Epiandrosterone

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  • Identifiers

    CAS number
    481-29-8

    Molecular formula
    C19H30O2

    SMILES
    C[C@]12CC[C@@H](C[C@@H]1CC[C@@H]3[C@@H]2CC[C@]4([C@H]3CCC4=O)C)O

    Safety labels

    Irritant
    Irritant

    Health Hazard
    Health

  • Odor profile

    Fragrance
    Woody 77.8%
    Herbal 47.22%
    Camphoreous 44.11%
    Cedar 43.67%
    Balsamic 42.15%
    Fresh 39.99%
    Mint 39.35%
    Amber 39.13%
    Earthy 38.13%
    Sweet 38.01%

     

    Flavor
    Minty 33.1%
    Earthy 30.78%
    Herbal 30.31%
    Camphor 30.03%
    Spicy 28.74%
    Herb 25.48%
    Fresh 25.27%
    Fruity 24.83%
    Beet 24.61%
    Bitter 24.47%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    3.7

    pKa est.
    7.86 (neutral)

    Molecular weight
    290.4 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Fast

    Boiling point est.
    369°C

    Flash point

    • 189.17 ˚C est.

  • Synonyms

    • EPIANDROSTERONE
    • 481-29-8
    • Isoandrosterone
    • trans-Androsterone
    • iso-Androsterone
    • d-Epiandrosterone
    • 3Beta-hydroxy-5alpha-androstan-17-one
    • epi-andosterone
    • 3beta-Hydroxyetioallocholan-17-one
    • Androstan-17-one, 3-hydroxy-, (3b,5a)-
    • Androsterone, epi-
    • Androsterone, (3beta)-
    • 5alpha-Androstan-3beta-ol-17-one
    • Androsterone, trans-
    • MLS001304190
    • 3beta-Hydroxy-androstan-17-one
    • 3-Epiandrosterone
    • CHEBI:541975
    • EINECS 207-563-3
    • NSC 93996
    • 8TR252Z538
    • EPIANDROSTERONE [MI]
    • (3beta,5alpha)-3-hydroxyandrostan-17-one
    • CHEMBL272195
    • DTXSID20289698
    • EC 207-563-3
    • NSC-93996
    • (3S,5S,8R,9S,10S,13S,14S)-3-hydroxy-10,13-dimethyl-1,2,3,4,5,6,7,8,9,11,12,14,15,16-tetradecahydrocyclopenta[a]phenanthren-17-one
    • 5alpha-Androstan-17-one, 3beta-hydroxy-
    • 3.beta.-Hydroxy-5.alpha.-androstan-17-one
    • 3b-Androsterone
    • epi-Androsterone
    • Epiandrosterone (1mg/mL in Acetonitrile)
    • SMR000718744
    • Epiandrosterone?
    • EpiA
    • UNII-8TR252Z538
    • (3S,5S,8R,9S,10S,13S,14S)-3-hydroxy-10,13-dimethyl-1,2,3,4,5,6,7,8,9,11,12,14,15,16-tetradecahydrocyclopenta(a)phenanthren-17-one
    • AOX
    • Prestwick_699
    • 3|A-androsterone;EpiA
    • ST072176
    • 3-beta-Hydroxy-5-alpha-androstan-17-one
    • Androstan-17-one, 3-hydroxy-, (3beta,5alpha)-
    • Prestwick0_000440
    • Prestwick1_000440
    • Prestwick2_000440
    • Prestwick3_000440
    • BSPBio_000460
    • MLS000563092
    • MLS001333976
    • MLS001333977
    • MLS002153812
    • SCHEMBL295167
    • SPBio_002399
    • BPBio1_000506
    • DTXCID601030608
    • HMS1569G22
    • HMS2096G22
    • HMS2235I04
    • HMS3713G22
    • HMS3884L18
    • Epiandrosterone (3|A-androsterone)
    • HY-I0352
    • BBL030012
    • BDBM50236240
    • LMST02020023
    • MFCD00064134
    • s2832
    • STK801866
    • AKOS001582886
    • CCG-220440
    • CS-5183
    • FE22714
    • NCGC00142619-02
    • NCGC00142619-04
    • (1S,2S,5S,7S,11S,15S,10R)-5-hydroxy-2,15-dimethyltetracyclo[8.7.0.0<2,7>.0<11, 15>]heptadecan-14-one
    • AC-16141
    • AS-13045
    • (3beta, 5alpha)-androstan-3-ol- 17-one
    • E0374
    • NS00067046
    • NS00124666
    • Epiandrosterone 100 microg/mL in Acetonitrile
    • C07635
    • D95819
    • 5alpha-Androstan-17-one, 3beta-hydroxy-(8CI)
    • 3-Androsterone;trans-Androsterone;iso-Androsterone
    • A827476
    • SR-01000837513
    • Q5382412
    • SR-01000837513-2
    • (3?,5?)-3-Hydroxyandrostan-17-one;3-Epiandrosterone;3?-Androsterone
    • (3S,5S,8R,10S,13S)-3-Hydroxy-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-17-one
    • (3S,5S,8R,9R,10S,13S,14S)-3-hydroxy-10,13-dimethyl-1,2,3,4,5,6,7,8,9,11,12,14,15,16-tetradecahydrocyclopenta[a]phenanthren-17-one

  • Applications

    Epiandrosterone (CAS 481-29-8) is primarily used as a steroid pharmaceutical intermediate, serving as a building block or starting material for the synthesis of steroid hormones and related APIs. In chemical manufacturing it is also employed as a research material and analytical reference standard for steroid quantification and for the development of customized synthesis routes. In endocrinology and enzymology research, it may be used as a substrate or model compound to study steroid metabolism and enzyme activity. Additionally, it can be used as a component in the synthesis of related steroid derivatives, subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 198.73
    methanol 231.55
    isopropanol 179.47
    water 2.79
    ethyl acetate 258.22
    n-propanol 168.33
    acetone 435.09
    n-butanol 177.55
    acetonitrile 188.91
    DMF 301.66
    toluene 331.16
    isobutanol 87.62
    1,4-dioxane 643.83
    methyl acetate 135.01
    THF 877.25
    2-butanone 167.26
    n-pentanol 25.7
    sec-butanol 26.61
    n-hexane 1.62
    ethylene glycol 27.0
    NMP 57.66
    cyclohexane 15.27
    DMSO 171.99
    n-butyl acetate 121.7
    n-octanol 16.58
    chloroform 542.71
    n-propyl acetate 80.93
    acetic acid 105.08
    dichloromethane 339.59
    cyclohexanone 281.13
    propylene glycol 21.57
    isopropyl acetate 247.11
    DMAc 116.73
    2-ethoxyethanol 102.91
    isopentanol 118.05
    n-heptane 2.35
    ethyl formate 118.97
    1,2-dichloroethane 220.02
    n-hexanol 56.54
    2-methoxyethanol 383.09
    isobutyl acetate 78.52
    tetrachloromethane 67.31
    n-pentyl acetate 73.11
    transcutol 596.17
    n-heptanol 33.05
    ethylbenzene 56.52
    MIBK 167.48
    2-propoxyethanol 226.87
    tert-butanol 133.0
    MTBE 89.52
    2-butoxyethanol 119.3
    propionic acid 65.11
    o-xylene 105.58
    formic acid 57.23
    diethyl ether 199.55
    m-xylene 165.6
    p-xylene 68.37
    chlorobenzene 204.39
    dimethyl carbonate 116.51
    n-octane 1.19
    formamide 136.1
    cyclopentanone 332.54
    2-pentanone 231.26
    anisole 146.17
    cyclopentyl methyl ether 189.62
    gamma-butyrolactone 309.06
    1-methoxy-2-propanol 276.46
    pyridine 420.74
    3-pentanone 120.59
    furfural 295.87
    n-dodecane 1.09
    diethylene glycol 182.18
    diisopropyl ether 49.89
    tert-amyl alcohol 24.0
    acetylacetone 383.97
    n-hexadecane 1.4
    acetophenone 112.95
    methyl propionate 150.96
    isopentyl acetate 139.15
    trichloroethylene 403.37
    n-nonanol 19.32
    cyclohexanol 77.95
    benzyl alcohol 96.6
    2-ethylhexanol 29.24
    isooctanol 29.07
    dipropyl ether 51.35
    1,2-dichlorobenzene 154.67
    ethyl lactate 49.21
    propylene carbonate 158.48
    n-methylformamide 204.37
    2-pentanol 52.62
    n-pentane 4.63
    1-propoxy-2-propanol 133.11
    1-methoxy-2-propyl acetate 244.37
    2-(2-methoxypropoxy) propanol 97.88
    mesitylene 82.97
    ε-caprolactone 189.8
    p-cymene 34.16
    epichlorohydrin 392.65
    1,1,1-trichloroethane 191.61
    2-aminoethanol 65.32
    morpholine-4-carbaldehyde 227.29
    sulfolane 185.05
    2,2,4-trimethylpentane 1.83
    2-methyltetrahydrofuran 167.18
    n-hexyl acetate 69.31
    isooctane 3.49
    2-(2-butoxyethoxy)ethanol 152.39
    sec-butyl acetate 74.02
    tert-butyl acetate 212.36
    decalin 4.7
    glycerin 61.81
    diglyme 360.38
    acrylic acid 65.68
    isopropyl myristate 32.19
    n-butyric acid 196.76
    acetyl acetate 213.38
    di(2-ethylhexyl) phthalate 41.23
    ethyl propionate 89.65
    nitromethane 283.33
    1,2-diethoxyethane 154.22
    benzonitrile 167.5
    trioctyl phosphate 26.43
    1-bromopropane 83.91
    gamma-valerolactone 514.04
    n-decanol 13.94
    triethyl phosphate 45.71
    4-methyl-2-pentanol 50.93
    propionitrile 190.19
    vinylene carbonate 196.75
    1,1,2-trichlorotrifluoroethane 179.6
    DMS 113.61
    cumene 32.08
    2-octanol 14.99
    2-hexanone 51.81
    octyl acetate 32.77
    limonene 30.62
    1,2-dimethoxyethane 253.1
    ethyl orthosilicate 44.82
    tributyl phosphate 30.73
    diacetone alcohol 148.96
    N,N-dimethylaniline 68.68
    acrylonitrile 235.38
    aniline 257.03
    1,3-propanediol 200.3
    bromobenzene 202.38
    dibromomethane 199.21
    1,1,2,2-tetrachloroethane 279.18
    2-methyl-cyclohexyl acetate 65.47
    tetrabutyl urea 36.26
    diisobutyl methanol 29.98
    2-phenylethanol 123.67
    styrene 73.05
    dioctyl adipate 48.55
    dimethyl sulfate 115.09
    ethyl butyrate 93.48
    methyl lactate 79.85
    butyl lactate 68.25
    diethyl carbonate 69.61
    propanediol butyl ether 71.99
    triethyl orthoformate 76.23
    p-tert-butyltoluene 35.8
    methyl 4-tert-butylbenzoate 106.16
    morpholine 462.07
    tert-butylamine 65.41
    n-dodecanol 10.08
    dimethoxymethane 510.58
    ethylene carbonate 191.29
    cyrene 78.77
    2-ethoxyethyl acetate 167.17
    2-ethylhexyl acetate 87.23
    1,2,4-trichlorobenzene 160.37
    4-methylpyridine 334.52
    dibutyl ether 27.22
    2,6-dimethyl-4-heptanol 29.98
    DEF 109.86
    dimethyl isosorbide 179.05
    tetrachloroethylene 204.76
    eugenol 106.09
    triacetin 113.93
    span 80 67.18
    1,4-butanediol 25.43
    1,1-dichloroethane 202.95
    2-methyl-1-pentanol 22.32
    methyl formate 146.49
    2-methyl-1-butanol 49.7
    n-decane 2.09
    butyronitrile 181.84
    3,7-dimethyl-1-octanol 26.2
    1-chlorooctane 10.83
    1-chlorotetradecane 4.29
    n-nonane 1.6
    undecane 1.44
    tert-butylcyclohexane 3.45
    cyclooctane 4.94
    cyclopentanol 64.95
    tetrahydropyran 404.25
    tert-amyl methyl ether 32.33
    2,5,8-trioxanonane 193.2
    1-hexene 7.97
    2-isopropoxyethanol 65.36
    2,2,2-trifluoroethanol 65.33
    methyl butyrate 92.7

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction