Ethyl 2-(1-ethoxyethoxy)propanoate

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  • Identifiers

    CAS number
    37101-80-7

    Molecular formula
    C9H18O4

    SMILES
    CCOC(C)OC(C)C(=O)OCC

    Safety labels

  • Odor profile

    Fragrance
    Fruity 91.75%
    Ethereal 42.58%
    Buttery 37.91%
    Sweet 33.44%
    Tropical 32.99%
    Fresh 31.13%
    Winey 30.52%
    Caramellic 30.12%
    Apple 29.59%
    Green 28.99%

     

    Flavor
    Fruity 83.79%
    Green 48.25%
    Sweet 42.07%
    Tropical 40.2%
    Fruit 40.11%
    Fatty 38.26%
    Pineapple 36.45%
    Creamy 32.6%
    Wine 30.3%
    Apple 29.74%

     

    Odor impact est.
    Medium

  • Properties

    XLogP3-AA
    1.5

    pKa est.
    7.24 (neutral)

    Molecular weight
    190.24 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Moderately fast

    Boiling point est.
    194°C

    Flash point

    • 66.88 ˚C est.

  • Synonyms

    • Ethyl 2-(1-ethoxyethoxy)propanoate
    • 37101-80-7
    • DTXSID60338937
    • RefChem:342341
    • DTXCID90290019
    • SCHEMBL10636719
    • Ethyl 2-(1-ethoxyethoxy)propanoate #
    • ethyl 2-[(1'-ethoxy)ethoxy]propanoate
    • DB-264895
    • Propanoic acid, 2-(1-ethoxyethoxy)-, ethyl ester
    • 37101-80-7

  • Applications

    Ethyl 2-(1-ethoxyethoxy)propanoate (CAS 37101-80-7) is used primarily as a versatile solvent and processing aid in coatings, inks, and industrial cleaners; it also serves as a common intermediate in organic synthesis for pharmaceuticals and agrochemicals, and can act as a building block for chiral lactic-acid–derived compounds; in fragrance and cosmetic science it may be evaluated as a solvent or carrier for fragrance ingredients; in polymer and adhesive formulations it can function as a processing solvent or compatible diluent; and it is occasionally considered for specialty electronics formulations, subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 1467.07
    methanol 2410.85
    isopropanol 1044.32
    water 21.69
    ethyl acetate 1552.02
    n-propanol 1212.8
    acetone 2279.65
    n-butanol 1028.33
    acetonitrile 2903.03
    DMF 2476.95
    toluene 959.95
    isobutanol 954.79
    1,4-dioxane 2336.3
    methyl acetate 1572.39
    THF 2065.54
    2-butanone 1579.37
    n-pentanol 808.03
    sec-butanol 1112.11
    n-hexane 282.55
    ethylene glycol 425.61
    NMP 2467.78
    cyclohexane 617.55
    DMSO 3331.11
    n-butyl acetate 988.31
    n-octanol 303.42
    chloroform 4799.79
    n-propyl acetate 888.67
    acetic acid 3921.49
    dichloromethane 5615.5
    cyclohexanone 2250.35
    propylene glycol 377.48
    isopropyl acetate 815.44
    DMAc 2641.87
    2-ethoxyethanol 1367.21
    isopentanol 836.14
    n-heptane 114.55
    ethyl formate 1192.98
    1,2-dichloroethane 3027.62
    n-hexanol 579.66
    2-methoxyethanol 1931.93
    isobutyl acetate 507.55
    tetrachloromethane 907.99
    n-pentyl acetate 607.48
    transcutol 2061.88
    n-heptanol 255.7
    ethylbenzene 615.14
    MIBK 593.45
    2-propoxyethanol 931.46
    tert-butanol 1330.51
    MTBE 1427.89
    2-butoxyethanol 485.33
    propionic acid 1503.36
    o-xylene 679.04
    formic acid 1706.33
    diethyl ether 1452.2
    m-xylene 539.58
    p-xylene 845.52
    chlorobenzene 1549.22
    dimethyl carbonate 505.35
    n-octane 51.8
    formamide 2086.77
    cyclopentanone 1892.06
    2-pentanone 1065.18
    anisole 993.23
    cyclopentyl methyl ether 1205.74
    gamma-butyrolactone 2512.49
    1-methoxy-2-propanol 1013.14
    pyridine 2585.15
    3-pentanone 1037.11
    furfural 2463.08
    n-dodecane 39.24
    diethylene glycol 761.38
    diisopropyl ether 352.35
    tert-amyl alcohol 1416.3
    acetylacetone 1348.86
    n-hexadecane 45.15
    acetophenone 1045.12
    methyl propionate 1085.17
    isopentyl acetate 819.15
    trichloroethylene 4958.24
    n-nonanol 250.6
    cyclohexanol 1377.19
    benzyl alcohol 910.8
    2-ethylhexanol 426.79
    isooctanol 218.52
    dipropyl ether 481.91
    1,2-dichlorobenzene 1435.92
    ethyl lactate 377.1
    propylene carbonate 1416.25
    n-methylformamide 1687.27
    2-pentanol 646.05
    n-pentane 224.65
    1-propoxy-2-propanol 576.25
    1-methoxy-2-propyl acetate 674.67
    2-(2-methoxypropoxy) propanol 505.47
    mesitylene 311.51
    ε-caprolactone 1975.77
    p-cymene 302.87
    epichlorohydrin 2601.91
    1,1,1-trichloroethane 2449.87
    2-aminoethanol 745.56
    morpholine-4-carbaldehyde 2132.8
    sulfolane 2838.82
    2,2,4-trimethylpentane 148.07
    2-methyltetrahydrofuran 1989.24
    n-hexyl acetate 777.57
    isooctane 64.5
    2-(2-butoxyethoxy)ethanol 611.43
    sec-butyl acetate 587.76
    tert-butyl acetate 760.04
    decalin 225.84
    glycerin 591.81
    diglyme 1421.32
    acrylic acid 1462.71
    isopropyl myristate 264.0
    n-butyric acid 1658.22
    acetyl acetate 1301.02
    di(2-ethylhexyl) phthalate 288.19
    ethyl propionate 809.41
    nitromethane 4770.07
    1,2-diethoxyethane 915.53
    benzonitrile 1426.77
    trioctyl phosphate 194.47
    1-bromopropane 1685.81
    gamma-valerolactone 2432.92
    n-decanol 169.51
    triethyl phosphate 391.25
    4-methyl-2-pentanol 323.83
    propionitrile 1685.81
    vinylene carbonate 1520.0
    1,1,2-trichlorotrifluoroethane 2054.15
    DMS 723.38
    cumene 381.17
    2-octanol 218.42
    2-hexanone 809.67
    octyl acetate 345.12
    limonene 470.17
    1,2-dimethoxyethane 2215.48
    ethyl orthosilicate 361.24
    tributyl phosphate 299.66
    diacetone alcohol 661.73
    N,N-dimethylaniline 705.53
    acrylonitrile 1970.6
    aniline 1151.05
    1,3-propanediol 974.17
    bromobenzene 1756.79
    dibromomethane 3517.56
    1,1,2,2-tetrachloroethane 3738.04
    2-methyl-cyclohexyl acetate 560.44
    tetrabutyl urea 366.37
    diisobutyl methanol 219.42
    2-phenylethanol 609.48
    styrene 829.23
    dioctyl adipate 441.2
    dimethyl sulfate 931.52
    ethyl butyrate 697.11
    methyl lactate 484.34
    butyl lactate 418.06
    diethyl carbonate 557.21
    propanediol butyl ether 434.28
    triethyl orthoformate 484.39
    p-tert-butyltoluene 265.33
    methyl 4-tert-butylbenzoate 568.44
    morpholine 2568.53
    tert-butylamine 977.32
    n-dodecanol 130.17
    dimethoxymethane 1218.81
    ethylene carbonate 1234.37
    cyrene 598.09
    2-ethoxyethyl acetate 752.05
    2-ethylhexyl acetate 698.83
    1,2,4-trichlorobenzene 1630.73
    4-methylpyridine 2454.63
    dibutyl ether 494.64
    2,6-dimethyl-4-heptanol 219.42
    DEF 1636.17
    dimethyl isosorbide 894.98
    tetrachloroethylene 2871.74
    eugenol 519.97
    triacetin 736.66
    span 80 437.92
    1,4-butanediol 480.0
    1,1-dichloroethane 2578.25
    2-methyl-1-pentanol 761.22
    methyl formate 1357.58
    2-methyl-1-butanol 978.21
    n-decane 68.9
    butyronitrile 1527.27
    3,7-dimethyl-1-octanol 323.25
    1-chlorooctane 282.77
    1-chlorotetradecane 106.39
    n-nonane 73.89
    undecane 48.85
    tert-butylcyclohexane 167.18
    cyclooctane 151.38
    cyclopentanol 1234.25
    tetrahydropyran 2231.47
    tert-amyl methyl ether 1131.23
    2,5,8-trioxanonane 873.71
    1-hexene 710.94
    2-isopropoxyethanol 802.35
    2,2,2-trifluoroethanol 1147.56
    methyl butyrate 1139.65

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction