Dolineone

Overview IFRA Request a quote

  • Identifiers

    CAS number
    10065-28-8

    Molecular formula
    C19H12O6

    SMILES
    C1C2C(C3=CC4=C(C=C3O1)OCO4)C(=O)C5=C(O2)C=C6C(=C5)C=CO6

    Safety labels

  • Odor profile

    Fragrance
    Sweet 40.72%
    Spicy 37.71%
    Floral 30.42%
    Coumarinic 29.49%
    Vanilla 29.06%
    Phenolic 27.54%
    Powdery 25.44%
    Coconut 25.29%
    Odorless 24.37%
    Green 23.29%

     

    Flavor
    Bitter 97.26%
    Cedarleaf 17.07%
    Sweet-like 16.95%
    Lovage 16.31%
    Parsley 16.16%
    Bland 16.04%
    Cereal 16.03%
    Indole 15.94%
    Very strong 15.93%
    Naphthalic 15.76%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    3.1

    pKa est.
    5.74 (weak acid)

    Molecular weight
    336.3 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    746°C

    Melting point expt.

    • 233 - 235 °C

    Flash point

    • 242.01 ˚C est.

  • Synonyms

    • Dolineone
    • Dolichone
    • 5,7,11,14,18-pentaoxahexacyclo[11.11.0.02,10.04,8.015,23.017,21]tetracosa-2,4(8),9,15(23),16,19,21-heptaen-24-one
    • 6a,13a-Dihydro-1,3-dioxolo[6,7][1]benzopyrano[3,4-b]furo[3,2-g][1]benzopyran-13(6H)-one, 9CI
    • 5,7,11,14,18-pentaoxahexacyclo(11.11.0.02,10.04,8.015,23.017,21)tetracosa-2,4(8),9,15(23),16,19,21-heptaen-24-one
    • 6a,13a-Dihydro-1,3-dioxolo(6,7)(1)benzopyrano(3,4-b)furo(3,2-g)(1)benzopyran-13(6H)-one, 9ci
    • RefChem:135596
    • 10065-28-8
    • SCHEMBL20138476
    • CHEBI:174526
    • LMPK12060008
    • 10065-28-8

  • Applications

    Dolineone (CAS 10065-28-8) is typically evaluated for fragrance-related applications as an odorant and potential fixative in perfumery, with additional roles as a processing solvent or intermediate in cosmetics and personal care formulations. It may also find use in household products and cleaning formulations as a fragrance component, and can serve as a reactive intermediate or formulation additive in coatings, inks, and polymer/plastics manufacturing within broader industrial contexts, subject to formulation limits and regulatory considerations.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 0.41
    methanol 0.56
    isopropanol 0.6
    water 0.01
    ethyl acetate 6.13
    n-propanol 0.52
    acetone 10.84
    n-butanol 0.6
    acetonitrile 7.32
    DMF 17.12
    toluene 2.38
    isobutanol 0.55
    1,4-dioxane 15.66
    methyl acetate 8.04
    THF 18.42
    2-butanone 7.42
    n-pentanol 0.67
    sec-butanol 0.41
    n-hexane 0.02
    ethylene glycol 1.33
    NMP 11.41
    cyclohexane 0.09
    DMSO 32.37
    n-butyl acetate 4.58
    n-octanol 1.18
    chloroform 6.4
    n-propyl acetate 5.14
    acetic acid 7.46
    dichloromethane 6.85
    cyclohexanone 14.23
    propylene glycol 0.51
    isopropyl acetate 5.73
    DMAc 35.15
    2-ethoxyethanol 6.07
    isopentanol 1.05
    n-heptane 0.07
    ethyl formate 5.01
    1,2-dichloroethane 5.24
    n-hexanol 0.69
    2-methoxyethanol 8.11
    isobutyl acetate 4.03
    tetrachloromethane 0.57
    n-pentyl acetate 4.28
    transcutol 29.51
    n-heptanol 1.01
    ethylbenzene 1.07
    MIBK 4.74
    2-propoxyethanol 8.0
    tert-butanol 1.11
    MTBE 0.89
    2-butoxyethanol 5.97
    propionic acid 3.07
    o-xylene 1.59
    formic acid 3.92
    diethyl ether 1.4
    m-xylene 1.43
    p-xylene 1.82
    chlorobenzene 2.97
    dimethyl carbonate 10.42
    n-octane 0.06
    formamide 8.89
    cyclopentanone 17.2
    2-pentanone 5.91
    anisole 4.36
    cyclopentyl methyl ether 4.08
    gamma-butyrolactone 19.53
    1-methoxy-2-propanol 5.13
    pyridine 13.75
    3-pentanone 5.56
    furfural 22.15
    n-dodecane 0.13
    diethylene glycol 11.26
    diisopropyl ether 0.67
    tert-amyl alcohol 0.65
    acetylacetone 20.09
    n-hexadecane 0.16
    acetophenone 8.31
    methyl propionate 6.55
    isopentyl acetate 5.51
    trichloroethylene 14.62
    n-nonanol 1.59
    cyclohexanol 1.33
    benzyl alcohol 4.65
    2-ethylhexanol 0.96
    isooctanol 1.18
    dipropyl ether 2.12
    1,2-dichlorobenzene 3.36
    ethyl lactate 4.39
    propylene carbonate 8.6
    n-methylformamide 7.01
    2-pentanol 0.46
    n-pentane 0.02
    1-propoxy-2-propanol 5.45
    1-methoxy-2-propyl acetate 10.76
    2-(2-methoxypropoxy) propanol 11.74
    mesitylene 0.92
    ε-caprolactone 10.93
    p-cymene 1.28
    epichlorohydrin 19.75
    1,1,1-trichloroethane 3.59
    2-aminoethanol 0.99
    morpholine-4-carbaldehyde 27.65
    sulfolane 22.55
    2,2,4-trimethylpentane 0.03
    2-methyltetrahydrofuran 4.36
    n-hexyl acetate 4.85
    isooctane 0.03
    2-(2-butoxyethoxy)ethanol 12.38
    sec-butyl acetate 3.9
    tert-butyl acetate 5.6
    decalin 0.1
    glycerin 3.15
    diglyme 28.27
    acrylic acid 5.52
    isopropyl myristate 3.61
    n-butyric acid 3.96
    acetyl acetate 10.04
    di(2-ethylhexyl) phthalate 4.43
    ethyl propionate 5.62
    nitromethane 30.14
    1,2-diethoxyethane 9.3
    benzonitrile 8.53
    trioctyl phosphate 2.69
    1-bromopropane 0.95
    gamma-valerolactone 34.68
    n-decanol 1.32
    triethyl phosphate 4.65
    4-methyl-2-pentanol 0.69
    propionitrile 4.92
    vinylene carbonate 12.16
    1,1,2-trichlorotrifluoroethane 18.22
    DMS 9.46
    cumene 0.77
    2-octanol 0.77
    2-hexanone 5.35
    octyl acetate 3.77
    limonene 1.25
    1,2-dimethoxyethane 16.97
    ethyl orthosilicate 4.0
    tributyl phosphate 3.77
    diacetone alcohol 7.18
    N,N-dimethylaniline 3.15
    acrylonitrile 11.3
    aniline 3.91
    1,3-propanediol 2.67
    bromobenzene 2.96
    dibromomethane 2.67
    1,1,2,2-tetrachloroethane 9.55
    2-methyl-cyclohexyl acetate 5.75
    tetrabutyl urea 6.79
    diisobutyl methanol 1.12
    2-phenylethanol 4.55
    styrene 1.32
    dioctyl adipate 6.46
    dimethyl sulfate 17.02
    ethyl butyrate 5.58
    methyl lactate 6.14
    butyl lactate 4.4
    diethyl carbonate 5.4
    propanediol butyl ether 3.95
    triethyl orthoformate 5.79
    p-tert-butyltoluene 1.06
    methyl 4-tert-butylbenzoate 8.58
    morpholine 9.98
    tert-butylamine 0.39
    n-dodecanol 1.14
    dimethoxymethane 15.21
    ethylene carbonate 10.19
    cyrene 11.08
    2-ethoxyethyl acetate 10.26
    2-ethylhexyl acetate 4.15
    1,2,4-trichlorobenzene 5.32
    4-methylpyridine 8.95
    dibutyl ether 2.77
    2,6-dimethyl-4-heptanol 1.12
    DEF 8.88
    dimethyl isosorbide 20.22
    tetrachloroethylene 6.0
    eugenol 8.74
    triacetin 11.87
    span 80 5.97
    1,4-butanediol 1.36
    1,1-dichloroethane 2.51
    2-methyl-1-pentanol 0.91
    methyl formate 7.93
    2-methyl-1-butanol 0.63
    n-decane 0.17
    butyronitrile 3.01
    3,7-dimethyl-1-octanol 1.67
    1-chlorooctane 0.78
    1-chlorotetradecane 0.52
    n-nonane 0.11
    undecane 0.15
    tert-butylcyclohexane 0.07
    cyclooctane 0.05
    cyclopentanol 1.38
    tetrahydropyran 4.51
    tert-amyl methyl ether 0.9
    2,5,8-trioxanonane 23.95
    1-hexene 0.12
    2-isopropoxyethanol 4.41
    2,2,2-trifluoroethanol 6.54
    methyl butyrate 6.42

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction