Eleutheroside B

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  • Identifiers

    CAS number
    118-34-3

    Molecular formula
    C17H24O9

    SMILES
    COC1=CC(=CC(=C1O[C@H]2[C@@H]([C@H]([C@@H]([C@H](O2)CO)O)O)O)OC)/C=C/CO

    Safety labels

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Odorless 57.63%
    Vanilla 45.59%
    Sweet 35.86%
    Milky 26.67%
    Creamy 24.13%
    Spicy 22.26%
    Balsamic 20.35%
    Savory 19.13%
    Caramellic 19.12%
    Warm 19.07%

     

    Flavor
    Bitter 64.34%
    Odorless 33.3%
    Bland 28.24%
    Sweet-like 27.33%
    Sweet 24.14%
    Parsley 20.74%
    Eugenol 20.69%
    Cedarleaf 20.45%
    Mild 20.44%
    Very mild 20.33%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    -1.3

    pKa est.
    7.29 (neutral)

    Molecular weight
    372.4 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    2059°C

    Flash point

    • 241.8 ˚C est.

  • Synonyms

    • Syringin
    • Eleutheroside B
    • 118-34-3
    • Syringoside
    • Lilacin
    • Methoxyconiferine
    • Ligustrin
    • Syrigin
    • Syringenin
    • MAGNOLENIN A
    • Sinapyl alcohol 4-O-glucoside
    • Ilexanthin A
    • Magnolenin
    • Magmolenin A
    • UNII-I6F5B11C96
    • CHEBI:9380
    • I6F5B11C96
    • NSC 287441
    • 4-[(1E)-3-hydroxyprop-1-en-1-yl]-2,6-dimethoxyphenyl beta-D-glucopyranoside
    • CHEMBL250872
    • (2R,3S,4S,5R,6S)-2-(hydroxymethyl)-6-(4-((E)-3-hydroxyprop-1-en-1-yl)-2,6-dimethoxyphenoxy)tetrahydro-2H-pyran-3,4,5-triol
    • (2R,3S,4S,5R,6S)-2-(hydroxymethyl)-6-[4-[(E)-3-hydroxyprop-1-enyl]-2,6-dimethoxyphenoxy]oxane-3,4,5-triol
    • DTXSID2042438
    • NSC-287441
    • Glucoside, 4-(3-hydroxypropenyl)-2,6-dimethoxyphenyl, D
    • sinapyl alcohol-4-O-beta-D-glucopyranoside
    • ELEUTHEROSIDE B (USP-RS)
    • ELEUTHEROSIDE B [USP-RS]
    • .beta.-Terpineol
    • beta-D-Glucopyranoside, 4-(3-hydroxy-1-propenyl)-2,6-dimethoxyphenyl
    • beta-D-Glucopyranoside, 4-((1E)-3-hydroxy-1-propenyl)-2,6-dimethoxyphenyl
    • Ligustrin (VAN)
    • Syringinenin
    • NSC287441
    • 4-((1E)-3-hydroxyprop-1-en-1-yl)-2,6-dimethoxyphenyl beta-D-glucopyranoside
    • MFCD00016778
    • Syringin (Standard)
    • SYRINGIN [MI]
    • bmse000613
    • MLS000574917
    • SCHEMBL409032
    • MEGxp0_000264
    • DTXCID0022438
    • ACon1_000108
    • HY-N0824R
    • QJVXKWHHAMZTBY-GCPOEHJPSA-N
    • HMS2217D04
    • HMS3885E08
    • HY-N0824
    • Eleutheroside B, analytical standard
    • BDBM50241356
    • NSC791584
    • s3841
    • AKOS015912605
    • CCG-268321
    • MS10479
    • NSC-791584
    • NCGC00180873-01
    • (2R,3S,4S,5R,6S)-2-(hydroxymethyl)-6-[4-[(E)-3-hydroxyprop-1-enyl]-2,6-dimethoxy-phenoxy]tetrahydropyran-3,4,5-triol
    • DA-58220
    • SMR000156227
    • CS-0009856
    • NS00023810
    • C01533
    • 4-O-(beta-D-glucosyl)-trans-4-sinapoyl alcohol
    • 4-O-(beta-D-glucosyl)-trans-4-sinapyl alcohol
    • ELEUTHEROSIDE B (CONSTITUENT OF ELEUTHERO)
    • Q891785
    • ELEUTHEROSIDE B (CONSTITUENT OF ELEUTHERO) [DSC]
    • Eleutheroside B, United States Pharmacopeia (USP) Reference Standard
    • Sinapyl alcohol 4-O-glucoside;Syringoside;Ligustrin;Eleutheroside B
    • (E)-4-[-3-Hydroxy-1-propenyl]-2,6-dimethoxyphenyl-beta-D-glucopyranoside
    • .beta.-D-Glucopyranoside, 4-(3-hydroxy-1-propenyl)-2,6-dimethoxyphenyl
    • 2-(hydroxymethyl)-6-[4-[(E)-3-hydroxyprop-1-enyl]-2,6-dimethoxyphenoxy]oxane-3,4,5-triol
    • 4-((1E)-3-HYDROXY-1-PROPEN-1-YL)-2,6-DIMETHOXYPHENYL-.BETA.-D-GLUCOPYRANOSIDE
    • 4-((1E)-3-HYDROXY-1-PROPEN-1-YL)-2,6-DIMETHOXYPHENYL-beta-D-GLUCOPYRANOSIDE
    • I(2)-D-Glucopyranoside, 4-[(1E)-3-hydroxy-1-propen-1-yl]-2,6-dimethoxyphenyl

  • Applications

    Eleutheroside B (CAS 118-34-3) is a lignan glycoside from Eleutherococcus senticosus. In practical applications, it is used as an analytical standard/quality-control marker for botanical extracts in HPLC/LC-MS analyses, as a studied component in pharmacological and nutraceutical research to assess bioactivity and support development of lignan derivatives, as a constituent of botanical extracts used in cosmetics and personal care products, as a potential intermediate or reference material in the synthesis of related lignan glycosides, and as a marker for supply-chain quality assessment of herbal materials.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 28.39
    methanol 62.58
    isopropanol 9.5
    water 31.8
    ethyl acetate 5.01
    n-propanol 14.05
    acetone 20.08
    n-butanol 9.57
    acetonitrile 7.23
    DMF 109.63
    toluene 1.33
    isobutanol 5.39
    1,4-dioxane 19.38
    methyl acetate 7.34
    THF 30.55
    2-butanone 8.2
    n-pentanol 4.53
    sec-butanol 6.65
    n-hexane 0.21
    ethylene glycol 117.47
    NMP 107.58
    cyclohexane 1.46
    DMSO 545.62
    n-butyl acetate 1.64
    n-octanol 3.69
    chloroform 3.37
    n-propyl acetate 2.32
    acetic acid 173.11
    dichloromethane 4.38
    cyclohexanone 17.62
    propylene glycol 60.92
    isopropyl acetate 2.76
    DMAc 118.25
    2-ethoxyethanol 42.09
    isopentanol 5.31
    n-heptane 0.6
    ethyl formate 9.74
    1,2-dichloroethane 5.36
    n-hexanol 3.95
    2-methoxyethanol 115.52
    isobutyl acetate 1.14
    tetrachloromethane 1.14
    n-pentyl acetate 2.54
    transcutol 53.63
    n-heptanol 4.59
    ethylbenzene 0.79
    MIBK 3.09
    2-propoxyethanol 22.31
    tert-butanol 9.63
    MTBE 2.18
    2-butoxyethanol 15.81
    propionic acid 27.38
    o-xylene 1.69
    formic acid 352.85
    diethyl ether 3.05
    m-xylene 1.16
    p-xylene 0.9
    chlorobenzene 1.21
    dimethyl carbonate 16.5
    n-octane 0.42
    formamide 306.35
    cyclopentanone 27.88
    2-pentanone 5.15
    anisole 2.58
    cyclopentyl methyl ether 7.21
    gamma-butyrolactone 40.19
    1-methoxy-2-propanol 49.86
    pyridine 9.84
    3-pentanone 4.97
    furfural 34.29
    n-dodecane 0.34
    diethylene glycol 64.97
    diisopropyl ether 0.87
    tert-amyl alcohol 7.26
    acetylacetone 15.95
    n-hexadecane 0.36
    acetophenone 5.23
    methyl propionate 9.45
    isopentyl acetate 1.71
    trichloroethylene 7.59
    n-nonanol 3.77
    cyclohexanol 11.36
    benzyl alcohol 7.92
    2-ethylhexanol 2.06
    isooctanol 3.41
    dipropyl ether 2.58
    1,2-dichlorobenzene 1.46
    ethyl lactate 10.59
    propylene carbonate 14.51
    n-methylformamide 65.74
    2-pentanol 4.12
    n-pentane 0.42
    1-propoxy-2-propanol 11.87
    1-methoxy-2-propyl acetate 6.68
    2-(2-methoxypropoxy) propanol 17.91
    mesitylene 0.86
    ε-caprolactone 15.7
    p-cymene 1.02
    epichlorohydrin 20.96
    1,1,1-trichloroethane 1.86
    2-aminoethanol 78.29
    morpholine-4-carbaldehyde 75.03
    sulfolane 123.86
    2,2,4-trimethylpentane 0.24
    2-methyltetrahydrofuran 8.87
    n-hexyl acetate 3.37
    isooctane 0.12
    2-(2-butoxyethoxy)ethanol 24.08
    sec-butyl acetate 1.31
    tert-butyl acetate 3.37
    decalin 0.35
    glycerin 172.49
    diglyme 37.99
    acrylic acid 49.39
    isopropyl myristate 1.87
    n-butyric acid 18.91
    acetyl acetate 6.65
    di(2-ethylhexyl) phthalate 3.89
    ethyl propionate 2.71
    nitromethane 124.97
    1,2-diethoxyethane 5.59
    benzonitrile 3.33
    trioctyl phosphate 3.38
    1-bromopropane 1.63
    gamma-valerolactone 52.41
    n-decanol 3.09
    triethyl phosphate 3.4
    4-methyl-2-pentanol 2.35
    propionitrile 4.35
    vinylene carbonate 13.84
    1,1,2-trichlorotrifluoroethane 73.75
    DMS 6.23
    cumene 0.68
    2-octanol 2.33
    2-hexanone 2.65
    octyl acetate 2.96
    limonene 1.7
    1,2-dimethoxyethane 26.18
    ethyl orthosilicate 3.01
    tributyl phosphate 3.15
    diacetone alcohol 15.3
    N,N-dimethylaniline 3.18
    acrylonitrile 9.26
    aniline 5.58
    1,3-propanediol 68.47
    bromobenzene 0.81
    dibromomethane 2.6
    1,1,2,2-tetrachloroethane 8.28
    2-methyl-cyclohexyl acetate 3.25
    tetrabutyl urea 5.8
    diisobutyl methanol 1.65
    2-phenylethanol 5.53
    styrene 0.85
    dioctyl adipate 4.57
    dimethyl sulfate 43.33
    ethyl butyrate 2.29
    methyl lactate 36.68
    butyl lactate 6.57
    diethyl carbonate 2.45
    propanediol butyl ether 20.63
    triethyl orthoformate 3.1
    p-tert-butyltoluene 1.05
    methyl 4-tert-butylbenzoate 9.61
    morpholine 29.26
    tert-butylamine 3.27
    n-dodecanol 2.48
    dimethoxymethane 38.16
    ethylene carbonate 11.17
    cyrene 31.92
    2-ethoxyethyl acetate 5.79
    2-ethylhexyl acetate 1.27
    1,2,4-trichlorobenzene 2.56
    4-methylpyridine 4.84
    dibutyl ether 1.79
    2,6-dimethyl-4-heptanol 1.65
    DEF 16.43
    dimethyl isosorbide 23.36
    tetrachloroethylene 7.35
    eugenol 11.31
    triacetin 8.82
    span 80 14.97
    1,4-butanediol 26.22
    1,1-dichloroethane 1.86
    2-methyl-1-pentanol 3.53
    methyl formate 48.16
    2-methyl-1-butanol 5.29
    n-decane 0.51
    butyronitrile 3.08
    3,7-dimethyl-1-octanol 2.47
    1-chlorooctane 1.17
    1-chlorotetradecane 0.7
    n-nonane 0.47
    undecane 0.41
    tert-butylcyclohexane 0.18
    cyclooctane 0.65
    cyclopentanol 14.59
    tetrahydropyran 7.9
    tert-amyl methyl ether 2.65
    2,5,8-trioxanonane 34.59
    1-hexene 0.52
    2-isopropoxyethanol 16.37
    2,2,2-trifluoroethanol 89.01
    methyl butyrate 3.82

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction