Dydrogesterone

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  • Identifiers

    CAS number
    152-62-5

    Molecular formula
    C21H28O2

    SMILES
    CC(=O)[C@H]1CC[C@@H]2[C@@]1(CC[C@@H]3[C@H]2C=CC4=CC(=O)CC[C@@]34C)C

    Safety labels

    Health Hazard
    Health

    Environmental Hazard
    Environmental

  • Odor profile

    Fragrance
    Woody 78.34%
    Fruity 71.76%
    Cedar 40.23%
    Floral 37.72%
    Berry 35.38%
    Orris 34.32%
    Amber 33.34%
    Dry 32.54%
    Fresh 31.17%
    Tobacco 30.26%

     

    Flavor
    Minty 32.09%
    Bitter 27.73%
    Mint 23.13%
    Spice 22.24%
    Spicy 21.93%
    Basil 21.3%
    Fresh 21.26%
    Herbal 21.11%
    Ripe apricot 20.73%
    Lovage 20.58%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    3.8

    pKa est.
    6.77 (neutral)

    Molecular weight
    312.4 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    436°C

    Melting point expt.

    • 168-169
    • 170 °C
    • 169.5 °C

    Flash point

    • 212.88 ˚C est.

    Solubility expt.

    • Soluble in acetone, chloroform (1 in 2), ethanol (1 in 40) and diethyl ether (1 in 200); slightly soluble in fixed oils; sparingly soluble in methanol.
    • 4.86e-03 g/L

  • Synonyms

    • dydrogesterone
    • 152-62-5
    • Isopregnenone
    • Hydrogesterone
    • Duphaston
    • Hydrogestrone
    • Gynorest
    • Gestatron
    • Diphaston
    • Dufaston
    • Duvaron
    • Prodel
    • Retrone
    • Terolut
    • 10alpha-Isopregnenone
    • Didrogesterone
    • Dydrogesteronum
    • Retro-6-dehydroprogesterone
    • delta(6)-Retroprogesterone
    • Didrogesterone [DCIT]
    • didrogesterona
    • 6-Dehydro-retro-progesterone
    • Dydrogesterona
    • delta(sup 6)-Retroprogesterone
    • Dydrogesteronum [INN-Latin]
    • Dydrogesterona [INN-Spanish]
    • 9beta,10alpha-Pregna-4,6-diene-3,20-dione
    • Retroprogesterone, 6-dehydro-
    • NSC 92336
    • 6-Dehydro-9beta,10alpha-progesterone
    • CCRIS 9069
    • HSDB 3321
    • 6-Dehydroretroprogesterone
    • (8S,9R,10S,13S,14S,17S)-17-acetyl-10,13-dimethyl-1,2,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-3-one
    • EINECS 205-806-8
    • UNII-90I02KLE8K
    • NSC-92336
    • 9-beta,10alpha-Pregna-4,6-diene-3,20-dione
    • 90I02KLE8K
    • DTXSID1022974
    • (9-beta,10-alpha)-Pregna-4,6-diene-3,20-dione
    • CHEBI:31527
    • Pregna-4,6-diene-3,20-dione, (9beta,10alpha)-
    • (9beta,10alpha)-pregna-4,6-diene-3,20-dione
    • 9-beta,10-alpha-Pregna-4,6-diene-3,20-dione
    • MLS002153947
    • DTXCID702974
    • Dehydrogesterone
    • NSC92336
    • Pregna-4,6-diene-3,20-dione, (9-beta,10-alpha)-
    • Dydrogesterone [USAN:USP:INN:BAN:JAN]
    • Dydrogesteronum (INN-Latin)
    • Dydrogesterona (INN-Spanish)
    • DYDROGESTERONE (MART.)
    • DYDROGESTERONE [MART.]
    • DYDROGESTERONE (USP-RS)
    • DYDROGESTERONE [USP-RS]
    • DYDROGESTERONE (EP MONOGRAPH)
    • DYDROGESTERONE [EP MONOGRAPH]
    • DYDROGESTERONE (USP MONOGRAPH)
    • DYDROGESTERONE [USP MONOGRAPH]
    • Duphaston (TN)
    • Gynorest (TN)
    • CAS-152-62-5
    • Dydrogesterone (USAN:USP:INN:BAN:JAN)
    • 6-Dehydro-9 beta-10 alpha-progesterone
    • MLS002695106
    • dibrogesterone
    • 6 Dehydro 9 beta 10 alpha progesterone
    • Dydrogesterone; 9beta,10alpha-Pregna-4,6-diene-3,20-dione
    • Dydrogesterone?
    • NCGC00016413-01
    • 10alpha-pregna-4,6-diene-3,20-dione
    • Dehydro-retroprogesterone
    • 6-Dehydro-9.beta.,10.alpha.-progesterone
    • Prestwick0_000671
    • Prestwick1_000671
    • Prestwick2_000671
    • Prestwick3_000671
    • Dydrogesterone (Standard)
    • DYDROGESTERONE [MI]
    • Pregna-4,6-diene-3,20-dione, (9b,10a)-
    • .DELTA.6-Retroprogesterone
    • DYDROGESTERONE [INN]
    • DYDROGESTERONE [JAN]
    • SCHEMBL37703
    • BSPBio_000761
    • DYDROGESTERONE [HSDB]
    • DYDROGESTERONE [USAN]
    • SPBio_002682
    • BPBio1_000839
    • GTPL2878
    • HY-B0257AR
    • DYDROGESTERONE [WHO-DD]
    • CHEMBL1200853
    • HY-B0257A
    • 9.beta.,6-diene-3,20-dione
    • G03DB01
    • Dydrogesterone (JP17/USP/INN)
    • HMS1570G03
    • HMS2097G03
    • HMS2230C10
    • HMS3714G03
    • 9-.beta.,6-diene-3,20-dione
    • BCP12878
    • DYDROGESTERONE [ORANGE BOOK]
    • Tox21_110429
    • s4097
    • AKOS015895532
    • Tox21_110429_1
    • CCG-220671
    • DB00378
    • FD22631
    • GS-6735
    • NCGC00179445-01
    • NCGC00179445-03
    • NCGC00179445-04
    • SMR001233286
    • AB00513884
    • NS00009687
    • D01217
    • H10151
    • Pregna-4,20-dione, (9.beta.,10.alpha.)-
    • AB00513884_04
    • EN300-19767791
    • SR-01000841256
    • Q4161380
    • SR-01000841256-2

  • Applications

    Dydrogesterone, CAS 152-62-5, is primarily used as an active pharmaceutical ingredient (API) in progestin-based pharmaceutical products for female health, including formulations for contraception and hormone replacement therapy. In the pharmaceutical industry, it is commonly employed as the active component in the development and manufacture of progestin-containing formulations, while supporting optimization of pharmacokinetic and formulation properties. In steroid chemistry laboratories, dydrogesterone can serve as an analytical reference standard and as an intermediate in synthetic routes to related steroid hormones. These applications emphasize pharmaceutical development and quality control within regulatory frameworks.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 26.56
    methanol 24.71
    isopropanol 23.04
    water 0.16
    ethyl acetate 53.7
    n-propanol 33.12
    acetone 65.46
    n-butanol 34.88
    acetonitrile 40.39
    DMF 80.74
    toluene 213.92
    isobutanol 21.28
    1,4-dioxane 141.82
    methyl acetate 35.27
    THF 201.18
    2-butanone 48.57
    n-pentanol 13.28
    sec-butanol 10.1
    n-hexane 1.02
    ethylene glycol 4.56
    NMP 43.82
    cyclohexane 8.84
    DMSO 30.69
    n-butyl acetate 34.26
    n-octanol 5.38
    chloroform 248.41
    n-propyl acetate 27.42
    acetic acid 23.74
    dichloromethane 146.33
    cyclohexanone 104.01
    propylene glycol 6.0
    isopropyl acetate 49.16
    DMAc 66.63
    2-ethoxyethanol 30.02
    isopentanol 28.01
    n-heptane 0.97
    ethyl formate 20.22
    1,2-dichloroethane 78.68
    n-hexanol 20.78
    2-methoxyethanol 64.55
    isobutyl acetate 26.91
    tetrachloromethane 21.15
    n-pentyl acetate 22.15
    transcutol 139.64
    n-heptanol 11.2
    ethylbenzene 31.35
    MIBK 43.93
    2-propoxyethanol 73.33
    tert-butanol 21.16
    MTBE 13.26
    2-butoxyethanol 36.99
    propionic acid 18.96
    o-xylene 53.68
    formic acid 9.4
    diethyl ether 36.62
    m-xylene 83.88
    p-xylene 37.38
    chlorobenzene 90.17
    dimethyl carbonate 34.21
    n-octane 0.42
    formamide 19.82
    cyclopentanone 105.13
    2-pentanone 55.19
    anisole 61.98
    cyclopentyl methyl ether 64.3
    gamma-butyrolactone 83.56
    1-methoxy-2-propanol 66.1
    pyridine 155.88
    3-pentanone 47.45
    furfural 85.57
    n-dodecane 0.41
    diethylene glycol 50.42
    diisopropyl ether 11.36
    tert-amyl alcohol 7.77
    acetylacetone 85.22
    n-hexadecane 0.53
    acetophenone 50.84
    methyl propionate 46.45
    isopentyl acetate 39.67
    trichloroethylene 171.74
    n-nonanol 6.8
    cyclohexanol 32.35
    benzyl alcohol 44.73
    2-ethylhexanol 12.59
    isooctanol 10.49
    dipropyl ether 17.29
    1,2-dichlorobenzene 68.53
    ethyl lactate 19.22
    propylene carbonate 44.44
    n-methylformamide 32.77
    2-pentanol 14.73
    n-pentane 1.9
    1-propoxy-2-propanol 45.64
    1-methoxy-2-propyl acetate 73.17
    2-(2-methoxypropoxy) propanol 35.83
    mesitylene 33.74
    ε-caprolactone 68.71
    p-cymene 15.0
    epichlorohydrin 118.16
    1,1,1-trichloroethane 70.27
    2-aminoethanol 13.73
    morpholine-4-carbaldehyde 94.78
    sulfolane 59.5
    2,2,4-trimethylpentane 0.84
    2-methyltetrahydrofuran 52.26
    n-hexyl acetate 22.15
    isooctane 1.16
    2-(2-butoxyethoxy)ethanol 47.22
    sec-butyl acetate 25.69
    tert-butyl acetate 43.82
    decalin 2.81
    glycerin 14.54
    diglyme 95.45
    acrylic acid 17.92
    isopropyl myristate 12.24
    n-butyric acid 42.14
    acetyl acetate 48.06
    di(2-ethylhexyl) phthalate 18.87
    ethyl propionate 30.38
    nitromethane 48.95
    1,2-diethoxyethane 38.53
    benzonitrile 64.75
    trioctyl phosphate 10.78
    1-bromopropane 40.53
    gamma-valerolactone 153.94
    n-decanol 5.03
    triethyl phosphate 19.39
    4-methyl-2-pentanol 14.03
    propionitrile 52.92
    vinylene carbonate 56.56
    1,1,2-trichlorotrifluoroethane 58.83
    DMS 39.03
    cumene 16.52
    2-octanol 5.18
    2-hexanone 24.53
    octyl acetate 12.97
    limonene 14.27
    1,2-dimethoxyethane 58.79
    ethyl orthosilicate 18.91
    tributyl phosphate 12.33
    diacetone alcohol 42.64
    N,N-dimethylaniline 33.58
    acrylonitrile 64.74
    aniline 109.32
    1,3-propanediol 32.76
    bromobenzene 101.58
    dibromomethane 90.54
    1,1,2,2-tetrachloroethane 127.89
    2-methyl-cyclohexyl acetate 31.86
    tetrabutyl urea 16.89
    diisobutyl methanol 10.24
    2-phenylethanol 54.14
    styrene 39.11
    dioctyl adipate 20.63
    dimethyl sulfate 37.34
    ethyl butyrate 28.94
    methyl lactate 26.7
    butyl lactate 23.09
    diethyl carbonate 23.18
    propanediol butyl ether 21.79
    triethyl orthoformate 26.61
    p-tert-butyltoluene 14.18
    methyl 4-tert-butylbenzoate 40.36
    morpholine 128.59
    tert-butylamine 12.44
    n-dodecanol 3.77
    dimethoxymethane 106.27
    ethylene carbonate 50.49
    cyrene 42.92
    2-ethoxyethyl acetate 47.87
    2-ethylhexyl acetate 28.95
    1,2,4-trichlorobenzene 78.51
    4-methylpyridine 146.69
    dibutyl ether 8.18
    2,6-dimethyl-4-heptanol 10.24
    DEF 40.29
    dimethyl isosorbide 71.39
    tetrachloroethylene 80.34
    eugenol 45.02
    triacetin 38.97
    span 80 27.58
    1,4-butanediol 8.57
    1,1-dichloroethane 71.26
    2-methyl-1-pentanol 12.23
    methyl formate 21.83
    2-methyl-1-butanol 17.56
    n-decane 0.75
    butyronitrile 42.15
    3,7-dimethyl-1-octanol 8.62
    1-chlorooctane 4.08
    1-chlorotetradecane 1.83
    n-nonane 0.57
    undecane 0.54
    tert-butylcyclohexane 1.89
    cyclooctane 2.27
    cyclopentanol 23.72
    tetrahydropyran 109.32
    tert-amyl methyl ether 9.49
    2,5,8-trioxanonane 64.56
    1-hexene 5.42
    2-isopropoxyethanol 24.27
    2,2,2-trifluoroethanol 13.37
    methyl butyrate 31.31

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction