Erythromycin

Overview IFRA Request a quote

  • Identifiers

    CAS number
    114-07-8

    Molecular formula
    C37H67NO13

    SMILES
    CC[C@@H]1[C@@]([C@@H]([C@H](C(=O)[C@@H](C[C@@]([C@@H]([C@H]([C@@H]([C@H](C(=O)O1)C)O[C@H]2C[C@@]([C@H]([C@@H](O2)C)O)(C)OC)C)O[C@H]3[C@@H]([C@H](C[C@H](O3)C)N(C)C)O)(C)O)C)C)O)(C)O

    Safety labels

    Irritant
    Irritant

    Health Hazard
    Health

  • Odor profile

    Fragrance
    Odorless 60.86%
    Sweet 27.24%
    Milky 24.67%
    Vanilla 22.51%
    Caramellic 22.02%
    Creamy 21.54%
    Cooling 20.99%
    Woody 19.49%
    Savory 19.31%
    Roasted 19.04%

     

    Flavor
    Bitter 51.34%
    Sweet 33.1%
    Odorless 28.03%
    Fatty 25.62%
    Sweet-like 25.0%
    Minty 23.25%
    Fruity 21.69%
    Cedarleaf 21.57%
    Mentholic 21.34%
    Cauliflower 21.31%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    2.7

    pKa est.
    6.68 (neutral)

    Molecular weight
    733.9 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra fast

    Melting point expt.

    • 212 to 219 °F (NTP, 1992)
    • 133-135
    • 191 °C
    • After melting /at 135-140 °C, it/ resolidifies with second melting point 190-193 °C. ... Readily forms salts with acids
    • MP: 92 °C. Slightly soluble in ethanol, ethyl ether, chloroform; insoluble in water. /Erythromycin stearate/
    • Crystals from acetone aqueous. MP: 222 °C. MW: 862.05. /Erythromycin ethyl succinate/

    Boiling point

    • 719.69 undefined

    Flash point

    • 142.78 ˚C est.

    Solubility expt.

    • less than 1 mg/mL at 72 °F (NTP, 1992)
    • Soluble in water at 2mg/ml
    • WHITE OR SLIGHTLY YELLOW CRYSTALS OR POWDER, PRACTICALLY ODORLESS. SOLN IS ALKALINE TO LITMUS. SOL IN METHANOL, CHLOROFORM. /Erythromycin stearate/
    • WHITE OR SLIGHTLY YELLOW, CRYSTALLINE POWDER. ODORLESS OR PRACTICALLY SO. PRACTICALLY TASTELESS. PKA 7. FREELY SOL IN ACETONE & CHLOROFORM; SOL IN 95% ETHANOL & BENZENE; SPARINGLY SOL IN ETHER; VERY SLIGHTLY SOL IN WATER. /Erythromycin ethyl succinate/
    • FREELY SOLUBLE IN ALC, SOL IN POLYETHYLENE GLYCOL /Erythromycin ethyl succinate
    • Very soluble in acetone, ethyl ether, ethanol, chloroform
    • Freely soluble in alcohols, acetone, chloroform, acetonitrile, ethyl acetate; moderately soluble in ether, ethylene dichloride, amyl acetate
    • Solubility in water: approx 2 mg/ML
    • SOL IN ALC, ETHER; PRACTICALLY INSOL IN WATER
    • SOL IN METHANOL, CHLOROFORM
    • 4.59e-01 g/L

  • Synonyms

    • erythromycin
    • 114-07-8
    • Erythromycin A
    • E-Mycin
    • Abomacetin
    • Erythromycinum
    • Emgel
    • Erymax
    • Ilotycin
    • Eritromicina
    • Erythromycine
    • Robimycin
    • Torlamicina
    • Eryderm
    • Erythro-Statin
    • Erythrocin
    • Erythromycin base
    • E-Glades
    • Ery-Tab
    • Erycette
    • Pantomicina
    • Erygel
    • Sansac
    • E-Base
    • Erythra-Derm
    • ERYC
    • Dumotrycin
    • Mephamycin
    • Ermycin
    • Eryacne
    • Stiemycin
    • Aknin
    • Erycen
    • Wemid
    • R-P Mycin
    • Eryc Sprinkles
    • Theramycin Z
    • Akne-Mycin
    • E-Solve 2
    • Ak-Mycin
    • Erythromast 36
    • T-Stat
    • Erytrociclin
    • Acneryne
    • Endoeritrin
    • Eritomicina
    • Eryacnen
    • Erydermer
    • Eryhexal
    • Erythroderm
    • Iloticina
    • Latotryd
    • Lederpax
    • Oftamolets
    • Pantoderm
    • Pantodrin
    • Pharyngocin
    • Primacine
    • Proterytrin
    • Stiemicyn
    • Tiprocin
    • Acnesol
    • Derimer
    • Deripil
    • Emuvin
    • Emycin
    • Erecin
    • Erisone
    • Erymed
    • Erysafe
    • Erytab
    • Erytop
    • Inderm
    • Mercina
    • Romycin
    • AustriaS
    • Eros
    • C-Solve-2
    • Ery-maxin
    • Erythro-Teva
    • Sans-acne
    • Erimycin-T
    • Ery-Diolan
    • Inderm Gel
    • Del-Mycin
    • Udima Ery Gel
    • Aknederm Ery Gel
    • Abboticin
    • Emu-Ve
    • Akne Cordes Losung
    • Eryc 125
    • Ilotycin T.S.
    • Skid Gel E
    • E-Mycin (base)
    • Emu-V
    • Ery-B
    • Ery-Tab (base)
    • E-Base (base)
    • ERYC (base)
    • erythromycin-A
    • A/T/S
    • Erythrogran
    • Erythroguent
    • Erythromid
    • Propiocine
    • Dotycin
    • Erycinum
    • Ilocaps
    • PCE Dispertab (base)
    • Erycin
    • Kesso-Mycin
    • Eryc-125
    • Eryc-250
    • Taimoxin-F
    • ERYTHROMYCIN STEARATE
    • erythro
    • Oftalmolosa Cusi Eritromicina
    • Eritrocina
    • Staticin
    • Retcin
    • erthromycin
    • MFCD00084654
    • Sentry AQ mardel maracyn
    • Eritromicina [INN-Spanish]
    • Erythromycine [INN-French]
    • Erythromycinum [INN-Latin]
    • Benzamycin
    • CCRIS 9078

  • Applications

    Erythromycin (CAS 114-07-8) is used in pharmaceutical applications as an active pharmaceutical ingredient (API) in macrolide antibiotic formulations, while also serving as a reference standard in analytical laboratories for method development and validation (e.g., HPLC, LC-MS). It is commonly evaluated in medicinal chemistry research as a lead scaffold for the design and optimization of macrolide derivatives. In veterinary medicine, erythromycin is used in certain antibiotic formulations for animals. Its use is subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 174.59
    methanol 347.63
    isopropanol 89.13
    water 1.24
    ethyl acetate 49.07
    n-propanol 129.99
    acetone 113.95
    n-butanol 59.74
    acetonitrile 23.03
    DMF 359.34
    toluene 10.56
    isobutanol 56.85
    1,4-dioxane 137.84
    methyl acetate 66.73
    THF 269.7
    2-butanone 84.99
    n-pentanol 42.68
    sec-butanol 56.91
    n-hexane 0.68
    ethylene glycol 75.74
    NMP 454.31
    cyclohexane 1.02
    DMSO 525.78
    n-butyl acetate 19.09
    n-octanol 13.28
    chloroform 69.56
    n-propyl acetate 26.53
    acetic acid 731.66
    dichloromethane 67.05
    cyclohexanone 104.05
    propylene glycol 132.93
    isopropyl acetate 28.73
    DMAc 386.36
    2-ethoxyethanol 175.23
    isopentanol 28.76
    n-heptane 0.57
    ethyl formate 60.82
    1,2-dichloroethane 42.69
    n-hexanol 21.57
    2-methoxyethanol 301.14
    isobutyl acetate 13.75
    tetrachloromethane 11.68
    n-pentyl acetate 24.88
    transcutol 171.65
    n-heptanol 18.16
    ethylbenzene 3.69
    MIBK 23.14
    2-propoxyethanol 125.65
    tert-butanol 44.57
    MTBE 19.15
    2-butoxyethanol 81.74
    propionic acid 148.26
    o-xylene 6.54
    formic acid 408.22
    diethyl ether 28.67
    m-xylene 5.65
    p-xylene 4.73
    chlorobenzene 13.96
    dimethyl carbonate 55.54
    n-octane 0.3
    formamide 279.23
    cyclopentanone 180.65
    2-pentanone 52.63
    anisole 16.89
    cyclopentyl methyl ether 50.89
    gamma-butyrolactone 242.33
    1-methoxy-2-propanol 188.45
    pyridine 90.21
    3-pentanone 36.38
    furfural 160.98
    n-dodecane 0.2
    diethylene glycol 123.43
    diisopropyl ether 4.34
    tert-amyl alcohol 37.93
    acetylacetone 81.61
    n-hexadecane 0.22
    acetophenone 27.95
    methyl propionate 63.56
    isopentyl acetate 15.9
    trichloroethylene 89.25
    n-nonanol 12.62
    cyclohexanol 34.44
    benzyl alcohol 38.21
    2-ethylhexanol 7.82
    isooctanol 11.38
    dipropyl ether 10.29
    1,2-dichlorobenzene 12.29
    ethyl lactate 31.41
    propylene carbonate 87.85
    n-methylformamide 244.77
    2-pentanol 24.5
    n-pentane 1.0
    1-propoxy-2-propanol 61.81
    1-methoxy-2-propyl acetate 41.78
    2-(2-methoxypropoxy) propanol 43.7
    mesitylene 2.73
    ε-caprolactone 117.61
    p-cymene 2.8
    epichlorohydrin 203.29
    1,1,1-trichloroethane 24.99
    2-aminoethanol 162.94
    morpholine-4-carbaldehyde 330.17
    sulfolane 373.07
    2,2,4-trimethylpentane 0.54
    2-methyltetrahydrofuran 97.73
    n-hexyl acetate 27.26
    isooctane 0.27
    2-(2-butoxyethoxy)ethanol 71.16
    sec-butyl acetate 14.48
    tert-butyl acetate 24.36
    decalin 0.56
    glycerin 194.47
    diglyme 126.34
    acrylic acid 174.77
    isopropyl myristate 5.59
    n-butyric acid 121.9
    acetyl acetate 44.29
    di(2-ethylhexyl) phthalate 13.6
    ethyl propionate 21.8
    nitromethane 385.78
    1,2-diethoxyethane 29.28
    benzonitrile 17.64
    trioctyl phosphate 9.27
    1-bromopropane 17.87
    gamma-valerolactone 376.96
    n-decanol 6.94
    triethyl phosphate 10.54
    4-methyl-2-pentanol 9.93
    propionitrile 20.17
    vinylene carbonate 86.35
    1,1,2-trichlorotrifluoroethane 241.96
    DMS 25.46
    cumene 2.72
    2-octanol 8.85
    2-hexanone 30.33
    octyl acetate 11.53
    limonene 4.38
    1,2-dimethoxyethane 126.29
    ethyl orthosilicate 10.0
    tributyl phosphate 8.77
    diacetone alcohol 58.84
    N,N-dimethylaniline 13.34
    acrylonitrile 36.39
    aniline 30.88
    1,3-propanediol 168.88
    bromobenzene 10.48
    dibromomethane 38.18
    1,1,2,2-tetrachloroethane 73.59
    2-methyl-cyclohexyl acetate 14.46
    tetrabutyl urea 13.64
    diisobutyl methanol 3.42
    2-phenylethanol 24.78
    styrene 4.55
    dioctyl adipate 14.38
    dimethyl sulfate 119.34
    ethyl butyrate 15.18
    methyl lactate 89.59
    butyl lactate 31.18
    diethyl carbonate 9.69
    propanediol butyl ether 78.91
    triethyl orthoformate 14.41
    p-tert-butyltoluene 2.86
    methyl 4-tert-butylbenzoate 33.34
    morpholine 209.64
    tert-butylamine 12.12
    n-dodecanol 3.8
    dimethoxymethane 167.1
    ethylene carbonate 67.19
    cyrene 88.6
    2-ethoxyethyl acetate 52.16
    2-ethylhexyl acetate 11.13
    1,2,4-trichlorobenzene 21.54
    4-methylpyridine 53.64
    dibutyl ether 5.84
    2,6-dimethyl-4-heptanol 3.42
    DEF 82.86
    dimethyl isosorbide 65.34
    tetrachloroethylene 50.79
    eugenol 33.78
    triacetin 43.54
    span 80 46.95
    1,4-butanediol 73.9
    1,1-dichloroethane 31.21
    2-methyl-1-pentanol 23.91
    methyl formate 172.5
    2-methyl-1-butanol 35.78
    n-decane 0.45
    butyronitrile 17.07
    3,7-dimethyl-1-octanol 7.77
    1-chlorooctane 3.36
    1-chlorotetradecane 0.86
    n-nonane 0.38
    undecane 0.28
    tert-butylcyclohexane 0.45
    cyclooctane 0.35
    cyclopentanol 77.05
    tetrahydropyran 69.89
    tert-amyl methyl ether 17.34
    2,5,8-trioxanonane 70.01
    1-hexene 3.27
    2-isopropoxyethanol 84.71
    2,2,2-trifluoroethanol 211.02
    methyl butyrate 32.34

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction