Ephedrine Sulfate

Overview IFRA Request a quote

  • Identifiers

    CAS number
    134-72-5

    Molecular formula
    C20H32N2O6S

    SMILES
    C[C@@H]([C@@H](C1=CC=CC=C1)O)NC.C[C@@H]([C@@H](C1=CC=CC=C1)O)NC.OS(=O)(=O)O

    Safety labels

    Acute Toxic
    Acute Toxic

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Odorless 41.29%
    Fishy 36.97%
    Sweet 30.45%
    Cooling 28.33%
    Savory 27.33%
    Bitter 25.07%
    Cheesy 22.71%
    Mint 22.46%
    Ripe 21.36%
    Animal 20.42%

     

    Flavor
    Odorless 33.92%
    Mild 33.48%
    Sweet 27.58%
    Sulfurous 24.5%
    Bitter 23.13%
    Fruity 21.94%
    Sweet-like 20.54%
    Yeasty 19.83%
    Bloody 19.47%
    Nitrile 19.41%

     

    Odor impact est.
    Low

  • Properties

    pKa est.
    6.84 (neutral)

    Molecular weight
    428.5 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    265°C

    Melting point expt.

    • 473 to 478 °F (decomposes) (NTP, 1992)

    Flash point

    • 113.58 ˚C est.

    Solubility expt.

    • greater than or equal to 100 mg/mL at 68 °F (NTP, 1992)

  • Synonyms

    • EPHEDRINE SULFATE
    • Ephedrine sulphate
    • Isofedrol
    • Akovaz
    • l-Ephedrine sulfate
    • Corphedra
    • Ephedrini sulfas
    • U6X61U5ZEG
    • EMERPHED
    • (-)-Ephedrine sulfate (2:1) (salt)
    • NCI-C55652
    • Ephedrine sulfate (USP)
    • Ephedrine sulfate [USP]
    • 1-Phenyl-2-methylamine-propanol-1-sulfate
    • DTXSID6020565
    • Expansyl
    • 1-alpha-(1-(Methylamino)ethyl)benzyl alcohol sulfate
    • Franol Plus
    • Franol-Plus
    • Benzenemethanol, alpha-(1-(methylamino)ethyl)-, (R-(R*,S*))-, sulfate (2:1) (salt)
    • Bronkaid Max
    • RefChem:55110
    • DTXCID20565
    • (R-(R*,S*))-alpha-(1-(methylamino)ethyl)benzenemethanol sulfate (2:1) (salt)
    • 205-154-4
    • Bronkaid
    • 134-72-5
    • (-)-Ephedrine hemisulfate
    • 134-72-5 (sulfate)
    • Benzenemethanol, alpha-((1S)-1-(methylamino)ethyl)-, (alphaR)-, sulfate (2:1) (salt)
    • UNII-U6X61U5ZEG
    • CCRIS 1351
    • Pazo Ointment
    • Pazo Suppositories
    • Corphedra (TN)
    • Emerphed (TN)
    • EINECS 205-154-4
    • Akovaz (TN)
    • Ephedrine l- sulfate
    • EC 205-154-4
    • SCHEMBL41262
    • (1R,2S)-1-Phenyl-2-methylaminopropanol-1 sulfate
    • EPHEDRINE SULFATE [MI]
    • CHEMBL1523964
    • EPHEDRINE SULFATE [VANDF]
    • EPHEDRINE SULFATE [MART.]
    • EPHEDRINE SULFATE [USP-RS]
    • EPHEDRINE SULFATE [WHO-DD]
    • EPHEDRINE SULFATE [WHO-IP]
    • (-)-erythro-1-Hydroxy-2-(methylamino)-1-phenylpropane sulfate
    • AKOS015901652
    • EPHEDRINE SULFATE [ORANGE BOOK]
    • EPHEDRINI SULFAS [WHO-IP LATIN]
    • EPHEDRINE SULFATE [USP MONOGRAPH]
    • NCGC00093901-01
    • Ephedrine sulfate (2:1) (salt), (-)-
    • EU-0100501
    • NS00079168
    • D04018
    • E 3250
    • Q27290771
    • Ephedrine Sulphate 1.0 mg/ml in Methanol (as free base)
    • (1R,2S)-2-(methylamino)-1-phenylpropan-1-ol;sulfuric acid
    • (1R,2S)-2-(methylamino)-1-phenylpropan-1-ol sulfate (2:1) (salt)
    • Bis((R-(R*,S*))-beta-hydroxy-alpha-methylphenethyl)methylammonium sulphate
    • Bis((R-(R*,S*))-beta-hydroxy-alpha-methylphenethyl)methylammonium) sulphate
    • Sulfuric acid--(1R,2S)-2-(methylamino)-1-phenylpropan-1-ol (1/2)
    • Benzenemethanol, alpha-((1S)-1-(methylamino)ethyl)-, (alphaR)-, sulfate (2:1)
    • Benzenemethanol, alpha-(1-(methylamino)ethyl)-, (theta-(theta,S))-, sulfate (2:1) (salt)
    • (R-(R*,S*))-.ALPHA.-(1-(METHYLAMINO)ETHYL)BENZENEMETHANOL SULFATE (2:1) (SALT) [WHO-IP]
    • BENZENEMETHANOL, .ALPHA.-(1-(METHYLAMINO)ETHYL)-, (R-(R*,S*))-, SULFATE (2:1) (SALT)
    • 134-72-5

  • Applications

    Ephedrine Sulfate (CAS 134-72-5) is primarily encountered as a pharmaceutical reagent and a chemical intermediate. In the pharmaceutical sector, it serves as an active ingredient in certain nasal decongestant and bronchodilator formulations and is used as a stimulant component in some combination drugs. In chemical manufacturing, it is employed as a chiral building block and a precursor for the synthesis of other alkaloid-like or sympathomimetic compounds. In research and development settings, it is used as a reagent for organic synthesis and, where appropriate, as a chiral auxiliary to aid enantioselective transformations. Subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 198.47
    methanol 309.29
    isopropanol 100.82
    water 16.7
    ethyl acetate 29.96
    n-propanol 126.27
    acetone 33.03
    n-butanol 89.87
    acetonitrile 56.9
    DMF 182.1
    toluene 9.57
    isobutanol 85.02
    1,4-dioxane 170.71
    methyl acetate 35.12
    THF 110.68
    2-butanone 29.49
    n-pentanol 63.08
    sec-butanol 57.87
    n-hexane 1.87
    ethylene glycol 143.11
    NMP 131.85
    cyclohexane 5.03
    DMSO 278.68
    n-butyl acetate 38.49
    n-octanol 33.68
    chloroform 172.16
    n-propyl acetate 32.15
    acetic acid 284.02
    dichloromethane 138.46
    cyclohexanone 97.98
    propylene glycol 100.48
    isopropyl acetate 17.87
    DMAc 128.71
    2-ethoxyethanol 130.38
    isopentanol 67.91
    n-heptane 4.04
    ethyl formate 68.62
    1,2-dichloroethane 72.05
    n-hexanol 85.64
    2-methoxyethanol 240.96
    isobutyl acetate 24.43
    tetrachloromethane 21.06
    n-pentyl acetate 23.5
    transcutol 213.33
    n-heptanol 50.19
    ethylbenzene 9.61
    MIBK 20.25
    2-propoxyethanol 126.64
    tert-butanol 104.88
    MTBE 33.11
    2-butoxyethanol 83.09
    propionic acid 126.93
    o-xylene 13.24
    formic acid 246.41
    diethyl ether 20.71
    m-xylene 11.16
    p-xylene 13.24
    chlorobenzene 37.2
    dimethyl carbonate 18.38
    n-octane 2.59
    formamide 224.47
    cyclopentanone 103.3
    2-pentanone 22.43
    anisole 30.06
    cyclopentyl methyl ether 42.35
    gamma-butyrolactone 146.86
    1-methoxy-2-propanol 115.88
    pyridine 91.66
    3-pentanone 17.51
    furfural 169.96
    n-dodecane 2.35
    diethylene glycol 151.15
    diisopropyl ether 7.31
    tert-amyl alcohol 67.49
    acetylacetone 32.67
    n-hexadecane 2.56
    acetophenone 39.47
    methyl propionate 29.27
    isopentyl acetate 36.33
    trichloroethylene 163.49
    n-nonanol 29.08
    cyclohexanol 62.04
    benzyl alcohol 49.23
    2-ethylhexanol 41.62
    isooctanol 39.0
    dipropyl ether 26.17
    1,2-dichlorobenzene 41.67
    ethyl lactate 36.84
    propylene carbonate 93.44
    n-methylformamide 161.33
    2-pentanol 38.47
    n-pentane 1.96
    1-propoxy-2-propanol 78.45
    1-methoxy-2-propyl acetate 41.56
    2-(2-methoxypropoxy) propanol 58.77
    mesitylene 9.4
    ε-caprolactone 84.9
    p-cymene 13.57
    epichlorohydrin 126.04
    1,1,1-trichloroethane 43.63
    2-aminoethanol 194.7
    morpholine-4-carbaldehyde 146.68
    sulfolane 205.85
    2,2,4-trimethylpentane 2.75
    2-methyltetrahydrofuran 66.67
    n-hexyl acetate 33.78
    isooctane 2.27
    2-(2-butoxyethoxy)ethanol 86.34
    sec-butyl acetate 17.06
    tert-butyl acetate 23.43
    decalin 4.13
    glycerin 181.77
    diglyme 150.78
    acrylic acid 134.73
    isopropyl myristate 14.23
    n-butyric acid 153.26
    acetyl acetate 25.63
    di(2-ethylhexyl) phthalate 26.14
    ethyl propionate 21.26
    nitromethane 237.52
    1,2-diethoxyethane 45.01
    benzonitrile 52.35
    trioctyl phosphate 20.46
    1-bromopropane 22.97
    gamma-valerolactone 155.02
    n-decanol 22.19
    triethyl phosphate 23.52
    4-methyl-2-pentanol 27.01
    propionitrile 44.63
    vinylene carbonate 97.9
    1,1,2-trichlorotrifluoroethane 166.97
    DMS 25.71
    cumene 11.81
    2-octanol 24.35
    2-hexanone 26.67
    octyl acetate 20.26
    limonene 19.72
    1,2-dimethoxyethane 131.72
    ethyl orthosilicate 23.17
    tributyl phosphate 20.54
    diacetone alcohol 51.28
    N,N-dimethylaniline 29.03
    acrylonitrile 73.46
    aniline 41.27
    1,3-propanediol 200.74
    bromobenzene 29.1
    dibromomethane 73.38
    1,1,2,2-tetrachloroethane 139.22
    2-methyl-cyclohexyl acetate 36.55
    tetrabutyl urea 28.26
    diisobutyl methanol 22.74
    2-phenylethanol 53.69
    styrene 11.75
    dioctyl adipate 25.54
    dimethyl sulfate 42.14
    ethyl butyrate 30.71
    methyl lactate 44.79
    butyl lactate 35.89
    diethyl carbonate 23.62
    propanediol butyl ether 75.07
    triethyl orthoformate 27.83
    p-tert-butyltoluene 13.0
    methyl 4-tert-butylbenzoate 47.51
    morpholine 178.09
    tert-butylamine 50.84
    n-dodecanol 17.35
    dimethoxymethane 61.34
    ethylene carbonate 77.82
    cyrene 74.31
    2-ethoxyethyl acetate 34.97
    2-ethylhexyl acetate 26.76
    1,2,4-trichlorobenzene 48.99
    4-methylpyridine 52.33
    dibutyl ether 19.87
    2,6-dimethyl-4-heptanol 22.74
    DEF 49.43
    dimethyl isosorbide 86.49
    tetrachloroethylene 110.56
    eugenol 57.2
    triacetin 39.18
    span 80 62.38
    1,4-butanediol 84.59
    1,1-dichloroethane 44.47
    2-methyl-1-pentanol 46.69
    methyl formate 100.1
    2-methyl-1-butanol 62.43
    n-decane 3.58
    butyronitrile 48.59
    3,7-dimethyl-1-octanol 27.46
    1-chlorooctane 14.34
    1-chlorotetradecane 6.13
    n-nonane 3.31
    undecane 2.84
    tert-butylcyclohexane 4.15
    cyclooctane 2.17
    cyclopentanol 74.43
    tetrahydropyran 77.61
    tert-amyl methyl ether 22.73
    2,5,8-trioxanonane 106.01
    1-hexene 7.69
    2-isopropoxyethanol 74.18
    2,2,2-trifluoroethanol 102.01
    methyl butyrate 40.93

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction