Ethyl 2-pyridinecarboxylate

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  • Identifiers

    CAS number
    2524-52-9

    Molecular formula
    C8H9NO2

    SMILES
    CCOC(=O)C1=CC=CC=N1

    Safety labels

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Fruity 69.34%
    Floral 56.45%
    Herbal 42.94%
    Sweet 37.88%
    Tobacco 33.07%
    Nutty 31.95%
    Grape 30.14%
    Caramellic 29.22%
    Cherry 28.46%
    Berry 28.43%

     

    Flavor
    Fruity 67.79%
    Sweet 42.76%
    Grape 40.62%
    Floral 32.26%
    Balsam 31.2%
    Strawberry 31.15%
    Tobacco 29.66%
    Bitter 29.24%
    Musty 27.55%
    Berry 26.51%

     

    Odor impact est.
    Medium

  • Properties

    XLogP3-AA
    0.9

    pKa est.
    5.18 (weak acid)

    Molecular weight
    151.16 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Slow

    Boiling point est.
    255°C

    Flash point

    • 95.26 ˚C est.

  • Synonyms

    • ETHYL PICOLINATE
    • 2524-52-9
    • Ethyl pyridine-2-carboxylate
    • Ethyl 2-pyridinecarboxylate
    • 2-Pyridinecarboxylic acid, ethyl ester
    • 2-pyridinecarboxylic acid ethyl ester
    • RW5EU98AZQ
    • NSC-959
    • NSC-31651
    • DTXSID9062489
    • RefChem:139045
    • DTXCID9037246
    • 219-758-0
    • Ethyl 2-picolinate
    • 2-Picolinic acid ethyl ester
    • 2-(Ethoxycarbonyl)pyridine
    • Picolinic acid ethyl ester
    • Picolinic acid, ethyl ester
    • MFCD00006292
    • Pyridine-2-carboxylic Acid Ethyl Ester
    • Pyridinecarboxylic acid, ethyl ester
    • Ethyl2-picolinate
    • NSC 959
    • EINECS 219-758-0
    • NSC 31651
    • UNII-RW5EU98AZQ
    • ethyl pyridin-2-carboxylate
    • Ethyl 2-picolinate, 99%
    • SCHEMBL126181
    • SCHEMBL127485
    • SCHEMBL130016
    • SCHEMBL131459
    • SCHEMBL132238
    • NSC959
    • orb3030373
    • SCHEMBL1818700
    • SCHEMBL1818702
    • CHEMBL2251607
    • SCHEMBL30016787
    • BB_SC-12669
    • NSC31651
    • STR01170
    • BBL036381
    • SBB065219
    • STL558973
    • AKOS008948057
    • CS-W008053
    • FP27037
    • FS-3192
    • AC-22481
    • SY020537
    • DB-046651
    • NS00027841
    • P1026
    • ST50308263
    • Ethyl 2-picolinate, purum, >=99.0% (GC)
    • F079053
    • F0001-0852
    • 2524-52-9

  • Applications

    Ethyl 2-pyridinecarboxylate (CAS 2524-52-9) is primarily used as an intermediate for the synthesis of pyridine-containing compounds. In pharmaceutical and agrochemical development, it serves as a building block for nicotinic acid derivatives and related heterocycles. It is also employed as an intermediate in materials chemistry, including routes to pyridine-containing polymers and as an additive or precursor for coatings and inks. In flavor and fragrance uses, it may be utilized as a fragrance precursor or note related to pyridine-based scents. Additionally, it is encountered in exploratory or custom synthesis work for research and development projects, subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 211.76
    methanol 351.34
    isopropanol 131.04
    water 3.73
    ethyl acetate 174.73
    n-propanol 160.1
    acetone 257.82
    n-butanol 155.82
    acetonitrile 286.15
    DMF 752.7
    toluene 104.32
    isobutanol 122.02
    1,4-dioxane 267.08
    methyl acetate 198.8
    THF 257.32
    2-butanone 171.12
    n-pentanol 136.43
    sec-butanol 122.81
    n-hexane 12.45
    ethylene glycol 119.78
    NMP 520.8
    cyclohexane 34.31
    DMSO 580.6
    n-butyl acetate 154.58
    n-octanol 99.71
    chloroform 816.03
    n-propyl acetate 131.13
    acetic acid 496.17
    dichloromethane 970.97
    cyclohexanone 322.7
    propylene glycol 82.62
    isopropyl acetate 79.2
    DMAc 507.42
    2-ethoxyethanol 221.66
    isopentanol 121.78
    n-heptane 12.11
    ethyl formate 247.22
    1,2-dichloroethane 548.51
    n-hexanol 116.51
    2-methoxyethanol 375.97
    isobutyl acetate 68.46
    tetrachloromethane 85.17
    n-pentyl acetate 104.82
    transcutol 520.98
    n-heptanol 77.48
    ethylbenzene 79.02
    MIBK 75.99
    2-propoxyethanol 184.16
    tert-butanol 148.61
    MTBE 85.3
    2-butoxyethanol 139.12
    propionic acid 239.74
    o-xylene 92.98
    formic acid 267.76
    diethyl ether 100.43
    m-xylene 73.12
    p-xylene 111.52
    chlorobenzene 296.92
    dimethyl carbonate 115.83
    n-octane 9.01
    formamide 396.16
    cyclopentanone 286.92
    2-pentanone 127.48
    anisole 156.64
    cyclopentyl methyl ether 109.73
    gamma-butyrolactone 425.98
    1-methoxy-2-propanol 211.52
    pyridine 436.57
    3-pentanone 112.06
    furfural 626.02
    n-dodecane 11.25
    diethylene glycol 209.44
    diisopropyl ether 28.4
    tert-amyl alcohol 128.72
    acetylacetone 164.63
    n-hexadecane 12.87
    acetophenone 180.29
    methyl propionate 164.82
    isopentyl acetate 112.62
    trichloroethylene 1076.65
    n-nonanol 83.21
    cyclohexanol 160.68
    benzyl alcohol 186.78
    2-ethylhexanol 83.16
    isooctanol 62.95
    dipropyl ether 62.17
    1,2-dichlorobenzene 300.82
    ethyl lactate 102.26
    propylene carbonate 290.21
    n-methylformamide 414.03
    2-pentanol 84.75
    n-pentane 13.93
    1-propoxy-2-propanol 129.9
    1-methoxy-2-propyl acetate 121.9
    2-(2-methoxypropoxy) propanol 141.9
    mesitylene 52.81
    ε-caprolactone 280.94
    p-cymene 53.89
    epichlorohydrin 442.92
    1,1,1-trichloroethane 299.68
    2-aminoethanol 159.87
    morpholine-4-carbaldehyde 436.59
    sulfolane 541.56
    2,2,4-trimethylpentane 10.42
    2-methyltetrahydrofuran 161.33
    n-hexyl acetate 161.52
    isooctane 6.83
    2-(2-butoxyethoxy)ethanol 201.87
    sec-butyl acetate 68.94
    tert-butyl acetate 80.06
    decalin 21.0
    glycerin 166.96
    diglyme 353.45
    acrylic acid 317.0
    isopropyl myristate 59.86
    n-butyric acid 262.03
    acetyl acetate 126.67
    di(2-ethylhexyl) phthalate 73.85
    ethyl propionate 113.36
    nitromethane 647.31
    1,2-diethoxyethane 145.66
    benzonitrile 330.22
    trioctyl phosphate 57.3
    1-bromopropane 202.17
    gamma-valerolactone 407.87
    n-decanol 62.76
    triethyl phosphate 72.7
    4-methyl-2-pentanol 51.34
    propionitrile 242.3
    vinylene carbonate 368.86
    1,1,2-trichlorotrifluoroethane 443.38
    DMS 140.54
    cumene 57.64
    2-octanol 60.87
    2-hexanone 116.93
    octyl acetate 82.97
    limonene 67.92
    1,2-dimethoxyethane 328.18
    ethyl orthosilicate 66.0
    tributyl phosphate 70.77
    diacetone alcohol 116.26
    N,N-dimethylaniline 124.94
    acrylonitrile 416.72
    aniline 193.27
    1,3-propanediol 197.54
    bromobenzene 298.94
    dibromomethane 546.33
    1,1,2,2-tetrachloroethane 734.78
    2-methyl-cyclohexyl acetate 90.71
    tetrabutyl urea 100.06
    diisobutyl methanol 48.66
    2-phenylethanol 145.52
    styrene 118.27
    dioctyl adipate 94.35
    dimethyl sulfate 205.89
    ethyl butyrate 114.35
    methyl lactate 137.92
    butyl lactate 106.6
    diethyl carbonate 105.82
    propanediol butyl ether 156.21
    triethyl orthoformate 84.76
    p-tert-butyltoluene 46.98
    methyl 4-tert-butylbenzoate 131.27
    morpholine 292.41
    tert-butylamine 94.87
    n-dodecanol 49.66
    dimethoxymethane 237.94
    ethylene carbonate 261.44
    cyrene 138.67
    2-ethoxyethyl acetate 130.88
    2-ethylhexyl acetate 91.35
    1,2,4-trichlorobenzene 314.74
    4-methylpyridine 343.07
    dibutyl ether 87.59
    2,6-dimethyl-4-heptanol 48.66
    DEF 268.87
    dimethyl isosorbide 196.39
    tetrachloroethylene 515.7
    eugenol 165.79
    triacetin 143.59
    span 80 123.42
    1,4-butanediol 109.37
    1,1-dichloroethane 373.34
    2-methyl-1-pentanol 117.57
    methyl formate 321.47
    2-methyl-1-butanol 123.27
    n-decane 15.5
    butyronitrile 241.31
    3,7-dimethyl-1-octanol 81.2
    1-chlorooctane 69.57
    1-chlorotetradecane 31.18
    n-nonane 14.12
    undecane 13.05
    tert-butylcyclohexane 16.03
    cyclooctane 10.75
    cyclopentanol 144.17
    tetrahydropyran 195.4
    tert-amyl methyl ether 78.93
    2,5,8-trioxanonane 262.33
    1-hexene 54.77
    2-isopropoxyethanol 127.88
    2,2,2-trifluoroethanol 159.72
    methyl butyrate 176.66

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction