Dopamine Hydrochloride

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  • Identifiers

    CAS number
    62-31-7

    Molecular formula
    C8H12ClNO2

    SMILES
    C1=CC(=C(C=C1CCN)O)O.Cl

    Safety labels

    Irritant
    Irritant

    Environmental Hazard
    Environmental

  • Odor profile

    Fragrance
    Odorless 54.68%
    Phenolic 41.09%
    Fishy 36.49%
    Meaty 35.54%
    Smoky 35.49%
    Burnt 32.26%
    Savory 29.01%
    Cheesy 27.55%
    Animal 27.09%
    Ripe 23.69%

     

    Flavor
    Phenolic 54.87%
    Mild 45.97%
    Meaty 42.83%
    Medicinal 32.43%
    Sweet 29.96%
    Sulfurous 28.02%
    Smoky 26.9%
    Phenol 24.57%
    Odorless 24.44%
    Bitter 24.12%

     

    Odor impact est.
    Low

  • Properties

    pKa est.
    8.72 (weak base)

    Molecular weight
    189.64 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    328°C

    Flash point

    • 166.49 ˚C est.

  • Synonyms

    • Dopamine hydrochloride
    • 62-31-7
    • 3-Hydroxytyramine hydrochloride
    • Dopamine HCl
    • intropin
    • 4-(2-aminoethyl)benzene-1,2-diol hydrochloride
    • Cardiosteril
    • Revivan
    • Dopastat
    • Dynatra
    • Inotropin
    • Tensamin
    • 1,2-Benzenediol, 4-(2-aminoethyl)-, hydrochloride
    • 3,4-Dihydroxyphenethylamine hydrochloride
    • Dopamine.HCl
    • Abbodop
    • 4-(2-Aminoethyl)pyrocatechol hydrochloride
    • ASL-279
    • 2-(3,4-Dihydroxyphenyl)ethylamine hydrochloride
    • m-Hydroxytyramine hydrochloride
    • Dopamine (hydrochloride)
    • 3-Hydroxytyramine, Hydrochloride
    • EINECS 200-527-8
    • NSC 169105
    • NSC-169105
    • UNII-7L3E358N9L
    • DTXSID7020550
    • Dopamini hydrochloridum
    • 7L3E358N9L
    • 3-Hydroxytyramine, HCl
    • P 498
    • beta-(3,4-Dihydroxyphenyl)ethylamine hydrochloride
    • DTXCID50550
    • MLS000069419
    • 2-(3,4-dihydroxyphenyl)ethyl-1-13c-amine hcl
    • Dopamine hydrochloride [USAN:USP:JAN]
    • SMR000059081
    • 4-(2-Aminoethyl)-1,2-benzenediol hydrochloride
    • 4-(2-aminoethyl)benzene-1,2-diol;hydrochloride
    • Dopamine chloride
    • Dopamine Fresenius
    • (Dopamine HCl)
    • 62-31-7 (HCl); 51-61-6 (free base)
    • 3-hydroxytyraminium chloride
    • Rascordin
    • Pyrocatechol, 4-(2-aminoethyl)-, hydrochloride
    • DOPAMINE HYDROCHLORIDE (MART.)
    • DOPAMINE HYDROCHLORIDE [MART.]
    • DOPAMINE HYDROCHLORIDE (USP-RS)
    • DOPAMINE HYDROCHLORIDE [USP-RS]
    • Dopamine hydrochloride (USAN:USP:JAN)
    • DOPAMINE HYDROCHLORIDE (EP MONOGRAPH)
    • DOPAMINE HYDROCHLORIDE [EP MONOGRAPH]
    • NSC169105
    • NSC173182
    • DOPAMINE HYDROCHLORIDE (USP MONOGRAPH)
    • DOPAMINE HYDROCHLORIDE [USP MONOGRAPH]
    • Dopaminergic
    • Actopamin
    • SR-01000075366
    • .beta.-(3,4-Dihydroxyphenyl)ethylamine hydrochloride
    • 3-Hydroxytyramine hydrochloride;2-(3,4-Dihydroxyphenyl)ethylamine hydrochloride
    • Actopamin (TN)
    • Dopamine HCl salt
    • 1,2-Benzenediol, 4-(2-aminoethyl)-, hydrochloride (1:1)
    • Intropin (TN)
    • MFCD00012898
    • Dopamine hydrochloride in dextrose 5%
    • Dopamine hydrochloride and dextrose 5%
    • DOPAMINE HCI
    • Hydrochloride, Dopamine
    • DOPAMINE PHENOLIC
    • Opera_ID_218
    • 3,4-dihydroxyphenyl-ethylamine hydrochloride
    • dopamine hydrogen chloride
    • Intropin [as hydrochloride]
    • CHEMBL1557
    • SCHEMBL40951
    • MLS001074180
    • SPECTRUM1500263
    • CHEBI:4698
    • SGCUT00110
    • HY-B0451A
    • Dopamine hydrochloride and dextrose 5% in plastic container
    • Dopamine hydrochloride in dextrose 5% in plastic container
    • Dopamine HCl - Bio-X trade mark
    • Dopamine hydrochloride (Inotropin)
    • HMS1920I18
    • KUC104380C
    • Pharmakon1600-01500263
    • DOPAMINE HYDROCHLORIDE [MI]
    • BCP06611
    • to_000060
    • Dopamine hydrochloride (JP18/USP)
    • DOPAMINE HYDROCHLORIDE [JAN]
    • Tox21_201018
    • Tox21_500586
    • CCG-40211
    • DOPAMINE HYDROCHLORIDE [USAN]
    • NSC756749
    • s2529
    • DOPAMINE HYDROCHLORIDE [VANDF]
    • AKOS008056421
    • 1, 4-(2-aminoethyl)-, hydrochloride
    • DOPAMINE HYDROCHLORIDE [WHO-DD]
    • DOPAMINE HYDROCHLORIDE [WHO-IP]
    • FD31938
    • KS-5304
    • KSC-10-159
    • LP00586
    • NC00545
    • NSC-756749
    • 3,4-dihydoxyphenethylamine hydrochloride
    • CAS-62-31-7
    • NCGC00093965-01
    • NCGC00093965-02
    • NCGC00093965-03
    • NCGC00093965-04
    • NCGC00258571-01
    • NCGC00261271-01
    • 3,4-dihydroxyphenylethylaminehydrochloride
    • AC-12190
    • BD166234
    • DB-023081
    • DOPAMINE HYDROCHLORIDE [ORANGE BOOK]
    • A0305
    • EU-0100586
    • NS00078923

  • Applications

    Dopamine Hydrochloride (CAS 62-31-7) is used primarily as an intermediate in the synthesis of catecholamine-related pharmaceuticals and their derivatives, and as a reference standard in analytical methods for quantifying catecholamines in biological samples. It also serves as a precursor for polydopamine formation, enabling surface coatings and functionalization of materials in the fields of materials science and bioengineering. In biochemical and analytical research, dopamine hydrochloride is commonly employed as a reagent standard or a substrate for dopamine-related assays. In short, typical applications include pharmaceutical synthesis intermediates, analytical reference standards, polydopamine-based surface coatings, and fundamental research reagents.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 8.06
    methanol 46.51
    isopropanol 3.01
    water 11.89
    ethyl acetate 3.72
    n-propanol 3.61
    acetone 6.85
    n-butanol 2.56
    acetonitrile 2.13
    DMF 18.4
    toluene 0.72
    isobutanol 2.99
    1,4-dioxane 4.23
    methyl acetate 2.63
    THF 24.47
    2-butanone 3.45
    n-pentanol 2.45
    sec-butanol 2.33
    n-hexane 0.1
    ethylene glycol 44.23
    NMP 135.12
    cyclohexane 0.17
    DMSO 302.97
    n-butyl acetate 8.13
    n-octanol 3.26
    chloroform 0.46
    n-propyl acetate 4.12
    acetic acid 90.5
    dichloromethane 0.85
    cyclohexanone 14.62
    propylene glycol 23.56
    isopropyl acetate 3.42
    DMAc 51.39
    2-ethoxyethanol 31.89
    isopentanol 4.54
    n-heptane 0.45
    ethyl formate 7.45
    1,2-dichloroethane 1.37
    n-hexanol 9.24
    2-methoxyethanol 60.71
    isobutyl acetate 2.3
    tetrachloromethane 0.98
    n-pentyl acetate 4.29
    transcutol 62.34
    n-heptanol 6.93
    ethylbenzene 0.76
    MIBK 5.03
    2-propoxyethanol 42.48
    tert-butanol 13.41
    MTBE 2.46
    2-butoxyethanol 22.87
    propionic acid 25.35
    o-xylene 1.69
    formic acid 209.2
    diethyl ether 0.63
    m-xylene 1.82
    p-xylene 1.01
    chlorobenzene 1.12
    dimethyl carbonate 7.26
    n-octane 0.18
    formamide 195.71
    cyclopentanone 35.26
    2-pentanone 3.84
    anisole 3.39
    cyclopentyl methyl ether 7.45
    gamma-butyrolactone 76.91
    1-methoxy-2-propanol 27.98
    pyridine 3.54
    3-pentanone 2.27
    furfural 66.34
    n-dodecane 0.14
    diethylene glycol 72.7
    diisopropyl ether 0.83
    tert-amyl alcohol 9.53
    acetylacetone 16.99
    n-hexadecane 0.15
    acetophenone 8.01
    methyl propionate 5.18
    isopentyl acetate 8.15
    trichloroethylene 3.1
    n-nonanol 3.32
    cyclohexanol 4.38
    benzyl alcohol 7.1
    2-ethylhexanol 6.28
    isooctanol 5.83
    dipropyl ether 3.08
    1,2-dichlorobenzene 2.37
    ethyl lactate 11.03
    propylene carbonate 31.42
    n-methylformamide 29.6
    2-pentanol 1.49
    n-pentane 0.08
    1-propoxy-2-propanol 24.52
    1-methoxy-2-propyl acetate 17.32
    2-(2-methoxypropoxy) propanol 23.42
    mesitylene 1.78
    ε-caprolactone 20.28
    p-cymene 2.42
    epichlorohydrin 21.22
    1,1,1-trichloroethane 1.27
    2-aminoethanol 42.83
    morpholine-4-carbaldehyde 64.53
    sulfolane 204.39
    2,2,4-trimethylpentane 0.24
    2-methyltetrahydrofuran 11.0
    n-hexyl acetate 5.58
    isooctane 0.21
    2-(2-butoxyethoxy)ethanol 29.63
    sec-butyl acetate 2.5
    tert-butyl acetate 8.12
    decalin 0.27
    glycerin 85.3
    diglyme 50.29
    acrylic acid 40.11
    isopropyl myristate 2.43
    n-butyric acid 21.63
    acetyl acetate 6.57
    di(2-ethylhexyl) phthalate 7.27
    ethyl propionate 3.79
    nitromethane 81.08
    1,2-diethoxyethane 5.64
    benzonitrile 4.24
    trioctyl phosphate 5.54
    1-bromopropane 0.32
    gamma-valerolactone 61.04
    n-decanol 2.63
    triethyl phosphate 6.88
    4-methyl-2-pentanol 2.87
    propionitrile 1.53
    vinylene carbonate 19.27
    1,1,2-trichlorotrifluoroethane 60.05
    DMS 7.91
    cumene 1.15
    2-octanol 2.73
    2-hexanone 3.43
    octyl acetate 4.13
    limonene 3.24
    1,2-dimethoxyethane 21.51
    ethyl orthosilicate 5.98
    tributyl phosphate 5.29
    diacetone alcohol 28.6
    N,N-dimethylaniline 4.3
    acrylonitrile 4.06
    aniline 3.2
    1,3-propanediol 37.6
    bromobenzene 0.78
    dibromomethane 0.48
    1,1,2,2-tetrachloroethane 2.93
    2-methyl-cyclohexyl acetate 8.5
    tetrabutyl urea 7.66
    diisobutyl methanol 4.25
    2-phenylethanol 11.04
    styrene 0.6
    dioctyl adipate 5.59
    dimethyl sulfate 34.44
    ethyl butyrate 6.41
    methyl lactate 23.73
    butyl lactate 10.53
    diethyl carbonate 5.14
    propanediol butyl ether 19.89
    triethyl orthoformate 6.1
    p-tert-butyltoluene 2.57
    methyl 4-tert-butylbenzoate 16.99
    morpholine 7.09
    tert-butylamine 3.46
    n-dodecanol 1.98
    dimethoxymethane 11.42
    ethylene carbonate 13.98
    cyrene 36.78
    2-ethoxyethyl acetate 9.28
    2-ethylhexyl acetate 5.25
    1,2,4-trichlorobenzene 3.8
    4-methylpyridine 2.92
    dibutyl ether 1.26
    2,6-dimethyl-4-heptanol 4.25
    DEF 8.73
    dimethyl isosorbide 42.23
    tetrachloroethylene 4.16
    eugenol 18.19
    triacetin 12.08
    span 80 19.26
    1,4-butanediol 14.53
    1,1-dichloroethane 0.43
    2-methyl-1-pentanol 4.1
    methyl formate 24.07
    2-methyl-1-butanol 3.72
    n-decane 0.19
    butyronitrile 1.54
    3,7-dimethyl-1-octanol 4.13
    1-chlorooctane 0.75
    1-chlorotetradecane 0.41
    n-nonane 0.16
    undecane 0.16
    tert-butylcyclohexane 0.3
    cyclooctane 0.16
    cyclopentanol 9.74
    tetrahydropyran 1.56
    tert-amyl methyl ether 2.85
    2,5,8-trioxanonane 39.74
    1-hexene 0.25
    2-isopropoxyethanol 17.24
    2,2,2-trifluoroethanol 44.69
    methyl butyrate 6.05

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction