Dodecamethylcyclohexasiloxane

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  • Identifiers

    CAS number
    540-97-6

    Molecular formula
    C12H36O6Si6

    SMILES
    C[Si]1(O[Si](O[Si](O[Si](O[Si](O[Si](O1)(C)C)(C)C)(C)C)(C)C)(C)C)C

  • Odor profile

    Fragrance
    Odorless 64.86%
    Fruity 20.97%
    Green 18.79%
    Fresh 16.84%
    Ethereal 15.95%
    Alcoholic 15.58%
    Cooling 14.33%
    Earthy 13.86%
    Creamy 13.65%
    Meaty 13.62%

     

    Flavor
    Green 55.7%
    Earthy 50.4%
    Vegetable 39.74%
    Sulfurous 26.54%
    Sweet 25.16%
    Blackberry 24.66%
    Burnt 24.51%
    Potato 21.91%
    Herbal 21.62%
    Musty 20.9%

     

    Odor impact est.
    Low

  • Properties

    pKa est.
    6.57 (neutral)

    Molecular weight
    444.92 g/mol

    Melting point expt.

    • -3 °C

    Boiling point

    • 245 °C

    Flash point

    • 100.63 ˚C est.
    • 91 °C (196 °F) - closed cup

    Solubility expt.

    • In water, 0.0051 mg/L at 23 °C

  • Synonyms

    • DODECAMETHYLCYCLOHEXASILOXANE
    • 540-97-6
    • Cyclohexasiloxane, dodecamethyl-
    • Cyclomethicone 6
    • 2,2,4,4,6,6,8,8,10,10,12,12-dodecamethyl-1,3,5,7,9,11-hexaoxa-2,4,6,8,10,12-hexasilacyclododecane
    • EINECS 208-762-8
    • XHK3U310BA
    • HSDB 7723
    • XIAMETER PMX-0246
    • DTXSID6027183
    • 2,2,4,4,6,6,8,8,10,10,12,12-Dodecamethylcyclohexasiloxane
    • EC 208-762-8
    • CYCLOMETHICONE 6 [USP-RS]
    • DODECAMETHYLCYCLOHEXASILOXANE [MI]
    • DODECAMETHYLCYCLOHEXASILOXANE [HSDB]
    • DODECAMETHYLCYCLOHEXASILOXANE [WHO-DD]
    • CYCLOMETHICONE 6 (USP-RS)
    • Cyclohexasiloxane, 2,2,4,4,6,6,8,8,10,10,12,12-dodecamethyl-
    • UNII-XHK3U310BA
    • MFCD00144215
    • dodecamethyl cyclohexasiloxane
    • SCHEMBL93785
    • UNII: XHK3U310BA
    • DTXCID507183
    • IUMSDRXLFWAGNT-UHFFFAOYSA-
    • CHEBI:191103
    • MSK002146
    • CYCLOHEXASILOXANE, DODECAMETHYL
    • AKOS015839990
    • FD22584
    • FS-5671
    • 1ST002146
    • DB-008587
    • MSK002146-1000
    • D2040
    • NS00042693
    • S08515
    • T71035
    • Dodecamethylcyclohexasiloxane, analytical standard
    • 1ST002146-1000
    • Q27293843
    • Dodecamethylcyclohexasiloxane Solution in Methanol, 1000?g/mL
    • Dodecamethylcyclohexasiloxane Solution in Methanol, 1000mug/mL
    • 2,2,4,4,6,6,8,8,10,10,12,12-Dodecamethylcyclohexasiloxane #
    • 2,2,4,4,6,6,8,8,10,10,12,12-Dodecamethylcyclohexasiloxane, 95%
    • 2,2,4,4,6,6,8,8,10,10,12,12-Dodecamethylcyclohexasiloxane, AldrichCPR
    • Cyclomethicone 6, United States Pharmacopeia (USP) Reference Standard
    • 2,2,4,4,6,6,8,8,10,10,12,12-dodecamethyl-1,3,5,7,9,11-hexaoxa-2,4,6,8,10,12-hexa
    • 2,2,4,4,6,6,8,8,10,10,12,12-Dodecamethylcyclohexasiloxane;DC 246 fluid;Dodecamethylhexacyclosiloxane
    • 208-762-8
    • D-6
    • InChI=1/C12H36O6Si6/c1-19(2)13-20(3,4)15-22(7,8)17-24(11,12)18-23(9,10)16-21(5,6)14-19/h1-12H3

  • Applications

    Dodecamethylcyclohexasiloxane (CAS 540-97-6) is a cyclic siloxane commonly used as a solvent and carrier in cosmetics and personal care, providing slip and carrying fragrances and actives while supporting quick evaporation and a light, silky feel on the skin. In polymer and silicone chemistry, it serves as a processing aid and a precursor for silicone fluids and elastomers (via ring-opening polymerization), and can be used to dilute or help transfer silicone formulations. It also functions as a processing solvent or carrier in coatings, inks and adhesives that incorporate silicone components, improving flow, leveling and spreadability. In industrial manufacturing, it is used as a low-volatility solvent and processing aid to dissolve or transport silicone additives and to support formulation workflows. In electronics-related materials, it may be used as a solvent or carrier for silicone-based encapsulants and dielectric formulations, subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 192.64
    methanol 236.92
    isopropanol 145.27
    water 43.82
    ethyl acetate 293.79
    n-propanol 175.41
    acetone 406.97
    n-butanol 148.0
    acetonitrile 158.02
    DMF 984.05
    toluene 193.12
    isobutanol 125.31
    1,4-dioxane 492.45
    methyl acetate 268.01
    THF 1123.61
    2-butanone 261.3
    n-pentanol 106.27
    sec-butanol 134.36
    n-hexane 30.3
    ethylene glycol 122.43
    NMP 1347.51
    cyclohexane 59.2
    DMSO 727.7
    n-butyl acetate 204.22
    n-octanol 106.67
    chloroform 486.61
    n-propyl acetate 201.66
    acetic acid 384.43
    dichloromethane 440.48
    cyclohexanone 535.07
    propylene glycol 185.85
    isopropyl acetate 238.5
    DMAc 771.72
    2-ethoxyethanol 236.12
    isopentanol 104.77
    n-heptane 37.69
    ethyl formate 237.23
    1,2-dichloroethane 285.56
    n-hexanol 138.55
    2-methoxyethanol 451.71
    isobutyl acetate 151.53
    tetrachloromethane 111.76
    n-pentyl acetate 221.72
    transcutol 375.79
    n-heptanol 112.16
    ethylbenzene 77.95
    MIBK 189.1
    2-propoxyethanol 359.62
    tert-butanol 158.61
    MTBE 135.43
    2-butoxyethanol 224.39
    propionic acid 264.27
    o-xylene 129.37
    formic acid 224.95
    diethyl ether 186.99
    m-xylene 151.02
    p-xylene 96.44
    chlorobenzene 239.45
    dimethyl carbonate 338.8
    n-octane 19.67
    formamide 346.57
    cyclopentanone 876.24
    2-pentanone 279.86
    anisole 186.21
    cyclopentyl methyl ether 438.2
    gamma-butyrolactone 1132.04
    1-methoxy-2-propanol 441.0
    pyridine 410.51
    3-pentanone 230.06
    furfural 838.19
    n-dodecane 16.45
    diethylene glycol 296.64
    diisopropyl ether 88.33
    tert-amyl alcohol 132.04
    acetylacetone 469.7
    n-hexadecane 18.66
    acetophenone 229.55
    methyl propionate 342.8
    isopentyl acetate 164.9
    trichloroethylene 555.64
    n-nonanol 108.33
    cyclohexanol 208.91
    benzyl alcohol 159.91
    2-ethylhexanol 92.23
    isooctanol 87.2
    dipropyl ether 166.46
    1,2-dichlorobenzene 239.64
    ethyl lactate 175.34
    propylene carbonate 624.27
    n-methylformamide 435.63
    2-pentanol 118.51
    n-pentane 39.1
    1-propoxy-2-propanol 278.62
    1-methoxy-2-propyl acetate 351.61
    2-(2-methoxypropoxy) propanol 210.83
    mesitylene 96.37
    ε-caprolactone 539.81
    p-cymene 71.57
    epichlorohydrin 667.27
    1,1,1-trichloroethane 273.87
    2-aminoethanol 190.41
    morpholine-4-carbaldehyde 967.27
    sulfolane 1319.9
    2,2,4-trimethylpentane 19.56
    2-methyltetrahydrofuran 481.81
    n-hexyl acetate 257.5
    isooctane 17.5
    2-(2-butoxyethoxy)ethanol 272.77
    sec-butyl acetate 153.81
    tert-butyl acetate 268.31
    decalin 30.93
    glycerin 322.07
    diglyme 400.73
    acrylic acid 292.48
    isopropyl myristate 121.38
    n-butyric acid 289.13
    acetyl acetate 311.08
    di(2-ethylhexyl) phthalate 137.7
    ethyl propionate 206.33
    nitromethane 704.06
    1,2-diethoxyethane 183.07
    benzonitrile 188.12
    trioctyl phosphate 109.46
    1-bromopropane 154.84
    gamma-valerolactone 1103.45
    n-decanol 85.02
    triethyl phosphate 130.9
    4-methyl-2-pentanol 79.3
    propionitrile 134.03
    vinylene carbonate 547.46
    1,1,2-trichlorotrifluoroethane 569.7
    DMS 293.89
    cumene 57.38
    2-octanol 90.44
    2-hexanone 173.14
    octyl acetate 159.37
    limonene 104.13
    1,2-dimethoxyethane 338.82
    ethyl orthosilicate 120.66
    tributyl phosphate 116.85
    diacetone alcohol 280.63
    N,N-dimethylaniline 160.76
    acrylonitrile 186.33
    aniline 230.21
    1,3-propanediol 210.63
    bromobenzene 245.52
    dibromomethane 277.97
    1,1,2,2-tetrachloroethane 461.31
    2-methyl-cyclohexyl acetate 187.12
    tetrabutyl urea 178.23
    diisobutyl methanol 65.95
    2-phenylethanol 185.2
    styrene 98.17
    dioctyl adipate 182.38
    dimethyl sulfate 621.93
    ethyl butyrate 183.27
    methyl lactate 323.51
    butyl lactate 220.68
    diethyl carbonate 136.71
    propanediol butyl ether 231.04
    triethyl orthoformate 163.23
    p-tert-butyltoluene 84.13
    methyl 4-tert-butylbenzoate 290.7
    morpholine 553.28
    tert-butylamine 104.79
    n-dodecanol 67.6
    dimethoxymethane 617.77
    ethylene carbonate 447.53
    cyrene 359.7
    2-ethoxyethyl acetate 289.85
    2-ethylhexyl acetate 149.07
    1,2,4-trichlorobenzene 307.95
    4-methylpyridine 359.97
    dibutyl ether 108.98
    2,6-dimethyl-4-heptanol 65.95
    DEF 386.62
    dimethyl isosorbide 487.73
    tetrachloroethylene 284.22
    eugenol 268.12
    triacetin 325.37
    span 80 266.87
    1,4-butanediol 95.4
    1,1-dichloroethane 234.63
    2-methyl-1-pentanol 81.54
    methyl formate 399.01
    2-methyl-1-butanol 113.17
    n-decane 26.59
    butyronitrile 136.08
    3,7-dimethyl-1-octanol 86.77
    1-chlorooctane 73.31
    1-chlorotetradecane 39.71
    n-nonane 24.13
    undecane 20.29
    tert-butylcyclohexane 28.19
    cyclooctane 32.12
    cyclopentanol 320.07
    tetrahydropyran 386.72
    tert-amyl methyl ether 145.04
    2,5,8-trioxanonane 326.28
    1-hexene 62.83
    2-isopropoxyethanol 162.31
    2,2,2-trifluoroethanol 249.93
    methyl butyrate 237.7

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction