Ethoxyacetic acid

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  • Identifiers

    CAS number
    627-03-2

    Molecular formula
    C4H8O3

    SMILES
    CCOCC(=O)O

    Safety labels

    Corrosive
    Corrosive

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Fruity 51.76%
    Caramellic 49.48%
    Buttery 44.28%
    Sour 40.19%
    Ethereal 38.13%
    Cheesy 32.38%
    Milky 32.08%
    Sharp 30.32%
    Dairy 30.2%
    Sweet 29.18%

     

    Flavor
    Sour 40.63%
    Acidic 39.86%
    Pungent 38.12%
    Rancid 37.14%
    Cheese 36.93%
    Sweat 35.47%
    Odorless 34.38%
    Sweet 34.37%
    Sharp 32.74%
    Fatty 30.45%

     

    Odor impact est.
    Low

  • Properties

    pKa est.
    7.42 (neutral)

    Molecular weight
    104.1 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Moderately slow

    Boiling point

    • 403 to 405 °F at 760 mmHg (NTP, 1992)

    Flash point

    • 82.21 ˚C est.
    • 208 °F (NTP, 1992)

    Solubility expt.

    • Soluble (NTP, 1992)

  • Synonyms

    • ETHOXYACETIC ACID
    • 2-Ethoxyacetic acid
    • 627-03-2
    • Ethoxy acetic acid
    • Acetic acid, 2-ethoxy-
    • DTXSID7031294
    • 467VW095BX
    • NSC-6750
    • DTXCID5011294
    • RefChem:138423
    • 210-978-2
    • Acetic acid, ethoxy-
    • O-Ethylglycolic acid
    • MFCD00004310
    • ethoxy-acetic acid
    • 2-ethoxy-acetic acid
    • CAS-627-03-2
    • CCRIS 7194
    • NSC 6750
    • EINECS 210-978-2
    • BRN 1743037
    • UNII-467VW095BX
    • AI3-24145
    • 2-Ethoxyaceticacid
    • RESOMER®
    • Ethoxyacetic acid, 98%
    • Glycolic acid ethyl ether
    • ETHOXYACETIC ACID (EGMEE (110-80-5))
    • SCHEMBL48574
    • orb1303803
    • SCHEMBL2849846
    • SCHEMBL4117138
    • SCHEMBL4128454
    • SCHEMBL4444502
    • CHEMBL1159929
    • YZGQDNOIGFBYKF-UHFFFAOYSA-
    • NSC6750
    • CHEBI:173365
    • STR05191
    • Tox21_202431
    • Tox21_303384
    • SBB069120
    • STL166132
    • AKOS000120246
    • EBC-615319
    • FP34560
    • HY-W027555
    • X 206 S
    • NCGC00090711-01
    • NCGC00090711-02
    • NCGC00257362-01
    • NCGC00259980-01
    • CS-0071579
    • E0377
    • Ethoxyacetic acid, purum, >=98.0% (GC)
    • NS00035134
    • EN300-21303
    • D73862
    • F461062
    • Q26841235
    • F2191-0091
    • Z104495232
    • InChI=1/C4H8O3/c1-2-7-3-4(5)6/h2-3H2,1H3,(H,5,6)
    • 627-03-2

  • Applications

    Ethoxyacetic acid (CAS 627-03-2) is primarily used as a reactive intermediate in organic synthesis, enabling the preparation of glycolate esters and related ether derivatives. It serves as a building block for surfactants and cleaning products through glycolate ester formation, and it is also employed as a precursor in pharmaceutical and agrochemical syntheses where its ester and ether functionalities are incorporated into target molecules. In coatings, inks, and polymer applications, derivatives of ethoxyacetic acid are used to impart glycolate functionality, improving solubility and processing characteristics. It may also function as a processing aid or solvent for specialty chemicals in industrial manufacturing, subject to formulation limits and local regulations.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 129.62
    methanol 298.38
    isopropanol 73.1
    water 176.66
    ethyl acetate 20.59
    n-propanol 76.42
    acetone 65.8
    n-butanol 54.74
    acetonitrile 39.16
    DMF 582.33
    toluene 3.66
    isobutanol 44.52
    1,4-dioxane 62.87
    methyl acetate 34.65
    THF 96.13
    2-butanone 28.69
    n-pentanol 29.89
    sec-butanol 42.44
    n-hexane 1.46
    ethylene glycol 285.53
    NMP 277.4
    cyclohexane 1.31
    DMSO 519.05
    n-butyl acetate 14.07
    n-octanol 19.63
    chloroform 16.0
    n-propyl acetate 12.05
    acetic acid 151.93
    dichloromethane 22.0
    cyclohexanone 43.58
    propylene glycol 178.0
    isopropyl acetate 11.88
    DMAc 307.56
    2-ethoxyethanol 100.91
    isopentanol 34.11
    n-heptane 1.81
    ethyl formate 56.19
    1,2-dichloroethane 20.15
    n-hexanol 31.37
    2-methoxyethanol 271.86
    isobutyl acetate 7.36
    tetrachloromethane 4.52
    n-pentyl acetate 10.7
    transcutol 120.15
    n-heptanol 17.06
    ethylbenzene 4.07
    MIBK 14.22
    2-propoxyethanol 85.12
    tert-butanol 77.11
    MTBE 20.69
    2-butoxyethanol 43.5
    propionic acid 87.36
    o-xylene 7.4
    formic acid 277.65
    diethyl ether 11.9
    m-xylene 6.17
    p-xylene 5.1
    chlorobenzene 7.21
    dimethyl carbonate 22.56
    n-octane 0.95
    formamide 200.91
    cyclopentanone 70.58
    2-pentanone 21.54
    anisole 16.13
    cyclopentyl methyl ether 23.56
    gamma-butyrolactone 100.7
    1-methoxy-2-propanol 137.36
    pyridine 26.88
    3-pentanone 14.85
    furfural 125.78
    n-dodecane 1.28
    diethylene glycol 154.55
    diisopropyl ether 3.84
    tert-amyl alcohol 49.34
    acetylacetone 34.81
    n-hexadecane 1.38
    acetophenone 21.56
    methyl propionate 32.46
    isopentyl acetate 13.75
    trichloroethylene 28.15
    n-nonanol 17.26
    cyclohexanol 33.04
    benzyl alcohol 29.28
    2-ethylhexanol 16.29
    isooctanol 13.44
    dipropyl ether 9.94
    1,2-dichlorobenzene 11.73
    ethyl lactate 29.48
    propylene carbonate 47.87
    n-methylformamide 254.47
    2-pentanol 22.05
    n-pentane 1.5
    1-propoxy-2-propanol 48.24
    1-methoxy-2-propyl acetate 27.12
    2-(2-methoxypropoxy) propanol 58.79
    mesitylene 5.48
    ε-caprolactone 44.49
    p-cymene 6.62
    epichlorohydrin 69.9
    1,1,1-trichloroethane 9.99
    2-aminoethanol 233.5
    morpholine-4-carbaldehyde 211.74
    sulfolane 178.86
    2,2,4-trimethylpentane 1.59
    2-methyltetrahydrofuran 38.72
    n-hexyl acetate 19.14
    isooctane 1.12
    2-(2-butoxyethoxy)ethanol 68.1
    sec-butyl acetate 7.31
    tert-butyl acetate 15.76
    decalin 1.7
    glycerin 303.12
    diglyme 100.99
    acrylic acid 110.12
    isopropyl myristate 9.7
    n-butyric acid 67.51
    acetyl acetate 16.63
    di(2-ethylhexyl) phthalate 18.95
    ethyl propionate 13.93
    nitromethane 164.49
    1,2-diethoxyethane 18.06
    benzonitrile 21.83
    trioctyl phosphate 14.06
    1-bromopropane 8.0
    gamma-valerolactone 123.71
    n-decanol 13.82
    triethyl phosphate 14.41
    4-methyl-2-pentanol 13.88
    propionitrile 28.8
    vinylene carbonate 50.29
    1,1,2-trichlorotrifluoroethane 125.65
    DMS 22.72
    cumene 5.1
    2-octanol 11.21
    2-hexanone 12.34
    octyl acetate 13.95
    limonene 9.3
    1,2-dimethoxyethane 111.2
    ethyl orthosilicate 12.3
    tributyl phosphate 14.86
    diacetone alcohol 47.04
    N,N-dimethylaniline 19.89
    acrylonitrile 58.19
    aniline 18.55
    1,3-propanediol 180.35
    bromobenzene 4.88
    dibromomethane 12.27
    1,1,2,2-tetrachloroethane 28.92
    2-methyl-cyclohexyl acetate 15.46
    tetrabutyl urea 25.98
    diisobutyl methanol 11.17
    2-phenylethanol 24.34
    styrene 4.41
    dioctyl adipate 18.1
    dimethyl sulfate 69.48
    ethyl butyrate 13.17
    methyl lactate 70.61
    butyl lactate 23.67
    diethyl carbonate 11.74
    propanediol butyl ether 62.71
    triethyl orthoformate 12.87
    p-tert-butyltoluene 6.74
    methyl 4-tert-butylbenzoate 31.47
    morpholine 90.82
    tert-butylamine 31.58
    n-dodecanol 10.91
    dimethoxymethane 99.88
    ethylene carbonate 35.49
    cyrene 61.93
    2-ethoxyethyl acetate 17.45
    2-ethylhexyl acetate 10.16
    1,2,4-trichlorobenzene 14.8
    4-methylpyridine 28.38
    dibutyl ether 8.75
    2,6-dimethyl-4-heptanol 11.17
    DEF 69.12
    dimethyl isosorbide 69.21
    tetrachloroethylene 22.88
    eugenol 43.38
    triacetin 26.31
    span 80 49.66
    1,4-butanediol 80.24
    1,1-dichloroethane 11.5
    2-methyl-1-pentanol 23.13
    methyl formate 163.78
    2-methyl-1-butanol 33.41
    n-decane 1.65
    butyronitrile 27.42
    3,7-dimethyl-1-octanol 18.06
    1-chlorooctane 6.3
    1-chlorotetradecane 3.47
    n-nonane 1.47
    undecane 1.41
    tert-butylcyclohexane 1.91
    cyclooctane 0.81
    cyclopentanol 53.84
    tetrahydropyran 25.35
    tert-amyl methyl ether 17.62
    2,5,8-trioxanonane 93.43
    1-hexene 4.23
    2-isopropoxyethanol 45.29
    2,2,2-trifluoroethanol 84.89
    methyl butyrate 23.2

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction