Dithiodiethyl bis-lactamide

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  • Identifiers

    CAS number
    168961-93-1

    Molecular formula
    C10H20N2O4S2

    SMILES
    CC(C(=O)NCCSSCCNC(=O)C(C)O)O

    Safety labels

  • Odor profile

    Fragrance
    Meaty 53.18%
    Savory 50.08%
    Odorless 34.91%
    Roasted 33.96%
    Cooked 30.87%
    Sweet 28.48%
    Sulfurous 27.84%
    Fishy 25.93%
    Beefy 23.49%
    Fatty 19.65%

     

    Flavor
    Odorless 50.28%
    Bland 31.67%
    Bitter 29.83%
    Mild 26.43%
    Sweet-like 25.15%
    Cooked 23.86%
    Very mild 21.32%
    Roasted 21.19%
    Yeast 20.5%
    Sulfury 19.86%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    -1.0

    pKa est.
    7.68 (neutral)

    Molecular weight
    296.4 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    731°C

    Flash point

    • 260.39 ˚C est.

  • Synonyms

    • Dithiodiethyl bis-lactamide
    • UNII-1S25T4LOU0
    • 1S25T4LOU0
    • Dithiodiethyl bis-lactamide [INCI]
    • 168961-93-1
    • Propanamide, N,N'-(dithiodi-2,1-ethanediyl)bis(2-hydroxy-
    • RefChem:135197
    • SCHEMBL3332159
    • DTXSID901021785
    • Q27252820
    • 168961-93-1

  • Applications

    Dithiodiethyl bis-lactamide (CAS 168961-93-1) is typically encountered as a reactive intermediate and crosslinking/curing agent in polymer and resin formulations. In polymers/plastics and coatings/inks, its disulfide and lactamide functionalities can enable dynamic covalent bonding or serve as a latent cure component for epoxy and polyurethane systems. It can also function as an intermediate in the synthesis of specialty resins and adhesive chemistries. As a sulfur-containing functional precursor, it may be explored for advanced materials in electronics and high-performance coatings. Additionally, formulators may evaluate it as an additive to improve processability and thermal stability of polymer formulations.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 3.51
    methanol 12.87
    isopropanol 1.58
    water 4.26
    ethyl acetate 1.61
    n-propanol 2.32
    acetone 3.37
    n-butanol 1.65
    acetonitrile 0.93
    DMF 87.08
    toluene 0.48
    isobutanol 1.49
    1,4-dioxane 4.09
    methyl acetate 2.17
    THF 12.51
    2-butanone 2.96
    n-pentanol 1.61
    sec-butanol 2.02
    n-hexane 0.08
    ethylene glycol 4.88
    NMP 86.16
    cyclohexane 0.22
    DMSO 136.55
    n-butyl acetate 1.43
    n-octanol 1.55
    chloroform 2.87
    n-propyl acetate 1.46
    acetic acid 25.54
    dichloromethane 2.3
    cyclohexanone 10.51
    propylene glycol 5.46
    isopropyl acetate 1.62
    DMAc 103.53
    2-ethoxyethanol 16.77
    isopentanol 1.78
    n-heptane 0.14
    ethyl formate 3.99
    1,2-dichloroethane 1.79
    n-hexanol 1.3
    2-methoxyethanol 27.72
    isobutyl acetate 0.87
    tetrachloromethane 0.72
    n-pentyl acetate 2.15
    transcutol 33.49
    n-heptanol 1.82
    ethylbenzene 0.42
    MIBK 2.12
    2-propoxyethanol 9.28
    tert-butanol 2.84
    MTBE 1.4
    2-butoxyethanol 7.8
    propionic acid 6.5
    o-xylene 0.99
    formic acid 50.19
    diethyl ether 0.71
    m-xylene 0.56
    p-xylene 0.63
    chlorobenzene 0.83
    dimethyl carbonate 3.17
    n-octane 0.11
    formamide 61.59
    cyclopentanone 16.86
    2-pentanone 2.34
    anisole 1.72
    cyclopentyl methyl ether 3.5
    gamma-butyrolactone 21.83
    1-methoxy-2-propanol 14.72
    pyridine 4.19
    3-pentanone 2.12
    furfural 33.33
    n-dodecane 0.07
    diethylene glycol 15.15
    diisopropyl ether 0.4
    tert-amyl alcohol 3.68
    acetylacetone 6.69
    n-hexadecane 0.08
    acetophenone 4.27
    methyl propionate 2.72
    isopentyl acetate 1.74
    trichloroethylene 5.57
    n-nonanol 1.66
    cyclohexanol 2.86
    benzyl alcohol 3.68
    2-ethylhexanol 1.04
    isooctanol 1.53
    dipropyl ether 0.95
    1,2-dichlorobenzene 1.56
    ethyl lactate 4.7
    propylene carbonate 10.62
    n-methylformamide 24.13
    2-pentanol 1.03
    n-pentane 0.07
    1-propoxy-2-propanol 6.2
    1-methoxy-2-propyl acetate 4.85
    2-(2-methoxypropoxy) propanol 11.89
    mesitylene 0.55
    ε-caprolactone 10.88
    p-cymene 0.69
    epichlorohydrin 11.43
    1,1,1-trichloroethane 1.35
    2-aminoethanol 8.54
    morpholine-4-carbaldehyde 55.8
    sulfolane 73.72
    2,2,4-trimethylpentane 0.13
    2-methyltetrahydrofuran 4.73
    n-hexyl acetate 2.7
    isooctane 0.06
    2-(2-butoxyethoxy)ethanol 13.25
    sec-butyl acetate 1.06
    tert-butyl acetate 2.7
    decalin 0.15
    glycerin 20.63
    diglyme 26.76
    acrylic acid 10.53
    isopropyl myristate 1.15
    n-butyric acid 7.03
    acetyl acetate 2.5
    di(2-ethylhexyl) phthalate 2.94
    ethyl propionate 1.57
    nitromethane 31.47
    1,2-diethoxyethane 3.01
    benzonitrile 2.43
    trioctyl phosphate 1.85
    1-bromopropane 0.55
    gamma-valerolactone 39.88
    n-decanol 1.18
    triethyl phosphate 2.53
    4-methyl-2-pentanol 0.9
    propionitrile 0.98
    vinylene carbonate 10.3
    1,1,2-trichlorotrifluoroethane 34.87
    DMS 3.49
    cumene 0.43
    2-octanol 1.19
    2-hexanone 1.76
    octyl acetate 1.73
    limonene 1.19
    1,2-dimethoxyethane 16.37
    ethyl orthosilicate 2.36
    tributyl phosphate 2.25
    diacetone alcohol 8.37
    N,N-dimethylaniline 2.68
    acrylonitrile 2.2
    aniline 1.85
    1,3-propanediol 8.87
    bromobenzene 0.61
    dibromomethane 1.27
    1,1,2,2-tetrachloroethane 6.11
    2-methyl-cyclohexyl acetate 2.63
    tetrabutyl urea 4.65
    diisobutyl methanol 0.99
    2-phenylethanol 2.81
    styrene 0.46
    dioctyl adipate 3.17
    dimethyl sulfate 16.86
    ethyl butyrate 1.88
    methyl lactate 9.37
    butyl lactate 5.1
    diethyl carbonate 1.56
    propanediol butyl ether 10.76
    triethyl orthoformate 2.46
    p-tert-butyltoluene 0.74
    methyl 4-tert-butylbenzoate 7.81
    morpholine 8.65
    tert-butylamine 1.16
    n-dodecanol 0.83
    dimethoxymethane 11.19
    ethylene carbonate 6.25
    cyrene 19.08
    2-ethoxyethyl acetate 4.52
    2-ethylhexyl acetate 1.27
    1,2,4-trichlorobenzene 2.33
    4-methylpyridine 3.56
    dibutyl ether 1.05
    2,6-dimethyl-4-heptanol 0.99
    DEF 10.14
    dimethyl isosorbide 18.63
    tetrachloroethylene 4.88
    eugenol 8.92
    triacetin 7.47
    span 80 8.88
    1,4-butanediol 4.74
    1,1-dichloroethane 0.83
    2-methyl-1-pentanol 1.75
    methyl formate 14.69
    2-methyl-1-butanol 1.92
    n-decane 0.14
    butyronitrile 0.95
    3,7-dimethyl-1-octanol 1.47
    1-chlorooctane 0.55
    1-chlorotetradecane 0.23
    n-nonane 0.13
    undecane 0.09
    tert-butylcyclohexane 0.12
    cyclooctane 0.11
    cyclopentanol 4.13
    tetrahydropyran 2.16
    tert-amyl methyl ether 2.03
    2,5,8-trioxanonane 21.01
    1-hexene 0.22
    2-isopropoxyethanol 7.11
    2,2,2-trifluoroethanol 17.85
    methyl butyrate 3.04

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction