Disulfoton

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  • Identifiers

    CAS number
    298-04-4

    Molecular formula
    C8H19O2PS3

    SMILES
    CCOP(=S)(OCC)SCCSCC

    Safety labels

    Acute Toxic
    Acute Toxic

    Environmental Hazard
    Environmental

  • Odor profile

    Fragrance
    Sulfurous 72.35%
    Onion 59.54%
    Meaty 54.98%
    Roasted 49.56%
    Savory 46.72%
    Garlic 43.62%
    Alliaceous 41.64%
    Cooked 36.68%
    Tropical 34.93%
    Pungent 26.04%

     

    Flavor
    Sulfurous 53.57%
    Onion 52.68%
    Sulfury 48.66%
    Garlic 42.13%
    Cabbage 38.61%
    Green 37.49%
    Meaty 33.88%
    Cooked 31.81%
    Tropical 31.69%
    Fruity 28.23%

     

    Odor impact est.
    Medium

  • Properties

    XLogP3-AA
    4.0

    pKa est.
    3.43 (weak acid)

    Molecular weight
    274.4 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Melting point expt.

    • Greater than -13 °F (EPA, 1998)
    • -25 °C
    • -13 °F
    • >-13 °F

    Boiling point

    • 270 to 271 °F at 1.5 mmHg (EPA, 1998)
    • 132-133 °C @ 1.5 mm Hg; 108 °C @ 0.01 mm Hg
    • Boiling point: 62 °C at 0.01 mm Hg
    • at 0.2kPa: 132-133 °C
    • 270-271 °F

    Flash point

    • 142.98 ˚C est.
    • greater than 180 °F (NIOSH, 2024)
    • 133 °C
    • >180 °F

    Solubility expt.

    • 0.003 % at 73 °F (NIOSH, 2024)
    • SOL IN MOST ORG LIQ & FATTY OILS
    • Miscible in n-hexane, dichloromethane, 2-propanol, toluene
    • In water, 16.3 mg/l @ 20 °C
    • Solubility in water: none
    • (73 °F): 0.003%

  • Synonyms

    • disulfoton
    • 298-04-4
    • Dithiodemeton
    • Dithiosystox
    • Thiodemeton
    • Di-syston
    • Glebofos
    • Solvigran
    • Solvirex
    • Dution
    • Frumin
    • Ethyl thiometon
    • Ethylthiometon B
    • Frumin G
    • Insyst-D
    • Ekatin TD
    • Frumin AL
    • Di-Syston G
    • Disulfaton
    • Ekatine
    • Rcra waste number P039
    • VUagT 1-4
    • Bayer 19639
    • BAY 19639
    • Ethylthiometon
    • VUagT 1964
    • Caswell No. 341
    • M-74 (Pesticide)
    • Disulfoton [BSI:ISO]
    • Disulfoton [ISO]
    • O,O-Diethyl S-(2-ethylmercaptoethyl) dithiophosphate
    • Thiodemetron
    • CCRIS 1011
    • Disipton
    • Disystox
    • HSDB 379
    • Dimaz
    • ENT 23,437
    • O,O-Diethyl 2-ethylthioethyl phosphorodithioate
    • 3CY5EKL6MT
    • O,O-Diethyl S-(2-(ethylthio)ethyl) dithiophosphate
    • S 276
    • EINECS 206-054-3
    • ENT 23437
    • EPA Pesticide Chemical Code 032501
    • BAYSISTON
    • BRN 1709167
    • O,O-Diethyl S-(2-eththioethyl) phosphorodithioate
    • DTXSID0022018
    • O,O-Diethyl S-(2-eththioethyl) thiothionophosphate
    • Phosphorodithioic acid, O,O-diethyl S-(2-(ethylthio)ethyl) ester
    • CHEBI:38661
    • M 74 (Pesticide)
    • AI3-23437
    • O,O-Diethyl S-(2-(ethylthio)ethyl)phosphorodithioate
    • DISULFOTON [MI]
    • O,O-Dietil-S-(2-etiltio-etil)-ditiofosfato
    • DISULFOTON [HSDB]
    • O,O-Diaethyl-S-(3-thia-pentyl)-dithiophosphat
    • O,O-Diethyl-S-(2-ethylthio-ethyl)-dithiofosfaat
    • O,O-Diethyl-S-ethylmercapto-ethyl dithiophosphate
    • S-2-(Ethylthio)ethyl O,O-diethyl ester of phosphorodithioic acid
    • O,O-Diethyl S-[2-(Ethylthio)ethyl] dithiophosphate
    • O,O-Diethyl S-2-(ethylthio)ethyl phosphorodithioate
    • O,O-Diaethyl-S-(2-aethylthio-aethyl)-dithiophosphat
    • O,O-Dietil-S-(2-etiltio-etil)-ditiofosfato [Italian]
    • O,O-Diaethyl-S-(3-thia-pentyl)-dithiophosphat [German]
    • BAY S276
    • BAY-S276
    • DTXCID702018
    • O,O-Diethyl-S-(2-ethylthio-ethyl)-dithiofosfaat [Dutch]
    • Dithiophosphate de O,O-diethyle et de S-(2-ethylthio-ethyle)
    • O,O-Diaethyl-S-(2-aethylthio-aethyl)-dithiophosphat [German]
    • Phosphorodithioic acid, O,O-diethyl S-[2-(ethylthio)ethyl] ester
    • O,O-diethyl-S-ethylmercaptoethyl dithiophosphate
    • Dithiophosphate de O,O-diethyle et de S-(2-ethylthio-ethyle) [French]
    • BAY-19639
    • ENT-23347
    • ENT-23437
    • O,O-diethyl S-(2-(ethylthio)ethyl) phosphorodithioate
    • o,o-Diethyl S-[2-(ethylsulfanyl)ethyl] dithiophosphate
    • S-[2-(Ethylsulfanyl)ethyl] o,o-dimethyl dithiophosphate
    • Disyston
    • O,O-Ethyl S-2(ethylthio)ethyl phosphorodithioate
    • O,O-Diethyl S-[2-(ethylthio)ethyl] phosphorodithioate
    • Phosphorodithionic acid, S-2-(ethylthio)ethyl-O,O-diethyl ester
    • Di Syston
    • CAS-298-04-4
    • UNII-3CY5EKL6MT
    • RCRA waste no. P039
    • O,O-Diethyl S-(2-(ethylsulfanyl)ethyl) dithiophosphate
    • S-(2-(ethylsulfanyl)ethyl) O,O-dimethyl dithiophosphate
    • M-74
    • O,O-DIAETHYL-S-(3-THIA-PENTYL)-DITHIOPHOSPHAT (GERMAN)
    • O,O-diethyl ((2-(ethylsulfanyl)ethyl)sulfanyl)phosphonothioate
    • O,O-diethyl {[2-(ethylsulfanyl)ethyl]sulfanyl}phosphonothioate
    • O,O-DIETIL-S-(2-ETILTIO-ETIL)-DITIOFOSFATO (ITALIAN)
    • InsystD
    • O,O-DIAETHYL-S-(2-AETHYLTHIO-AETHYL)-DITHIOPHOSPHAT (GERMAN)
    • O,O-DIETHYL-S-(2-ETHYLTHIO-ETHYL)-DITHIOFOSFAAT (DUTCH)
    • DiSyston G
    • Disulfoton mixture
    • DITHIOPHOSPHATE DE O,O-DIETHYLE ET DE S-(2-ETHYLTHIO-ETHYLE) (FRENCH)
    • Disyston FE-10
    • M74 (Pesticide)
    • Bayer Advanced Garden
    • Disulfoton (ACGIH)
    • Vuagt 14
    • Spectrum_001771
    • SpecPlus_000354
    • Spectrum2_001856
    • Spectrum3_000807
    • Spectrum4_000647
    • Spectrum5_001926
    • M 74(PESTICIDE)
    • O,O-diethyl 2-(ethylthio)ethyl dithiophosphate
    • Pesticide Code 032501
    • Bayer 19 639
    • SCHEMBL27180
    • BSPBio_002273
    • KBioGR_000993
    • KBioSS_002252
    • MLS001065622
    • DivK1c_006450
    • SPBio_001672
    • CHEMBL1332314
    • DOFZAZXDOSGAJZ-UHFFFAOYSA-
    • KBio1_001394

  • Applications

    Disulfoton (CAS 298-04-4) is primarily used as an organophosphate insecticide in agriculture to control soil- and crop-dwelling pests in crops such as rice, vegetables, and grains; it is commonly applied as a soil spray or seed treatment to protect seedlings from root- and soil-dwelling pests. Commercial formulations are typically available as emulsifiable concentrates or granules and are implemented within integrated pest management (IPM) programs. In addition to agricultural use, it has been evaluated for storage-protection against stored-product pests and may be discussed in the context of chemical research related to insecticides, but all usage is subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 595.48
    methanol 736.22
    isopropanol 449.58
    water 2.3
    ethyl acetate 748.82
    n-propanol 570.41
    acetone 1214.53
    n-butanol 493.18
    acetonitrile 920.01
    DMF 2611.2
    toluene 680.46
    isobutanol 422.15
    1,4-dioxane 1430.75
    methyl acetate 867.73
    THF 2054.44
    2-butanone 984.61
    n-pentanol 388.71
    sec-butanol 472.17
    n-hexane 66.36
    ethylene glycol 202.65
    NMP 2735.01
    cyclohexane 334.09
    DMSO 2561.51
    n-butyl acetate 777.51
    n-octanol 282.6
    chloroform 3873.21
    n-propyl acetate 642.5
    acetic acid 1195.53
    dichloromethane 3379.65
    cyclohexanone 2224.88
    propylene glycol 245.02
    isopropyl acetate 499.18
    DMAc 1804.73
    2-ethoxyethanol 614.21
    isopentanol 375.07
    n-heptane 99.73
    ethyl formate 699.92
    1,2-dichloroethane 1949.18
    n-hexanol 413.87
    2-methoxyethanol 974.01
    isobutyl acetate 425.52
    tetrachloromethane 629.05
    n-pentyl acetate 680.34
    transcutol 1197.87
    n-heptanol 256.7
    ethylbenzene 298.54
    MIBK 467.49
    2-propoxyethanol 644.5
    tert-butanol 494.69
    MTBE 552.24
    2-butoxyethanol 454.97
    propionic acid 707.38
    o-xylene 411.61
    formic acid 469.65
    diethyl ether 645.79
    m-xylene 371.14
    p-xylene 378.85
    chlorobenzene 1160.73
    dimethyl carbonate 431.25
    n-octane 50.12
    formamide 716.26
    cyclopentanone 2287.16
    2-pentanone 787.33
    anisole 608.44
    cyclopentyl methyl ether 1085.74
    gamma-butyrolactone 2337.15
    1-methoxy-2-propanol 620.78
    pyridine 1794.91
    3-pentanone 745.04
    furfural 2288.09
    n-dodecane 39.49
    diethylene glycol 505.51
    diisopropyl ether 211.2
    tert-amyl alcohol 466.04
    acetylacetone 957.16
    n-hexadecane 45.96
    acetophenone 727.9
    methyl propionate 705.89
    isopentyl acetate 631.85
    trichloroethylene 3751.38
    n-nonanol 250.03
    cyclohexanol 765.2
    benzyl alcohol 546.74
    2-ethylhexanol 311.96
    isooctanol 216.1
    dipropyl ether 429.61
    1,2-dichlorobenzene 1079.0
    ethyl lactate 296.68
    propylene carbonate 1209.47
    n-methylformamide 1118.72
    2-pentanol 329.68
    n-pentane 101.44
    1-propoxy-2-propanol 514.47
    1-methoxy-2-propyl acetate 661.74
    2-(2-methoxypropoxy) propanol 367.35
    mesitylene 251.39
    ε-caprolactone 1659.99
    p-cymene 253.27
    epichlorohydrin 2168.47
    1,1,1-trichloroethane 1760.18
    2-aminoethanol 358.29
    morpholine-4-carbaldehyde 2174.62
    sulfolane 3026.21
    2,2,4-trimethylpentane 60.87
    2-methyltetrahydrofuran 1454.42
    n-hexyl acetate 699.99
    isooctane 38.82
    2-(2-butoxyethoxy)ethanol 500.04
    sec-butyl acetate 414.05
    tert-butyl acetate 552.28
    decalin 104.96
    glycerin 393.29
    diglyme 1028.87
    acrylic acid 734.88
    isopropyl myristate 260.33
    n-butyric acid 858.95
    acetyl acetate 630.22
    di(2-ethylhexyl) phthalate 281.06
    ethyl propionate 487.99
    nitromethane 2382.13
    1,2-diethoxyethane 656.8
    benzonitrile 1031.42
    trioctyl phosphate 212.02
    1-bromopropane 993.53
    gamma-valerolactone 2958.18
    n-decanol 184.34
    triethyl phosphate 313.85
    4-methyl-2-pentanol 185.34
    propionitrile 796.96
    vinylene carbonate 1361.29
    1,1,2-trichlorotrifluoroethane 1705.22
    DMS 563.65
    cumene 190.13
    2-octanol 224.23
    2-hexanone 605.01
    octyl acetate 333.54
    limonene 410.41
    1,2-dimethoxyethane 1067.29
    ethyl orthosilicate 299.73
    tributyl phosphate 274.77
    diacetone alcohol 512.13
    N,N-dimethylaniline 443.82
    acrylonitrile 1043.17
    aniline 716.84
    1,3-propanediol 464.32
    bromobenzene 1294.66
    dibromomethane 2238.11
    1,1,2,2-tetrachloroethane 2849.34
    2-methyl-cyclohexyl acetate 534.65
    tetrabutyl urea 377.46
    diisobutyl methanol 199.71
    2-phenylethanol 527.06
    styrene 431.52
    dioctyl adipate 397.32
    dimethyl sulfate 815.92
    ethyl butyrate 544.56
    methyl lactate 386.62
    butyl lactate 461.88
    diethyl carbonate 409.75
    propanediol butyl ether 449.56
    triethyl orthoformate 431.94
    p-tert-butyltoluene 238.64
    methyl 4-tert-butylbenzoate 532.95
    morpholine 1622.75
    tert-butylamine 314.51
    n-dodecanol 145.07
    dimethoxymethane 976.04
    ethylene carbonate 1135.38
    cyrene 616.77
    2-ethoxyethyl acetate 759.7
    2-ethylhexyl acetate 581.37
    1,2,4-trichlorobenzene 1230.51
    4-methylpyridine 1640.95
    dibutyl ether 405.67
    2,6-dimethyl-4-heptanol 199.71
    DEF 1105.52
    dimethyl isosorbide 835.9
    tetrachloroethylene 1856.9
    eugenol 501.72
    triacetin 674.55
    span 80 446.07
    1,4-butanediol 243.83
    1,1-dichloroethane 1640.37
    2-methyl-1-pentanol 332.09
    methyl formate 898.95
    2-methyl-1-butanol 408.19
    n-decane 69.37
    butyronitrile 808.07
    3,7-dimethyl-1-octanol 249.02
    1-chlorooctane 290.38
    1-chlorotetradecane 114.13
    n-nonane 68.21
    undecane 49.21
    tert-butylcyclohexane 77.17
    cyclooctane 104.36
    cyclopentanol 803.04
    tetrahydropyran 1548.64
    tert-amyl methyl ether 463.58
    2,5,8-trioxanonane 656.6
    1-hexene 224.75
    2-isopropoxyethanol 422.8
    2,2,2-trifluoroethanol 554.66
    methyl butyrate 682.91

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction