Droperidol

Overview IFRA Request a quote

  • Identifiers

    CAS number
    548-73-2

    Molecular formula
    C22H22FN3O2

    SMILES
    C1CN(CC=C1N2C3=CC=CC=C3NC2=O)CCCC(=O)C4=CC=C(C=C4)F

    Safety labels

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Odorless 49.62%
    Savory 28.63%
    Roasted 27.53%
    Meaty 27.51%
    Cooked 27.35%
    Animal 25.57%
    Burnt 23.9%
    Bitter 21.43%
    Grape 21.43%
    Popcorn 19.07%

     

    Flavor
    Bitter 88.0%
    Odorless 33.71%
    Nitrile 20.2%
    Very strong 19.89%
    Cedarleaf 19.74%
    Bland 19.73%
    Indole 19.5%
    Sweet-like 19.49%
    Cereal 19.01%
    Orange flower 18.87%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    3.5

    pKa est.
    8.05 (weak base)

    Molecular weight
    379.4 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    752°C

    Melting point expt.

    • 145-146.5
    • 145-146 °C
    • MP: 144-148 °C (after vacuum drying at 70 °C for 4 hr)
    • 145.75 °C

    Flash point

    • 264.75 ˚C est.

    Solubility expt.

    • 33.4 [ug/mL] (The mean of the results at pH 7.4)
    • 4.21 mg/L
    • 1 g soluble in 5.5 mL chloroform, 600 mL alcohol, 10,000 mL water; slightly soluble in ether
    • 9.66e-02 g/L

  • Synonyms

    • droperidol
    • 548-73-2
    • Droleptan
    • Dehydrobenzperidol
    • Inapsine
    • Dridol
    • Properidol
    • Sintodril
    • Sintosian
    • Halkan
    • Inapsin
    • Vetkalm
    • Deidrobenzperidolo
    • Inopsin
    • McN-JR-4749
    • Inappin
    • Innovan
    • Innovar
    • Inoval
    • Droperidolo
    • Droperidolum
    • Dehidrobenzperidol
    • Dihidrobenzperidol
    • Dehydrobenzoperidol
    • Leptofen
    • Thalamanol
    • Thalamonal
    • Innovar-vet
    • R-4749
    • McN-JR 4749
    • R 4749
    • NSC 169874
    • Droperidolum [INN-Latin]
    • component of Innovar
    • 1-(1-(3-(p-Fluorobenzoyl)propyl)-1,2,3,6-tetrahydro-4-pyridyl)-2-benzimidazolinone
    • CCRIS 9070
    • HSDB 3320
    • 1-(1-(4-(p-Fluorophenyl)-4-oxobutyl)-1,2,3,6-tetrahydro-4-pyridyl)-2-benzimidazolinone
    • 3-[1-[4-(4-fluorophenyl)-4-oxobutyl]-3,6-dihydro-2H-pyridin-4-yl]-1H-benzimidazol-2-one
    • R4749
    • EINECS 208-957-8
    • UNII-O9U0F09D5X
    • NSC-169874
    • BRN 0579168
    • CHEBI:4717
    • O9U0F09D5X
    • DTXSID6022973
    • NSC169874
    • 2H-Benzimidazol-2-one, 1-(1-(4-(4-fluorophenyl)-4-oxobutyl)-1,2,3,6-tetrahydro-4-pyridinyl)-1,3-dihydro-
    • CHEMBL1108
    • MLS000028671
    • DTXCID302973
    • 1-{1-[4-(4-fluorophenyl)-4-oxobutyl]-1,2,3,6-tetrahydropyridin-4-yl}-1,3-dihydro-2H-benzimidazol-2-one
    • 2H-Benzimidazol-2-one, 1-[1-[4-(4-fluorophenyl)-4-oxobutyl]-1,2,3,6-tetrahydro-4-pyridinyl]-1,3-dihydro-
    • INNOVAR COMPONENT DROPERIDOL
    • 5-24-02-00388 (Beilstein Handbook Reference)
    • MFCD00083290
    • 1-[1-[3-(p-Fluorobenzoyl)propyl]-1,2,3,6-tetrahydro-4-pyridyl]-2-benzimidazolinone
    • 1-(1-(4-(4-fluorophenyl)-4-oxobutyl)-1,2,3,6-tetrahydropyridin-4-yl)-1H-benzo[d]imidazol-2(3H)-one
    • 1-{1-[4-(4-Fluoro-phenyl)-4-oxo-butyl]-1,2,3,6-tetrahydro-pyridin-4-yl}-1,3-dihydro-benzoimidazol-2-one
    • Droperidol [USAN:USP:INN:BAN:JAN]
    • NCGC00016504-01
    • CAS-548-73-2
    • Droperidolo [DCIT]
    • SMR000058855
    • Droperidolum (INN-Latin)
    • DROPERIDOL (MART.)
    • DROPERIDOL [MART.]
    • 2-Benzimidazolinone, 1-(1-(3-(p-fluorobenzoyl)propyl)-1,2,3,6-tetrahydro-4-pyridyl)-
    • DROPERIDOL (USP-RS)
    • DROPERIDOL [USP-RS]
    • C22H22FN3O2
    • 1-(1-(4-(4-Fluorophenyl)-4-oxobutyl)-1,2,3,6-tetrahydro-4-pyridinyl)-1,3-dihydro-2H-benzimidazol-2-one
    • 1-{1-[4-(4-fluorophenyl)-4-oxobutyl]-1,2,3,6-tetrahydro-4-pyridinyl}-2,3-dihydro-1H-benzo[d]imidazol-2-one
    • DROPERIDOL (EP MONOGRAPH)
    • DROPERIDOL [EP MONOGRAPH]
    • Neurolidol
    • DROPERIDOL (USP MONOGRAPH)
    • DROPERIDOL [USP MONOGRAPH]
    • Ina.psi.ne
    • Droperidol (USAN:USP:INN:BAN:JAN)
    • Ina.psi.n
    • Ino.psi.n
    • 1-[1-[4-(p-Fluorophenyl)-4-oxobutyl]-1,2,3,6-tetrahydro-4-pyridyl]-2-benzimidazolinone
    • 2-Benzimidazolinone, 1-[1-[3-(p-fluorobenzoyl)propyl]-1,2,3,6-tetrahydro-4-pyridyl]-
    • Droleptan (TN)
    • 1-{1-[4-(4-fluorophenyl)-4-oxobutyl]-1,2,3,6-tetrahydropyridin-4-yl}-2,3-dihydro-1H-1,3-benzodiazol-2-one
    • 3-[1-[4-(4-fluorophenyl)-4-oxidanylidene-butyl]-2,3,4,5-tetrahydropyridin-4-yl]-1~{H}-benzimidazol-2-one
    • SR-05000001546
    • INAPSINE (TN)
    • 1-(1-[3-(p-fluorobenzoyl)propyl]-1,2,3,6-tetrahydro-4-pyridyl)-2-benzimidazolinone
    • 1-(1-(4-(4-Fluoro-phenyl)-4-oxo-butyl)-1,2,3,6-tetrahydro-pyridin-4-yl)-1,3-dihydro-benzoimidazol-2-one
    • 1-(1-(4-(4-fluorophenyl)-4-oxobutyl)-1,2,3,6-tetrahydro-4-pyridinyl)-2,3-dihydro-1H-benzo(d)imidazol-2-one
    • 1-(1-(4-(4-Fluorophenyl)-4-oxobutyl)-1,2,3,6-tetrahydropyridin-4-yl)-1,3-dihydro-2H-benzimidazol-2-one
    • Droperidol; 1-[1-[4-(4-Fluorophenyl)-4-oxobutyl]-1,2,3,6-tetrahydropyridin-4-yl]-1,3-dihydro-2H-benzimidazol-2-one
    • Prestwick_705
    • Innovar (Salt/Mix)
    • HS-0065
    • Leptanal (Salt/Mix)
    • Leptofen (Salt/Mix)
    • Droperidol (Standard)
    • Spectrum_001220
    • Thalamonal (Salt/Mix)
    • DROPERIDOL [MI]
    • DROPERIDOL [INN]
    • DROPERIDOL [JAN]
    • Innovar-vet (Salt/Mix)
    • Opera_ID_1751
    • Prestwick0_000360
    • Prestwick1_000360
    • Prestwick2_000360
    • Prestwick3_000360
    • Spectrum2_001386
    • Spectrum3_001426
    • Spectrum4_000407
    • Spectrum5_001305
    • DROPERIDOL [HSDB]
    • DROPERIDOL [USAN]
    • DROPERIDOL [VANDF]
    • DROPERIDOL [WHO-DD]
    • SCHEMBL41426
    • BSPBio_000459
    • BSPBio_003132
    • KBioGR_000674
    • KBioSS_001700
    • MLS000758203
    • MLS001148120
    • MLS001424134

  • Applications

    Droperidol is primarily used as an active pharmaceutical ingredient (API) in formulations for antiemetic and sedative needs in surgical and perioperative care, aiding control of postoperative nausea and providing short-acting tranquilization during anesthesia; in addition, it is used as a reference compound and analytical standard in pharmaceutical research and development related to butyrophenone dopamine D2 antagonists, with all uses subject to stringent regulatory controls.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 1.94
    methanol 2.62
    isopropanol 1.29
    water 0.02
    ethyl acetate 0.76
    n-propanol 2.29
    acetone 1.92
    n-butanol 2.33
    acetonitrile 0.4
    DMF 8.07
    toluene 0.11
    isobutanol 1.78
    1,4-dioxane 1.49
    methyl acetate 1.44
    THF 4.83
    2-butanone 5.56
    n-pentanol 1.77
    sec-butanol 2.7
    n-hexane 0.01
    ethylene glycol 1.35
    NMP 8.39
    cyclohexane 0.01
    DMSO 12.73
    n-butyl acetate 0.84
    n-octanol 0.38
    chloroform 1.92
    n-propyl acetate 1.06
    acetic acid 6.36
    dichloromethane 2.22
    cyclohexanone 4.7
    propylene glycol 3.21
    isopropyl acetate 0.57
    DMAc 31.05
    2-ethoxyethanol 12.01
    isopentanol 2.15
    n-heptane 0.01
    ethyl formate 1.52
    1,2-dichloroethane 0.96
    n-hexanol 0.58
    2-methoxyethanol 18.87
    isobutyl acetate 0.61
    tetrachloromethane 0.13
    n-pentyl acetate 1.02
    transcutol 28.44
    n-heptanol 0.7
    ethylbenzene 0.12
    MIBK 1.09
    2-propoxyethanol 8.63
    tert-butanol 0.83
    MTBE 0.36
    2-butoxyethanol 7.04
    propionic acid 3.07
    o-xylene 0.1
    formic acid 7.44
    diethyl ether 0.28
    m-xylene 0.08
    p-xylene 0.18
    chlorobenzene 0.23
    dimethyl carbonate 1.05
    n-octane 0.01
    formamide 10.33
    cyclopentanone 6.03
    2-pentanone 2.11
    anisole 0.67
    cyclopentyl methyl ether 0.54
    gamma-butyrolactone 5.27
    1-methoxy-2-propanol 10.7
    pyridine 2.34
    3-pentanone 1.5
    furfural 8.19
    n-dodecane 0.01
    diethylene glycol 9.71
    diisopropyl ether 0.07
    tert-amyl alcohol 1.65
    acetylacetone 2.33
    n-hexadecane 0.01
    acetophenone 1.38
    methyl propionate 1.39
    isopentyl acetate 1.1
    trichloroethylene 3.26
    n-nonanol 0.47
    cyclohexanol 0.96
    benzyl alcohol 2.02
    2-ethylhexanol 0.4
    isooctanol 0.67
    dipropyl ether 0.28
    1,2-dichlorobenzene 0.32
    ethyl lactate 2.46
    propylene carbonate 2.14
    n-methylformamide 4.44
    2-pentanol 0.96
    n-pentane 0.01
    1-propoxy-2-propanol 4.14
    1-methoxy-2-propyl acetate 2.13
    2-(2-methoxypropoxy) propanol 8.4
    mesitylene 0.05
    ε-caprolactone 4.44
    p-cymene 0.1
    epichlorohydrin 8.69
    1,1,1-trichloroethane 0.4
    2-aminoethanol 3.76
    morpholine-4-carbaldehyde 10.83
    sulfolane 9.92
    2,2,4-trimethylpentane 0.01
    2-methyltetrahydrofuran 1.68
    n-hexyl acetate 1.13
    isooctane 0.01
    2-(2-butoxyethoxy)ethanol 10.41
    sec-butyl acetate 0.71
    tert-butyl acetate 0.63
    decalin 0.01
    glycerin 9.3
    diglyme 16.94
    acrylic acid 3.67
    isopropyl myristate 0.42
    n-butyric acid 3.63
    acetyl acetate 0.58
    di(2-ethylhexyl) phthalate 1.49
    ethyl propionate 1.02
    nitromethane 8.24
    1,2-diethoxyethane 1.9
    benzonitrile 0.96
    trioctyl phosphate 0.7
    1-bromopropane 0.41
    gamma-valerolactone 16.06
    n-decanol 0.33
    triethyl phosphate 1.07
    4-methyl-2-pentanol 0.53
    propionitrile 0.68
    vinylene carbonate 2.3
    1,1,2-trichlorotrifluoroethane 13.87
    DMS 1.4
    cumene 0.11
    2-octanol 0.34
    2-hexanone 2.09
    octyl acetate 0.68
    limonene 0.11
    1,2-dimethoxyethane 10.54
    ethyl orthosilicate 0.95
    tributyl phosphate 0.92
    diacetone alcohol 3.15
    N,N-dimethylaniline 0.54
    acrylonitrile 1.28
    aniline 0.65
    1,3-propanediol 7.58
    bromobenzene 0.17
    dibromomethane 0.81
    1,1,2,2-tetrachloroethane 2.62
    2-methyl-cyclohexyl acetate 1.16
    tetrabutyl urea 1.66
    diisobutyl methanol 0.22
    2-phenylethanol 1.29
    styrene 0.13
    dioctyl adipate 1.34
    dimethyl sulfate 2.62
    ethyl butyrate 0.99
    methyl lactate 3.97
    butyl lactate 2.91
    diethyl carbonate 0.86
    propanediol butyl ether 5.75
    triethyl orthoformate 1.17
    p-tert-butyltoluene 0.08
    methyl 4-tert-butylbenzoate 2.56
    morpholine 3.51
    tert-butylamine 0.21
    n-dodecanol 0.23
    dimethoxymethane 3.55
    ethylene carbonate 1.46
    cyrene 8.51
    2-ethoxyethyl acetate 2.92
    2-ethylhexyl acetate 0.79
    1,2,4-trichlorobenzene 0.59
    4-methylpyridine 1.35
    dibutyl ether 0.38
    2,6-dimethyl-4-heptanol 0.22
    DEF 2.92
    dimethyl isosorbide 7.91
    tetrachloroethylene 1.4
    eugenol 5.14
    triacetin 2.74
    span 80 4.41
    1,4-butanediol 3.19
    1,1-dichloroethane 0.55
    2-methyl-1-pentanol 2.04
    methyl formate 2.54
    2-methyl-1-butanol 2.9
    n-decane 0.01
    butyronitrile 0.81
    3,7-dimethyl-1-octanol 0.44
    1-chlorooctane 0.08
    1-chlorotetradecane 0.04
    n-nonane 0.01
    undecane 0.01
    tert-butylcyclohexane 0.01
    cyclooctane 0.0
    cyclopentanol 1.43
    tetrahydropyran 0.74
    tert-amyl methyl ether 0.56
    2,5,8-trioxanonane 12.23
    1-hexene 0.09
    2-isopropoxyethanol 5.63
    2,2,2-trifluoroethanol 2.72
    methyl butyrate 1.8

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction