Dl-Tryptophan

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  • Identifiers

    CAS number
    54-12-6

    Molecular formula
    C11H12N2O2

    SMILES
    C1=CC=C2C(=C1)C(=CN2)CC(C(=O)O)N

    Safety labels

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Odorless 67.83%
    Savory 30.83%
    Cooked 25.27%
    Grape 24.92%
    Bitter 24.84%
    Meaty 22.29%
    Milky 21.59%
    Fruity 19.55%
    Burnt 18.12%
    Animal 18.09%

     

    Flavor
    Bitter 72.53%
    Odorless 61.15%
    Mild 33.19%
    Bland 29.2%
    Sweet-like 22.44%
    Nitrile 21.16%
    Yeast 20.71%
    Very mild 20.54%
    Orange flower 19.64%
    Very strong 19.37%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    -1.1

    pKa est.
    5.5 (weak acid)

    Molecular weight
    204.22 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Melting point expt.

    • 293 °C

    Boiling point

    • 289.00 to 291.00 °C. @ 760.00 mm Hg

    Flash point

    • 244.34 ˚C est.

  • Synonyms

    • DL-Tryptophan
    • 2-amino-3-(1H-indol-3-yl)propanoic acid
    • (+-)-Tryptophan
    • Tryptophan, DL
    • TRYPTOPHAN, DL-
    • CCRIS 719
    • NSC 13118
    • EINECS 200-194-9
    • DTXSID0021418
    • AI3-24395
    • X9U7434L7A
    • NSC-13118
    • DL-TRYPTOPHAN [FCC]
    • DTXCID401418
    • DLTrytophane
    • DL3betaIndolylalanine
    • RefChem:589984
    • DLalphaAmino3indolepropionic acid
    • 200-194-9
    • 54-12-6
    • DL-Trytophan
    • Racemic Tryptophan
    • DL-Trytophane
    • H-DL-Trp-OH
    • DL-tryptophane
    • DL-3beta-Indolylalanine
    • d,l-tryptophan
    • DL-alpha-Amino-3-indolepropionic acid
    • MFCD00064339
    • 27813-82-7
    • NSC13119
    • DL-.alpha.-Amino-3-indolepropionic acid
    • (+/-)-alpha-Amino-3-indolepropionic acid
    • (+/-)-2-Amino-3-(3-indolyl)propionic acid
    • F3145-2942
    • DL-Tryptophan, >=99% (HPLC)
    • 3-beta-Indolylalanine
    • SR-01000597138
    • evonymitol
    • Htrp
    • UNII-X9U7434L7A
    • Tryptophan; N-Acetyltryptophan Imp. A (EP); N-Acetyltryptophan Impurity A
    • Propionic acid, 2-amino-3-indol-3-yl
    • DL-2-Amino-3-indolepropionic acid
    • 80206-30-0
    • (R)-2-Amino-3-(3-indolyl)propionic acid
    • (+/-)-Tryptophan
    • beta-3-indolylalanine
    • DL-3A-Indolylalanine
    • Spectrum_000087
    • Spectrum2_001102
    • Spectrum3_001379
    • Spectrum4_000579
    • Spectrum5_001310
    • (.+/-.)-Tryptophan
    • (r)-(+)l-trp
    • SCHEMBL7327
    • NCIOpen2_006535
    • BSPBio_002938
    • KBioGR_001018
    • KBioSS_000507
    • SPECTRUM1500600
    • SPBio_001204
    • a-amino-3-indolepropionic acid
    • CHEMBL484901
    • SCHEMBL1119641
    • SCHEMBL1132530
    • SCHEMBL9346984
    • SCHEMBL9347052
    • SCHEMBL9444047
    • SCHEMBL19161120
    • SCHEMBL29086836
    • ACon1_001815
    • KBio2_000507
    • KBio2_003075
    • KBio2_005643
    • KBio3_002158
    • HMS1648B01
    • HMS1921I11
    • HMS2092A20
    • HMS5082P11
    • SMSSF-0053656
    • 202406-50-6
    • ALBB-007460
    • GDA20192
    • NSC13118
    • WLN: T56 BMJ D1YZVQ -L
    • Tox21_202793
    • BBL004467
    • CCG-40280
    • EBC-03679
    • NSC122286
    • STK029637
    • 2-amino-3-(3-indolyl)propionic acid
    • AKOS000118922
    • AKOS016038053
    • L-Tryptophan , from non-animal origin
    • CS-W013196
    • FT09075
    • HY-W012480
    • NSC-122286
    • SB14995
    • SB14996
    • SB14997
    • SDCCGMLS-0066645.P001
    • alpha-amino-beta-3-indolepropionic acid
    • CAS-54-12-6
    • ( inverted exclamation markA)-Tryptophan
    • NCGC00015994-02
    • NCGC00015994-03
    • NCGC00015994-04
    • NCGC00015994-05
    • NCGC00015994-06
    • NCGC00015994-09
    • NCGC00015994-10
    • NCGC00015994-12
    • NCGC00094805-01
    • NCGC00094805-02
    • NCGC00094805-03
    • NCGC00094805-04
    • NCGC00260339-01
    • 2-amino-3-(1H-indol-3-yl)propanoicacid
    • AC-24066
    • AS-11002
    • BP-12575
    • Dl-2-amino-3-(3-indolyl)propionic acid
    • NCI60_000685
    • 54-12-6

  • Applications

    Dl-Tryptophan (CAS 54-12-6) is primarily used as a nutritional feed additive to supply essential amino acids in animal nutrition; it serves as an intermediate for the synthesis of tryptophan-containing peptides and certain indole derivatives in pharmaceutical manufacturing; it is used as a substrate in biochemical research and enzyme studies, and in analytical and synthetic workflows; it can be employed as a building block in pharmaceutical development for indole-related compounds; it may be included in dietary supplement formulations subject to local regulations.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 0.62
    methanol 2.66
    isopropanol 0.17
    water 16.16
    ethyl acetate 0.39
    n-propanol 0.25
    acetone 0.35
    n-butanol 0.22
    acetonitrile 0.14
    DMF 10.58
    toluene 0.05
    isobutanol 0.21
    1,4-dioxane 0.25
    methyl acetate 0.28
    THF 1.38
    2-butanone 0.47
    n-pentanol 0.31
    sec-butanol 0.25
    n-hexane 0.02
    ethylene glycol 10.16
    NMP 32.63
    cyclohexane 0.01
    DMSO 6.94
    n-butyl acetate 0.45
    n-octanol 0.04
    chloroform 0.03
    n-propyl acetate 0.38
    acetic acid 7.1
    dichloromethane 0.05
    cyclohexanone 0.78
    propylene glycol 4.1
    isopropyl acetate 0.37
    DMAc 25.45
    2-ethoxyethanol 7.3
    isopentanol 0.39
    n-heptane 0.04
    ethyl formate 0.51
    1,2-dichloroethane 0.07
    n-hexanol 0.43
    2-methoxyethanol 11.25
    isobutyl acetate 0.22
    tetrachloromethane 0.05
    n-pentyl acetate 0.24
    transcutol 8.18
    n-heptanol 0.24
    ethylbenzene 0.08
    MIBK 0.54
    2-propoxyethanol 5.41
    tert-butanol 0.43
    MTBE 0.16
    2-butoxyethanol 2.52
    propionic acid 1.3
    o-xylene 0.11
    formic acid 67.25
    diethyl ether 0.12
    m-xylene 0.1
    p-xylene 0.14
    chlorobenzene 0.04
    dimethyl carbonate 1.19
    n-octane 0.02
    formamide 48.22
    cyclopentanone 2.18
    2-pentanone 0.49
    anisole 0.3
    cyclopentyl methyl ether 0.54
    gamma-butyrolactone 4.34
    1-methoxy-2-propanol 5.57
    pyridine 0.4
    3-pentanone 0.45
    furfural 6.41
    n-dodecane 0.01
    diethylene glycol 20.33
    diisopropyl ether 0.12
    tert-amyl alcohol 0.73
    acetylacetone 1.54
    n-hexadecane 0.01
    acetophenone 0.88
    methyl propionate 0.74
    isopentyl acetate 0.65
    trichloroethylene 0.15
    n-nonanol 0.06
    cyclohexanol 0.3
    benzyl alcohol 0.72
    2-ethylhexanol 0.35
    isooctanol 0.27
    dipropyl ether 0.33
    1,2-dichlorobenzene 0.08
    ethyl lactate 2.26
    propylene carbonate 2.3
    n-methylformamide 4.42
    2-pentanol 0.23
    n-pentane 0.01
    1-propoxy-2-propanol 2.56
    1-methoxy-2-propyl acetate 1.96
    2-(2-methoxypropoxy) propanol 4.29
    mesitylene 0.1
    ε-caprolactone 1.44
    p-cymene 0.14
    epichlorohydrin 1.21
    1,1,1-trichloroethane 0.04
    2-aminoethanol 6.0
    morpholine-4-carbaldehyde 11.25
    sulfolane 13.04
    2,2,4-trimethylpentane 0.02
    2-methyltetrahydrofuran 0.58
    n-hexyl acetate 0.15
    isooctane 0.01
    2-(2-butoxyethoxy)ethanol 3.84
    sec-butyl acetate 0.35
    tert-butyl acetate 0.74
    decalin 0.02
    glycerin 35.3
    diglyme 6.24
    acrylic acid 3.24
    isopropyl myristate 0.11
    n-butyric acid 1.51
    acetyl acetate 0.4
    di(2-ethylhexyl) phthalate 0.57
    ethyl propionate 0.55
    nitromethane 5.58
    1,2-diethoxyethane 0.43
    benzonitrile 0.22
    trioctyl phosphate 0.27
    1-bromopropane 0.03
    gamma-valerolactone 5.47
    n-decanol 0.06
    triethyl phosphate 0.99
    4-methyl-2-pentanol 0.34
    propionitrile 0.1
    vinylene carbonate 1.16
    1,1,2-trichlorotrifluoroethane 7.79
    DMS 0.84
    cumene 0.11
    2-octanol 0.1
    2-hexanone 0.4
    octyl acetate 0.14
    limonene 0.16
    1,2-dimethoxyethane 3.32
    ethyl orthosilicate 0.9
    tributyl phosphate 0.36
    diacetone alcohol 3.79
    N,N-dimethylaniline 0.5
    acrylonitrile 0.26
    aniline 0.22
    1,3-propanediol 4.02
    bromobenzene 0.03
    dibromomethane 0.03
    1,1,2,2-tetrachloroethane 0.15
    2-methyl-cyclohexyl acetate 0.8
    tetrabutyl urea 0.65
    diisobutyl methanol 0.32
    2-phenylethanol 0.8
    styrene 0.06
    dioctyl adipate 0.27
    dimethyl sulfate 4.24
    ethyl butyrate 0.61
    methyl lactate 4.91
    butyl lactate 1.3
    diethyl carbonate 0.54
    propanediol butyl ether 2.34
    triethyl orthoformate 0.85
    p-tert-butyltoluene 0.13
    methyl 4-tert-butylbenzoate 1.78
    morpholine 0.54
    tert-butylamine 0.14
    n-dodecanol 0.05
    dimethoxymethane 2.52
    ethylene carbonate 0.73
    cyrene 11.05
    2-ethoxyethyl acetate 0.8
    2-ethylhexyl acetate 0.47
    1,2,4-trichlorobenzene 0.15
    4-methylpyridine 0.26
    dibutyl ether 0.08
    2,6-dimethyl-4-heptanol 0.32
    DEF 1.82
    dimethyl isosorbide 7.82
    tetrachloroethylene 0.23
    eugenol 3.25
    triacetin 1.24
    span 80 2.26
    1,4-butanediol 2.81
    1,1-dichloroethane 0.03
    2-methyl-1-pentanol 0.55
    methyl formate 2.34
    2-methyl-1-butanol 0.41
    n-decane 0.01
    butyronitrile 0.12
    3,7-dimethyl-1-octanol 0.1
    1-chlorooctane 0.02
    1-chlorotetradecane 0.01
    n-nonane 0.01
    undecane 0.01
    tert-butylcyclohexane 0.02
    cyclooctane 0.01
    cyclopentanol 0.58
    tetrahydropyran 0.13
    tert-amyl methyl ether 0.36
    2,5,8-trioxanonane 6.26
    1-hexene 0.06
    2-isopropoxyethanol 3.25
    2,2,2-trifluoroethanol 7.05
    methyl butyrate 0.77

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction