DMDM Hydantoin

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  • Identifiers

    CAS number
    6440-58-0

    Molecular formula
    C7H12N2O4

    SMILES
    CC1(C(=O)N(C(=O)N1CO)CO)C

    Safety labels

    Irritant
    Irritant

    Health Hazard
    Health

  • Odor profile

    Fragrance
    Odorless 62.35%
    Sweet 29.51%
    Cooling 26.1%
    Mint 19.31%
    Savory 18.62%
    Bitter 17.77%
    Burnt 17.2%
    Nutty 16.82%
    Popcorn 15.62%
    Roasted 15.29%

     

    Flavor
    Bitter 61.73%
    Odorless 36.93%
    Very mild 24.49%
    Sweet-like 22.08%
    Bland 21.45%
    Yeast 19.81%
    Cotton candy 19.5%
    Cedarleaf 19.48%
    Bread crust 19.34%
    Taco 19.33%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    -0.2

    pKa est.
    6.85 (neutral)

    Molecular weight
    188.18 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Slow

    Melting point expt.

    • 90 °C /OECD Guideline 102/
    • MP: 102-104 °C /Technical/

    Boiling point

    • 198-200 °C, decomposes with boiling

    Flash point

    • 172.01 ˚C est.

    Solubility expt.

    • In water, 77.3 g/100 cc
    • In ethanol, 56.4 g/100 cc; in hexane, 0.02 g/100 cc

  • Synonyms

    • 6440-58-0
    • 1,3-Bis(hydroxymethyl)-5,5-dimethylimidazolidine-2,4-dione
    • DMDM Hydantoin
    • Dmdmh
    • Dimethyloldimethyl hydantoin
    • Glydant
    • 1,3-Bis(hydroxymethyl)-5,5-dimethylhydantoin
    • 1,3-Dimethylol-5,5-dimethylhydantoin
    • Dantoin-DMDMH
    • Glycoserve-DMDMH
    • Dantoin dmdmh 55
    • Dimethylol-5,5-dimethylhydantoin
    • Dmdmh 55
    • Caswell No. 273AB
    • 2,4-Imidazolidinedione, 1,3-bis(hydroxymethyl)-5,5-dimethyl-
    • dimethyloldimethylhydantoin
    • UNII-BYR0546TOW
    • EINECS 229-222-8
    • BYR0546TOW
    • EPA Pesticide Chemical Code 115501
    • 1,3-Bis(hydroxymethyl)-5,5-dimethyl-2,4-imidazolidinedione
    • BRN 0882348
    • DTXSID8035217
    • HSDB 7488
    • 1,3-Di(hydroxymethyl)-5,5-dimethylhydantoin
    • MFCD00467199
    • DTXCID6015217
    • 1,3-DIMETHYLOL-5,5-DIMETHYL-HYDANTOIN
    • EC 229-222-8
    • Hydantoin, 1,3-bis(hydroxymethyl)-5,5-dimethyl-
    • DMDM HYDANTOIN (II)
    • DMDM HYDANTOIN [II]
    • Dantoguard
    • 1,3-DIHYDROXYMETHYL-5,5-DIMETHYLHYDANTOIN
    • Dantion DMDMH 55
    • DMDM HYDANTION
    • SCHEMBL69185
    • DMDM HYDANTION [VANDF]
    • DMDM HYDANTOIN [VANDF]
    • DDAC0.6%
    • DDAC0.15%
    • Tox21_303842
    • AKOS006345746
    • n,n'-dimethylol-5,5-dimethylhydantoin
    • CS-W021276
    • FD31768
    • USEPA/OPP Pesticide Code: 115501
    • NCGC00356947-01
    • AS-10924
    • SY101650
    • CAS-6440-58-0
    • DMDM hydantoin, 50% min aqueous solution
    • NS00007210
    • H11751
    • Q5205613
    • 1,3-DIMETHYLOL-5,5-DIMETHYLHYDANTOIN [HSDB]
    • 1,3-Bis (hydroxymethyl)-5,5-dimethylimidazolidine-2,4-dione
    • 1,3 BIS(HYDROXYMETHYL)-5,5- DIMETHYLHYDANTOINDIMETHYLHYDANTOIN
    • 1,3 BIS(HYDROXYMETHYL)-5,5-DIMETHYLHYDANTOINDIMETHYLHYDANTOIN
    • 1 pound not3-Bis(hydroxymethyl)-5 pound not5-dimethylimidazolidine-2 pound not4-dione
    • 229-222-8

  • Applications

    DMDM Hydantoin (CAS 6440-58-0) is primarily used as a formaldehyde-releasing preservative in cosmetic and personal care formulations, helping inhibit microbial growth in water-based products such as shampoos, lotions, creams, and makeup; it is also employed in some household cleaning products and detergents to extend shelf life by reducing microbial spoilage; in industrial manufacturing it may be added to water-based coatings, adhesives, and printing inks to improve microbial stability of formulations; as a chemical intermediate, it can serve in the synthesis of related hydantoin derivatives for specialty applications; and its use is subject to local regulations and formulation limits due to formaldehyde release.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 47.61
    methanol 119.81
    isopropanol 37.53
    water 55.91
    ethyl acetate 16.73
    n-propanol 36.98
    acetone 38.33
    n-butanol 29.4
    acetonitrile 38.59
    DMF 243.54
    toluene 6.42
    isobutanol 25.49
    1,4-dioxane 56.73
    methyl acetate 23.19
    THF 80.6
    2-butanone 24.66
    n-pentanol 21.58
    sec-butanol 27.02
    n-hexane 0.45
    ethylene glycol 80.29
    NMP 170.89
    cyclohexane 0.62
    DMSO 262.81
    n-butyl acetate 11.62
    n-octanol 8.78
    chloroform 48.72
    n-propyl acetate 10.21
    acetic acid 50.72
    dichloromethane 71.49
    cyclohexanone 44.42
    propylene glycol 53.54
    isopropyl acetate 11.97
    DMAc 151.1
    2-ethoxyethanol 66.74
    isopentanol 21.96
    n-heptane 0.61
    ethyl formate 40.03
    1,2-dichloroethane 35.53
    n-hexanol 18.01
    2-methoxyethanol 144.73
    isobutyl acetate 6.39
    tetrachloromethane 7.42
    n-pentyl acetate 9.73
    transcutol 18.02
    n-heptanol 11.5
    ethylbenzene 3.63
    MIBK 17.01
    2-propoxyethanol 66.09
    tert-butanol 36.4
    MTBE 9.4
    2-butoxyethanol 27.58
    propionic acid 32.71
    o-xylene 6.75
    formic acid 142.62
    diethyl ether 9.2
    m-xylene 7.4
    p-xylene 5.83
    chlorobenzene 13.2
    dimethyl carbonate 22.65
    n-octane 0.41
    formamide 148.61
    cyclopentanone 70.72
    2-pentanone 21.91
    anisole 10.8
    cyclopentyl methyl ether 19.31
    gamma-butyrolactone 111.41
    1-methoxy-2-propanol 93.52
    pyridine 34.53
    3-pentanone 14.14
    furfural 110.89
    n-dodecane 0.41
    diethylene glycol 87.44
    diisopropyl ether 2.76
    tert-amyl alcohol 25.46
    acetylacetone 31.21
    n-hexadecane 0.48
    acetophenone 19.52
    methyl propionate 26.14
    isopentyl acetate 10.68
    trichloroethylene 68.11
    n-nonanol 8.15
    cyclohexanol 20.55
    benzyl alcohol 25.7
    2-ethylhexanol 8.52
    isooctanol 9.14
    dipropyl ether 5.62
    1,2-dichlorobenzene 16.07
    ethyl lactate 20.74
    propylene carbonate 51.07
    n-methylformamide 139.19
    2-pentanol 14.63
    n-pentane 0.59
    1-propoxy-2-propanol 29.94
    1-methoxy-2-propyl acetate 23.08
    2-(2-methoxypropoxy) propanol 18.32
    mesitylene 4.85
    ε-caprolactone 45.0
    p-cymene 4.4
    epichlorohydrin 102.66
    1,1,1-trichloroethane 20.67
    2-aminoethanol 80.37
    morpholine-4-carbaldehyde 126.28
    sulfolane 141.81
    2,2,4-trimethylpentane 0.59
    2-methyltetrahydrofuran 32.83
    n-hexyl acetate 11.09
    isooctane 0.41
    2-(2-butoxyethoxy)ethanol 19.04
    sec-butyl acetate 6.33
    tert-butyl acetate 13.17
    decalin 0.63
    glycerin 108.86
    diglyme 36.13
    acrylic acid 38.92
    isopropyl myristate 4.65
    n-butyric acid 37.2
    acetyl acetate 14.13
    di(2-ethylhexyl) phthalate 9.65
    ethyl propionate 11.14
    nitromethane 101.83
    1,2-diethoxyethane 7.66
    benzonitrile 28.79
    trioctyl phosphate 7.8
    1-bromopropane 11.26
    gamma-valerolactone 113.95
    n-decanol 5.81
    triethyl phosphate 9.31
    4-methyl-2-pentanol 9.82
    propionitrile 27.99
    vinylene carbonate 55.08
    1,1,2-trichlorotrifluoroethane 96.29
    DMS 13.74
    cumene 3.47
    2-octanol 7.38
    2-hexanone 12.44
    octyl acetate 6.8
    limonene 5.36
    1,2-dimethoxyethane 61.47
    ethyl orthosilicate 7.73
    tributyl phosphate 7.04
    diacetone alcohol 35.98
    N,N-dimethylaniline 11.44
    acrylonitrile 51.08
    aniline 16.72
    1,3-propanediol 82.81
    bromobenzene 11.0
    dibromomethane 30.14
    1,1,2,2-tetrachloroethane 50.67
    2-methyl-cyclohexyl acetate 10.74
    tetrabutyl urea 11.85
    diisobutyl methanol 5.63
    2-phenylethanol 22.55
    styrene 3.61
    dioctyl adipate 7.48
    dimethyl sulfate 58.64
    ethyl butyrate 10.11
    methyl lactate 45.45
    butyl lactate 13.05
    diethyl carbonate 7.58
    propanediol butyl ether 21.79
    triethyl orthoformate 8.56
    p-tert-butyltoluene 4.37
    methyl 4-tert-butylbenzoate 21.87
    morpholine 70.45
    tert-butylamine 12.35
    n-dodecanol 4.2
    dimethoxymethane 81.64
    ethylene carbonate 40.52
    cyrene 47.34
    2-ethoxyethyl acetate 12.49
    2-ethylhexyl acetate 8.21
    1,2,4-trichlorobenzene 20.51
    4-methylpyridine 36.29
    dibutyl ether 3.37
    2,6-dimethyl-4-heptanol 5.63
    DEF 43.72
    dimethyl isosorbide 36.02
    tetrachloroethylene 31.4
    eugenol 24.72
    triacetin 12.65
    span 80 15.46
    1,4-butanediol 45.95
    1,1-dichloroethane 24.52
    2-methyl-1-pentanol 16.09
    methyl formate 116.12
    2-methyl-1-butanol 21.24
    n-decane 0.63
    butyronitrile 28.95
    3,7-dimethyl-1-octanol 7.9
    1-chlorooctane 3.35
    1-chlorotetradecane 1.44
    n-nonane 0.54
    undecane 0.5
    tert-butylcyclohexane 0.65
    cyclooctane 0.37
    cyclopentanol 37.77
    tetrahydropyran 19.09
    tert-amyl methyl ether 10.59
    2,5,8-trioxanonane 27.48
    1-hexene 1.94
    2-isopropoxyethanol 34.61
    2,2,2-trifluoroethanol 54.26
    methyl butyrate 17.77

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction