Ethyl 5-hydroxyhexanoate

Overview IFRA Request a quote

  • Identifiers

    CAS number
    20266-62-0

    Molecular formula
    C8H16O3

    SMILES
    CCOC(=O)CCCC(C)O

    Safety labels

  • Odor profile

    Fragrance
    Fruity 88.29%
    Sweet 45.1%
    Winey 37.39%
    Fresh 36.11%
    Tropical 32.8%
    Oily 31.88%
    Pineapple 31.12%
    Fatty 29.99%
    Grape 29.52%
    Caramellic 29.24%

     

    Flavor
    Fruity 87.61%
    Pineapple 56.37%
    Tropical 48.49%
    Sweet 47.34%
    Fruit 44.2%
    Green 42.75%
    Grape 37.31%
    Berry 33.78%
    Ripe 31.69%
    Apple 31.11%

     

    Odor impact est.
    High

  • Properties

    XLogP3-AA
    0.9

    pKa est.
    8.51 (weak base)

    Molecular weight
    160.21 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Slow

    Boiling point est.
    225°C

    Flash point

    • 96.89 ˚C est.

  • Synonyms

    • Ethyl 5-hydroxyhexanoate
    • 20266-62-0
    • DTXSID40497910
    • RefChem:138822
    • DTXCID40448720
    • YUQVKXFPYUHIIF-UHFFFAOYSA-N
    • MFCD25960763
    • Hexanoic acid, 5-hydroxy-, ethyl ester
    • ethyl (s)-5-hydroxyhexanoate
    • 5-Hydroxyhexanoic acid ethyl ester
    • 118627-53-5
    • Ethyl5-hydroxyhexanoate
    • SCHEMBL2112334
    • 5-Hydroxy-hexanoic acid ethyl ester
    • SY320605
    • 20266-62-0

  • Applications

    Ethyl 5-hydroxyhexanoate (CAS 20266-62-0) is an ester of gamma-hydroxyhexanoic acid and is primarily used as a fragrance ingredient, delivering subtle floral/fruit notes in perfumery and in cosmetic formulations. It also serves as a chemical intermediate for the synthesis of aroma-related derivatives and can act as a building block for polymer or resin formulations where hydroxyl functionality is desired. Additionally, it may be used as a fragrance additive in household cleaning products and other consumer-care items, with suitability depending on formulation constraints and local regulations.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 3313.3
    methanol 5743.33
    isopropanol 2348.18
    water 52.42
    ethyl acetate 1014.17
    n-propanol 1870.19
    acetone 2815.01
    n-butanol 1500.54
    acetonitrile 1467.82
    DMF 3597.62
    toluene 141.0
    isobutanol 1231.67
    1,4-dioxane 1744.99
    methyl acetate 919.09
    THF 2715.44
    2-butanone 1042.12
    n-pentanol 891.8
    sec-butanol 1347.71
    n-hexane 50.75
    ethylene glycol 1039.35
    NMP 2565.88
    cyclohexane 57.7
    DMSO 3743.2
    n-butyl acetate 457.91
    n-octanol 294.14
    chloroform 1015.76
    n-propyl acetate 470.05
    acetic acid 5562.9
    dichloromethane 987.34
    cyclohexanone 1582.62
    propylene glycol 1234.22
    isopropyl acetate 591.23
    DMAc 2034.25
    2-ethoxyethanol 1427.22
    isopentanol 991.9
    n-heptane 21.1
    ethyl formate 787.85
    1,2-dichloroethane 673.11
    n-hexanol 553.18
    2-methoxyethanol 2743.54
    isobutyl acetate 289.75
    tetrachloromethane 111.84
    n-pentyl acetate 307.07
    transcutol 3173.7
    n-heptanol 206.87
    ethylbenzene 87.89
    MIBK 502.46
    2-propoxyethanol 1058.22
    tert-butanol 2098.18
    MTBE 823.39
    2-butoxyethanol 470.75
    propionic acid 1909.18
    o-xylene 126.71
    formic acid 2461.66
    diethyl ether 780.75
    m-xylene 131.65
    p-xylene 139.7
    chlorobenzene 308.73
    dimethyl carbonate 323.09
    n-octane 10.71
    formamide 2271.19
    cyclopentanone 1866.21
    2-pentanone 991.06
    anisole 315.12
    cyclopentyl methyl ether 912.54
    gamma-butyrolactone 2289.12
    1-methoxy-2-propanol 1812.79
    pyridine 753.46
    3-pentanone 511.04
    furfural 1525.16
    n-dodecane 12.06
    diethylene glycol 1045.79
    diisopropyl ether 159.59
    tert-amyl alcohol 1295.15
    acetylacetone 1107.77
    n-hexadecane 13.58
    acetophenone 355.56
    methyl propionate 740.25
    isopentyl acetate 392.92
    trichloroethylene 1260.87
    n-nonanol 232.03
    cyclohexanol 1111.64
    benzyl alcohol 398.32
    2-ethylhexanol 230.74
    isooctanol 161.5
    dipropyl ether 219.06
    1,2-dichlorobenzene 284.74
    ethyl lactate 280.71
    propylene carbonate 988.85
    n-methylformamide 1914.45
    2-pentanol 850.01
    n-pentane 46.82
    1-propoxy-2-propanol 638.84
    1-methoxy-2-propyl acetate 479.73
    2-(2-methoxypropoxy) propanol 503.75
    mesitylene 86.78
    ε-caprolactone 1337.15
    p-cymene 64.56
    epichlorohydrin 1637.16
    1,1,1-trichloroethane 461.68
    2-aminoethanol 1645.35
    morpholine-4-carbaldehyde 2087.38
    sulfolane 2340.92
    2,2,4-trimethylpentane 30.74
    2-methyltetrahydrofuran 1576.74
    n-hexyl acetate 524.68
    isooctane 21.72
    2-(2-butoxyethoxy)ethanol 767.12
    sec-butyl acetate 298.25
    tert-butyl acetate 606.67
    decalin 32.9
    glycerin 1525.25
    diglyme 1174.48
    acrylic acid 1627.51
    isopropyl myristate 153.75
    n-butyric acid 2077.59
    acetyl acetate 663.76
    di(2-ethylhexyl) phthalate 171.12
    ethyl propionate 380.03
    nitromethane 4570.52
    1,2-diethoxyethane 569.74
    benzonitrile 476.87
    trioctyl phosphate 127.94
    1-bromopropane 331.96
    gamma-valerolactone 2342.22
    n-decanol 157.13
    triethyl phosphate 137.88
    4-methyl-2-pentanol 348.79
    propionitrile 785.09
    vinylene carbonate 873.93
    1,1,2-trichlorotrifluoroethane 1319.27
    DMS 387.51
    cumene 72.37
    2-octanol 162.15
    2-hexanone 500.72
    octyl acetate 214.29
    limonene 115.35
    1,2-dimethoxyethane 1576.21
    ethyl orthosilicate 135.37
    tributyl phosphate 182.27
    diacetone alcohol 853.56
    N,N-dimethylaniline 218.36
    acrylonitrile 965.25
    aniline 454.18
    1,3-propanediol 1916.74
    bromobenzene 244.07
    dibromomethane 572.26
    1,1,2,2-tetrachloroethane 987.07
    2-methyl-cyclohexyl acetate 230.55
    tetrabutyl urea 233.15
    diisobutyl methanol 124.23
    2-phenylethanol 281.25
    styrene 115.66
    dioctyl adipate 273.75
    dimethyl sulfate 593.05
    ethyl butyrate 264.06
    methyl lactate 545.31
    butyl lactate 322.62
    diethyl carbonate 183.43
    propanediol butyl ether 706.43
    triethyl orthoformate 204.47
    p-tert-butyltoluene 64.99
    methyl 4-tert-butylbenzoate 316.84
    morpholine 2373.98
    tert-butylamine 953.52
    n-dodecanol 111.66
    dimethoxymethane 1192.4
    ethylene carbonate 746.51
    cyrene 474.03
    2-ethoxyethyl acetate 453.45
    2-ethylhexyl acetate 271.43
    1,2,4-trichlorobenzene 380.82
    4-methylpyridine 838.97
    dibutyl ether 263.12
    2,6-dimethyl-4-heptanol 124.23
    DEF 1158.21
    dimethyl isosorbide 661.0
    tetrachloroethylene 634.52
    eugenol 325.7
    triacetin 535.77
    span 80 492.3
    1,4-butanediol 728.33
    1,1-dichloroethane 644.12
    2-methyl-1-pentanol 616.18
    methyl formate 1233.58
    2-methyl-1-butanol 928.34
    n-decane 21.55
    butyronitrile 881.57
    3,7-dimethyl-1-octanol 257.01
    1-chlorooctane 114.31
    1-chlorotetradecane 41.6
    n-nonane 20.19
    undecane 15.43
    tert-butylcyclohexane 34.75
    cyclooctane 16.57
    cyclopentanol 1357.23
    tetrahydropyran 1435.76
    tert-amyl methyl ether 532.42
    2,5,8-trioxanonane 798.86
    1-hexene 209.11
    2-isopropoxyethanol 755.89
    2,2,2-trifluoroethanol 1248.9
    methyl butyrate 574.45

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction