Ethoxyquin

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  • Identifiers

    CAS number
    91-53-2

    Molecular formula
    C14H19NO

    SMILES
    CCOC1=CC2=C(C=C1)NC(C=C2C)(C)C

    Safety labels

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Fruity 43.93%
    Sweet 40.78%
    Woody 37.17%
    Floral 34.9%
    Musk 31.37%
    Powdery 30.73%
    Animal 29.94%
    Spicy 28.25%
    Dry 26.55%
    Phenolic 25.7%

     

    Flavor
    Bitter 49.43%
    Woody 27.15%
    Camphor 23.1%
    Floral 22.15%
    Wood 22.0%
    Herbal 21.14%
    Parsley 20.53%
    Red fruit 20.34%
    Ripe apricot 20.31%
    Broom 19.82%

     

    Odor impact est.
    Medium

  • Properties

    XLogP3-AA
    3.1

    pKa est.
    8.29 (weak base)

    Molecular weight
    217.31 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Melting point expt.

    • less than 32 °F (NTP, 1992)
    • Approximately 0 °C

    Boiling point

    • 253 to 257 °F at 2 mmHg (NTP, 1992)
    • 123-125 °C AT 2 MM HG

    Flash point

    • 136.19 ˚C est.
    • 225 °F (NTP, 1992)

    Solubility expt.

    • less than 1 mg/mL at 68 °F (NTP, 1992)

  • Synonyms

    • ethoxyquin
    • 91-53-2
    • 6-Ethoxy-2,2,4-trimethyl-1,2-dihydroquinoline
    • Ethoxyquine
    • Santoquin
    • Santoquine
    • Niflex
    • Antioxidant EC
    • Santoflex A
    • Santoflex AW
    • Stop-Scald
    • Dawe's nutrigard
    • Nix-Scald
    • Nocrack AW
    • Quinol ED
    • Aries Antox
    • Permanax 103
    • Amea 100
    • Niflex D
    • Antage AW
    • Nocrac AW
    • Ethoxychin
    • Alterungsschutzmittel EC
    • Ethoxyquin [ISO]
    • Quinoline, 6-ethoxy-1,2-dihydro-2,2,4-trimethyl-
    • Santoquine (VAN)
    • Usaf B-24
    • 1,2-Dihydro-6-ethoxy-2,2,4-trimethylquinoline
    • 6-Ethoxy-1,2-dihydro-2,2,4-trimethylquinoline
    • Ethoxychin [Czech]
    • Santoflex
    • Antox
    • Caswell No. 427D
    • NSC-6795
    • 1,2-Dihydro-2,2,4-trimethyl-6-ethoxyquinoline
    • 6-ethoxy-2,2,4-trimethyl-1H-quinoline
    • 2,2,4-Trimethyl-6-ethoxy-1,2-dihydroquinoline
    • CCRIS 2513
    • HSDB 400
    • SantoquinEQ
    • 6-ETMDQ
    • EINECS 202-075-7
    • EMQ
    • EPA Pesticide Chemical Code 055501
    • UNII-9T1410R4OR
    • DTXSID9020582
    • CHEBI:77323
    • AI3-17715
    • 9T1410R4OR
    • ETHOXYQUIN [MI]
    • ETHOXYQUIN [FCC]
    • ETHOXYQUIN [HSDB]
    • EQ
    • ETHOXYQUIN [MART.]
    • 6-(ethyloxy)-2,2,4-trimethyl-1,2-dihydroquinoline
    • DTXCID70582
    • NSC 6795
    • Ethyl 2,2,4-trimethyl-1,2-dihydro-6-quinolinyl ether
    • CAS-91-53-2
    • NCGC00016348-02
    • E324
    • E 324
    • ETHOXYQUIN (MART.)
    • 2,2, 4-Trimethyl-6-ethoxy-1,2-dihydroquinoline
    • 6-Ethoxy-1, 2-dihydro-2,2,4-trimethylquinoline
    • 6-Ethoxy-2,2,4-trimethyl-1, 2-dihydroquinoline
    • 6-Ethoxy-1,2-dihydro-2,2,4-trimethyl-Quinoline
    • 6-Ethoxy-1,2-dihydro-2,2,4-trimethylquinoline, 9CI, 8CI
    • 1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLIN-6-YL ETHYL ETHER
    • StopScald
    • NixScald
    • MFCD00023883
    • Prestwick_1064
    • RALUQUIN
    • Ethoxyquin (Standard)
    • Spectrum_001214
    • Prestwick0_000765
    • Prestwick1_000765
    • Prestwick2_000765
    • Prestwick3_000765
    • Spectrum2_001384
    • Spectrum3_001423
    • Spectrum4_000404
    • Spectrum5_001530
    • Pesticide Code 055501
    • SCHEMBL21601
    • BSPBio_000810
    • BSPBio_003126
    • KBioGR_000668
    • KBioSS_001694
    • MLS001055488
    • BIDD:GT0822
    • DivK1c_000183
    • SPECTRUM1500998
    • SPBio_001368
    • SPBio_002749
    • BPBio1_000892
    • CHEMBL172064
    • HMS500J05
    • HY-B1425R
    • KBio1_000183
    • KBio2_001694
    • KBio2_004262
    • KBio2_006830
    • KBio3_002346
    • NSC6795
    • NINDS_000183
    • HMS1570I12
    • HMS1923K03
    • HMS2097I12
    • HMS3714I12
    • 1,2,4-trimethyl-6-ethoxyquinoline
    • HY-B1425
    • 6-Ethoxy-1,2,4-trimethylquinoline
    • Tox21_110388
    • Tox21_201336
    • Tox21_300328
    • CCG-39002
    • Ethoxyquin, >=75% (capillary GC)
    • s5369
    • STK772149
    • AKOS000121441
    • CS-8200
    • FE22911
    • IDI1_000183
    • NCGC00016348-01
    • NCGC00016348-03
    • NCGC00016348-04

  • Applications

    Ethoxyquin (CAS 91-53-2) is a synthetic antioxidant used primarily as a stabilizer in animal feeds and pet foods to prevent oxidation of fats and oils, particularly in fish oils used in aquaculture diets. It is also used as a stabilizer and antioxidant in polymer formulations for plastics and rubber to reduce oxidative degradation during processing and service. In some industrial oil and lubricant systems, it may be used as an antioxidant additive.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 84.86
    methanol 96.05
    isopropanol 67.32
    water 0.37
    ethyl acetate 196.38
    n-propanol 100.45
    acetone 227.51
    n-butanol 113.47
    acetonitrile 123.73
    DMF 364.83
    toluene 173.93
    isobutanol 93.21
    1,4-dioxane 376.21
    methyl acetate 232.26
    THF 441.93
    2-butanone 246.04
    n-pentanol 95.7
    sec-butanol 88.99
    n-hexane 41.48
    ethylene glycol 40.42
    NMP 481.09
    cyclohexane 54.33
    DMSO 320.27
    n-butyl acetate 192.46
    n-octanol 89.39
    chloroform 608.99
    n-propyl acetate 120.61
    acetic acid 124.73
    dichloromethane 494.96
    cyclohexanone 340.81
    propylene glycol 56.41
    isopropyl acetate 133.42
    DMAc 565.31
    2-ethoxyethanol 139.28
    isopentanol 112.97
    n-heptane 24.53
    ethyl formate 109.44
    1,2-dichloroethane 327.59
    n-hexanol 145.31
    2-methoxyethanol 192.62
    isobutyl acetate 110.14
    tetrachloromethane 98.92
    n-pentyl acetate 137.22
    transcutol 669.43
    n-heptanol 72.41
    ethylbenzene 85.93
    MIBK 130.29
    2-propoxyethanol 248.09
    tert-butanol 98.93
    MTBE 196.87
    2-butoxyethanol 135.58
    propionic acid 121.89
    o-xylene 113.47
    formic acid 47.16
    diethyl ether 229.6
    m-xylene 121.66
    p-xylene 108.83
    chlorobenzene 221.65
    dimethyl carbonate 133.16
    n-octane 11.67
    formamide 60.01
    cyclopentanone 382.32
    2-pentanone 192.12
    anisole 161.84
    cyclopentyl methyl ether 285.16
    gamma-butyrolactone 382.41
    1-methoxy-2-propanol 163.59
    pyridine 263.06
    3-pentanone 233.88
    furfural 336.4
    n-dodecane 10.44
    diethylene glycol 177.23
    diisopropyl ether 79.38
    tert-amyl alcohol 115.99
    acetylacetone 225.74
    n-hexadecane 12.22
    acetophenone 154.56
    methyl propionate 212.78
    isopentyl acetate 191.59
    trichloroethylene 635.99
    n-nonanol 81.88
    cyclohexanol 143.78
    benzyl alcohol 111.43
    2-ethylhexanol 106.01
    isooctanol 61.84
    dipropyl ether 123.99
    1,2-dichlorobenzene 198.5
    ethyl lactate 80.48
    propylene carbonate 224.31
    n-methylformamide 125.1
    2-pentanol 84.33
    n-pentane 31.38
    1-propoxy-2-propanol 171.54
    1-methoxy-2-propyl acetate 219.39
    2-(2-methoxypropoxy) propanol 170.01
    mesitylene 81.36
    ε-caprolactone 295.88
    p-cymene 66.91
    epichlorohydrin 441.88
    1,1,1-trichloroethane 322.1
    2-aminoethanol 64.01
    morpholine-4-carbaldehyde 432.86
    sulfolane 457.36
    2,2,4-trimethylpentane 23.98
    2-methyltetrahydrofuran 361.45
    n-hexyl acetate 227.82
    isooctane 14.91
    2-(2-butoxyethoxy)ethanol 218.54
    sec-butyl acetate 104.66
    tert-butyl acetate 151.48
    decalin 34.8
    glycerin 91.86
    diglyme 401.56
    acrylic acid 118.86
    isopropyl myristate 81.28
    n-butyric acid 142.48
    acetyl acetate 165.44
    di(2-ethylhexyl) phthalate 86.38
    ethyl propionate 123.26
    nitromethane 226.8
    1,2-diethoxyethane 245.27
    benzonitrile 154.35
    trioctyl phosphate 62.03
    1-bromopropane 202.46
    gamma-valerolactone 413.23
    n-decanol 61.2
    triethyl phosphate 90.05
    4-methyl-2-pentanol 60.38
    propionitrile 113.03
    vinylene carbonate 213.45
    1,1,2-trichlorotrifluoroethane 311.85
    DMS 227.74
    cumene 69.05
    2-octanol 55.19
    2-hexanone 142.6
    octyl acetate 111.58
    limonene 93.87
    1,2-dimethoxyethane 253.85
    ethyl orthosilicate 88.3
    tributyl phosphate 83.2
    diacetone alcohol 145.56
    N,N-dimethylaniline 125.54
    acrylonitrile 131.01
    aniline 160.85
    1,3-propanediol 87.06
    bromobenzene 243.46
    dibromomethane 343.73
    1,1,2,2-tetrachloroethane 529.57
    2-methyl-cyclohexyl acetate 131.35
    tetrabutyl urea 105.23
    diisobutyl methanol 57.01
    2-phenylethanol 140.35
    styrene 98.09
    dioctyl adipate 109.57
    dimethyl sulfate 236.8
    ethyl butyrate 124.33
    methyl lactate 109.3
    butyl lactate 115.88
    diethyl carbonate 97.14
    propanediol butyl ether 147.77
    triethyl orthoformate 109.94
    p-tert-butyltoluene 67.25
    methyl 4-tert-butylbenzoate 147.51
    morpholine 350.77
    tert-butylamine 73.42
    n-dodecanol 48.35
    dimethoxymethane 277.79
    ethylene carbonate 187.1
    cyrene 160.39
    2-ethoxyethyl acetate 217.7
    2-ethylhexyl acetate 183.63
    1,2,4-trichlorobenzene 266.76
    4-methylpyridine 289.86
    dibutyl ether 125.71
    2,6-dimethyl-4-heptanol 57.01
    DEF 246.37
    dimethyl isosorbide 271.0
    tetrachloroethylene 321.55
    eugenol 137.47
    triacetin 214.64
    span 80 141.47
    1,4-butanediol 50.44
    1,1-dichloroethane 283.87
    2-methyl-1-pentanol 105.86
    methyl formate 121.58
    2-methyl-1-butanol 123.42
    n-decane 17.68
    butyronitrile 115.83
    3,7-dimethyl-1-octanol 86.98
    1-chlorooctane 81.61
    1-chlorotetradecane 32.84
    n-nonane 17.49
    undecane 13.18
    tert-butylcyclohexane 32.03
    cyclooctane 25.91
    cyclopentanol 131.28
    tetrahydropyran 342.58
    tert-amyl methyl ether 185.98
    2,5,8-trioxanonane 273.06
    1-hexene 92.99
    2-isopropoxyethanol 121.18
    2,2,2-trifluoroethanol 74.13
    methyl butyrate 142.82

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction