Ethyl 4-hydroxyphenylacetate

Overview IFRA Request a quote

  • Identifiers

    CAS number
    17138-28-2

    Molecular formula
    C10H12O3

    SMILES
    CCOC(=O)CC1=CC=C(C=C1)O

    Safety labels

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Floral 60.43%
    Phenolic 59.71%
    Animal 50.42%
    Sweet 49.33%
    Fruity 47.38%
    Honey 46.42%
    Aromatic 36.32%
    Spicy 35.95%
    Powdery 35.19%
    Balsamic 34.63%

     

    Flavor
    Sweet 86.75%
    Floral 74.41%
    Fruity 50.9%
    Balsam 49.16%
    Honey 44.69%
    Powdery 41.46%
    Flower 34.99%
    Spicy 34.77%
    Bitter 34.04%
    Chocolate 33.12%

     

    Odor impact est.
    Medium

  • Properties

    XLogP3-AA
    1.9

    pKa est.
    9.24 (weak base)

    Molecular weight
    180.2 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    300°C

    Flash point

    • 140.43 ˚C est.

  • Synonyms

    • Ethyl 4-hydroxyphenylacetate
    • ethyl 2-(4-hydroxyphenyl)acetate
    • Benzeneacetic acid, 4-hydroxy-, ethyl ester
    • 4-Hydroxyphenylacetic acid ethyl ester
    • ethyl (4-hydroxyphenyl)acetate
    • Ethyl (p-hydroxyphenyl)acetate
    • 94NWB742CW
    • EINECS 241-197-5
    • DTXSID0066165
    • Acetic acid, (p-hydroxyphenyl)-, ethyl ester
    • (4-Hydroxy-phenyl)-acetic acid ethylester
    • RefChem:138772
    • DTXCID2035487
    • Ethyl 2-(4-hydroxyphenyl)acetic acid
    • 241-197-5
    • Ethyl 4-hydroxyphenylacetic acid
    • HYUPPKVFCGIMDB-UHFFFAOYSA-N
    • InChI=1/C10H12O3/c1-2-13-10(12)7-8-3-5-9(11)6-4-8/h3-6,11H,2,7H2,1H
    • 17138-28-2
    • MFCD00016491
    • ETHYL-4-HYDROXYPHENYLACETATE
    • P-Hydroxyphenyl Acetic Acid Ethyl Ester
    • Ethyl p-hydroxyphenylacetate
    • UNII-94NWB742CW
    • ethyl (4hydroxyphenyl)acetate
    • orb1311058
    • SCHEMBL1179218
    • SCHEMBL5545889
    • thyl 2-(4-hydroxyphenyl)acetate
    • Metoprolol Hydroxy Ester Impurity
    • AKOS000280327
    • 4-Hydroxybenzeneacetic acid ethyl ester
    • CS-W017199
    • EBC-617524
    • FE23013
    • HY-W016483
    • 4-hydroxy-phenylacetic acid ethyl ester
    • 4-hydroxyphenyl acetic acid ethyl ester
    • (p-Hydroxyphenyl)acetic acid ethyl ester
    • AS-10794
    • SY015387
    • (4-hydroxy-phenyl)-acetic acid ethyl ester
    • DB-023047
    • E1034
    • NS00025628
    • ST50407272
    • EN300-49188
    • 138E282
    • F018683
    • Q67879878
    • F0001-0623
    • 17138-28-2

  • Applications

    Ethyl 4-hydroxyphenylacetate (CAS 17138-28-2) is primarily used in fragrance chemistry as an aroma ingredient and potential fixative, contributing fruity-floral notes in perfumes and cosmetic formulations. It is commonly employed in cosmetics and personal care products to impart a lasting scent, and it also appears in household product fragrances (cleaners, air fresheners) for aroma enhancement. It may serve as an intermediate in organic synthesis to access related aroma compounds, and, where permitted, may be used as a flavor/aroma ingredient in certain formulations. Use is subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 388.16
    methanol 505.87
    isopropanol 322.16
    water 1.88
    ethyl acetate 100.6
    n-propanol 260.79
    acetone 221.52
    n-butanol 201.81
    acetonitrile 196.61
    DMF 624.02
    toluene 33.87
    isobutanol 139.79
    1,4-dioxane 436.15
    methyl acetate 150.1
    THF 344.06
    2-butanone 155.25
    n-pentanol 140.31
    sec-butanol 193.08
    n-hexane 2.72
    ethylene glycol 140.84
    NMP 165.27
    cyclohexane 3.37
    DMSO 700.17
    n-butyl acetate 54.11
    n-octanol 41.26
    chloroform 177.02
    n-propyl acetate 55.22
    acetic acid 236.22
    dichloromethane 137.2
    cyclohexanone 129.8
    propylene glycol 199.7
    isopropyl acetate 47.9
    DMAc 588.51
    2-ethoxyethanol 308.59
    isopentanol 125.86
    n-heptane 1.62
    ethyl formate 88.56
    1,2-dichloroethane 107.85
    n-hexanol 89.94
    2-methoxyethanol 563.59
    isobutyl acetate 33.89
    tetrachloromethane 11.03
    n-pentyl acetate 28.32
    transcutol 479.71
    n-heptanol 34.13
    ethylbenzene 22.49
    MIBK 63.39
    2-propoxyethanol 210.17
    tert-butanol 386.77
    MTBE 108.55
    2-butoxyethanol 88.27
    propionic acid 144.55
    o-xylene 26.4
    formic acid 144.8
    diethyl ether 102.89
    m-xylene 23.08
    p-xylene 29.16
    chlorobenzene 43.27
    dimethyl carbonate 51.31
    n-octane 1.23
    formamide 221.11
    cyclopentanone 140.65
    2-pentanone 98.65
    anisole 101.47
    cyclopentyl methyl ether 78.81
    gamma-butyrolactone 154.71
    1-methoxy-2-propanol 326.08
    pyridine 144.6
    3-pentanone 66.38
    furfural 176.42
    n-dodecane 2.09
    diethylene glycol 239.2
    diisopropyl ether 15.99
    tert-amyl alcohol 205.62
    acetylacetone 115.63
    n-hexadecane 2.35
    acetophenone 76.32
    methyl propionate 96.39
    isopentyl acetate 51.44
    trichloroethylene 174.03
    n-nonanol 38.23
    cyclohexanol 107.93
    benzyl alcohol 98.14
    2-ethylhexanol 40.4
    isooctanol 27.82
    dipropyl ether 30.06
    1,2-dichlorobenzene 40.92
    ethyl lactate 51.86
    propylene carbonate 76.47
    n-methylformamide 250.27
    2-pentanol 95.23
    n-pentane 1.71
    1-propoxy-2-propanol 115.66
    1-methoxy-2-propyl acetate 78.51
    2-(2-methoxypropoxy) propanol 114.59
    mesitylene 13.79
    ε-caprolactone 104.35
    p-cymene 14.4
    epichlorohydrin 210.42
    1,1,1-trichloroethane 64.1
    2-aminoethanol 251.04
    morpholine-4-carbaldehyde 298.35
    sulfolane 201.05
    2,2,4-trimethylpentane 2.8
    2-methyltetrahydrofuran 152.64
    n-hexyl acetate 52.93
    isooctane 1.99
    2-(2-butoxyethoxy)ethanol 153.42
    sec-butyl acetate 37.03
    tert-butyl acetate 66.01
    decalin 4.25
    glycerin 247.2
    diglyme 244.03
    acrylic acid 121.98
    isopropyl myristate 24.78
    n-butyric acid 140.52
    acetyl acetate 54.71
    di(2-ethylhexyl) phthalate 30.87
    ethyl propionate 52.15
    nitromethane 332.79
    1,2-diethoxyethane 94.92
    benzonitrile 78.9
    trioctyl phosphate 20.59
    1-bromopropane 49.69
    gamma-valerolactone 233.49
    n-decanol 29.95
    triethyl phosphate 31.84
    4-methyl-2-pentanol 46.35
    propionitrile 124.46
    vinylene carbonate 82.05
    1,1,2-trichlorotrifluoroethane 195.34
    DMS 56.75
    cumene 17.42
    2-octanol 23.66
    2-hexanone 69.39
    octyl acetate 31.38
    limonene 19.39
    1,2-dimethoxyethane 379.17
    ethyl orthosilicate 29.36
    tributyl phosphate 27.96
    diacetone alcohol 140.52
    N,N-dimethylaniline 60.49
    acrylonitrile 159.32
    aniline 95.19
    1,3-propanediol 323.62
    bromobenzene 33.99
    dibromomethane 80.92
    1,1,2,2-tetrachloroethane 159.09
    2-methyl-cyclohexyl acetate 40.74
    tetrabutyl urea 39.82
    diisobutyl methanol 24.94
    2-phenylethanol 70.02
    styrene 30.87
    dioctyl adipate 39.48
    dimethyl sulfate 102.51
    ethyl butyrate 40.92
    methyl lactate 85.0
    butyl lactate 42.1
    diethyl carbonate 35.15
    propanediol butyl ether 106.97
    triethyl orthoformate 35.37
    p-tert-butyltoluene 14.82
    methyl 4-tert-butylbenzoate 59.0
    morpholine 496.88
    tert-butylamine 134.46
    n-dodecanol 23.42
    dimethoxymethane 238.42
    ethylene carbonate 65.64
    cyrene 91.94
    2-ethoxyethyl acetate 55.83
    2-ethylhexyl acetate 36.0
    1,2,4-trichlorobenzene 52.86
    4-methylpyridine 136.19
    dibutyl ether 34.91
    2,6-dimethyl-4-heptanol 24.94
    DEF 135.68
    dimethyl isosorbide 126.08
    tetrachloroethylene 82.95
    eugenol 74.69
    triacetin 64.41
    span 80 78.47
    1,4-butanediol 129.89
    1,1-dichloroethane 93.6
    2-methyl-1-pentanol 95.1
    methyl formate 141.9
    2-methyl-1-butanol 112.7
    n-decane 3.05
    butyronitrile 108.93
    3,7-dimethyl-1-octanol 41.72
    1-chlorooctane 16.1
    1-chlorotetradecane 8.0
    n-nonane 2.52
    undecane 2.48
    tert-butylcyclohexane 4.35
    cyclooctane 1.11
    cyclopentanol 107.75
    tetrahydropyran 213.64
    tert-amyl methyl ether 72.36
    2,5,8-trioxanonane 198.0
    1-hexene 21.62
    2-isopropoxyethanol 158.97
    2,2,2-trifluoroethanol 69.87
    methyl butyrate 71.87

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction