DL-panthenol

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  • Identifiers

    CAS number
    16485-10-2

    Molecular formula
    C9H19NO4

    SMILES
    CC(C)(CO)C(C(=O)NCCCO)O

    Safety labels

  • Odor profile

    Fragrance
    Odorless 51.09%
    Cooling 35.69%
    Sweet 33.17%
    Mint 29.2%
    Savory 27.5%
    Fishy 24.73%
    Alcoholic 23.8%
    Milky 19.87%
    Bitter 16.92%
    Oily 16.39%

     

    Flavor
    Odorless 51.46%
    Sweet 30.35%
    Fruity 27.31%
    Bitter 27.04%
    Sweet-like 26.73%
    Mild 23.6%
    Bland 22.87%
    Very mild 21.94%
    Very slight 21.14%
    Yeast 19.37%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    -0.9

    pKa est.
    7.41 (neutral)

    Molecular weight
    205.25 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    487°C

    Flash point

    • 192.04 ˚C est.

    Solubility expt.

    • >30.8 [ug/mL] (The mean of the results at pH 7.4)

  • Synonyms

    • DL-Panthenol
    • panthenol
    • 16485-10-2
    • DL-Pantothenol
    • DL-Pantothenyl alcohol
    • Pantenol
    • Panthenolum
    • Panthenol, racemic
    • Pantenolo
    • 2,4-Dihydroxy-N-(3-hydroxypropyl)-3,3-dimethylbutyramide
    • WV9CM0O67Z
    • NSC-759899
    • DTXSID3044598
    • DTXCID1024598
    • Purple Toner
    • ELF Perm
    • Roota Re F Tonic
    • Roota Re V Tonic
    • Mannitol, Panthenol
    • AAPE Hair Ampoule
    • Eyelash Growth Serum
    • Roota Re F for men
    • Panthenol, Niacinamide
    • BREXTEM H
    • Roota Re V for women
    • RefChem:55808
    • NGF 574H HAIR
    • Hyaluronic Acid Facial Serum
    • SHINMO SAENGBALEUM HAIR
    • NGF 574H HAIR TONIC
    • SHINMO SAENGBALEUM TREATMENT
    • EH Hair Plus Regeneration Hair Care
    • CURESTEM CELL HEALER C5 PROGRAM
    • ReOrganic Eyelash Growth Boosting Serum
    • CURESTEM CELL HEALER C10 PROGRAM
    • ZHANGGUANG 101 HAIR FOLLICLE TONIC
    • Panthenol, Niacinamide, Menthol, Salicylic Acid
    • Butanamide, 2,4-dihydroxy-N-(3-hydroxypropyl)-3,3-dimethyl-
    • MFCD00002944
    • 62507-76-0
    • Dexpanthenol Racemate
    • (+-)-Pantothenyl alcohol
    • DL-Pantothenol;DL-Pantothenyl alcohol
    • Alcool DL-pantotenilico
    • Pantenolo [DCIT]
    • 3-(2,4-Dihydroxy-3,3-dimethylbutyramido)-1-propanol
    • Panthenol , DL-form
    • Pantenol [INN-Spanish]
    • (R)-(+)-2,4-Dihydroxy-N-(3-hydroxypropyl)-3,3-dimethylbutyramide
    • Panthenolum [INN-Latin]
    • component of Zentinic
    • Dexpanthenol [USAN)
    • SMR000857333
    • Alcool DL-pantotenilico [Italian]
    • SR-05000001760
    • EINECS 240-540-6
    • UNII-WV9CM0O67Z
    • d,l- panthenol
    • NCGC00186658-01
    • pantothenylol alcohol
    • Panthenol [USAN:USP:INN:BAN:JAN]
    • 2,3-dimethylbutyramide
    • DL-Panthenol, 99%
    • Panthenol (USP/INN)
    • PANTHENOL [INN]
    • PANTHENOL, DL-
    • PANTHENOL [USAN]
    • (+-)-2,4-Dihydroxy-N-(3-hydroxypropyl)-3,3-dimethylbutyramide
    • PANTHENOL [VANDF]
    • PANTHENOL [MART.]
    • Butanamide, 2,4-dihydroxy-N-(3-hydroxypropyl)-3,3-dimethyl-, (+)- (9CI)
    • EC 240-540-6
    • DL-PANTHENOL [FCC]
    • PANTHENOL [WHO-DD]
    • SCHEMBL15567
    • DL-PANTHENOL [VANDF]
    • (R)-2,4-Dihydroxy-3,3-dimethylbutyric 3-hydroxypropylamide
    • MLS001336015
    • MLS001336016
    • orb1308759
    • CHEMBL1371937
    • D-(+)-2,3-dimethylbutyramide
    • PANTHENOL [USP MONOGRAPH]
    • 2,4-dihydroxy-N-(3-hydroxypropyl)-3,3-dimethyl-butanamide
    • HMS2093B14
    • HMS2234M16
    • HMS3371M11
    • HMS5083J13
    • HMS5083O16
    • Pharmakon1600-01505420
    • Pharmakon1600-01505656
    • (+/-)-PANTOTHENYL ALCOHOL
    • HY-B1024
    • MSK28214
    • PANTHENOL, RACEMIC [USP-RS]
    • Tox21_302660
    • Butanamide, 2,4-dihydroxy-N-(3-hydroxypropyl)-3,3-dimethyl-, (+-)-
    • Butyramide, 2,4-dihydroxy-N-(3-hydroxypropyl)-3,3-dimethyl-, DL-
    • NSC759127
    • NSC759899
    • s4566
    • STL453540
    • DL-Pantothenol,DL-Pantothenyl alcohol
    • AKOS015841508
    • Butanamide, 2,4-dihydroxy-N-(3-hydroxypropyl)-3,3-dimethyl-, (+/-)-
    • CCG-213502
    • CS-4541
    • NSC 759899
    • NSC-759127
    • SB44496
    • NCGC00256864-01
    • AS-56363
    • DA-09547
    • FD170517
    • SBI-0206818.P001
    • CAS-16485-10-2
    • DB-056494
    • NS00000985
    • P1318
    • D03726
    • H11256
    • AB00918367_05
    • F225733
    • Q196473
    • SR-05000001760-1
    • SR-05000001760-3
    • BRD-A59413292-001-04-1
    • 16485-10-2

  • Applications

    DL-panthenol, a form of provitamin B5, is commonly used in cosmetics and personal care as a humectant and conditioning agent, helping skin and hair feel moisturized and softened. In hair care products such as shampoos and conditioners, it improves manageability and shine; in skin care formulations like creams, lotions, and serums it provides moisture retention and a smooth feel. It is also used as a vitamin B5 source in topical pharmaceutical formulations, contributing to the formulation by supplying a nutrient component in the product. Depending on local regulations and formulation limits, DL-panthenol may be evaluated and included at varying concentrations in these systems.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 118.41
    methanol 513.94
    isopropanol 37.12
    water 751.02
    ethyl acetate 5.37
    n-propanol 63.04
    acetone 5.42
    n-butanol 35.96
    acetonitrile 4.08
    DMF 248.14
    toluene 0.93
    isobutanol 30.24
    1,4-dioxane 44.29
    methyl acetate 5.09
    THF 44.84
    2-butanone 5.15
    n-pentanol 13.99
    sec-butanol 30.63
    n-hexane 0.45
    ethylene glycol 507.56
    NMP 208.06
    cyclohexane 2.18
    DMSO 369.82
    n-butyl acetate 3.63
    n-octanol 8.9
    chloroform 7.14
    n-propyl acetate 3.66
    acetic acid 407.09
    dichloromethane 5.16
    cyclohexanone 29.11
    propylene glycol 336.69
    isopropyl acetate 4.35
    DMAc 162.08
    2-ethoxyethanol 125.96
    isopentanol 21.26
    n-heptane 0.86
    ethyl formate 15.13
    1,2-dichloroethane 4.02
    n-hexanol 16.33
    2-methoxyethanol 364.4
    isobutyl acetate 3.01
    tetrachloromethane 2.93
    n-pentyl acetate 4.53
    transcutol 112.0
    n-heptanol 13.81
    ethylbenzene 1.31
    MIBK 6.87
    2-propoxyethanol 63.37
    tert-butanol 52.66
    MTBE 6.84
    2-butoxyethanol 45.19
    propionic acid 90.06
    o-xylene 2.5
    formic acid 1513.53
    diethyl ether 3.15
    m-xylene 1.95
    p-xylene 1.97
    chlorobenzene 1.75
    dimethyl carbonate 9.68
    n-octane 0.59
    formamide 808.05
    cyclopentanone 32.56
    2-pentanone 5.05
    anisole 4.05
    cyclopentyl methyl ether 12.57
    gamma-butyrolactone 57.68
    1-methoxy-2-propanol 124.43
    pyridine 10.25
    3-pentanone 4.44
    furfural 69.89
    n-dodecane 0.42
    diethylene glycol 186.37
    diisopropyl ether 1.63
    tert-amyl alcohol 45.51
    acetylacetone 12.32
    n-hexadecane 0.44
    acetophenone 9.64
    methyl propionate 9.22
    isopentyl acetate 4.87
    trichloroethylene 10.1
    n-nonanol 8.04
    cyclohexanol 41.71
    benzyl alcohol 16.91
    2-ethylhexanol 7.08
    isooctanol 10.41
    dipropyl ether 3.05
    1,2-dichlorobenzene 3.31
    ethyl lactate 20.72
    propylene carbonate 29.83
    n-methylformamide 182.01
    2-pentanol 13.11
    n-pentane 0.68
    1-propoxy-2-propanol 29.11
    1-methoxy-2-propyl acetate 11.96
    2-(2-methoxypropoxy) propanol 34.39
    mesitylene 2.21
    ε-caprolactone 34.36
    p-cymene 2.32
    epichlorohydrin 27.44
    1,1,1-trichloroethane 2.68
    2-aminoethanol 510.72
    morpholine-4-carbaldehyde 174.98
    sulfolane 158.74
    2,2,4-trimethylpentane 0.86
    2-methyltetrahydrofuran 18.97
    n-hexyl acetate 7.7
    isooctane 0.54
    2-(2-butoxyethoxy)ethanol 50.94
    sec-butyl acetate 2.86
    tert-butyl acetate 8.09
    decalin 0.89
    glycerin 658.85
    diglyme 78.68
    acrylic acid 132.63
    isopropyl myristate 2.77
    n-butyric acid 66.1
    acetyl acetate 6.24
    di(2-ethylhexyl) phthalate 9.44
    ethyl propionate 3.95
    nitromethane 122.08
    1,2-diethoxyethane 6.13
    benzonitrile 6.1
    trioctyl phosphate 7.39
    1-bromopropane 1.43
    gamma-valerolactone 99.91
    n-decanol 5.71
    triethyl phosphate 5.6
    4-methyl-2-pentanol 9.49
    propionitrile 4.26
    vinylene carbonate 26.98
    1,1,2-trichlorotrifluoroethane 147.65
    DMS 8.49
    cumene 1.79
    2-octanol 6.5
    2-hexanone 3.71
    octyl acetate 4.54
    limonene 3.68
    1,2-dimethoxyethane 56.26
    ethyl orthosilicate 5.13
    tributyl phosphate 6.31
    diacetone alcohol 37.92
    N,N-dimethylaniline 6.45
    acrylonitrile 9.01
    aniline 7.2
    1,3-propanediol 363.89
    bromobenzene 1.18
    dibromomethane 2.99
    1,1,2,2-tetrachloroethane 13.12
    2-methyl-cyclohexyl acetate 7.2
    tetrabutyl urea 9.67
    diisobutyl methanol 5.17
    2-phenylethanol 12.55
    styrene 1.12
    dioctyl adipate 6.6
    dimethyl sulfate 33.82
    ethyl butyrate 3.58
    methyl lactate 52.77
    butyl lactate 15.99
    diethyl carbonate 2.97
    propanediol butyl ether 64.48
    triethyl orthoformate 4.99
    p-tert-butyltoluene 2.57
    methyl 4-tert-butylbenzoate 19.65
    morpholine 78.73
    tert-butylamine 15.6
    n-dodecanol 4.14
    dimethoxymethane 36.22
    ethylene carbonate 19.96
    cyrene 72.14
    2-ethoxyethyl acetate 8.38
    2-ethylhexyl acetate 3.41
    1,2,4-trichlorobenzene 5.23
    4-methylpyridine 6.06
    dibutyl ether 2.24
    2,6-dimethyl-4-heptanol 5.17
    DEF 25.62
    dimethyl isosorbide 50.06
    tetrachloroethylene 14.95
    eugenol 26.53
    triacetin 14.56
    span 80 39.27
    1,4-butanediol 128.67
    1,1-dichloroethane 1.76
    2-methyl-1-pentanol 13.62
    methyl formate 86.94
    2-methyl-1-butanol 24.49
    n-decane 0.65
    butyronitrile 4.16
    3,7-dimethyl-1-octanol 7.82
    1-chlorooctane 1.76
    1-chlorotetradecane 0.85
    n-nonane 0.61
    undecane 0.5
    tert-butylcyclohexane 0.73
    cyclooctane 1.01
    cyclopentanol 56.04
    tetrahydropyran 14.66
    tert-amyl methyl ether 8.38
    2,5,8-trioxanonane 55.84
    1-hexene 0.89
    2-isopropoxyethanol 44.01
    2,2,2-trifluoroethanol 199.08
    methyl butyrate 7.14

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction