Ethyl 2,4-dimethyl-1,3-dioxolane-2-acetate

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  • Identifiers

    CAS number
    6290-17-1

    Molecular formula
    C9H16O4

    SMILES
    CCOC(=O)CC1(OCC(O1)C)C

  • Odor profile

    Fragrance
    Fruity 88.34%
    Sweet 66.37%
    Apple 55.07%
    Green 52.99%
    Fresh 46.69%
    Tropical 42.83%
    Winey 38.6%
    Pineapple 38.16%
    Ethereal 36.03%
    Woody 34.24%

     

    Flavor
    Fruity 73.71%
    Green 61.05%
    Sweet 47.82%
    Pineapple 41.46%
    Fruit 40.93%
    Tropical 38.22%
    Earthy 34.34%
    Bitter 33.13%
    Vegetable 31.69%
    Nutty 27.47%

     

    Odor impact est.
    Medium

  • Properties

    XLogP3-AA
    0.7

    pKa est.
    6.7 (neutral)

    Molecular weight
    188.22 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Moderate

    Boiling point est.
    215°C

    Flash point

    • 77.97 ˚C est.

    Solubility expt.

    • Insoluble in water
    • Soluble (in ethanol)

  • Synonyms

    • 6290-17-1
    • ethyl 2-(2,4-dimethyl-1,3-dioxolan-2-yl)acetate
    • Ethyl acetoacetate propylene glycol ketal
    • Ethyl 2,4-dimethyl-1,3-dioxolane-2-acetate
    • 1,3-Dioxolane-2-acetic acid, 2,4-dimethyl-, ethyl ester
    • DTXSID4047549
    • UNII-087792Q4F6
    • NSC 6547
    • EINECS 228-536-2
    • Acetoacetic acid, ethyl ester, 1,2-propylene ketal
    • cis- and trans-Ethyl 2,4-dimethyl-1,3-dioxolane-2-acetate
    • DTXCID2027549
    • NSC-6547
    • 087792Q4F6
    • ethyl (2,4-dimethyl-1,3-dioxolan-2-yl)acetate
    • 293292-51-0
    • Fraistone
    • fruity ketal
    • Ethyl dimethyl dioxolane acetate
    • MFCD00151819
    • SCHEMBL528798
    • CHEMBL3183430
    • Ethyl 2,3-dioxolane-2-acetate
    • FEMA NO. 4294
    • NSC6547
    • CHEBI:173896
    • GSIXJEIRJVOUFB-UHFFFAOYSA-N
    • Tox21_302457
    • LMFA07010803
    • STK096389
    • AKOS005395944
    • Acetoacetic acid, 1,2-propylene ketal
    • CS-W016805
    • NCGC00256795-01
    • BS-17275
    • CAS-6290-17-1
    • DB-054323
    • E1417
    • NS00012394
    • E75757
    • Ethyl 2, 4-dimethyl-1,3-dioxolane-2-acetate
    • ethyl2-(2,4-dimethyl-1,3-dioxolan-2-yl)acetate
    • ETHYL 2,4-DIMETHYL-1,3-DIOXOLANE-2-CARBOXYLATE
    • 2,4-DIMETHYL-2-((ETHOXYCARBONYL)METHYL)-1,3-DIOXOLANE
    • CIS-AND TRANS-ETHYL 2,4-DIMETHYL-1,3-DIOXOLANE-2-ACETATE
    • ETHYL 2,4-DIMETHYL-1,3-DIOXOLANE-2-ACETATE, (E)-AND (Z)-
    • CIS-AND TRANS-ETHYL 2,4-DIMETHYL-1,3-DIOXOLANE-2-ACETATE [FHFI]
    • 228-536-2

  • Applications

    Ethyl 2,4-dimethyl-1,3-dioxolane-2-acetate (CAS 6290-17-1) is used primarily as an intermediate in organic synthesis, providing a building block for the production of fine chemicals including pharmaceuticals, agrochemicals, and specialty materials. It serves as an acetal/ketal-protected form of carbonyl substrates, enabling selective transformations in multi-step sequences. The compound is a precursor to acetal-containing monomers or derivatives for polymers and specialty plastics. In fragrance and flavor chemistry, it may be evaluated as a building block for fragrance compounds or as a formulation precursor, subject to regulatory constraints and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 820.05
    methanol 1302.83
    isopropanol 679.44
    water 132.62
    ethyl acetate 727.13
    n-propanol 542.44
    acetone 1049.15
    n-butanol 460.55
    acetonitrile 701.87
    DMF 1567.06
    toluene 277.08
    isobutanol 388.81
    1,4-dioxane 1408.31
    methyl acetate 791.0
    THF 1490.01
    2-butanone 520.74
    n-pentanol 249.4
    sec-butanol 451.05
    n-hexane 23.99
    ethylene glycol 551.61
    NMP 1747.79
    cyclohexane 72.18
    DMSO 1002.3
    n-butyl acetate 188.08
    n-octanol 162.98
    chloroform 1886.93
    n-propyl acetate 220.47
    acetic acid 1972.42
    dichloromethane 1457.5
    cyclohexanone 807.12
    propylene glycol 554.21
    isopropyl acetate 392.57
    DMAc 1711.46
    2-ethoxyethanol 605.6
    isopentanol 348.76
    n-heptane 13.1
    ethyl formate 560.69
    1,2-dichloroethane 635.57
    n-hexanol 196.33
    2-methoxyethanol 1414.14
    isobutyl acetate 161.25
    tetrachloromethane 193.29
    n-pentyl acetate 151.74
    transcutol 1200.11
    n-heptanol 90.46
    ethylbenzene 103.03
    MIBK 262.22
    2-propoxyethanol 587.24
    tert-butanol 754.4
    MTBE 364.98
    2-butoxyethanol 247.57
    propionic acid 848.67
    o-xylene 188.65
    formic acid 1304.09
    diethyl ether 377.15
    m-xylene 195.53
    p-xylene 161.48
    chlorobenzene 407.98
    dimethyl carbonate 443.4
    n-octane 7.35
    formamide 1121.34
    cyclopentanone 919.87
    2-pentanone 406.23
    anisole 341.1
    cyclopentyl methyl ether 572.19
    gamma-butyrolactone 1458.81
    1-methoxy-2-propanol 952.1
    pyridine 715.54
    3-pentanone 343.94
    furfural 1369.33
    n-dodecane 12.57
    diethylene glycol 666.37
    diisopropyl ether 108.53
    tert-amyl alcohol 466.29
    acetylacetone 703.75
    n-hexadecane 14.38
    acetophenone 342.01
    methyl propionate 631.3
    isopentyl acetate 170.76
    trichloroethylene 1406.55
    n-nonanol 142.04
    cyclohexanol 576.48
    benzyl alcohol 347.12
    2-ethylhexanol 102.79
    isooctanol 75.81
    dipropyl ether 103.55
    1,2-dichlorobenzene 381.01
    ethyl lactate 212.64
    propylene carbonate 858.76
    n-methylformamide 926.4
    2-pentanol 273.19
    n-pentane 29.18
    1-propoxy-2-propanol 297.82
    1-methoxy-2-propyl acetate 339.95
    2-(2-methoxypropoxy) propanol 361.86
    mesitylene 110.44
    ε-caprolactone 876.39
    p-cymene 62.69
    epichlorohydrin 1303.57
    1,1,1-trichloroethane 723.84
    2-aminoethanol 654.98
    morpholine-4-carbaldehyde 1604.21
    sulfolane 1148.05
    2,2,4-trimethylpentane 21.98
    2-methyltetrahydrofuran 916.71
    n-hexyl acetate 302.03
    isooctane 14.98
    2-(2-butoxyethoxy)ethanol 454.58
    sec-butyl acetate 182.74
    tert-butyl acetate 352.14
    decalin 33.43
    glycerin 851.44
    diglyme 718.45
    acrylic acid 889.79
    isopropyl myristate 115.66
    n-butyric acid 810.65
    acetyl acetate 710.71
    di(2-ethylhexyl) phthalate 150.85
    ethyl propionate 275.59
    nitromethane 2326.6
    1,2-diethoxyethane 259.67
    benzonitrile 405.28
    trioctyl phosphate 91.83
    1-bromopropane 272.3
    gamma-valerolactone 1531.75
    n-decanol 99.34
    triethyl phosphate 115.05
    4-methyl-2-pentanol 156.34
    propionitrile 396.11
    vinylene carbonate 846.37
    1,1,2-trichlorotrifluoroethane 1180.68
    DMS 358.58
    cumene 79.5
    2-octanol 76.58
    2-hexanone 188.31
    octyl acetate 156.62
    limonene 87.6
    1,2-dimethoxyethane 807.24
    ethyl orthosilicate 105.77
    tributyl phosphate 121.48
    diacetone alcohol 446.53
    N,N-dimethylaniline 222.54
    acrylonitrile 557.27
    aniline 453.15
    1,3-propanediol 779.34
    bromobenzene 378.11
    dibromomethane 763.08
    1,1,2,2-tetrachloroethane 1044.14
    2-methyl-cyclohexyl acetate 157.72
    tetrabutyl urea 165.96
    diisobutyl methanol 66.83
    2-phenylethanol 233.22
    styrene 134.41
    dioctyl adipate 195.7
    dimethyl sulfate 640.43
    ethyl butyrate 164.39
    methyl lactate 463.24
    butyl lactate 158.7
    diethyl carbonate 147.45
    propanediol butyl ether 322.28
    triethyl orthoformate 128.57
    p-tert-butyltoluene 64.4
    methyl 4-tert-butylbenzoate 298.85
    morpholine 1450.28
    tert-butylamine 376.34
    n-dodecanol 75.75
    dimethoxymethane 915.71
    ethylene carbonate 683.45
    cyrene 388.63
    2-ethoxyethyl acetate 271.53
    2-ethylhexyl acetate 129.59
    1,2,4-trichlorobenzene 525.06
    4-methylpyridine 802.18
    dibutyl ether 120.75
    2,6-dimethyl-4-heptanol 66.83
    DEF 627.61
    dimethyl isosorbide 510.2
    tetrachloroethylene 636.51
    eugenol 268.43
    triacetin 407.22
    span 80 297.7
    1,4-butanediol 273.34
    1,1-dichloroethane 779.4
    2-methyl-1-pentanol 206.84
    methyl formate 857.25
    2-methyl-1-butanol 337.6
    n-decane 17.96
    butyronitrile 368.23
    3,7-dimethyl-1-octanol 138.73
    1-chlorooctane 77.94
    1-chlorotetradecane 39.95
    n-nonane 15.7
    undecane 14.52
    tert-butylcyclohexane 29.04
    cyclooctane 19.57
    cyclopentanol 648.47
    tetrahydropyran 805.47
    tert-amyl methyl ether 276.88
    2,5,8-trioxanonane 566.95
    1-hexene 75.44
    2-isopropoxyethanol 373.91
    2,2,2-trifluoroethanol 898.32
    methyl butyrate 318.52

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction