Ethyl 2-Methoxybenzoate

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  • Identifiers

    CAS number
    7335-26-4

    Molecular formula
    C10H12O3

    SMILES
    CCOC(=O)C1=CC=CC=C1OC

    Safety labels

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Fruity 89.86%
    Floral 84.93%
    Sweet 78.98%
    Herbal 50.63%
    Anisic 48.36%
    Cherry 45.5%
    Green 43.78%
    Balsamic 36.26%
    Jasmin 36.04%
    Spicy 36.0%

     

    Flavor
    Fruity 72.28%
    Balsam 57.43%
    Floral 55.65%
    Sweet 49.8%
    Herbal 39.75%
    Bitter 38.79%
    Grape 36.32%
    Wintergreen 35.49%
    Strawberry 34.88%
    Plum 32.89%

     

    Odor impact est.
    Medium

  • Properties

    XLogP3-AA
    2.4

    pKa est.
    6.58 (neutral)

    Molecular weight
    180.2 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Slow

    Boiling point est.
    263°C

    Flash point

    • 104.24 ˚C est.

  • Synonyms

    • Ethyl 2-methoxybenzoate
    • 7335-26-4
    • Ethyl o-anisate
    • 2-Methoxybenzoic acid ethyl ester
    • Ethyl ortho-anisate
    • Ethyl o-methoxybenzoate
    • Benzoic acid, 2-methoxy-, ethyl ester
    • o-Anisic acid, ethyl ester
    • DTXSID9047126
    • UNII-1OB313918P
    • 2-methoxy-benzoic acid ethyl ester
    • EINECS 230-843-1
    • 1OB313918P
    • ETHYLMETHOXY SALICYLATE
    • AI3-30234
    • DTXCID7027126
    • o-Methoxybenzoic acid, ethyl ester
    • ETHYLMETHOXY SALICYLATE [WHO-DD]
    • MFCD00015148
    • SCHEMBL873499
    • CHEMBL3183817
    • Ethyl 2-methoxybenzoate, AldrichCPR
    • Tox21_302680
    • AKOS008947856
    • FA02025
    • GS-6891
    • NCGC00256713-01
    • CAS-7335-26-4
    • DB-021043
    • CS-0100631
    • NS00012439
    • H10032
    • Ethyl o-anisate;2-Methoxybenzoic acid ethyl ester
    • Q27252685
    • 670-271-3

  • Applications

    Ethyl 2-Methoxybenzoate (CAS 7335-26-4, also known as ethyl o-anisate) is widely used as a fragrance ingredient in perfumery, contributing fruity/floral notes and often serving as a minor fixative in complex scent formulations. It is also employed in cosmetics and personal care products as a fragrance additive, and in household products such as detergents and cleaners to impart a fresh aroma. In the flavor and food-analog sector, it may be evaluated as a flavor/aroma compound under regulatory approvals, while in industrial manufacturing it can serve as an intermediate in the synthesis of fragrance-related chemicals. Additionally, it may function as a solvent or processing aid in fragrance formulations, with use governed by local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 318.3
    methanol 437.9
    isopropanol 207.83
    water 0.63
    ethyl acetate 257.92
    n-propanol 230.94
    acetone 413.72
    n-butanol 218.29
    acetonitrile 337.85
    DMF 917.18
    toluene 189.12
    isobutanol 163.82
    1,4-dioxane 605.6
    methyl acetate 309.99
    THF 586.72
    2-butanone 283.75
    n-pentanol 162.46
    sec-butanol 180.02
    n-hexane 20.92
    ethylene glycol 166.97
    NMP 641.84
    cyclohexane 78.49
    DMSO 651.74
    n-butyl acetate 158.42
    n-octanol 91.83
    chloroform 1444.31
    n-propyl acetate 148.5
    acetic acid 444.63
    dichloromethane 1403.32
    cyclohexanone 511.81
    propylene glycol 121.07
    isopropyl acetate 122.32
    DMAc 537.43
    2-ethoxyethanol 272.32
    isopentanol 166.98
    n-heptane 17.29
    ethyl formate 285.82
    1,2-dichloroethane 853.73
    n-hexanol 153.86
    2-methoxyethanol 571.08
    isobutyl acetate 95.57
    tetrachloromethane 166.81
    n-pentyl acetate 103.12
    transcutol 379.12
    n-heptanol 83.88
    ethylbenzene 110.32
    MIBK 123.12
    2-propoxyethanol 271.38
    tert-butanol 264.57
    MTBE 163.26
    2-butoxyethanol 152.18
    propionic acid 259.42
    o-xylene 127.29
    formic acid 175.6
    diethyl ether 207.97
    m-xylene 122.45
    p-xylene 136.85
    chlorobenzene 366.25
    dimethyl carbonate 186.41
    n-octane 11.0
    formamide 302.22
    cyclopentanone 564.02
    2-pentanone 206.81
    anisole 221.36
    cyclopentyl methyl ether 246.24
    gamma-butyrolactone 657.79
    1-methoxy-2-propanol 317.14
    pyridine 595.79
    3-pentanone 179.43
    furfural 658.59
    n-dodecane 12.58
    diethylene glycol 312.41
    diisopropyl ether 49.72
    tert-amyl alcohol 192.98
    acetylacetone 272.04
    n-hexadecane 14.77
    acetophenone 219.93
    methyl propionate 252.9
    isopentyl acetate 136.94
    trichloroethylene 1545.33
    n-nonanol 81.44
    cyclohexanol 272.52
    benzyl alcohol 229.55
    2-ethylhexanol 98.6
    isooctanol 69.16
    dipropyl ether 89.96
    1,2-dichlorobenzene 329.98
    ethyl lactate 115.27
    propylene carbonate 375.13
    n-methylformamide 460.15
    2-pentanol 120.08
    n-pentane 20.49
    1-propoxy-2-propanol 158.05
    1-methoxy-2-propyl acetate 158.87
    2-(2-methoxypropoxy) propanol 143.65
    mesitylene 79.1
    ε-caprolactone 371.28
    p-cymene 63.38
    epichlorohydrin 811.24
    1,1,1-trichloroethane 634.95
    2-aminoethanol 212.23
    morpholine-4-carbaldehyde 540.34
    sulfolane 742.61
    2,2,4-trimethylpentane 15.96
    2-methyltetrahydrofuran 353.89
    n-hexyl acetate 166.09
    isooctane 12.2
    2-(2-butoxyethoxy)ethanol 190.28
    sec-butyl acetate 92.79
    tert-butyl acetate 144.89
    decalin 35.83
    glycerin 228.35
    diglyme 376.73
    acrylic acid 297.27
    isopropyl myristate 70.11
    n-butyric acid 323.94
    acetyl acetate 205.31
    di(2-ethylhexyl) phthalate 83.66
    ethyl propionate 144.11
    nitromethane 658.28
    1,2-diethoxyethane 143.48
    benzonitrile 298.26
    trioctyl phosphate 62.14
    1-bromopropane 329.57
    gamma-valerolactone 597.21
    n-decanol 63.3
    triethyl phosphate 91.38
    4-methyl-2-pentanol 70.8
    propionitrile 274.53
    vinylene carbonate 415.52
    1,1,2-trichlorotrifluoroethane 603.95
    DMS 166.79
    cumene 73.88
    2-octanol 59.34
    2-hexanone 150.52
    octyl acetate 92.17
    limonene 93.42
    1,2-dimethoxyethane 471.8
    ethyl orthosilicate 82.78
    tributyl phosphate 73.66
    diacetone alcohol 196.54
    N,N-dimethylaniline 146.96
    acrylonitrile 414.04
    aniline 279.62
    1,3-propanediol 289.94
    bromobenzene 394.62
    dibromomethane 834.09
    1,1,2,2-tetrachloroethane 1129.26
    2-methyl-cyclohexyl acetate 118.04
    tetrabutyl urea 101.53
    diisobutyl methanol 61.22
    2-phenylethanol 179.83
    styrene 160.74
    dioctyl adipate 107.54
    dimethyl sulfate 279.55
    ethyl butyrate 134.57
    methyl lactate 174.26
    butyl lactate 100.68
    diethyl carbonate 128.51
    propanediol butyl ether 136.18
    triethyl orthoformate 100.57
    p-tert-butyltoluene 61.35
    methyl 4-tert-butylbenzoate 157.96
    morpholine 613.13
    tert-butylamine 152.78
    n-dodecanol 51.46
    dimethoxymethane 437.44
    ethylene carbonate 315.44
    cyrene 188.46
    2-ethoxyethyl acetate 136.61
    2-ethylhexyl acetate 113.28
    1,2,4-trichlorobenzene 375.58
    4-methylpyridine 469.56
    dibutyl ether 90.9
    2,6-dimethyl-4-heptanol 61.22
    DEF 322.0
    dimethyl isosorbide 230.08
    tetrachloroethylene 722.94
    eugenol 174.68
    triacetin 150.48
    span 80 131.32
    1,4-butanediol 126.27
    1,1-dichloroethane 646.77
    2-methyl-1-pentanol 142.59
    methyl formate 409.58
    2-methyl-1-butanol 165.94
    n-decane 18.0
    butyronitrile 270.06
    3,7-dimethyl-1-octanol 83.63
    1-chlorooctane 77.83
    1-chlorotetradecane 36.84
    n-nonane 16.86
    undecane 14.7
    tert-butylcyclohexane 27.41
    cyclooctane 21.06
    cyclopentanol 273.67
    tetrahydropyran 474.28
    tert-amyl methyl ether 129.83
    2,5,8-trioxanonane 265.27
    1-hexene 81.05
    2-isopropoxyethanol 168.64
    2,2,2-trifluoroethanol 171.17
    methyl butyrate 217.17

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction