Dodecyl Gallate

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  • Identifiers

    CAS number
    1166-52-5

    Molecular formula
    C19H30O5

    SMILES
    CCCCCCCCCCCCOC(=O)C1=CC(=C(C(=C1)O)O)O

    Safety labels

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Odorless 58.04%
    Balsamic 30.03%
    Spicy 27.33%
    Waxy 23.6%
    Phenolic 23.26%
    Milky 21.28%
    Animal 19.9%
    Burnt 19.36%
    Savory 19.19%
    Fatty 18.81%

     

    Flavor
    Bland 34.38%
    Mild 31.0%
    Bitter 30.4%
    Odorless 29.45%
    Woody 27.32%
    Herbal 26.08%
    Faint 23.1%
    Waxy 22.26%
    Parsley 21.48%
    Oily 21.42%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    5.8

    pKa est.
    8.78 (weak base)

    Molecular weight
    338.4 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    525°C

    Melting point expt.

    • Between 95 °C and 98 °C after drying at 90 °C for six hours
    • 96 - 97 °C

    Flash point

    • 205.29 ˚C est.

    Solubility expt.

    • Insoluble in water, freely soluble in ethanol and ether

  • Synonyms

    • Dodecyl gallate
    • Lauryl gallate
    • 1166-52-5
    • Dodecyl 3,4,5-trihydroxybenzoate
    • Nipagallin LA
    • Progallin LA
    • BENZOIC ACID, 3,4,5-TRIHYDROXY-, DODECYL ESTER
    • n-Dodecyl gallate
    • Gallic acid, dodecyl ester
    • n-dodecylgallate
    • Gallic acid, lauryl ester
    • Lauryl 3,4,5-trihydroxybenzoate
    • Dodecylester kyseliny gallove
    • CCRIS 5568
    • GALLIC ACID LAURYL ESTER
    • Gallic acid n-dodecyl ester
    • EINECS 214-620-6
    • NSC 133463
    • BRN 2701981
    • DTXSID0048189
    • UNII-45612DY463
    • Gallic acid-dodecyl ester
    • MFCD00002195
    • NSC-133463
    • E312
    • Gallic acid, n-dodecyl ester
    • CHEMBL16121
    • INS NO.312
    • Lauryl Gallate(Dodecyl Gallate)
    • 3,4,5-Trihydroxybenzoic acid, dodecyl ester
    • DODECYL GALLATE [MART.]
    • DTXCID5028164
    • INS-312
    • Dodecyl-3,4,5-trihydroxybenzoate
    • 4-10-00-02006 (Beilstein Handbook Reference)
    • DODECYL ESTER OF GALLIC ACID
    • NSC133463
    • DODECYL GALLATE [EP MONOGRAPH]
    • 45612DY463
    • E-312
    • Gallic Acid Dodecyl Ester
    • antioxidant E 312
    • antioxidant E-312
    • E 312 antioxidant
    • E-312 antioxidant
    • DODECYL GALLATE (MART.)
    • N-DODECYL (OR LAURYL) ESTER OF 3,4,5-TRIHYDROXYBENZOIC ACID
    • DODECYL GALLATE (EP MONOGRAPH)
    • CAS-1166-52-5
    • Dodecylester kyseliny gallove [Czech]
    • dodecylgallat
    • Dodecyl 3
    • Dodecyl gallic acid
    • N-Dodecylgallic acid
    • 45-Trihydroxybenzoate
    • 45-Trihydroxybenzoic acid
    • Dodecyl gallate (Standard)
    • SCHEMBL36820
    • 149030-04-6
    • BIDD:ER0314
    • Lauryl 3,5-trihydroxybenzoate
    • DODECYL GALLATE [INCI]
    • WLN: QR BQ CQ EVO12
    • CHEBI:175304
    • Gallic acid, dodecyl ester (8CI)
    • BCP15874
    • Tox21_202724
    • Tox21_303487
    • BDBM50093887
    • s6229
    • AKOS001482340
    • Dodecyl 3,4,5-trihydroxybenzoic acid
    • dodecyl 3,4,5-tris(oxidanyl)benzoate
    • FL33333
    • GS-3008
    • HY-124082R
    • NCGC00257297-01
    • NCGC00260272-01
    • SY048252
    • DB-108599
    • HY-124082
    • 3,4,5-Trihydroxy-benzoic acid dodecyl ester
    • Benzoic acid,4,5-trihydroxy-, dodecyl ester
    • CS-0084125
    • G0015
    • Lauryl gallate, analytical reference material
    • NS00013651
    • D70249
    • Lauryl gallate, antioxidant, >=99.0% (HPLC)
    • A803659
    • Dodecyl gallate; Dodecyl 3,4,5-trihydroxybenzoate
    • Q418209
    • 3,4,5-TRIHYDROXYBENZOIC ACID DODECYL ESTER
    • Dodecyl gallate, European Pharmacopoeia (EP) Reference Standard

  • Applications

    Dodecyl Gallate is primarily used as an antioxidant and stabilizer in oil- and fat-containing formulations to inhibit oxidation and extend product shelf life; it is also employed as an antioxidant additive in plastics, polymers, and coatings to improve oxidative stability during processing and service. In cosmetics and personal care, it may be added to stabilize oil components and fragrance ingredients. It is used in rubber and elastomer formulations to enhance aging resistance. It may also function as a processing aid or stabilizer in adhesive and resin systems to improve oxidative stability.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 962.13
    methanol 1567.28
    isopropanol 562.36
    water 0.75
    ethyl acetate 1135.74
    n-propanol 791.84
    acetone 1490.87
    n-butanol 408.3
    acetonitrile 511.37
    DMF 2255.05
    toluene 112.95
    isobutanol 368.64
    1,4-dioxane 541.61
    methyl acetate 1108.32
    THF 1713.6
    2-butanone 1110.78
    n-pentanol 210.52
    sec-butanol 525.05
    n-hexane 5.57
    ethylene glycol 98.01
    NMP 1338.69
    cyclohexane 17.99
    DMSO 3588.52
    n-butyl acetate 337.01
    n-octanol 78.09
    chloroform 358.79
    n-propyl acetate 430.64
    acetic acid 785.54
    dichloromethane 583.02
    cyclohexanone 905.37
    propylene glycol 201.66
    isopropyl acetate 578.47
    DMAc 2104.96
    2-ethoxyethanol 716.93
    isopentanol 289.57
    n-heptane 5.0
    ethyl formate 346.74
    1,2-dichloroethane 679.6
    n-hexanol 131.07
    2-methoxyethanol 1397.96
    isobutyl acetate 201.29
    tetrachloromethane 71.06
    n-pentyl acetate 286.43
    transcutol 1185.64
    n-heptanol 93.95
    ethylbenzene 58.19
    MIBK 367.0
    2-propoxyethanol 469.17
    tert-butanol 692.64
    MTBE 674.45
    2-butoxyethanol 315.94
    propionic acid 706.09
    o-xylene 93.99
    formic acid 322.25
    diethyl ether 480.05
    m-xylene 75.44
    p-xylene 72.22
    chlorobenzene 145.17
    dimethyl carbonate 397.13
    n-octane 4.77
    formamide 1131.11
    cyclopentanone 1429.71
    2-pentanone 756.09
    anisole 206.47
    cyclopentyl methyl ether 533.58
    gamma-butyrolactone 1637.99
    1-methoxy-2-propanol 941.17
    pyridine 557.61
    3-pentanone 566.52
    furfural 687.35
    n-dodecane 4.09
    diethylene glycol 280.76
    diisopropyl ether 108.22
    tert-amyl alcohol 582.82
    acetylacetone 1015.83
    n-hexadecane 4.73
    acetophenone 260.29
    methyl propionate 1000.38
    isopentyl acetate 290.19
    trichloroethylene 906.71
    n-nonanol 75.48
    cyclohexanol 303.1
    benzyl alcohol 196.49
    2-ethylhexanol 74.57
    isooctanol 82.81
    dipropyl ether 107.37
    1,2-dichlorobenzene 152.28
    ethyl lactate 196.58
    propylene carbonate 595.35
    n-methylformamide 1246.45
    2-pentanol 255.29
    n-pentane 7.53
    1-propoxy-2-propanol 302.68
    1-methoxy-2-propyl acetate 420.14
    2-(2-methoxypropoxy) propanol 231.95
    mesitylene 47.56
    ε-caprolactone 799.32
    p-cymene 36.39
    epichlorohydrin 1595.59
    1,1,1-trichloroethane 437.6
    2-aminoethanol 394.85
    morpholine-4-carbaldehyde 902.7
    sulfolane 1959.43
    2,2,4-trimethylpentane 11.38
    2-methyltetrahydrofuran 936.73
    n-hexyl acetate 271.03
    isooctane 6.14
    2-(2-butoxyethoxy)ethanol 345.51
    sec-butyl acetate 267.76
    tert-butyl acetate 600.93
    decalin 11.2
    glycerin 261.86
    diglyme 768.96
    acrylic acid 461.04
    isopropyl myristate 81.49
    n-butyric acid 785.44
    acetyl acetate 519.11
    di(2-ethylhexyl) phthalate 75.74
    ethyl propionate 390.07
    nitromethane 2042.23
    1,2-diethoxyethane 377.24
    benzonitrile 186.66
    trioctyl phosphate 62.82
    1-bromopropane 225.66
    gamma-valerolactone 1476.28
    n-decanol 51.54
    triethyl phosphate 103.81
    4-methyl-2-pentanol 120.14
    propionitrile 389.21
    vinylene carbonate 412.39
    1,1,2-trichlorotrifluoroethane 834.91
    DMS 304.15
    cumene 39.12
    2-octanol 71.09
    2-hexanone 308.54
    octyl acetate 115.18
    limonene 61.8
    1,2-dimethoxyethane 755.44
    ethyl orthosilicate 98.0
    tributyl phosphate 81.24
    diacetone alcohol 692.56
    N,N-dimethylaniline 123.17
    acrylonitrile 496.24
    aniline 226.74
    1,3-propanediol 553.68
    bromobenzene 136.09
    dibromomethane 297.71
    1,1,2,2-tetrachloroethane 764.92
    2-methyl-cyclohexyl acetate 152.31
    tetrabutyl urea 104.97
    diisobutyl methanol 50.75
    2-phenylethanol 145.21
    styrene 75.88
    dioctyl adipate 134.86
    dimethyl sulfate 701.38
    ethyl butyrate 206.75
    methyl lactate 383.45
    butyl lactate 227.94
    diethyl carbonate 136.7
    propanediol butyl ether 224.48
    triethyl orthoformate 136.41
    p-tert-butyltoluene 38.34
    methyl 4-tert-butylbenzoate 232.32
    morpholine 1067.04
    tert-butylamine 282.99
    n-dodecanol 36.92
    dimethoxymethane 1228.47
    ethylene carbonate 393.97
    cyrene 242.88
    2-ethoxyethyl acetate 494.19
    2-ethylhexyl acetate 184.14
    1,2,4-trichlorobenzene 214.83
    4-methylpyridine 430.53
    dibutyl ether 102.95
    2,6-dimethyl-4-heptanol 50.75
    DEF 914.04
    dimethyl isosorbide 401.07
    tetrachloroethylene 447.65
    eugenol 195.07
    triacetin 317.22
    span 80 172.17
    1,4-butanediol 155.07
    1,1-dichloroethane 452.83
    2-methyl-1-pentanol 181.34
    methyl formate 646.6
    2-methyl-1-butanol 315.09
    n-decane 7.51
    butyronitrile 279.34
    3,7-dimethyl-1-octanol 82.95
    1-chlorooctane 47.96
    1-chlorotetradecane 16.88
    n-nonane 6.42
    undecane 5.26
    tert-butylcyclohexane 9.73
    cyclooctane 5.88
    cyclopentanol 445.07
    tetrahydropyran 674.21
    tert-amyl methyl ether 464.29
    2,5,8-trioxanonane 425.28
    1-hexene 38.66
    2-isopropoxyethanol 409.27
    2,2,2-trifluoroethanol 312.47
    methyl butyrate 483.35

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction