Drometrizole

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  • Identifiers

    CAS number
    2440-22-4

    Molecular formula
    C13H11N3O

    SMILES
    CC1=CC(=C(C=C1)O)N2N=C3C=CC=CC3=N2

    Safety labels

    Irritant
    Irritant

    Environmental Hazard
    Environmental

  • Odor profile

    Fragrance
    Fruity 47.97%
    Animal 38.82%
    Phenolic 37.32%
    Burnt 32.69%
    Floral 31.4%
    Sweet 31.09%
    Bitter 28.28%
    Grape 26.57%
    Musty 25.59%
    Odorless 24.4%

     

    Flavor
    Bitter 83.18%
    Very strong 25.52%
    Indole 24.65%
    Cereal 22.7%
    Moth ball 22.35%
    Naphthelene 22.13%
    Bread crust 21.9%
    Nitrile 21.84%
    Soybean 21.63%
    Scallion 21.6%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    4.3

    pKa est.
    5.88 (weak acid)

    Molecular weight
    225.25 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    412°C

    Flash point

    • 213.08 ˚C est.

  • Synonyms

    • Drometrizole
    • 2440-22-4
    • 2-(2-HYDROXY-5-METHYLPHENYL)BENZOTRIAZOLE
    • 2-(2H-Benzotriazol-2-yl)-4-methylphenol
    • Drometrizol
    • 2-(2'-Hydroxy-5'-methylphenyl)benzotriazole
    • Drometrizolum
    • Phenol, 2-(2H-benzotriazol-2-yl)-4-methyl-
    • DTXSID1027479
    • 5X93W9OFZL
    • NSC-91885
    • DTXCID207479
    • 219-470-5
    • RefChem:590441
    • 607-063-9
    • Benazol P
    • 2-(2H-Benzotriazol-2-yl)-p-cresol
    • Tinuvin P
    • 2-(2H-benzo[d][1,2,3]triazol-2-yl)-4-methylphenol
    • 2-(2-Benzotriazolyl)-p-cresol
    • UV Absorber-1
    • Tin P
    • Porex P
    • UV-P
    • 2-Benzotriazolyl-4-methylphenol
    • 2240-22-4
    • 2-(2-Hydroxy-5-methylphenyl)-2H-benzotriazole
    • 2-(benzotriazol-2-yl)-4-methylphenol
    • p-Cresol, 2-(2H-benzotriazol-2-yl)-
    • 2-(2H-1,2,3-Benzotriazol-2-yl)-4-methylphenol
    • Ultraviolet Absorbent UV-P
    • NSC 91885
    • MFCD00022903
    • 2-Benzotriazol-2-yl-4-methyl-phenol
    • 2-(2'-Hydroxy-5-methylphenyl)benzotriazole
    • NCGC00166243-01
    • benazol II
    • Tinuvin II
    • Drometrizole [USAN:INN]
    • Drometrizolum [INN-Latin]
    • CAS-2440-22-4
    • Drometrizol [INN-Spanish, French]
    • EINECS 219-470-5
    • UNII-5X93W9OFZL
    • BRN 0615546
    • BenazolP
    • Uvazol P
    • Lowilite 55
    • Topanex 100BT
    • UV-P (drometrizole)
    • 2-(benzotriazol-2-yl)-4-methyl-phenol
    • Drometrizole (Standard)
    • DROMETRIZOLE [MI]
    • ChemDiv2_000180
    • Drometrizole (USAN/INN)
    • DROMETRIZOLE [INN]
    • DROMETRIZOLE [USAN]
    • EC 219-470-5
    • NCIOpen2_005624
    • SCHEMBL15616
    • DROMETRIZOLE [MART.]
    • MLS000713327
    • DROMETRIZOLE [USP-RS]
    • DROMETRIZOLE [WHO-DD]
    • orb3025596
    • CHEMBL1564747
    • SCHEMBL11462292
    • SCHEMBL11594636
    • SCHEMBL29046137
    • SCHEMBL29350665
    • MCPKSFINULVDNX-UHFFFAOYSA-
    • MSK3457
    • CHEBI:134926
    • HMS1369I04
    • HMS2650F14
    • 2-(2H-bentriazol-2-yl)-p-cresol
    • BB_SC-00233
    • NSC91885
    • Tox21_112369
    • Tox21_200876
    • Tox21_303578
    • WLN: T56 BNNNJ CR BQ E1
    • BBL013151
    • STK096143
    • (BENZOTRIAZOL-2-YL)-P-CRESOL
    • AKOS000369894
    • Tox21_112369_1
    • CCG-103301
    • HY-131551R
    • NCGC00166243-02
    • NCGC00166243-03
    • NCGC00257391-01
    • NCGC00258430-01
    • 2(2'hydroxy5'-methylphenyl)benzotriazole
    • AC-11259
    • AS-12550
    • DA-52699
    • MSK3457-1000
    • SMR000272808
    • 4-methyl-2-(2H-benzotriazol-2-yl)phenol
    • o-[2H-benzotriazol-2-yl)-4-methylphenol
    • phenol, 2-(benzotriazol-2-yl)-4-methyl-
    • 2-(2-hydroxy-5-methylphenyl) benzotriazole
    • 2-(2H-benzotriazol-2-yl)-4-methyl-phenol
    • 2-(2h-benzotriazole-2-yl)-4-methylphenol
    • DB-226477
    • DB-226478
    • HY-131551
    • 2-(2-hydroxyl-5-methylphenyl) benzotriazole
    • CS-0136496
    • EU-0000279
    • H0560
    • NS00010695
    • ST50271127
    • 2-(2'-hydroxy-5'-methylphenyl) benzotriazol
    • 2-(2-hydrobenzotriazol-2-yl)-4-methylphenol
    • 2-(2'-hydroxy-5'-methylphenyl) benzotriazole
    • 2-(2'-hydroxy-5'-methylphenyl)-benzotriazole
    • D03913
    • 2-(2'-Hydroxy-5-methylphenyl)2H-benzotriazole
    • 2-(2-Hydroxy-5-methylphenyl)benzotriazole, 97%
    • AE-641/02338040
    • F238745
    • SR-01000390735
    • 3-(2H-benzotriazole-2-yl)-4-hydroxyphenyl methane
    • SR-01000390735-1
    • 2-(2H-1,2,3-Benzotriazol-2-yl)-4-methylphenol #
    • 2440-22-4

  • Applications

    Drometrizole (CAS 2440-22-4) is an organic UV absorber used primarily as a UV filter in cosmetics and personal care products, notably sunscreen formulations designed to reduce UV exposure on the skin. It is also employed as a UV stabilizer in plastics and coatings to protect materials from UV degradation and color fading. In the coatings and inks sector, drometrizole can be added as a UV absorber to enhance photostability and service life of formulations. Additionally, it is evaluated for industrial outdoor applications, such as UV-stabilized polymers and packaging materials, to extend product longevity under sunlight.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 29.58
    methanol 33.8
    isopropanol 15.38
    water 0.02
    ethyl acetate 31.11
    n-propanol 26.33
    acetone 49.43
    n-butanol 24.39
    acetonitrile 15.93
    DMF 130.45
    toluene 4.13
    isobutanol 16.47
    1,4-dioxane 41.35
    methyl acetate 45.59
    THF 160.72
    2-butanone 72.07
    n-pentanol 19.74
    sec-butanol 22.0
    n-hexane 0.21
    ethylene glycol 10.01
    NMP 41.07
    cyclohexane 0.24
    DMSO 80.73
    n-butyl acetate 25.96
    n-octanol 8.32
    chloroform 25.14
    n-propyl acetate 22.87
    acetic acid 28.12
    dichloromethane 22.27
    cyclohexanone 46.36
    propylene glycol 18.84
    isopropyl acetate 17.73
    DMAc 139.65
    2-ethoxyethanol 54.94
    isopentanol 24.79
    n-heptane 0.33
    ethyl formate 24.19
    1,2-dichloroethane 24.78
    n-hexanol 20.49
    2-methoxyethanol 120.49
    isobutyl acetate 17.24
    tetrachloromethane 1.29
    n-pentyl acetate 17.17
    transcutol 233.49
    n-heptanol 11.66
    ethylbenzene 4.94
    MIBK 22.47
    2-propoxyethanol 62.93
    tert-butanol 19.07
    MTBE 15.09
    2-butoxyethanol 35.46
    propionic acid 22.61
    o-xylene 3.11
    formic acid 17.3
    diethyl ether 13.22
    m-xylene 3.01
    p-xylene 7.38
    chlorobenzene 11.51
    dimethyl carbonate 20.65
    n-octane 0.23
    formamide 41.22
    cyclopentanone 76.42
    2-pentanone 37.73
    anisole 23.39
    cyclopentyl methyl ether 20.53
    gamma-butyrolactone 70.52
    1-methoxy-2-propanol 82.1
    pyridine 54.87
    3-pentanone 26.32
    furfural 67.69
    n-dodecane 0.44
    diethylene glycol 59.43
    diisopropyl ether 2.98
    tert-amyl alcohol 23.49
    acetylacetone 38.69
    n-hexadecane 0.49
    acetophenone 25.24
    methyl propionate 34.17
    isopentyl acetate 27.88
    trichloroethylene 55.08
    n-nonanol 9.34
    cyclohexanol 13.66
    benzyl alcohol 26.02
    2-ethylhexanol 12.95
    isooctanol 10.6
    dipropyl ether 9.98
    1,2-dichlorobenzene 11.1
    ethyl lactate 21.41
    propylene carbonate 36.61
    n-methylformamide 46.73
    2-pentanol 14.09
    n-pentane 0.14
    1-propoxy-2-propanol 38.74
    1-methoxy-2-propyl acetate 36.19
    2-(2-methoxypropoxy) propanol 47.42
    mesitylene 1.86
    ε-caprolactone 42.81
    p-cymene 4.5
    epichlorohydrin 112.48
    1,1,1-trichloroethane 9.57
    2-aminoethanol 24.76
    morpholine-4-carbaldehyde 62.84
    sulfolane 62.34
    2,2,4-trimethylpentane 0.4
    2-methyltetrahydrofuran 48.79
    n-hexyl acetate 20.06
    isooctane 0.26
    2-(2-butoxyethoxy)ethanol 71.91
    sec-butyl acetate 17.15
    tert-butyl acetate 19.55
    decalin 0.47
    glycerin 35.23
    diglyme 102.88
    acrylic acid 23.58
    isopropyl myristate 9.61
    n-butyric acid 33.38
    acetyl acetate 14.34
    di(2-ethylhexyl) phthalate 14.0
    ethyl propionate 24.71
    nitromethane 68.68
    1,2-diethoxyethane 40.93
    benzonitrile 21.34
    trioctyl phosphate 9.12
    1-bromopropane 8.96
    gamma-valerolactone 96.12
    n-decanol 7.81
    triethyl phosphate 13.3
    4-methyl-2-pentanol 11.61
    propionitrile 20.72
    vinylene carbonate 35.11
    1,1,2-trichlorotrifluoroethane 54.27
    DMS 25.8
    cumene 4.14
    2-octanol 7.02
    2-hexanone 29.74
    octyl acetate 12.81
    limonene 5.36
    1,2-dimethoxyethane 87.73
    ethyl orthosilicate 12.35
    tributyl phosphate 11.9
    diacetone alcohol 42.86
    N,N-dimethylaniline 13.62
    acrylonitrile 34.3
    aniline 16.31
    1,3-propanediol 37.74
    bromobenzene 8.01
    dibromomethane 10.8
    1,1,2,2-tetrachloroethane 41.58
    2-methyl-cyclohexyl acetate 17.25
    tetrabutyl urea 16.06
    diisobutyl methanol 7.9
    2-phenylethanol 25.73
    styrene 5.87
    dioctyl adipate 16.92
    dimethyl sulfate 27.37
    ethyl butyrate 20.51
    methyl lactate 33.6
    butyl lactate 23.06
    diethyl carbonate 16.02
    propanediol butyl ether 35.85
    triethyl orthoformate 16.18
    p-tert-butyltoluene 4.03
    methyl 4-tert-butylbenzoate 21.38
    morpholine 67.16
    tert-butylamine 7.28
    n-dodecanol 6.29
    dimethoxymethane 75.2
    ethylene carbonate 24.7
    cyrene 32.5
    2-ethoxyethyl acetate 33.28
    2-ethylhexyl acetate 20.53
    1,2,4-trichlorobenzene 15.05
    4-methylpyridine 33.73
    dibutyl ether 10.67
    2,6-dimethyl-4-heptanol 7.9
    DEF 36.96
    dimethyl isosorbide 58.52
    tetrachloroethylene 20.01
    eugenol 31.84
    triacetin 23.3
    span 80 29.9
    1,4-butanediol 13.84
    1,1-dichloroethane 13.07
    2-methyl-1-pentanol 22.71
    methyl formate 37.2
    2-methyl-1-butanol 23.47
    n-decane 0.53
    butyronitrile 20.87
    3,7-dimethyl-1-octanol 12.69
    1-chlorooctane 3.26
    1-chlorotetradecane 1.87
    n-nonane 0.37
    undecane 0.48
    tert-butylcyclohexane 0.53
    cyclooctane 0.1
    cyclopentanol 17.25
    tetrahydropyran 34.89
    tert-amyl methyl ether 15.76
    2,5,8-trioxanonane 78.61
    1-hexene 2.47
    2-isopropoxyethanol 33.16
    2,2,2-trifluoroethanol 11.71
    methyl butyrate 32.57

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction