Ethanaminium, 2-(hexadecyloxy)-N,N,N-trimethyl-2-oxo-, chloride

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  • Identifiers

    CAS number
    52132-48-6

    Molecular formula
    C21H44ClNO2

    SMILES
    CCCCCCCCCCCCCCCCOC(=O)C[N+](C)(C)C.[Cl-]

    Safety labels

  • Odor profile

    Fragrance
    Waxy 67.06%
    Fatty 58.26%
    Oily 52.53%
    Fruity 36.88%
    Floral 30.73%
    Sweet 30.49%
    Creamy 28.07%
    Woody 25.93%
    Clean 25.32%
    Fresh 25.22%

     

    Flavor
    Mild 40.83%
    Waxy 40.09%
    Oily 39.66%
    Bland 34.06%
    Fatty 29.14%
    Faint 25.36%
    Slightly waxy 23.67%
    Delicate 23.07%
    Beer 23.04%
    Soapy 22.56%

     

    Odor impact est.
    Low

  • Properties

    pKa est.
    6.42 (neutral)

    Molecular weight
    378.0 g/mol

    Flash point

    • -34.25 ˚C est.

  • Synonyms

    • cetyl betainate chloride
    • 52132-48-6
    • Betainester C16
    • Cetylbetanate chloride
    • Ethanaminium, 2-(hexadecyloxy)-N,N,N-trimethyl-2-oxo-, chloride
    • UNII-XLM3K6M5SG
    • XLM3K6M5SG
    • Betaine cetyl ester chloride
    • (2-hexadecoxy-2-oxoethyl)-trimethylazanium;chloride
    • Cetylbetanate chloride [INCI]
    • (Hexadecyloxycarbonylmethyl)trimethylammonium chloride
    • (Carboxymethyl)trimethylammonium chloride, hexadecyl ester
    • Ethanaminium, 2-(hexadecyloxy)-n,N,N-trimethyl-2-oxo-, chloride (1:1)
    • hexadecyl 2-(trimethylamino)acetate, chloride
    • SCHEMBL4651180
    • NIOSH/BP3141600
    • DTXSID60200140
    • BOJMFXHREPVXFN-UHFFFAOYSA-M
    • SBB056735
    • AKOS024354415
    • BP31416000
    • ST50981070
    • Q27293893
    • (Carboxymethyl)trimethylammonium chloride ester with 1-hexadecanol
    • 2-(Hexadecyloxy)-N,N,N-trimethyl-2-oxoethan-1-aminium chloride
    • Ammonium, (carboxymethyl)trimethyl-, chloride, ester with 1-hexadecanol
    • 52132-48-6

  • Applications

    Ethanaminium, 2-(hexadecyloxy)-N,N,N-trimethyl-2-oxo-, chloride (CAS 52132-48-6) is a cationic surfactant featuring a long hydrophobic tail, and is commonly evaluated for real-world use across multiple industries. In cosmetics and personal care, it can function as a cationic surfactant and conditioning agent. In household cleaning formulations, it acts as a surfactant and emulsifier to aid cleaning and oil dispersion. In coatings and inks, it serves as a surface-active additive to improve wetting and pigment dispersion. In polymers and plastics processing, it can act as an emulsifier or processing aid, stabilizing blends or latex formulations. In adhesives and sealants, it can be used as a surfactant or wetting agent to enhance adhesion and dispersion of components. Subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 328.6
    methanol 434.87
    isopropanol 295.96
    water 3.72
    ethyl acetate 615.87
    n-propanol 365.64
    acetone 568.47
    n-butanol 346.31
    acetonitrile 277.84
    DMF 631.1
    toluene 258.59
    isobutanol 357.85
    1,4-dioxane 682.76
    methyl acetate 498.83
    THF 1112.88
    2-butanone 571.27
    n-pentanol 235.05
    sec-butanol 354.67
    n-hexane 83.02
    ethylene glycol 63.17
    NMP 1230.29
    cyclohexane 407.46
    DMSO 687.03
    n-butyl acetate 549.11
    n-octanol 250.94
    chloroform 2683.68
    n-propyl acetate 588.97
    acetic acid 970.69
    dichloromethane 2281.1
    cyclohexanone 1645.79
    propylene glycol 121.67
    isopropyl acetate 480.72
    DMAc 844.0
    2-ethoxyethanol 403.96
    isopentanol 335.43
    n-heptane 82.17
    ethyl formate 469.01
    1,2-dichloroethane 1407.73
    n-hexanol 219.38
    2-methoxyethanol 554.97
    isobutyl acetate 416.24
    tetrachloromethane 653.11
    n-pentyl acetate 842.52
    transcutol 1218.26
    n-heptanol 263.32
    ethylbenzene 166.07
    MIBK 378.63
    2-propoxyethanol 399.8
    tert-butanol 397.66
    MTBE 342.4
    2-butoxyethanol 544.86
    propionic acid 596.7
    o-xylene 256.15
    formic acid 317.67
    diethyl ether 332.42
    m-xylene 199.72
    p-xylene 273.85
    chlorobenzene 547.73
    dimethyl carbonate 208.45
    n-octane 44.89
    formamide 404.51
    cyclopentanone 1330.39
    2-pentanone 539.71
    anisole 261.74
    cyclopentyl methyl ether 689.03
    gamma-butyrolactone 1511.53
    1-methoxy-2-propanol 456.38
    pyridine 733.61
    3-pentanone 498.19
    furfural 1087.49
    n-dodecane 22.13
    diethylene glycol 233.32
    diisopropyl ether 141.85
    tert-amyl alcohol 422.98
    acetylacetone 625.42
    n-hexadecane 26.55
    acetophenone 416.42
    methyl propionate 523.98
    isopentyl acetate 486.01
    trichloroethylene 2527.26
    n-nonanol 237.25
    cyclohexanol 771.34
    benzyl alcohol 270.78
    2-ethylhexanol 226.45
    isooctanol 261.17
    dipropyl ether 308.44
    1,2-dichlorobenzene 621.58
    ethyl lactate 312.25
    propylene carbonate 965.98
    n-methylformamide 448.51
    2-pentanol 282.43
    n-pentane 73.7
    1-propoxy-2-propanol 412.68
    1-methoxy-2-propyl acetate 451.39
    2-(2-methoxypropoxy) propanol 319.54
    mesitylene 152.36
    ε-caprolactone 1424.05
    p-cymene 158.09
    epichlorohydrin 1353.29
    1,1,1-trichloroethane 1507.67
    2-aminoethanol 182.37
    morpholine-4-carbaldehyde 875.74
    sulfolane 1876.92
    2,2,4-trimethylpentane 62.24
    2-methyltetrahydrofuran 892.25
    n-hexyl acetate 720.49
    isooctane 28.32
    2-(2-butoxyethoxy)ethanol 478.43
    sec-butyl acetate 406.33
    tert-butyl acetate 518.09
    decalin 98.64
    glycerin 184.88
    diglyme 974.1
    acrylic acid 486.03
    isopropyl myristate 208.79
    n-butyric acid 1023.32
    acetyl acetate 468.84
    di(2-ethylhexyl) phthalate 203.1
    ethyl propionate 477.4
    nitromethane 1025.54
    1,2-diethoxyethane 464.7
    benzonitrile 398.21
    trioctyl phosphate 180.29
    1-bromopropane 686.62
    gamma-valerolactone 1630.87
    n-decanol 148.58
    triethyl phosphate 283.88
    4-methyl-2-pentanol 180.23
    propionitrile 312.75
    vinylene carbonate 879.25
    1,1,2-trichlorotrifluoroethane 1324.56
    DMS 420.45
    cumene 138.07
    2-octanol 226.6
    2-hexanone 449.98
    octyl acetate 289.13
    limonene 293.85
    1,2-dimethoxyethane 649.29
    ethyl orthosilicate 275.09
    tributyl phosphate 222.14
    diacetone alcohol 476.6
    N,N-dimethylaniline 211.68
    acrylonitrile 364.04
    aniline 354.66
    1,3-propanediol 300.57
    bromobenzene 559.5
    dibromomethane 1482.71
    1,1,2,2-tetrachloroethane 2364.37
    2-methyl-cyclohexyl acetate 445.49
    tetrabutyl urea 281.16
    diisobutyl methanol 155.65
    2-phenylethanol 239.33
    styrene 182.88
    dioctyl adipate 349.71
    dimethyl sulfate 380.22
    ethyl butyrate 479.81
    methyl lactate 276.59
    butyl lactate 561.05
    diethyl carbonate 315.96
    propanediol butyl ether 405.08
    triethyl orthoformate 405.55
    p-tert-butyltoluene 140.78
    methyl 4-tert-butylbenzoate 498.27
    morpholine 906.11
    tert-butylamine 267.85
    n-dodecanol 101.56
    dimethoxymethane 400.08
    ethylene carbonate 809.58
    cyrene 375.28
    2-ethoxyethyl acetate 735.93
    2-ethylhexyl acetate 453.22
    1,2,4-trichlorobenzene 738.79
    4-methylpyridine 611.59
    dibutyl ether 337.74
    2,6-dimethyl-4-heptanol 155.65
    DEF 695.23
    dimethyl isosorbide 563.18
    tetrachloroethylene 1735.29
    eugenol 374.67
    triacetin 715.92
    span 80 408.63
    1,4-butanediol 132.83
    1,1-dichloroethane 1202.35
    2-methyl-1-pentanol 237.88
    methyl formate 349.73
    2-methyl-1-butanol 354.62
    n-decane 52.38
    butyronitrile 364.17
    3,7-dimethyl-1-octanol 224.43
    1-chlorooctane 251.97
    1-chlorotetradecane 69.31
    n-nonane 53.95
    undecane 31.69
    tert-butylcyclohexane 69.64
    cyclooctane 93.98
    cyclopentanol 709.73
    tetrahydropyran 977.5
    tert-amyl methyl ether 337.94
    2,5,8-trioxanonane 527.93
    1-hexene 191.41
    2-isopropoxyethanol 322.87
    2,2,2-trifluoroethanol 538.87
    methyl butyrate 702.2

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction