formate 549.86
    2-methyl-1-butanol 247.33
    n-decane 46.7
    butyronitrile 377.43
    3,7-dimethyl-1-octanol 135.25
    1-chlorooctane 145.28
    1-chlorotetradecane 65.68
    n-nonane 46.72
    undecane 35.29
    tert-butylcyclohexane 51.66
    cyclooctane 64.23
    cyclopentanol 491.23
    tetrahydropyran 647.65
    tert-amyl methyl ether 175.55
    2,5,8-trioxanonane 376.4
    1-hexene 172.16
    2-isopropoxyethanol 265.53
    2,2,2-trifluoroethanol 388.19
    methyl butyrate 347.17

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction