Drometrizole trisiloxane

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  • Identifiers

    CAS number
    155633-54-8

    Molecular formula
    C24H39N3O3Si3

    SMILES
    CC1=CC(=C(C(=C1)N2N=C3C=CC=CC3=N2)O)CC(C)C[Si](C)(O[Si](C)(C)C)O[Si](C)(C)C

    Safety labels

  • Odor profile

    Fragrance
    Floral 39.68%
    Odorless 31.57%
    Fruity 28.52%
    Animal 28.01%
    Musk 25.21%
    Woody 24.44%
    Fresh 21.26%
    Grapefruit 21.14%
    Powdery 21.08%
    Lily 20.78%

     

    Flavor
    Bitter 50.01%
    Mild 27.69%
    Bland 21.91%
    Green pepper 21.0%
    Carrot 20.35%
    Cedarleaf 19.76%
    Syrup 19.62%
    Heather 19.59%
    Tomato leaf 19.56%
    Green 19.53%

     

    Odor impact est.
    Odorless

  • Properties

    pKa est.
    6.77 (neutral)

    Molecular weight
    501.8 g/mol

    Flash point

    • 159.82 ˚C est.

  • Synonyms

    • Drometrizole trisiloxane
    • 155633-54-8
    • Silatrizole
    • Mexoryl XL
    • OR 10154
    • OR-10154
    • HC22845I1X
    • Phenol, 2-(2H-benzotriazol-2-yl)-4-methyl-6-[2-methyl-3-[1,3,3,3-tetramethyl-1-[(trimethylsilyl)oxy]-1-disiloxanyl]propyl]-
    • DTXSID40431753
    • 2-(2H-1,2,3-benzotriazol-2-yl)-4-methyl-6-[2-methyl-3-(2,2,4,6,6-pentamethyl-3,5-dioxa-2,4,6-trisilaheptan-4-yl)propyl]phenol
    • Phenol, 2-(2H-benzotriazol-2-yl)-4-methyl-6-(2-methyl-3-(1,3,3,3-tetramethyl-1-((trimethylsilyl)oxy)-1-disiloxanyl)propyl)-
    • Phenol, 2-(2H-benzotriazol-2-yl)-4-methyl-6-(2-methyl-3-(1,3,3,3-tetramethyl-1-((trimethylsilyl)oxy)disiloxanyl)propyl)-
    • 2-(2H-1,2,3-benzotriazol-2-yl)-4-methyl-6-(2-methyl-3-(2,2,4,6,6-pentamethyl-3,5-dioxa-2,4,6-trisilaheptan-4-yl)propyl)phenol
    • RefChem:135828
    • DTXCID30382583
    • 919-634-2
    • Drometrizole trisiloxane [WHO-DD]
    • 2-(benzotriazol-2-yl)-4-methyl-6-[2-methyl-3-[methyl-bis(trimethylsilyloxy)silyl]propyl]phenol
    • 2-(2H-Benzo[d][1,2,3]triazol-2-yl)-6-(3-(1,1,1,3,5,5,5-heptamethyltrisiloxan-3-yl)-2-methylpropyl)-4-methylphenol
    • UNII-HC22845I1X
    • Drometrizole trisiloxane [INCI]
    • 2-(2H-Benzo[d][1,2,3]triazol-2-yl)-6-[3-(1,1,1,3,5,5,5-heptamethyltrisiloxan-3-yl)-2-methylpropyl]-4-methylphenol
    • SCHEMBL15380
    • orb1298028
    • SCHEMBL29362516
    • MSK21427
    • EBC-27246
    • MFCD22373626
    • AKOS030621544
    • DB11585
    • HY-W419643
    • DROMETRIZOLE TRISILOXANE [USP-RS]
    • NCGC00532508-01
    • 2-(2h-benzotriazol-2-yl)-4-methyl-6-[2-methyl-3-[1,3,3,3-tetramethyl-1-[(trimethylsilyl)oxy]disiloxanyl]propyl]phenol
    • SY284373
    • TS-10004
    • DB-091411
    • CS-0539357
    • Drometrizole trisiloxane, analytical standard
    • G76453
    • EN300-19999992
    • Q5308268
    • Drometrizole trisiloxane, United States Pharmacopeia (USP) Reference Standard
    • 2-(2H-1,2,3-Benzotriazol-2-yl)-6-[3-(1,1,1,3,5,5,5-heptamethyltrisiloxan-3-yl)-2-methylpropyl]-4-methylphenol
    • 2-(2h-benzotriazol-2-yl)-4-methyl-6-(2-methyl-3-(1,3,3,3-tetramethyl-1-(trimethylsilyloxy)-disiloxanyl)propyl)phenol
    • 320341-73-9
    • 155633-54-8

  • Applications

    Drometrizole trisiloxane (CAS 155633-54-8) is a UV-absorbing filter widely used in cosmetics and personal care, notably in sunscreen formulations and makeup products to provide broad-spectrum protection. It is also evaluated as a UV stabilizer/additive in polymers and plastics to improve long-term lightfastness, and as an ultraviolet absorber in coatings and inks to enhance outdoor durability. In specialty applications, it may be considered for protective films or coatings for electronics or outdoor materials, subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 42.41
    methanol 43.77
    isopropanol 18.13
    water 0.24
    ethyl acetate 25.18
    n-propanol 40.73
    acetone 37.76
    n-butanol 36.09
    acetonitrile 13.29
    DMF 70.83
    toluene 19.46
    isobutanol 26.55
    1,4-dioxane 48.65
    methyl acetate 26.3
    THF 186.71
    2-butanone 51.79
    n-pentanol 40.06
    sec-butanol 26.49
    n-hexane 2.62
    ethylene glycol 5.62
    NMP 125.47
    cyclohexane 3.58
    DMSO 57.61
    n-butyl acetate 39.95
    n-octanol 30.27
    chloroform 86.67
    n-propyl acetate 34.06
    acetic acid 37.79
    dichloromethane 77.05
    cyclohexanone 88.48
    propylene glycol 16.94
    isopropyl acetate 18.63
    DMAc 91.96
    2-ethoxyethanol 59.05
    isopentanol 25.42
    n-heptane 3.84
    ethyl formate 31.92
    1,2-dichloroethane 37.59
    n-hexanol 35.54
    2-methoxyethanol 66.58
    isobutyl acetate 27.48
    tetrachloromethane 9.16
    n-pentyl acetate 52.96
    transcutol 99.98
    n-heptanol 31.63
    ethylbenzene 10.85
    MIBK 24.67
    2-propoxyethanol 78.03
    tert-butanol 13.54
    MTBE 14.17
    2-butoxyethanol 63.72
    propionic acid 30.48
    o-xylene 8.74
    formic acid 18.52
    diethyl ether 19.43
    m-xylene 9.52
    p-xylene 13.85
    chlorobenzene 33.09
    dimethyl carbonate 15.43
    n-octane 1.92
    formamide 23.85
    cyclopentanone 124.9
    2-pentanone 40.5
    anisole 28.19
    cyclopentyl methyl ether 50.45
    gamma-butyrolactone 115.94
    1-methoxy-2-propanol 54.54
    pyridine 75.85
    3-pentanone 30.18
    furfural 97.19
    n-dodecane 1.62
    diethylene glycol 36.04
    diisopropyl ether 4.91
    tert-amyl alcohol 19.59
    acetylacetone 35.45
    n-hexadecane 1.82
    acetophenone 37.5
    methyl propionate 30.81
    isopentyl acetate 34.62
    trichloroethylene 77.91
    n-nonanol 30.71
    cyclohexanol 29.1
    benzyl alcohol 36.1
    2-ethylhexanol 24.28
    isooctanol 25.53
    dipropyl ether 25.51
    1,2-dichlorobenzene 27.06
    ethyl lactate 23.96
    propylene carbonate 58.36
    n-methylformamide 40.61
    2-pentanol 17.92
    n-pentane 2.35
    1-propoxy-2-propanol 57.8
    1-methoxy-2-propyl acetate 40.6
    2-(2-methoxypropoxy) propanol 49.35
    mesitylene 4.71
    ε-caprolactone 82.59
    p-cymene 9.76
    epichlorohydrin 116.63
    1,1,1-trichloroethane 23.98
    2-aminoethanol 23.02
    morpholine-4-carbaldehyde 97.14
    sulfolane 121.58
    2,2,4-trimethylpentane 1.28
    2-methyltetrahydrofuran 84.33
    n-hexyl acetate 54.85
    isooctane 0.74
    2-(2-butoxyethoxy)ethanol 69.84
    sec-butyl acetate 21.72
    tert-butyl acetate 19.62
    decalin 2.18
    glycerin 22.08
    diglyme 84.93
    acrylic acid 27.22
    isopropyl myristate 19.75
    n-butyric acid 45.15
    acetyl acetate 14.33
    di(2-ethylhexyl) phthalate 28.54
    ethyl propionate 25.33
    nitromethane 42.57
    1,2-diethoxyethane 40.61
    benzonitrile 31.78
    trioctyl phosphate 19.96
    1-bromopropane 28.13
    gamma-valerolactone 164.35
    n-decanol 21.43
    triethyl phosphate 16.82
    4-methyl-2-pentanol 11.46
    propionitrile 20.68
    vinylene carbonate 54.76
    1,1,2-trichlorotrifluoroethane 75.08
    DMS 24.4
    cumene 7.92
    2-octanol 22.58
    2-hexanone 46.11
    octyl acetate 30.73
    limonene 13.85
    1,2-dimethoxyethane 68.85
    ethyl orthosilicate 17.35
    tributyl phosphate 20.74
    diacetone alcohol 30.59
    N,N-dimethylaniline 21.48
    acrylonitrile 24.25
    aniline 28.67
    1,3-propanediol 31.31
    bromobenzene 29.57
    dibromomethane 50.17
    1,1,2,2-tetrachloroethane 63.02
    2-methyl-cyclohexyl acetate 35.17
    tetrabutyl urea 36.45
    diisobutyl methanol 10.32
    2-phenylethanol 39.15
    styrene 13.54
    dioctyl adipate 31.72
    dimethyl sulfate 21.72
    ethyl butyrate 32.38
    methyl lactate 26.22
    butyl lactate 50.54
    diethyl carbonate 18.48
    propanediol butyl ether 62.77
    triethyl orthoformate 28.58
    p-tert-butyltoluene 8.55
    methyl 4-tert-butylbenzoate 41.26
    morpholine 77.8
    tert-butylamine 7.82
    n-dodecanol 14.56
    dimethoxymethane 51.48
    ethylene carbonate 42.93
    cyrene 62.56
    2-ethoxyethyl acetate 58.5
    2-ethylhexyl acetate 31.67
    1,2,4-trichlorobenzene 36.24
    4-methylpyridine 58.06
    dibutyl ether 24.29
    2,6-dimethyl-4-heptanol 10.32
    DEF 42.35
    dimethyl isosorbide 76.84
    tetrachloroethylene 38.53
    eugenol 48.97
    triacetin 40.46
    span 80 55.99
    1,4-butanediol 18.09
    1,1-dichloroethane 27.45
    2-methyl-1-pentanol 33.33
    methyl formate 30.73
    2-methyl-1-butanol 29.78
    n-decane 3.17
    butyronitrile 24.81
    3,7-dimethyl-1-octanol 21.66
    1-chlorooctane 15.0
    1-chlorotetradecane 5.58
    n-nonane 2.65
    undecane 2.17
    tert-butylcyclohexane 1.86
    cyclooctane 1.21
    cyclopentanol 42.72
    tetrahydropyran 63.96
    tert-amyl methyl ether 16.91
    2,5,8-trioxanonane 62.87
    1-hexene 13.05
    2-isopropoxyethanol 41.69
    2,2,2-trifluoroethanol 13.46
    methyl butyrate 37.4

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction