Disodium hydroxyethyliminodiacetate

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  • Identifiers

    CAS number
    135-37-5

    Molecular formula
    C6H9NNa2O5

    SMILES
    C(CO)N(CC(=O)[O-])CC(=O)[O-].[Na+].[Na+]

    Safety labels

    Irritant
    Irritant

    Health Hazard
    Health

  • Odor profile

    Fragrance
    Odorless 61.79%
    Sweet 49.54%
    Savory 24.1%
    Fishy 21.65%
    Alcoholic 19.0%
    Oily 15.97%
    Milky 15.2%
    Buttery 15.06%
    Clean 14.8%
    Fatty 13.91%

     

    Flavor
    Odorless 64.32%
    Mild 31.98%
    Bland 28.75%
    Very mild 25.66%
    Bitter 24.45%
    Sweet-like 23.07%
    Yeast 21.54%
    Faint 20.42%
    Bread crust 19.37%
    Taco 19.19%

     

    Odor impact est.
    Low

  • Properties

    pKa est.
    2.63 (strong acid)

    Molecular weight
    221.12 g/mol

    Flash point

    • 180.77 ˚C est.

  • Synonyms

    • Glycine, N-(carboxymethyl)-N-(2-hydroxyethyl)-, disodium salt
    • Caswell No. 404
    • disodium hydroxyethyliminodiacetate
    • Disodium 2-hydroxyethyliminodi(acetate)
    • VERSENE HEIDA
    • SODIUM HENDINATE
    • EINECS 205-187-4
    • EPA Pesticide Chemical Code 039102
    • Q796430V9N
    • DTXSID8042008
    • EC 205-187-4
    • Glycine, N-(carboxymethyl)-N-(2-hydroxyethyl)-, sodium salt (1:2)
    • VERSENE HEIDA CHELATING AGENT
    • 2-HYDROXYETHYLIMINODIACETIC ACID SODIUM SALT
    • (2-HYDROXYETHYL)IMINODIACETIC ACID DISODIUM SALT
    • N-(2-HYDROXYETHYL)IMINODIACETIC ACID DISODIUM SALT
    • ACETIC ACID, ((2-HYDROXYETHYL)IMINO)DI-, DISODIUM SALT
    • RefChem:589501
    • DTXCID6022008
    • DISODIUM HYDROXYETHYLIMINODIACETATE [INCI]
    • GLYCINE, N-(CARBOXYMETHYL)-N-(2-HYDROXYETHYL)-DISODIUM SALT
    • 135-37-5
    • ethanoldiglycine disodium salt
    • disodium;2-[carboxylatomethyl(2-hydroxyethyl)amino]acetate
    • Disodium N-(2-hydroxyethyl)iminodiacetate
    • UNII-Q796430V9N
    • SCHEMBL382697
    • CHEBI:182027
    • ZTVCAEHRNBOTLI-UHFFFAOYSA-L
    • sodium 2-hydroxyethyliminodiacetate
    • NS00078138
    • Sodium 2,2'-((2-hydroxyethyl)azanediyl)diacetate
    • Disodium 2,2'-[(2-hydroxyethyl)azanediyl]diacetate
    • Q27287081
    • GLYCINE, N-(CARBOXYMETHYL)-N-(2-HYDROXYETHYL)- DISODIUM SALT
    • 135-37-5

  • Applications

    Disodium hydroxyethyliminodiacetate (CAS 135-37-5) is commonly used as a metal-chelating agent to sequester trace metal ions and reduce catalytic side reactions, thereby supporting formulation stability and performance across several industries. In detergents and household cleaners, it helps prevent precipitation and enhances cleaning efficiency; in cosmetics and personal care, it stabilizes formulations and helps preserve color; in industrial cleaning and metal finishing, it mitigates metal-ion-catalyzed degradation and corrosion; in coatings and inks, it improves color stability and shelf life by chelating trace metals; in paper and pulping, it minimizes metal-catalyzed degradation during processing; and in agriculture, it may be used to form micronutrient chelates for fertilizers and foliar sprays. Its role is primarily as a chelating agent or stabilizer, with specific applications governed by formulation needs and local regulations.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 13.38
    methanol 58.72
    isopropanol 3.28
    water 139.74
    ethyl acetate 5.73
    n-propanol 7.09
    acetone 6.36
    n-butanol 3.7
    acetonitrile 4.69
    DMF 257.84
    toluene 0.86
    isobutanol 2.99
    1,4-dioxane 6.16
    methyl acetate 7.7
    THF 13.85
    2-butanone 5.38
    n-pentanol 1.79
    sec-butanol 2.68
    n-hexane 0.09
    ethylene glycol 78.69
    NMP 563.6
    cyclohexane 0.12
    DMSO 221.29
    n-butyl acetate 4.76
    n-octanol 1.81
    chloroform 0.87
    n-propyl acetate 3.31
    acetic acid 70.83
    dichloromethane 2.59
    cyclohexanone 14.03
    propylene glycol 42.83
    isopropyl acetate 2.6
    DMAc 215.67
    2-ethoxyethanol 23.18
    isopentanol 1.96
    n-heptane 0.25
    ethyl formate 11.59
    1,2-dichloroethane 2.75
    n-hexanol 2.91
    2-methoxyethanol 87.91
    isobutyl acetate 1.44
    tetrachloromethane 0.23
    n-pentyl acetate 2.8
    transcutol 58.57
    n-heptanol 2.03
    ethylbenzene 0.55
    MIBK 1.9
    2-propoxyethanol 28.08
    tert-butanol 2.95
    MTBE 0.93
    2-butoxyethanol 11.97
    propionic acid 39.9
    o-xylene 1.67
    formic acid 340.56
    diethyl ether 1.02
    m-xylene 1.18
    p-xylene 0.73
    chlorobenzene 1.13
    dimethyl carbonate 19.38
    n-octane 0.09
    formamide 282.82
    cyclopentanone 26.22
    2-pentanone 3.68
    anisole 2.28
    cyclopentyl methyl ether 5.23
    gamma-butyrolactone 95.88
    1-methoxy-2-propanol 39.19
    pyridine 8.02
    3-pentanone 4.35
    furfural 95.2
    n-dodecane 0.08
    diethylene glycol 62.57
    diisopropyl ether 0.35
    tert-amyl alcohol 2.96
    acetylacetone 9.1
    n-hexadecane 0.08
    acetophenone 7.07
    methyl propionate 17.11
    isopentyl acetate 3.1
    trichloroethylene 4.38
    n-nonanol 1.8
    cyclohexanol 3.82
    benzyl alcohol 5.86
    2-ethylhexanol 1.84
    isooctanol 1.4
    dipropyl ether 1.97
    1,2-dichlorobenzene 2.03
    ethyl lactate 14.12
    propylene carbonate 34.78
    n-methylformamide 140.72
    2-pentanol 1.41
    n-pentane 0.1
    1-propoxy-2-propanol 15.87
    1-methoxy-2-propyl acetate 13.26
    2-(2-methoxypropoxy) propanol 20.61
    mesitylene 0.81
    ε-caprolactone 28.96
    p-cymene 1.14
    epichlorohydrin 22.11
    1,1,1-trichloroethane 0.66
    2-aminoethanol 68.0
    morpholine-4-carbaldehyde 207.7
    sulfolane 214.97
    2,2,4-trimethylpentane 0.08
    2-methyltetrahydrofuran 5.67
    n-hexyl acetate 3.78
    isooctane 0.04
    2-(2-butoxyethoxy)ethanol 23.19
    sec-butyl acetate 1.56
    tert-butyl acetate 2.75
    decalin 0.13
    glycerin 144.06
    diglyme 33.7
    acrylic acid 82.8
    isopropyl myristate 1.47
    n-butyric acid 18.65
    acetyl acetate 4.47
    di(2-ethylhexyl) phthalate 4.76
    ethyl propionate 4.95
    nitromethane 97.04
    1,2-diethoxyethane 3.91
    benzonitrile 4.33
    trioctyl phosphate 3.32
    1-bromopropane 0.67
    gamma-valerolactone 92.36
    n-decanol 1.36
    triethyl phosphate 4.78
    4-methyl-2-pentanol 0.77
    propionitrile 3.72
    vinylene carbonate 37.68
    1,1,2-trichlorotrifluoroethane 63.48
    DMS 12.52
    cumene 0.54
    2-octanol 0.96
    2-hexanone 2.0
    octyl acetate 2.54
    limonene 1.58
    1,2-dimethoxyethane 14.3
    ethyl orthosilicate 3.52
    tributyl phosphate 4.19
    diacetone alcohol 10.63
    N,N-dimethylaniline 3.93
    acrylonitrile 12.83
    aniline 4.39
    1,3-propanediol 35.43
    bromobenzene 0.72
    dibromomethane 1.06
    1,1,2,2-tetrachloroethane 3.56
    2-methyl-cyclohexyl acetate 4.32
    tetrabutyl urea 7.86
    diisobutyl methanol 1.07
    2-phenylethanol 5.7
    styrene 0.58
    dioctyl adipate 4.67
    dimethyl sulfate 77.7
    ethyl butyrate 4.7
    methyl lactate 53.38
    butyl lactate 9.5
    diethyl carbonate 3.86
    propanediol butyl ether 18.62
    triethyl orthoformate 4.12
    p-tert-butyltoluene 1.09
    methyl 4-tert-butylbenzoate 11.92
    morpholine 16.63
    tert-butylamine 1.1
    n-dodecanol 1.02
    dimethoxymethane 30.14
    ethylene carbonate 21.47
    cyrene 46.53
    2-ethoxyethyl acetate 7.51
    2-ethylhexyl acetate 2.51
    1,2,4-trichlorobenzene 3.27
    4-methylpyridine 7.57
    dibutyl ether 1.01
    2,6-dimethyl-4-heptanol 1.07
    DEF 26.92
    dimethyl isosorbide 36.46
    tetrachloroethylene 2.84
    eugenol 14.97
    triacetin 13.22
    span 80 17.89
    1,4-butanediol 12.05
    1,1-dichloroethane 0.75
    2-methyl-1-pentanol 1.24
    methyl formate 79.35
    2-methyl-1-butanol 2.56
    n-decane 0.11
    butyronitrile 2.1
    3,7-dimethyl-1-octanol 1.57
    1-chlorooctane 0.47
    1-chlorotetradecane 0.26
    n-nonane 0.1
    undecane 0.09
    tert-butylcyclohexane 0.1
    cyclooctane 0.09
    cyclopentanol 6.98
    tetrahydropyran 2.27
    tert-amyl methyl ether 1.52
    2,5,8-trioxanonane 30.23
    1-hexene 0.26
    2-isopropoxyethanol 8.24
    2,2,2-trifluoroethanol 54.05
    methyl butyrate 6.75

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction