Dithiodiethyl bis-salicylamide

Overview IFRA Request a quote

  • Identifiers

    CAS number
    168961-92-0

    Molecular formula
    C18H20N2O4S2

    SMILES
    C1=CC=C(C(=C1)C(=O)NCCSSCCNC(=O)C2=CC=CC=C2O)O

    Safety labels

  • Odor profile

    Fragrance
    Meaty 49.79%
    Savory 47.37%
    Odorless 41.9%
    Cooked 33.64%
    Roasted 30.38%
    Sulfurous 24.08%
    Burnt 22.66%
    Pungent 20.35%
    Cheesy 19.57%
    Beefy 19.43%

     

    Flavor
    Bitter 67.04%
    Odorless 42.97%
    Bland 30.13%
    Mild 28.43%
    Sweet-like 21.62%
    Nitrile 21.06%
    Roasted 20.64%
    Scallion 20.6%
    Cedarleaf 20.03%
    Taco 19.89%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    3.2

    pKa est.
    9.0 (weak base)

    Molecular weight
    392.5 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Very fast

    Boiling point est.
    346°C

    Flash point

    • 272.98 ˚C est.

  • Synonyms

    • Dithiodiethyl bis-salicylamide
    • UNII-7OEA4Z5W9W
    • 7OEA4Z5W9W
    • Dithiodiethyl bis-salicylamide [INCI]
    • Benzamide, N,N'-(dithiodi-2,1-ethanediyl)bis(2-hydroxy-
    • 168961-92-0
    • RefChem:135198
    • SCHEMBL3341896
    • DTXSID701021353
    • Q27268645
    • 168961-92-0

  • Applications

    Dithiodiethyl bis-salicylamide (CAS 168961-92-0) is used as a precursor and additive in industrial formulations, with typical applications including: acting as a stabilizer and processing aid in polymer systems to improve durability and oxidative stability; serving as an additive in coatings and inks to enhance adhesion and mechanical properties of the film; potentially functioning as a crosslinking or strengthening agent in adhesive formulations; functioning as a metal-chelating agent in cleaning formulations or metal-treatment systems to improve formulation stability; and acting as a precursor for the synthesis of specialty chemicals in various manufacturing workflows.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 2.23
    methanol 3.31
    isopropanol 1.55
    water 0.01
    ethyl acetate 2.22
    n-propanol 2.55
    acetone 7.26
    n-butanol 1.98
    acetonitrile 1.03
    DMF 86.92
    toluene 1.3
    isobutanol 1.4
    1,4-dioxane 6.14
    methyl acetate 2.81
    THF 57.71
    2-butanone 9.17
    n-pentanol 1.62
    sec-butanol 2.01
    n-hexane 0.05
    ethylene glycol 0.85
    NMP 87.68
    cyclohexane 0.09
    DMSO 109.87
    n-butyl acetate 2.21
    n-octanol 1.16
    chloroform 4.22
    n-propyl acetate 1.95
    acetic acid 5.33
    dichloromethane 3.47
    cyclohexanone 23.84
    propylene glycol 2.45
    isopropyl acetate 1.95
    DMAc 133.88
    2-ethoxyethanol 7.4
    isopentanol 1.53
    n-heptane 0.08
    ethyl formate 3.28
    1,2-dichloroethane 3.07
    n-hexanol 1.3
    2-methoxyethanol 15.41
    isobutyl acetate 1.0
    tetrachloromethane 0.52
    n-pentyl acetate 2.54
    transcutol 11.09
    n-heptanol 1.44
    ethylbenzene 0.56
    MIBK 3.01
    2-propoxyethanol 8.58
    tert-butanol 1.84
    MTBE 1.05
    2-butoxyethanol 5.55
    propionic acid 3.84
    o-xylene 0.91
    formic acid 4.8
    diethyl ether 0.93
    m-xylene 0.75
    p-xylene 0.77
    chlorobenzene 1.55
    dimethyl carbonate 4.36
    n-octane 0.06
    formamide 11.63
    cyclopentanone 45.46
    2-pentanone 6.11
    anisole 1.71
    cyclopentyl methyl ether 5.58
    gamma-butyrolactone 34.13
    1-methoxy-2-propanol 12.37
    pyridine 9.95
    3-pentanone 5.17
    furfural 24.88
    n-dodecane 0.05
    diethylene glycol 6.64
    diisopropyl ether 0.26
    tert-amyl alcohol 2.06
    acetylacetone 8.62
    n-hexadecane 0.07
    acetophenone 4.07
    methyl propionate 4.74
    isopentyl acetate 2.15
    trichloroethylene 9.1
    n-nonanol 1.35
    cyclohexanol 2.98
    benzyl alcohol 3.17
    2-ethylhexanol 0.96
    isooctanol 1.15
    dipropyl ether 1.2
    1,2-dichlorobenzene 1.66
    ethyl lactate 3.37
    propylene carbonate 10.71
    n-methylformamide 16.24
    2-pentanol 1.07
    n-pentane 0.05
    1-propoxy-2-propanol 6.29
    1-methoxy-2-propyl acetate 6.13
    2-(2-methoxypropoxy) propanol 6.76
    mesitylene 0.43
    ε-caprolactone 14.28
    p-cymene 0.53
    epichlorohydrin 24.99
    1,1,1-trichloroethane 1.68
    2-aminoethanol 2.63
    morpholine-4-carbaldehyde 39.77
    sulfolane 86.92
    2,2,4-trimethylpentane 0.05
    2-methyltetrahydrofuran 8.77
    n-hexyl acetate 2.67
    isooctane 0.02
    2-(2-butoxyethoxy)ethanol 7.38
    sec-butyl acetate 1.29
    tert-butyl acetate 2.61
    decalin 0.07
    glycerin 6.52
    diglyme 14.76
    acrylic acid 4.8
    isopropyl myristate 1.19
    n-butyric acid 4.88
    acetyl acetate 1.97
    di(2-ethylhexyl) phthalate 2.17
    ethyl propionate 2.11
    nitromethane 12.86
    1,2-diethoxyethane 3.02
    benzonitrile 3.09
    trioctyl phosphate 1.52
    1-bromopropane 1.14
    gamma-valerolactone 48.92
    n-decanol 0.97
    triethyl phosphate 2.12
    4-methyl-2-pentanol 0.67
    propionitrile 1.85
    vinylene carbonate 9.38
    1,1,2-trichlorotrifluoroethane 25.3
    DMS 3.14
    cumene 0.36
    2-octanol 0.93
    2-hexanone 3.64
    octyl acetate 1.71
    limonene 0.92
    1,2-dimethoxyethane 12.52
    ethyl orthosilicate 1.78
    tributyl phosphate 1.78
    diacetone alcohol 7.5
    N,N-dimethylaniline 1.88
    acrylonitrile 3.23
    aniline 3.22
    1,3-propanediol 4.04
    bromobenzene 1.14
    dibromomethane 1.87
    1,1,2,2-tetrachloroethane 9.1
    2-methyl-cyclohexyl acetate 2.62
    tetrabutyl urea 3.85
    diisobutyl methanol 0.63
    2-phenylethanol 2.98
    styrene 0.65
    dioctyl adipate 2.76
    dimethyl sulfate 14.98
    ethyl butyrate 2.45
    methyl lactate 8.36
    butyl lactate 4.19
    diethyl carbonate 1.63
    propanediol butyl ether 4.9
    triethyl orthoformate 2.42
    p-tert-butyltoluene 0.53
    methyl 4-tert-butylbenzoate 6.19
    morpholine 13.22
    tert-butylamine 0.63
    n-dodecanol 0.68
    dimethoxymethane 17.39
    ethylene carbonate 6.64
    cyrene 12.89
    2-ethoxyethyl acetate 4.19
    2-ethylhexyl acetate 1.66
    1,2,4-trichlorobenzene 2.72
    4-methylpyridine 7.46
    dibutyl ether 1.15
    2,6-dimethyl-4-heptanol 0.63
    DEF 14.1
    dimethyl isosorbide 14.15
    tetrachloroethylene 4.78
    eugenol 6.03
    triacetin 4.74
    span 80 5.22
    1,4-butanediol 1.53
    1,1-dichloroethane 1.54
    2-methyl-1-pentanol 1.48
    methyl formate 9.23
    2-methyl-1-butanol 1.76
    n-decane 0.1
    butyronitrile 1.89
    3,7-dimethyl-1-octanol 1.02
    1-chlorooctane 0.58
    1-chlorotetradecane 0.23
    n-nonane 0.08
    undecane 0.07
    tert-butylcyclohexane 0.05
    cyclooctane 0.05
    cyclopentanol 5.71
    tetrahydropyran 5.93
    tert-amyl methyl ether 1.54
    2,5,8-trioxanonane 11.19
    1-hexene 0.29
    2-isopropoxyethanol 3.94
    2,2,2-trifluoroethanol 3.92
    methyl butyrate 3.65

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction