Ethyl 2-hydroxy-4-methoxybenzoate

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  • Identifiers

    CAS number
    35031-00-6

    Molecular formula
    C10H12O4

    SMILES
    CCOC(=O)C1=C(C=C(C=C1)OC)O

  • Odor profile

    Fragrance
    Sweet 76.68%
    Floral 72.1%
    Fruity 56.43%
    Green 48.44%
    Herbal 46.41%
    Spicy 41.81%
    Phenolic 39.17%
    Balsamic 38.26%
    Anisic 37.96%
    Woody 35.85%

     

    Flavor
    Bitter 52.84%
    Floral 33.17%
    Balsam 31.55%
    Wintergreen 30.26%
    Fruity 27.12%
    Herbal 25.91%
    Sweet 24.06%
    Odorless 23.47%
    Ethyl benzoate 23.43%
    Mild 23.3%

     

    Odor impact est.
    Medium

  • Properties

    XLogP3-AA
    2.7

    pKa est.
    8.09 (weak base)

    Molecular weight
    196.2 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Very slow

    Boiling point est.
    275°C

    Flash point

    • 128.84 ˚C est.

  • Synonyms

    • ethyl 2-hydroxy-4-methoxybenzoate
    • Ethyl 4-methoxysalicylate
    • 35031-00-6
    • Benzoic acid, 2-hydroxy-4-methoxy-, ethyl ester
    • SCHEMBL17779153
    • DTXSID401299096
    • AKOS008948907
    • FS-7830
    • DB-129851

  • Applications

    Ethyl 2-hydroxy-4-methoxybenzoate (CAS 35031-00-6) is commonly used as a fragrance ingredient and flavor precursor, contributing vanilla- and fruit-like notes in perfumery and taste formulations. In cosmetics and personal care, it often serves as an aroma component in creams, lotions, and lip products. It may also be used in household products such as air fresheners and cleaning agents to impart pleasant scents, and in coatings and inks as a fragrance additive. Additionally, it can function as an intermediate in the synthesis of other aroma chemicals for the fragrance and flavor industries, with use governed by local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 94.04
    methanol 118.41
    isopropanol 73.27
    water 0.14
    ethyl acetate 153.81
    n-propanol 68.72
    acetone 423.9
    n-butanol 72.25
    acetonitrile 192.63
    DMF 953.45
    toluene 19.45
    isobutanol 48.96
    1,4-dioxane 213.29
    methyl acetate 180.75
    THF 493.24
    2-butanone 188.25
    n-pentanol 53.88
    sec-butanol 59.61
    n-hexane 2.74
    ethylene glycol 64.74
    NMP 719.88
    cyclohexane 3.38
    DMSO 1801.78
    n-butyl acetate 97.91
    n-octanol 25.36
    chloroform 206.37
    n-propyl acetate 98.84
    acetic acid 216.02
    dichloromethane 286.93
    cyclohexanone 256.66
    propylene glycol 76.8
    isopropyl acetate 84.1
    DMAc 610.46
    2-ethoxyethanol 157.74
    isopentanol 64.81
    n-heptane 2.02
    ethyl formate 113.19
    1,2-dichloroethane 255.96
    n-hexanol 48.86
    2-methoxyethanol 329.18
    isobutyl acetate 49.71
    tetrachloromethane 19.41
    n-pentyl acetate 44.22
    transcutol 392.94
    n-heptanol 22.48
    ethylbenzene 19.01
    MIBK 91.76
    2-propoxyethanol 141.8
    tert-butanol 136.26
    MTBE 74.72
    2-butoxyethanol 64.07
    propionic acid 127.21
    o-xylene 23.18
    formic acid 100.7
    diethyl ether 73.71
    m-xylene 24.31
    p-xylene 25.25
    chlorobenzene 64.45
    dimethyl carbonate 133.25
    n-octane 0.9
    formamide 251.12
    cyclopentanone 470.95
    2-pentanone 170.72
    anisole 86.45
    cyclopentyl methyl ether 146.25
    gamma-butyrolactone 581.14
    1-methoxy-2-propanol 233.42
    pyridine 120.0
    3-pentanone 113.77
    furfural 360.69
    n-dodecane 1.36
    diethylene glycol 172.2
    diisopropyl ether 20.93
    tert-amyl alcohol 96.1
    acetylacetone 277.23
    n-hexadecane 1.63
    acetophenone 102.27
    methyl propionate 173.4
    isopentyl acetate 79.25
    trichloroethylene 433.0
    n-nonanol 23.42
    cyclohexanol 75.29
    benzyl alcohol 76.16
    2-ethylhexanol 33.41
    isooctanol 20.33
    dipropyl ether 35.66
    1,2-dichlorobenzene 76.19
    ethyl lactate 78.81
    propylene carbonate 225.92
    n-methylformamide 326.45
    2-pentanol 47.65
    n-pentane 1.8
    1-propoxy-2-propanol 100.45
    1-methoxy-2-propyl acetate 133.02
    2-(2-methoxypropoxy) propanol 110.51
    mesitylene 18.82
    ε-caprolactone 206.15
    p-cymene 18.82
    epichlorohydrin 527.79
    1,1,1-trichloroethane 148.24
    2-aminoethanol 85.17
    morpholine-4-carbaldehyde 424.92
    sulfolane 925.93
    2,2,4-trimethylpentane 2.88
    2-methyltetrahydrofuran 218.58
    n-hexyl acetate 72.15
    isooctane 2.24
    2-(2-butoxyethoxy)ethanol 125.92
    sec-butyl acetate 56.94
    tert-butyl acetate 113.36
    decalin 4.66
    glycerin 162.12
    diglyme 260.39
    acrylic acid 151.72
    isopropyl myristate 28.83
    n-butyric acid 131.6
    acetyl acetate 110.85
    di(2-ethylhexyl) phthalate 37.12
    ethyl propionate 100.89
    nitromethane 632.49
    1,2-diethoxyethane 84.92
    benzonitrile 90.35
    trioctyl phosphate 27.17
    1-bromopropane 65.44
    gamma-valerolactone 443.65
    n-decanol 18.17
    triethyl phosphate 52.89
    4-methyl-2-pentanol 31.28
    propionitrile 96.51
    vinylene carbonate 187.23
    1,1,2-trichlorotrifluoroethane 353.82
    DMS 108.02
    cumene 17.72
    2-octanol 16.91
    2-hexanone 102.39
    octyl acetate 38.45
    limonene 28.45
    1,2-dimethoxyethane 288.1
    ethyl orthosilicate 41.91
    tributyl phosphate 39.26
    diacetone alcohol 175.25
    N,N-dimethylaniline 63.02
    acrylonitrile 163.71
    aniline 65.56
    1,3-propanediol 130.06
    bromobenzene 56.35
    dibromomethane 156.06
    1,1,2,2-tetrachloroethane 312.04
    2-methyl-cyclohexyl acetate 66.65
    tetrabutyl urea 54.34
    diisobutyl methanol 21.61
    2-phenylethanol 66.01
    styrene 24.0
    dioctyl adipate 56.5
    dimethyl sulfate 327.13
    ethyl butyrate 75.33
    methyl lactate 148.87
    butyl lactate 53.42
    diethyl carbonate 62.99
    propanediol butyl ether 83.26
    triethyl orthoformate 54.4
    p-tert-butyltoluene 18.56
    methyl 4-tert-butylbenzoate 84.43
    morpholine 271.18
    tert-butylamine 53.52
    n-dodecanol 14.05
    dimethoxymethane 324.02
    ethylene carbonate 145.57
    cyrene 143.34
    2-ethoxyethyl acetate 80.33
    2-ethylhexyl acetate 59.31
    1,2,4-trichlorobenzene 100.45
    4-methylpyridine 126.16
    dibutyl ether 30.75
    2,6-dimethyl-4-heptanol 21.61
    DEF 226.83
    dimethyl isosorbide 194.73
    tetrachloroethylene 144.57
    eugenol 84.89
    triacetin 99.44
    span 80 74.76
    1,4-butanediol 48.62
    1,1-dichloroethane 158.29
    2-methyl-1-pentanol 50.95
    methyl formate 280.63
    2-methyl-1-butanol 56.81
    n-decane 2.13
    butyronitrile 97.24
    3,7-dimethyl-1-octanol 31.73
    1-chlorooctane 15.19
    1-chlorotetradecane 6.63
    n-nonane 1.76
    undecane 1.67
    tert-butylcyclohexane 4.44
    cyclooctane 1.39
    cyclopentanol 106.04
    tetrahydropyran 140.65
    tert-amyl methyl ether 62.33
    2,5,8-trioxanonane 186.85
    1-hexene 15.01
    2-isopropoxyethanol 95.68
    2,2,2-trifluoroethanol 102.56
    methyl butyrate 137.13

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction