Dulcin

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  • Identifiers

    CAS number
    150-69-6

    Molecular formula
    C9H12N2O2

    SMILES
    CCOC1=CC=C(C=C1)NC(=O)N

    Safety labels

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Odorless 39.17%
    Grape 34.32%
    Meaty 33.33%
    Savory 31.85%
    Fruity 29.11%
    Cooked 25.54%
    Roasted 25.15%
    Animal 22.8%
    Cheesy 21.64%
    Cooling 21.04%

     

    Flavor
    Fruity 50.89%
    Sweet 37.22%
    Mild 36.55%
    Odorless 32.56%
    Grape 29.33%
    Floral 28.42%
    Powdery 27.83%
    Bitter 25.82%
    Orange flower 21.93%
    Orange blossom 21.54%

     

    Odor impact est.
    Odorless

  • Properties

    XLogP3-AA
    1.0

    pKa est.
    7.36 (neutral)

    Molecular weight
    180.2 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Melting point expt.

    • 343 to 345 °F (NTP, 1992)
    • 173.5 °C
    • 173 - 174 °C

    Boiling point

    • Decomposes (NTP, 1992)
    • Decomposes

    Flash point

    • 167.27 ˚C est.

    Solubility expt.

    • Slightly soluble (NTP, 1992)
    • In water, 1.21 g/L at 21 °C
    • Soluble in 800 parts cold water, 50 parts boiling water, 25 parts alcohol
    • 1.21 mg/mL at 21 °C

  • Synonyms

    • Dulcin
    • 150-69-6
    • N-(4-Ethoxyphenyl)urea
    • 1-(4-Ethoxyphenyl)urea
    • (4-ethoxyphenyl)urea
    • Sucrol
    • Valzin
    • p-Ethoxyphenylurea
    • p-Phenetylurea
    • Phenetolcarbamide
    • Dulcine
    • Suesstoff
    • Dulein
    • p-Phenetolcarbamide
    • p-Phenethylurea
    • p-Phenetolecarbamide
    • 4-ETHOXYPHENYLUREA
    • Urea, (p-ethoxyphenyl)-
    • Phenethylcarbamid
    • p-Phenetolcarbamid
    • Urea, (4-ethoxyphenyl)-
    • p-Aethoxyphenylharnstoff
    • 4-Ethoxy-phenylurea
    • p-Ethoxyfenylmocovina
    • NCI-C02073
    • Phenethylcarbamid [German]
    • p-Phenetolcarbamid [German]
    • NSC 1839
    • p-Ethoxyfenylmocovina [Czech]
    • Urea, N-(4-ethoxyphenyl)-
    • CCRIS 5913
    • p-Aethoxyphenylharnstoff [German]
    • 4-Ureidophenetole
    • EINECS 205-767-7
    • UNII-8U78KF577Z
    • BRN 2096445
    • DTXSID9020580
    • AI3-08931
    • HSDB 8048
    • 8U78KF577Z
    • DULCIN [IARC]
    • NSC-1839
    • DULCIN [MI]
    • 4-ETHOXYPHENYL)UREA
    • (P-ETHOXYPHENYL)UREA
    • DTXCID10580
    • CHEBI:82462
    • UREA,(4-ETHOXYPHENYL)-
    • 4-13-00-01154 (Beilstein Handbook Reference)
    • DULCIN (IARC)
    • Phenethylcarbamid (German)
    • p-Phenetolcarbamid (German)
    • p-Ureidophenetole
    • Dulcin?
    • 4-ethoxyphenyl urea
    • p-Phenetol-carbamide
    • MFCD00025431
    • p-Aethoxyphylharnstoff
    • (4-ethoxyphenyl)-urea
    • Maybridge1_002383
    • WLN: ZVMR DO2
    • DULCIN (SWEETENER)
    • PARA-PHENETOLECABAMIDE
    • Oprea1_621725
    • MLS000056892
    • DivK1c_001135
    • SCHEMBL177957
    • p-Aethoxyphylharnstoff (German)
    • CHEMBL1330343
    • HMS548E07
    • NSC1839
    • Urea, (4-ethoxyphenyl)-(9CI)
    • HMS2487K12
    • Urea, (4-ethoxyphenyl)- (9CI)
    • Tox21_301340
    • BBL004546
    • STK400289
    • AKOS000113528
    • HY-W150251
    • PS-4228
    • CDS1_000095
    • NCGC00255360-01
    • CAS-150-69-6
    • SMR000065473
    • CS-0206739
    • E1171
    • NS00021681
    • C19415
    • T71814
    • Q423302
    • Z56754688

  • Applications

    Dulcin (CAS 150-69-6) is a compound historically used as an artificial sweetener in foods and beverages. It has also been studied and employed as an organic synthesis intermediate, potentially serving as a precursor for pharmaceutical compounds and dye-related materials. In the fragrance and cosmetics industries, dulcin is considered as an odorant or as a fragrance intermediate for perfume formulations and personal care products. Other industrial applications may include roles as a building block or additive in complex synthetic processes, depending on local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 28.43
    methanol 47.13
    isopropanol 16.16
    water 2.78
    ethyl acetate 7.0
    n-propanol 17.73
    acetone 28.32
    n-butanol 15.46
    acetonitrile 12.2
    DMF 186.82
    toluene 0.57
    isobutanol 11.11
    1,4-dioxane 10.24
    methyl acetate 12.68
    THF 31.09
    2-butanone 17.98
    n-pentanol 11.7
    sec-butanol 11.72
    n-hexane 0.33
    ethylene glycol 32.68
    NMP 83.65
    cyclohexane 0.08
    DMSO 321.35
    n-butyl acetate 8.45
    n-octanol 5.29
    chloroform 10.52
    n-propyl acetate 5.59
    acetic acid 39.35
    dichloromethane 10.31
    cyclohexanone 15.59
    propylene glycol 34.77
    isopropyl acetate 5.09
    DMAc 232.49
    2-ethoxyethanol 33.62
    isopentanol 12.49
    n-heptane 0.21
    ethyl formate 9.95
    1,2-dichloroethane 6.56
    n-hexanol 8.91
    2-methoxyethanol 69.63
    isobutyl acetate 4.67
    tetrachloromethane 1.84
    n-pentyl acetate 4.92
    transcutol 69.1
    n-heptanol 4.24
    ethylbenzene 0.99
    MIBK 8.89
    2-propoxyethanol 34.07
    tert-butanol 19.0
    MTBE 9.21
    2-butoxyethanol 15.9
    propionic acid 20.07
    o-xylene 1.33
    formic acid 47.55
    diethyl ether 4.84
    m-xylene 1.03
    p-xylene 1.59
    chlorobenzene 2.64
    dimethyl carbonate 11.3
    n-octane 0.13
    formamide 52.53
    cyclopentanone 28.32
    2-pentanone 11.03
    anisole 8.03
    cyclopentyl methyl ether 7.15
    gamma-butyrolactone 29.65
    1-methoxy-2-propanol 42.93
    pyridine 8.17
    3-pentanone 8.39
    furfural 40.52
    n-dodecane 0.2
    diethylene glycol 48.48
    diisopropyl ether 1.35
    tert-amyl alcohol 15.55
    acetylacetone 16.44
    n-hexadecane 0.23
    acetophenone 10.5
    methyl propionate 11.62
    isopentyl acetate 10.61
    trichloroethylene 14.94
    n-nonanol 5.02
    cyclohexanol 5.75
    benzyl alcohol 9.26
    2-ethylhexanol 5.56
    isooctanol 3.85
    dipropyl ether 3.88
    1,2-dichlorobenzene 4.36
    ethyl lactate 11.46
    propylene carbonate 16.92
    n-methylformamide 48.1
    2-pentanol 7.01
    n-pentane 0.17
    1-propoxy-2-propanol 22.11
    1-methoxy-2-propyl acetate 17.89
    2-(2-methoxypropoxy) propanol 29.8
    mesitylene 0.93
    ε-caprolactone 14.31
    p-cymene 2.1
    epichlorohydrin 28.2
    1,1,1-trichloroethane 5.52
    2-aminoethanol 36.94
    morpholine-4-carbaldehyde 61.49
    sulfolane 72.51
    2,2,4-trimethylpentane 0.31
    2-methyltetrahydrofuran 12.34
    n-hexyl acetate 8.86
    isooctane 0.2
    2-(2-butoxyethoxy)ethanol 29.37
    sec-butyl acetate 4.39
    tert-butyl acetate 8.37
    decalin 0.29
    glycerin 71.98
    diglyme 45.63
    acrylic acid 25.89
    isopropyl myristate 4.51
    n-butyric acid 17.92
    acetyl acetate 6.42
    di(2-ethylhexyl) phthalate 8.95
    ethyl propionate 6.41
    nitromethane 57.97
    1,2-diethoxyethane 10.69
    benzonitrile 7.84
    trioctyl phosphate 5.75
    1-bromopropane 3.13
    gamma-valerolactone 41.52
    n-decanol 3.91
    triethyl phosphate 9.05
    4-methyl-2-pentanol 5.1
    propionitrile 8.6
    vinylene carbonate 15.78
    1,1,2-trichlorotrifluoroethane 54.33
    DMS 11.43
    cumene 1.5
    2-octanol 2.9
    2-hexanone 8.79
    octyl acetate 6.14
    limonene 2.84
    1,2-dimethoxyethane 41.32
    ethyl orthosilicate 8.05
    tributyl phosphate 8.09
    diacetone alcohol 21.38
    N,N-dimethylaniline 8.39
    acrylonitrile 13.23
    aniline 5.49
    1,3-propanediol 34.87
    bromobenzene 1.93
    dibromomethane 5.51
    1,1,2,2-tetrachloroethane 14.34
    2-methyl-cyclohexyl acetate 9.85
    tetrabutyl urea 11.63
    diisobutyl methanol 3.73
    2-phenylethanol 9.37
    styrene 1.15
    dioctyl adipate 8.85
    dimethyl sulfate 41.63
    ethyl butyrate 7.38
    methyl lactate 23.64
    butyl lactate 10.34
    diethyl carbonate 7.04
    propanediol butyl ether 22.63
    triethyl orthoformate 7.95
    p-tert-butyltoluene 2.13
    methyl 4-tert-butylbenzoate 16.0
    morpholine 18.68
    tert-butylamine 7.09
    n-dodecanol 3.05
    dimethoxymethane 34.91
    ethylene carbonate 10.84
    cyrene 27.21
    2-ethoxyethyl acetate 9.83
    2-ethylhexyl acetate 7.55
    1,2,4-trichlorobenzene 6.8
    4-methylpyridine 9.65
    dibutyl ether 3.91
    2,6-dimethyl-4-heptanol 3.73
    DEF 21.15
    dimethyl isosorbide 39.4
    tetrachloroethylene 7.94
    eugenol 18.35
    triacetin 14.14
    span 80 18.4
    1,4-butanediol 16.72
    1,1-dichloroethane 5.09
    2-methyl-1-pentanol 10.62
    methyl formate 27.21
    2-methyl-1-butanol 12.01
    n-decane 0.29
    butyronitrile 8.81
    3,7-dimethyl-1-octanol 5.85
    1-chlorooctane 1.7
    1-chlorotetradecane 0.9
    n-nonane 0.24
    undecane 0.24
    tert-butylcyclohexane 0.41
    cyclooctane 0.05
    cyclopentanol 9.23
    tetrahydropyran 5.17
    tert-amyl methyl ether 8.76
    2,5,8-trioxanonane 41.31
    1-hexene 1.48
    2-isopropoxyethanol 18.92
    2,2,2-trifluoroethanol 21.07
    methyl butyrate 8.72

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction