Ethenzamide

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  • Identifiers

    CAS number
    938-73-8

    Molecular formula
    C9H11NO2

    SMILES
    CCOC1=CC=CC=C1C(=O)N

  • Odor profile

    Fragrance
    Sweet 49.81%
    Grape 41.46%
    Floral 40.04%
    Fruity 33.79%
    Vanilla 30.25%
    Powdery 25.56%
    Balsamic 25.07%
    Phenolic 24.91%
    Odorless 24.86%
    Bitter 23.61%

     

    Flavor
    Sweet 59.31%
    Fruity 40.56%
    Floral 39.41%
    Powdery 38.67%
    Balsam 33.63%
    Grape 33.33%
    Bitter 30.27%
    Wintergreen 29.56%
    Mild 28.02%
    Balsamic 25.81%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    1.2

    pKa est.
    6.09 (neutral)

    Molecular weight
    165.19 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    313°C

    Melting point expt.

    • 270 to 273 °F (NTP, 1992)

    Flash point

    • 138.1 ˚C est.

    Solubility expt.

    • less than 1 mg/mL at 61 °F (NTP, 1992)

  • Synonyms

    • 2-ETHOXYBENZAMIDE
    • ethenzamide
    • 938-73-8
    • o-Ethoxybenzamide
    • Benzamide, 2-ethoxy-
    • Etenzamide
    • Ethbenzamide
    • Ethenzamid
    • Ethosalicyl
    • Lucamide
    • Pirosolvina
    • Etamide
    • Etosalicil
    • Etosalicyl
    • Katagrippe
    • Protopyrin
    • Trancalgyl
    • Anovigam
    • Etocil
    • Eusal
    • Benzamide, o-ethoxy-
    • Etenzamida
    • Etenzamide [DCIT]
    • Ethenzamidum
    • Ethoxybenzamide
    • Etenzamida [INN-Spanish]
    • Ethenzamidum [INN-Latin]
    • NSC 28787
    • CCRIS 9124
    • UNII-L929ZCK4BF
    • EINECS 213-346-4
    • L929ZCK4BF
    • Ethenzamide (TN)
    • MFCD00007977
    • NSC-28787
    • Ethenzamide [INN:BAN:JAN]
    • BRN 2208582
    • DTXSID4020581
    • H.P. 209
    • ETHENZAMIDE [MI]
    • ETHENZAMIDE [INN]
    • ETHENZAMIDE [JAN]
    • Ethenzamide (JP17/INN)
    • J3.352I
    • ETHENZAMIDE [MART.]
    • ETHENZAMIDE [WHO-DD]
    • DTXCID40581
    • 4-10-00-00175 (Beilstein Handbook Reference)
    • NCGC00091616-01
    • Ethenzamide 100 microg/mL in Acetonitrile
    • Etenzamida (INN-Spanish)
    • Ethenzamidum (INN-Latin)
    • ETHENZAMIDE (MART.)
    • 2-ethoxy-benzamide
    • 2-Eethoxybenzamide
    • CAS-938-73-8
    • Ethanzamide
    • Orthoethoxybenzamide
    • 2-Ethoxybenzoylamide
    • 2-Ethoxybenzamide, 97%
    • WLN: ZVR BO2
    • SCHEMBL25624
    • 2-Ethoxybenzamide (Standard)
    • MLS002302987
    • CHEMBL1483877
    • CHEBI:31564
    • HY-B1428R
    • N02BA07
    • HMS3039J16
    • Ethenzamide 1.0 mg/ml in Methanol
    • HY-B1428
    • NSC28787
    • Tox21_111156
    • Tox21_200025
    • s4524
    • STK105005
    • AKOS003280312
    • Tox21_111156_1
    • CCG-213844
    • CS-4916
    • DB13544
    • FE34644
    • KS-5320
    • NCGC00091616-02
    • NCGC00091616-03
    • NCGC00257579-01
    • AC-11991
    • SMR001307304
    • SY015492
    • DB-057442
    • DB-370072
    • E0222
    • NS00002670
    • D01466
    • D70657
    • SBI-0653503.0001
    • AB01010349_03
    • EN300-6492973
    • Q553324
    • SR-01000877236
    • SR-01000877236-2
    • BRD-K88308881-001-06-8
    • Z54953371
    • 213-346-4

  • Applications

    Ethenzamide (CAS 938-73-8) is primarily used in the pharmaceutical sector as an intermediate in the synthesis of amide-containing compounds and, in some formulations, may serve as an active pharmaceutical ingredient in analgesic or combination products; in industrial manufacturing it functions as a building block for specialty chemicals and process development. In analytical and research contexts, it is used as a reference material and model compound for method development and characterization of amide chemistries.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 47.98
    methanol 87.22
    isopropanol 26.6
    water 1.34
    ethyl acetate 14.93
    n-propanol 33.08
    acetone 55.29
    n-butanol 25.5
    acetonitrile 31.64
    DMF 237.02
    toluene 14.21
    isobutanol 23.4
    1,4-dioxane 54.64
    methyl acetate 28.75
    THF 97.94
    2-butanone 34.43
    n-pentanol 23.13
    sec-butanol 21.75
    n-hexane 2.16
    ethylene glycol 60.82
    NMP 209.77
    cyclohexane 3.94
    DMSO 370.83
    n-butyl acetate 17.75
    n-octanol 20.78
    chloroform 102.54
    n-propyl acetate 16.91
    acetic acid 66.81
    dichloromethane 123.29
    cyclohexanone 68.66
    propylene glycol 43.01
    isopropyl acetate 13.41
    DMAc 177.43
    2-ethoxyethanol 44.27
    isopentanol 21.7
    n-heptane 3.23
    ethyl formate 29.91
    1,2-dichloroethane 60.02
    n-hexanol 27.68
    2-methoxyethanol 92.45
    isobutyl acetate 15.26
    tetrachloromethane 14.51
    n-pentyl acetate 16.68
    transcutol 65.43
    n-heptanol 17.59
    ethylbenzene 13.76
    MIBK 22.86
    2-propoxyethanol 58.41
    tert-butanol 35.19
    MTBE 18.66
    2-butoxyethanol 31.85
    propionic acid 44.64
    o-xylene 17.91
    formic acid 37.5
    diethyl ether 15.25
    m-xylene 17.02
    p-xylene 17.43
    chlorobenzene 35.55
    dimethyl carbonate 32.53
    n-octane 2.01
    formamide 50.63
    cyclopentanone 99.81
    2-pentanone 24.62
    anisole 37.02
    cyclopentyl methyl ether 31.27
    gamma-butyrolactone 111.75
    1-methoxy-2-propanol 60.11
    pyridine 49.25
    3-pentanone 24.29
    furfural 118.0
    n-dodecane 2.94
    diethylene glycol 83.76
    diisopropyl ether 6.66
    tert-amyl alcohol 25.69
    acetylacetone 44.45
    n-hexadecane 3.3
    acetophenone 42.37
    methyl propionate 27.71
    isopentyl acetate 20.24
    trichloroethylene 112.73
    n-nonanol 19.74
    cyclohexanol 27.22
    benzyl alcohol 40.22
    2-ethylhexanol 19.93
    isooctanol 15.35
    dipropyl ether 15.67
    1,2-dichlorobenzene 41.67
    ethyl lactate 31.8
    propylene carbonate 68.28
    n-methylformamide 75.18
    2-pentanol 14.32
    n-pentane 2.12
    1-propoxy-2-propanol 35.9
    1-methoxy-2-propyl acetate 34.44
    2-(2-methoxypropoxy) propanol 47.39
    mesitylene 13.58
    ε-caprolactone 53.23
    p-cymene 15.24
    epichlorohydrin 98.9
    1,1,1-trichloroethane 41.98
    2-aminoethanol 57.32
    morpholine-4-carbaldehyde 132.63
    sulfolane 237.36
    2,2,4-trimethylpentane 2.36
    2-methyltetrahydrofuran 39.04
    n-hexyl acetate 27.8
    isooctane 1.97
    2-(2-butoxyethoxy)ethanol 49.01
    sec-butyl acetate 12.91
    tert-butyl acetate 22.59
    decalin 4.64
    glycerin 77.66
    diglyme 79.71
    acrylic acid 61.3
    isopropyl myristate 18.53
    n-butyric acid 36.31
    acetyl acetate 22.87
    di(2-ethylhexyl) phthalate 29.98
    ethyl propionate 18.58
    nitromethane 89.95
    1,2-diethoxyethane 20.59
    benzonitrile 43.97
    trioctyl phosphate 21.23
    1-bromopropane 23.4
    gamma-valerolactone 103.63
    n-decanol 17.35
    triethyl phosphate 26.35
    4-methyl-2-pentanol 12.64
    propionitrile 27.39
    vinylene carbonate 71.89
    1,1,2-trichlorotrifluoroethane 106.96
    DMS 35.59
    cumene 14.06
    2-octanol 13.29
    2-hexanone 22.13
    octyl acetate 23.06
    limonene 20.12
    1,2-dimethoxyethane 71.84
    ethyl orthosilicate 21.77
    tributyl phosphate 22.23
    diacetone alcohol 41.48
    N,N-dimethylaniline 34.18
    acrylonitrile 47.07
    aniline 30.27
    1,3-propanediol 49.46
    bromobenzene 35.63
    dibromomethane 71.05
    1,1,2,2-tetrachloroethane 87.82
    2-methyl-cyclohexyl acetate 33.64
    tetrabutyl urea 33.85
    diisobutyl methanol 14.04
    2-phenylethanol 38.27
    styrene 16.66
    dioctyl adipate 33.29
    dimethyl sulfate 89.33
    ethyl butyrate 21.75
    methyl lactate 47.26
    butyl lactate 24.58
    diethyl carbonate 24.49
    propanediol butyl ether 35.84
    triethyl orthoformate 21.22
    p-tert-butyltoluene 14.46
    methyl 4-tert-butylbenzoate 50.09
    morpholine 52.78
    tert-butylamine 20.42
    n-dodecanol 14.9
    dimethoxymethane 82.7
    ethylene carbonate 48.64
    cyrene 70.66
    2-ethoxyethyl acetate 23.83
    2-ethylhexyl acetate 16.83
    1,2,4-trichlorobenzene 51.14
    4-methylpyridine 43.07
    dibutyl ether 15.01
    2,6-dimethyl-4-heptanol 14.04
    DEF 45.76
    dimethyl isosorbide 80.88
    tetrachloroethylene 53.43
    eugenol 52.21
    triacetin 40.03
    span 80 45.17
    1,4-butanediol 29.61
    1,1-dichloroethane 40.79
    2-methyl-1-pentanol 21.68
    methyl formate 70.47
    2-methyl-1-butanol 21.31
    n-decane 3.72
    butyronitrile 25.27
    3,7-dimethyl-1-octanol 20.36
    1-chlorooctane 14.46
    1-chlorotetradecane 8.75
    n-nonane 3.19
    undecane 3.27
    tert-butylcyclohexane 4.18
    cyclooctane 2.0
    cyclopentanol 36.88
    tetrahydropyran 33.04
    tert-amyl methyl ether 18.08
    2,5,8-trioxanonane 78.94
    1-hexene 8.2
    2-isopropoxyethanol 30.0
    2,2,2-trifluoroethanol 33.78
    methyl butyrate 26.78

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction