Ethyl arachidonate

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  • Identifiers

    CAS number
    1808-26-0

    Molecular formula
    C22H36O2

    SMILES
    CCCCC/C=C\C/C=C\C/C=C\C/C=C\CCCC(=O)OCC

    Safety labels

  • Odor profile

    Fragrance
    Fatty 79.11%
    Oily 63.68%
    Fruity 45.39%
    Waxy 37.0%
    Fishy 26.36%
    Sweet 26.16%
    Green 25.74%
    Pear 24.81%
    Herbal 23.88%
    Woody 23.72%

     

    Flavor
    Faint 19.27%
    Oriental 18.61%
    Diterpene 18.14%
    Low 18.02%
    Delicate 17.8%
    Pumpkin 17.76%
    Honeydew 17.61%
    Slightly waxy 17.28%
    Skunky 17.23%
    Terpentine 17.01%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    7.0

    pKa est.
    7.93 (neutral)

    Molecular weight
    332.5 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    336°C

    Flash point

    • 204.53 ˚C est.

  • Synonyms

    • Ethyl arachidonate
    • 1808-26-0
    • ethyl (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate
    • 3NU6034AW3
    • CHEBI:84873
    • DTXSID301016455
    • RefChem:138881
    • DTXCID201474646
    • Arachidonic acid ethyl ester
    • Arachidonic acid, ethyl ester
    • 5,8,11,14-Eicosatetraenoic acid, ethyl ester, (5Z,8Z,11Z,14Z)-
    • 5,8,11,14-Eicosatetraenoic acid, ethyl ester
    • (5Z,8Z,11Z,14Z)-Ethyl icosa-5,8,11,14-tetraenoate
    • 5,8,11,14-Eicosatetraenoic acid, ethyl ester, (all-Z)-
    • UNII-3NU6034AW3
    • Ethyl 5,8,11,14-eicosatetraenoate (all Z)
    • ethyl (5Z,8Z,11Z,14Z)-eicosatetraenoate
    • ethyl (5Z,8Z,11Z,14Z)-icosatetraenoate
    • arachidonic ethyl ester
    • Ethyl arachidonate,10%
    • ethyl (5Z,8Z,11Z,14Z)-eicosa-5,8,11,14-tetraenoate
    • SCHEMBL24208
    • orb1680015
    • 5,8,11,14-Eicosatetraenoic acid, ethyl ester, (all Z)-
    • HMS3650O13
    • (5Z,8Z,11Z,14Z)-5,8,11,14-Eicosatetraenoic Acid Ethyl Ester
    • MSK15426
    • MFCD00038340
    • AKOS040763745
    • CS-W013930
    • HY-W013214
    • Ethyl Arachidonate (solution in ethanol)
    • AC-33775
    • AS-75579
    • BP-29840
    • cis-5,8,11,14-Eicosic Acidtraenoic Acid
    • Ethyl arachidonate, >=98.5% (GC), liquid
    • F95711
    • F865776
    • SR-01000946819
    • Ethyl 5(Z),8(Z),11(Z),14(Z)-Eicosatetraenoate
    • SR-01000946819-1
    • Q27158140
    • (5Z,8Z,11Z,14Z)-Ethylicosa-5,8,11,14-tetraenoate
    • Ethyl (5Z,8Z,11Z,14Z)-5,8,11,14-icosatetraenoate #
    • (5Z,8Z,11Z,14Z)-5,8,11,14-EICOSATETRAENOIC ACID, ETHYL ESTER
    • Ethyl arachidonate

  • Applications

    Ethyl arachidonate, the ethyl ester of arachidonic acid (CAS 1808-26-0), is commonly used as a synthetic intermediate for preparing arachidonic‑acid–derived esters and prostaglandin analogs in chemical research; it also serves as a reference lipid standard in analytical lipidomics (GC/LC–MS) and may function as a specialty solvent or co‑solvent in laboratory formulations. In materials and cosmetics, it can be employed as an emollient component or processing aid in niche cosmetic or polymer formulations; it may also act as a precursor for further esterification or derivatization in industrial R&D. Use is subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 73.69
    methanol 72.82
    isopropanol 69.7
    water 0.01
    ethyl acetate 348.71
    n-propanol 92.04
    acetone 271.73
    n-butanol 117.29
    acetonitrile 87.34
    DMF 262.19
    toluene 164.27
    isobutanol 81.78
    1,4-dioxane 355.86
    methyl acetate 189.92
    THF 863.88
    2-butanone 331.11
    n-pentanol 107.63
    sec-butanol 114.66
    n-hexane 48.24
    ethylene glycol 3.22
    NMP 546.17
    cyclohexane 181.9
    DMSO 454.32
    n-butyl acetate 324.55
    n-octanol 67.99
    chloroform 927.01
    n-propyl acetate 381.97
    acetic acid 89.13
    dichloromethane 1135.86
    cyclohexanone 831.56
    propylene glycol 12.8
    isopropyl acetate 283.18
    DMAc 596.73
    2-ethoxyethanol 178.66
    isopentanol 139.29
    n-heptane 35.72
    ethyl formate 119.34
    1,2-dichloroethane 772.99
    n-hexanol 91.76
    2-methoxyethanol 154.39
    isobutyl acetate 236.7
    tetrachloromethane 162.23
    n-pentyl acetate 342.84
    transcutol 1042.4
    n-heptanol 67.66
    ethylbenzene 126.59
    MIBK 286.03
    2-propoxyethanol 184.75
    tert-butanol 132.48
    MTBE 281.54
    2-butoxyethanol 166.11
    propionic acid 84.31
    o-xylene 130.49
    formic acid 15.56
    diethyl ether 314.17
    m-xylene 118.2
    p-xylene 165.59
    chlorobenzene 264.97
    dimethyl carbonate 62.06
    n-octane 15.24
    formamide 33.03
    cyclopentanone 685.57
    2-pentanone 376.29
    anisole 261.76
    cyclopentyl methyl ether 490.85
    gamma-butyrolactone 537.67
    1-methoxy-2-propanol 164.11
    pyridine 405.06
    3-pentanone 305.66
    furfural 372.09
    n-dodecane 9.72
    diethylene glycol 60.85
    diisopropyl ether 104.27
    tert-amyl alcohol 168.45
    acetylacetone 391.83
    n-hexadecane 11.86
    acetophenone 288.55
    methyl propionate 215.91
    isopentyl acetate 309.57
    trichloroethylene 1100.65
    n-nonanol 71.87
    cyclohexanol 215.41
    benzyl alcohol 131.56
    2-ethylhexanol 101.76
    isooctanol 73.5
    dipropyl ether 246.19
    1,2-dichlorobenzene 294.66
    ethyl lactate 100.26
    propylene carbonate 293.41
    n-methylformamide 76.08
    2-pentanol 98.75
    n-pentane 29.58
    1-propoxy-2-propanol 188.41
    1-methoxy-2-propyl acetate 294.09
    2-(2-methoxypropoxy) propanol 196.82
    mesitylene 89.76
    ε-caprolactone 601.07
    p-cymene 78.72
    epichlorohydrin 755.01
    1,1,1-trichloroethane 609.06
    2-aminoethanol 18.54
    morpholine-4-carbaldehyde 398.14
    sulfolane 754.67
    2,2,4-trimethylpentane 28.35
    2-methyltetrahydrofuran 666.24
    n-hexyl acetate 328.59
    isooctane 15.22
    2-(2-butoxyethoxy)ethanol 266.5
    sec-butyl acetate 278.84
    tert-butyl acetate 362.49
    decalin 65.42
    glycerin 20.99
    diglyme 613.95
    acrylic acid 53.28
    isopropyl myristate 112.4
    n-butyric acid 230.82
    acetyl acetate 184.43
    di(2-ethylhexyl) phthalate 94.06
    ethyl propionate 308.74
    nitromethane 215.85
    1,2-diethoxyethane 464.36
    benzonitrile 177.33
    trioctyl phosphate 64.85
    1-bromopropane 472.37
    gamma-valerolactone 738.69
    n-decanol 47.6
    triethyl phosphate 153.77
    4-methyl-2-pentanol 69.78
    propionitrile 120.65
    vinylene carbonate 216.25
    1,1,2-trichlorotrifluoroethane 353.4
    DMS 178.9
    cumene 86.76
    2-octanol 57.99
    2-hexanone 366.5
    octyl acetate 134.79
    limonene 156.11
    1,2-dimethoxyethane 489.01
    ethyl orthosilicate 163.35
    tributyl phosphate 94.05
    diacetone alcohol 264.79
    N,N-dimethylaniline 180.9
    acrylonitrile 103.09
    aniline 139.83
    1,3-propanediol 43.86
    bromobenzene 336.72
    dibromomethane 726.87
    1,1,2,2-tetrachloroethane 1013.39
    2-methyl-cyclohexyl acetate 274.2
    tetrabutyl urea 149.31
    diisobutyl methanol 75.81
    2-phenylethanol 121.42
    styrene 159.18
    dioctyl adipate 200.62
    dimethyl sulfate 137.97
    ethyl butyrate 320.46
    methyl lactate 70.08
    butyl lactate 178.72
    diethyl carbonate 173.98
    propanediol butyl ether 121.18
    triethyl orthoformate 237.52
    p-tert-butyltoluene 71.55
    methyl 4-tert-butylbenzoate 247.28
    morpholine 483.79
    tert-butylamine 96.99
    n-dodecanol 35.44
    dimethoxymethane 242.92
    ethylene carbonate 206.23
    cyrene 205.47
    2-ethoxyethyl acetate 378.96
    2-ethylhexyl acetate 271.37
    1,2,4-trichlorobenzene 339.23
    4-methylpyridine 410.76
    dibutyl ether 265.25
    2,6-dimethyl-4-heptanol 75.81
    DEF 434.85
    dimethyl isosorbide 445.24
    tetrachloroethylene 586.77
    eugenol 187.66
    triacetin 333.21
    span 80 186.29
    1,4-butanediol 21.83
    1,1-dichloroethane 574.73
    2-methyl-1-pentanol 135.84
    methyl formate 53.14
    2-methyl-1-butanol 133.52
    n-decane 20.6
    butyronitrile 179.07
    3,7-dimethyl-1-octanol 87.32
    1-chlorooctane 101.78
    1-chlorotetradecane 32.46
    n-nonane 19.95
    undecane 13.2
    tert-butylcyclohexane 43.32
    cyclooctane 39.84
    cyclopentanol 164.4
    tetrahydropyran 684.09
    tert-amyl methyl ether 271.63
    2,5,8-trioxanonane 381.79
    1-hexene 140.94
    2-isopropoxyethanol 160.46
    2,2,2-trifluoroethanol 30.68
    methyl butyrate 436.98

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction