Ethyl 2-hydroxy-4-methylbenzoate

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  • Identifiers

    CAS number
    60770-00-5

    Molecular formula
    C10H12O3

    SMILES
    CCOC(=O)C1=C(C=C(C=C1)C)O

  • Odor profile

    Fragrance
    Floral 79.13%
    Sweet 56.77%
    Fruity 56.42%
    Phenolic 44.19%
    Herbal 38.94%
    Green 36.65%
    Grape 36.42%
    Woody 34.03%
    Aromatic 33.96%
    Animal 33.88%

     

    Flavor
    Bitter 48.74%
    Floral 42.44%
    Sweet 40.51%
    Balsam 34.14%
    Wintergreen 33.64%
    Woody 32.1%
    Herbal 31.37%
    Powdery 29.91%
    Spicy 28.28%
    Minty 27.06%

     

    Odor impact est.
    High

  • Properties

    XLogP3-AA
    3.7

    pKa est.
    8.46 (weak base)

    Molecular weight
    180.2 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Slow

    Boiling point est.
    247°C

    Flash point

    • 124.78 ˚C est.

  • Synonyms

    • ethyl 2-hydroxy-4-methylbenzoate
    • 60770-00-5
    • ethyl 4-methylsalicylate
    • Benzoic acid, 2-hydroxy-4-methyl-, ethyl ester
    • UNII-T28WB9L56F
    • T28WB9L56F
    • Ethyl 4-methyl salicylate
    • ETHYL 4 METHYL SALICYLATE (LICORIS)
    • DTXSID1074963
    • 50-85-1-BDMS-Et, + Et
    • 2,4-CRESOTIC ACID, ETHYL ESTER
    • 2-hydroxy-4-methylbenzoic acid ethyl ester
    • SCHEMBL3309126
    • ethyl2-hydroxy-4-methylbenzoate
    • DTXCID5042877
    • ethyl-2-hydroxy-4-methylbenzoate
    • MFCD06204737
    • AKOS008948863
    • DA-41981
    • NS00124588
    • G72377
    • Q27289567

  • Applications

    Ethyl 2-hydroxy-4-methylbenzoate, CAS 60770-00-5, is used primarily in fragrance and cosmetics as an aroma ingredient and, in some formulations, as a fragrance fixative to help extend scent longevity. It is commonly evaluated as an intermediate for the synthesis of more complex aroma compounds and may be incorporated into household cleaning products to impart a mild floral/green note. In cosmetics and personal care, it can serve as a scent component in creams, lotions, soaps, and other products. In industrial manufacturing, it functions as a building block for other fragrance-related chemicals and as a starting material in organic synthesis, subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 927.69
    methanol 1032.86
    isopropanol 736.87
    water 0.53
    ethyl acetate 461.97
    n-propanol 657.62
    acetone 1032.74
    n-butanol 577.83
    acetonitrile 608.51
    DMF 2302.4
    toluene 73.66
    isobutanol 432.51
    1,4-dioxane 1052.43
    methyl acetate 490.41
    THF 1876.43
    2-butanone 518.43
    n-pentanol 326.97
    sec-butanol 443.02
    n-hexane 12.04
    ethylene glycol 234.13
    NMP 1130.43
    cyclohexane 18.94
    DMSO 1677.83
    n-butyl acetate 234.11
    n-octanol 124.32
    chloroform 595.35
    n-propyl acetate 215.33
    acetic acid 706.3
    dichloromethane 630.88
    cyclohexanone 666.53
    propylene glycol 376.53
    isopropyl acetate 228.34
    DMAc 759.67
    2-ethoxyethanol 410.82
    isopentanol 388.2
    n-heptane 8.49
    ethyl formate 346.15
    1,2-dichloroethane 535.8
    n-hexanol 307.39
    2-methoxyethanol 1179.31
    isobutyl acetate 130.21
    tetrachloromethane 42.71
    n-pentyl acetate 122.77
    transcutol 667.92
    n-heptanol 116.05
    ethylbenzene 48.35
    MIBK 249.08
    2-propoxyethanol 514.17
    tert-butanol 829.31
    MTBE 309.77
    2-butoxyethanol 215.0
    propionic acid 428.81
    o-xylene 53.76
    formic acid 210.17
    diethyl ether 336.51
    m-xylene 71.15
    p-xylene 65.17
    chlorobenzene 173.28
    dimethyl carbonate 258.91
    n-octane 5.26
    formamide 421.18
    cyclopentanone 1125.27
    2-pentanone 464.3
    anisole 194.66
    cyclopentyl methyl ether 502.52
    gamma-butyrolactone 1279.6
    1-methoxy-2-propanol 893.89
    pyridine 376.25
    3-pentanone 248.6
    furfural 653.42
    n-dodecane 7.76
    diethylene glycol 481.61
    diisopropyl ether 75.59
    tert-amyl alcohol 445.66
    acetylacetone 513.19
    n-hexadecane 8.94
    acetophenone 176.92
    methyl propionate 415.98
    isopentyl acetate 195.6
    trichloroethylene 802.1
    n-nonanol 105.45
    cyclohexanol 396.58
    benzyl alcohol 190.14
    2-ethylhexanol 122.36
    isooctanol 93.94
    dipropyl ether 109.93
    1,2-dichlorobenzene 150.45
    ethyl lactate 140.96
    propylene carbonate 564.29
    n-methylformamide 830.98
    2-pentanol 339.91
    n-pentane 10.97
    1-propoxy-2-propanol 303.41
    1-methoxy-2-propyl acetate 273.04
    2-(2-methoxypropoxy) propanol 201.9
    mesitylene 51.45
    ε-caprolactone 529.23
    p-cymene 41.99
    epichlorohydrin 1269.88
    1,1,1-trichloroethane 328.98
    2-aminoethanol 439.12
    morpholine-4-carbaldehyde 848.46
    sulfolane 1333.31
    2,2,4-trimethylpentane 11.4
    2-methyltetrahydrofuran 884.14
    n-hexyl acetate 207.83
    isooctane 11.28
    2-(2-butoxyethoxy)ethanol 303.77
    sec-butyl acetate 127.87
    tert-butyl acetate 278.56
    decalin 15.4
    glycerin 448.42
    diglyme 510.82
    acrylic acid 383.66
    isopropyl myristate 81.98
    n-butyric acid 580.42
    acetyl acetate 252.36
    di(2-ethylhexyl) phthalate 84.04
    ethyl propionate 196.54
    nitromethane 1151.24
    1,2-diethoxyethane 193.12
    benzonitrile 199.42
    trioctyl phosphate 71.09
    1-bromopropane 221.25
    gamma-valerolactone 1076.28
    n-decanol 81.94
    triethyl phosphate 83.66
    4-methyl-2-pentanol 164.11
    propionitrile 378.47
    vinylene carbonate 452.95
    1,1,2-trichlorotrifluoroethane 551.12
    DMS 190.67
    cumene 42.81
    2-octanol 86.56
    2-hexanone 229.2
    octyl acetate 109.25
    limonene 67.21
    1,2-dimethoxyethane 656.78
    ethyl orthosilicate 74.89
    tributyl phosphate 83.92
    diacetone alcohol 444.09
    N,N-dimethylaniline 112.56
    acrylonitrile 487.3
    aniline 205.43
    1,3-propanediol 670.18
    bromobenzene 143.57
    dibromomethane 370.03
    1,1,2,2-tetrachloroethane 616.06
    2-methyl-cyclohexyl acetate 135.15
    tetrabutyl urea 110.07
    diisobutyl methanol 79.7
    2-phenylethanol 177.01
    styrene 62.02
    dioctyl adipate 117.73
    dimethyl sulfate 397.07
    ethyl butyrate 146.04
    methyl lactate 284.46
    butyl lactate 124.46
    diethyl carbonate 110.61
    propanediol butyl ether 229.83
    triethyl orthoformate 101.07
    p-tert-butyltoluene 45.68
    methyl 4-tert-butylbenzoate 165.69
    morpholine 1337.63
    tert-butylamine 322.63
    n-dodecanol 62.75
    dimethoxymethane 912.98
    ethylene carbonate 384.8
    cyrene 245.43
    2-ethoxyethyl acetate 177.95
    2-ethylhexyl acetate 135.69
    1,2,4-trichlorobenzene 196.59
    4-methylpyridine 377.95
    dibutyl ether 102.2
    2,6-dimethyl-4-heptanol 79.7
    DEF 489.6
    dimethyl isosorbide 360.94
    tetrachloroethylene 288.86
    eugenol 171.87
    triacetin 173.2
    span 80 186.66
    1,4-butanediol 199.19
    1,1-dichloroethane 480.6
    2-methyl-1-pentanol 231.28
    methyl formate 654.93
    2-methyl-1-butanol 339.23
    n-decane 10.91
    butyronitrile 401.22
    3,7-dimethyl-1-octanol 116.67
    1-chlorooctane 60.77
    1-chlorotetradecane 27.39
    n-nonane 9.47
    undecane 9.26
    tert-butylcyclohexane 16.87
    cyclooctane 5.73
    cyclopentanol 616.12
    tetrahydropyran 816.81
    tert-amyl methyl ether 209.52
    2,5,8-trioxanonane 352.7
    1-hexene 70.03
    2-isopropoxyethanol 264.65
    2,2,2-trifluoroethanol 202.29
    methyl butyrate 273.21

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction