Dodemorph

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  • Identifiers

    CAS number
    1593-77-7

    Molecular formula
    C18H35NO

    SMILES
    CC1CN(CC(O1)C)C2CCCCCCCCCCC2

    Safety labels

    Corrosive
    Corrosive

    Irritant
    Irritant

    Health Hazard
    Health

    Environmental Hazard
    Environmental

  • Odor profile

    Fragrance
    Floral 49.61%
    Woody 43.13%
    Animal 39.81%
    Green 35.8%
    Earthy 33.47%
    Herbal 32.89%
    Fresh 31.29%
    Mint 28.8%
    Natural 28.35%
    Musk 28.29%

     

    Flavor
    Sweet 35.15%
    Animal 32.96%
    Fruity 26.71%
    Floral 26.19%
    Alkaline 26.1%
    Earthy 25.64%
    Shrimp 23.82%
    Spicy 23.31%
    Bitter 23.24%
    Beet 22.96%

     

    Odor impact est.
    Medium

  • Properties

    XLogP3-AA
    5.8

    pKa est.
    8.76 (weak base)

    Molecular weight
    281.5 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    349°C

    Flash point

    • 123.23 ˚C est.

  • Synonyms

    • Dodemorph
    • 1593-77-7
    • Meltatox
    • 4-Cyclododecyl-2,6-dimethylmorpholine
    • Doazine
    • Dodemorphe
    • Morpholine, 4-cyclododecyl-2,6-dimethyl-
    • Dodemorph [BSI:ISO]
    • Dodemorphe [ISO-French]
    • Cyclododecane, morpholine deriv.
    • EINECS 216-474-9
    • UNII-22O8GR86F0
    • DTXSID5041019
    • CHEBI:81960
    • 22O8GR86F0
    • Dodemorphe (ISO-French)
    • Dodemorph [ISO]
    • DODEMORPH [MI]
    • RefChem:135544
    • 4-Cyclododecyl-2,6-dimethylmorpholine (8CI)
    • 4-Cyclododecyl-2,6-dimethylmorpholine (8CI)(9CI)
    • DTXCID3021019
    • Cyclododecane, morpholine deriv. (9CI)
    • 216-474-9
    • JMXKCYUTURMERF-UHFFFAOYSA-N
    • Doazine; Dodemorph; Meltatox
    • Dodemorph II
    • SCHEMBL29393
    • MSK21146
    • 4-Cyclododecyl-2,6-dimethylmorpholine #
    • NS00010382
    • Dodemorph, PESTANAL(R), analytical standard
    • C18786
    • H57970
    • Q2642073
    • 1593-77-7

  • Applications

    Dodemorph (CAS 1593-77-7) is used primarily as an intermediate in the synthesis of morphinan derivatives for pharmaceutical research and development; it is also employed as a reactive building block in specialized medicinal chemistry workflows and as an analytical reference standard in method development and quality control. In industrial contexts, dodemorph may be processed as a precursor for the synthesis of related compounds at laboratory or pilot scales, supporting pharmaceutical manufacturing and related chemical production. Its use is typically limited to laboratory or controlled pilot environments, and handling should comply with local regulations and safety requirements.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 291.5
    methanol 166.3
    isopropanol 308.94
    water 0.27
    ethyl acetate 1017.74
    n-propanol 436.32
    acetone 770.87
    n-butanol 452.88
    acetonitrile 347.77
    DMF 483.59
    toluene 857.32
    isobutanol 440.93
    1,4-dioxane 1057.76
    methyl acetate 713.89
    THF 1783.65
    2-butanone 822.44
    n-pentanol 316.52
    sec-butanol 431.3
    n-hexane 304.31
    ethylene glycol 45.05
    NMP 1030.42
    cyclohexane 882.71
    DMSO 687.63
    n-butyl acetate 999.15
    n-octanol 291.27
    chloroform 3362.94
    n-propyl acetate 757.96
    acetic acid 547.72
    dichloromethane 2742.06
    cyclohexanone 1833.11
    propylene glycol 99.08
    isopropyl acetate 853.19
    DMAc 692.8
    2-ethoxyethanol 388.71
    isopentanol 477.11
    n-heptane 332.18
    ethyl formate 525.63
    1,2-dichloroethane 1567.05
    n-hexanol 435.4
    2-methoxyethanol 441.46
    isobutyl acetate 622.92
    tetrachloromethane 860.51
    n-pentyl acetate 828.81
    transcutol 1370.16
    n-heptanol 293.96
    ethylbenzene 385.69
    MIBK 599.99
    2-propoxyethanol 557.17
    tert-butanol 420.95
    MTBE 686.51
    2-butoxyethanol 476.27
    propionic acid 578.16
    o-xylene 551.31
    formic acid 93.19
    diethyl ether 815.27
    m-xylene 561.26
    p-xylene 513.71
    chlorobenzene 1062.77
    dimethyl carbonate 294.25
    n-octane 114.83
    formamide 116.97
    cyclopentanone 1646.75
    2-pentanone 819.08
    anisole 463.1
    cyclopentyl methyl ether 1319.31
    gamma-butyrolactone 1723.97
    1-methoxy-2-propanol 444.2
    pyridine 1118.31
    3-pentanone 840.06
    furfural 1245.76
    n-dodecane 66.55
    diethylene glycol 277.01
    diisopropyl ether 450.64
    tert-amyl alcohol 478.36
    acetylacetone 884.1
    n-hexadecane 79.63
    acetophenone 528.35
    methyl propionate 729.91
    isopentyl acetate 902.21
    trichloroethylene 2652.76
    n-nonanol 280.94
    cyclohexanol 907.41
    benzyl alcohol 366.75
    2-ethylhexanol 437.08
    isooctanol 288.72
    dipropyl ether 847.56
    1,2-dichlorobenzene 982.65
    ethyl lactate 311.31
    propylene carbonate 1132.91
    n-methylformamide 280.21
    2-pentanol 419.17
    n-pentane 282.92
    1-propoxy-2-propanol 604.15
    1-methoxy-2-propyl acetate 778.39
    2-(2-methoxypropoxy) propanol 383.63
    mesitylene 403.19
    ε-caprolactone 1482.21
    p-cymene 353.2
    epichlorohydrin 1619.25
    1,1,1-trichloroethane 1955.5
    2-aminoethanol 129.3
    morpholine-4-carbaldehyde 798.45
    sulfolane 1746.5
    2,2,4-trimethylpentane 170.43
    2-methyltetrahydrofuran 1545.08
    n-hexyl acetate 857.53
    isooctane 105.2
    2-(2-butoxyethoxy)ethanol 495.76
    sec-butyl acetate 620.55
    tert-butyl acetate 838.61
    decalin 257.06
    glycerin 129.78
    diglyme 1047.82
    acrylic acid 422.09
    isopropyl myristate 359.39
    n-butyric acid 945.35
    acetyl acetate 834.22
    di(2-ethylhexyl) phthalate 281.25
    ethyl propionate 687.89
    nitromethane 682.6
    1,2-diethoxyethane 847.68
    benzonitrile 600.62
    trioctyl phosphate 229.8
    1-bromopropane 1186.87
    gamma-valerolactone 1547.29
    n-decanol 203.31
    triethyl phosphate 390.25
    4-methyl-2-pentanol 288.14
    propionitrile 453.73
    vinylene carbonate 954.55
    1,1,2-trichlorotrifluoroethane 1016.06
    DMS 585.6
    cumene 287.95
    2-octanol 240.82
    2-hexanone 605.07
    octyl acetate 419.22
    limonene 556.05
    1,2-dimethoxyethane 697.61
    ethyl orthosilicate 386.65
    tributyl phosphate 303.74
    diacetone alcohol 545.7
    N,N-dimethylaniline 322.38
    acrylonitrile 424.37
    aniline 648.11
    1,3-propanediol 254.34
    bromobenzene 1308.75
    dibromomethane 1986.01
    1,1,2,2-tetrachloroethane 2463.27
    2-methyl-cyclohexyl acetate 614.49
    tetrabutyl urea 332.45
    diisobutyl methanol 304.09
    2-phenylethanol 410.2
    styrene 437.28
    dioctyl adipate 480.99
    dimethyl sulfate 437.93
    ethyl butyrate 819.26
    methyl lactate 324.21
    butyl lactate 516.72
    diethyl carbonate 515.55
    propanediol butyl ether 358.68
    triethyl orthoformate 631.6
    p-tert-butyltoluene 317.15
    methyl 4-tert-butylbenzoate 503.77
    morpholine 1049.09
    tert-butylamine 352.57
    n-dodecanol 159.96
    dimethoxymethane 509.43
    ethylene carbonate 972.77
    cyrene 376.39
    2-ethoxyethyl acetate 858.93
    2-ethylhexyl acetate 812.09
    1,2,4-trichlorobenzene 1118.05
    4-methylpyridine 1031.83
    dibutyl ether 645.62
    2,6-dimethyl-4-heptanol 304.09
    DEF 817.64
    dimethyl isosorbide 734.13
    tetrachloroethylene 1683.38
    eugenol 365.95
    triacetin 763.22
    span 80 416.76
    1,4-butanediol 126.13
    1,1-dichloroethane 1592.37
    2-methyl-1-pentanol 352.77
    methyl formate 271.71
    2-methyl-1-butanol 491.69
    n-decane 132.22
    butyronitrile 534.61
    3,7-dimethyl-1-octanol 347.59
    1-chlorooctane 411.47
    1-chlorotetradecane 160.42
    n-nonane 137.5
    undecane 88.3
    tert-butylcyclohexane 199.87
    cyclooctane 315.68
    cyclopentanol 796.1
    tetrahydropyran 1594.1
    tert-amyl methyl ether 677.63
    2,5,8-trioxanonane 602.77
    1-hexene 493.33
    2-isopropoxyethanol 353.57
    2,2,2-trifluoroethanol 287.54
    methyl butyrate 829.01

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction