Disodium Glycyrrhizate

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  • Identifiers

    CAS number
    71277-79-7

    Molecular formula
    C42H59Na2O16-

    SMILES
    C[C@]12CC[C@](C[C@H]1C3=CC(=O)[C@@H]4[C@]5(CC[C@@H](C([C@@H]5CC[C@]4([C@@]3(CC2)C)C)(C)C)O[C@@H]6[C@@H]([C@H]([C@@H]([C@H](O6)C(=O)[O-])O)O)O[C@H]7[C@@H]([C@H]([C@@H]([C@H](O7)C(=O)[O-])O)O)O)C)(C)C(=O)[O-].[Na+].[Na+]

    Safety labels

  • Odor profile

    Fragrance
    Odorless 52.76%
    Woody 40.87%
    Spicy 35.25%
    Dry 26.57%
    Cooling 25.95%
    Amber 25.76%
    Balsamic 23.76%
    Cedar 22.68%
    Warm 21.25%
    Sweet 20.7%

     

    Flavor
    Bitter 77.2%
    Odorless 28.43%
    Bland 26.52%
    Sweet-like 23.86%
    Cedarleaf 22.5%
    Ripe apricot 20.6%
    Red fruit 20.24%
    Parsley 20.07%
    Patchouli 19.68%
    Leaves 19.62%

     

    Odor impact est.
    Odorless

  • Properties

    pKa est.
    -0.91 (strong acid)

    Molecular weight
    865.9 g/mol

    Flash point

    • 248.29 ˚C est.

  • Synonyms

    • 71277-79-7
    • Disodium glycyrrhizin
    • Disodium glycyrrhizate
    • UNII-L8Q0US0J7V
    • L8Q0US0J7V
    • CCRIS 1966
    • Glycyrrhizinic acid disodium salt
    • DISODIUM GLYCYRRHIZATE [WHO-DD]
    • alpha-D-Glucopyranosiduronic acid, (3-beta,20-beta)-20-carboxy-11-oxo-30-norolean-12-en-3-yl-2-O-beta-D-glucopyranuronosyl-, disodium salt
    • RefChem:200673
    • DISODIUM GLYCYRRHIZATE [INCI]
    • Disodium glycyrrhizinate
    • disodium;(2S,3S,4S,5R,6R)-6-[(2S,3R,4S,5S,6S)-2-[[(3S,4aR,6aR,6bS,8aS,11S,12aR,14aR,14bS)-11-carboxylato-4,4,6a,6b,8a,11,14b-heptamethyl-14-oxo-2,3,4a,5,6,7,8,9,10,12,12a,14a-dodecahydro-1H-picen-3-yl]oxy]-6-carboxylato-4,5-dihydroxyoxan-3-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylate
    • Glycyrrhizinate, disodium
    • Q27282842
    • 71277-79-7

  • Applications

    Disodium Glycyrrhizate (CAS 71277-79-7) is used as a functional additive across several industries: in cosmetics and personal care as a mild surfactant and skin-conditioning agent with soothing and anti-irritant properties; in household cleaning products as a surfactant and emulsifier to improve wetting and dispersion; in industrial manufacturing, coatings, inks and adhesives as a dispersing aid and wetting and stabilizing additive to enhance formulation compatibility; in pharmaceuticals as an excipient, solubilizer and formulation aid; and in specialty formulations where licorice-derived components contribute to texture or compatibility, subject to local regulations.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 3.42
    methanol 23.05
    isopropanol 1.2
    water 0.07
    ethyl acetate 2.65
    n-propanol 1.83
    acetone 10.08
    n-butanol 0.65
    acetonitrile 2.6
    DMF 95.28
    toluene 0.95
    isobutanol 0.67
    1,4-dioxane 13.74
    methyl acetate 4.71
    THF 28.57
    2-butanone 3.99
    n-pentanol 0.63
    sec-butanol 0.56
    n-hexane 0.03
    ethylene glycol 7.38
    NMP 68.62
    cyclohexane 0.05
    DMSO 76.77
    n-butyl acetate 0.92
    n-octanol 0.51
    chloroform 5.37
    n-propyl acetate 1.37
    acetic acid 39.85
    dichloromethane 5.43
    cyclohexanone 4.22
    propylene glycol 6.31
    isopropyl acetate 1.52
    DMAc 57.96
    2-ethoxyethanol 10.23
    isopentanol 0.35
    n-heptane 0.04
    ethyl formate 2.87
    1,2-dichloroethane 2.7
    n-hexanol 0.45
    2-methoxyethanol 25.13
    isobutyl acetate 0.63
    tetrachloromethane 0.58
    n-pentyl acetate 1.35
    transcutol 15.25
    n-heptanol 0.57
    ethylbenzene 0.3
    MIBK 1.22
    2-propoxyethanol 10.34
    tert-butanol 0.81
    MTBE 0.68
    2-butoxyethanol 4.79
    propionic acid 4.4
    o-xylene 0.56
    formic acid 39.76
    diethyl ether 1.19
    m-xylene 0.58
    p-xylene 0.42
    chlorobenzene 0.96
    dimethyl carbonate 10.66
    n-octane 0.02
    formamide 34.33
    cyclopentanone 15.99
    2-pentanone 2.31
    anisole 1.73
    cyclopentyl methyl ether 3.26
    gamma-butyrolactone 26.37
    1-methoxy-2-propanol 13.77
    pyridine 8.29
    3-pentanone 2.13
    furfural 21.76
    n-dodecane 0.02
    diethylene glycol 16.65
    diisopropyl ether 0.21
    tert-amyl alcohol 0.51
    acetylacetone 10.38
    n-hexadecane 0.02
    acetophenone 2.69
    methyl propionate 5.32
    isopentyl acetate 0.63
    trichloroethylene 9.81
    n-nonanol 0.53
    cyclohexanol 0.51
    benzyl alcohol 2.12
    2-ethylhexanol 0.19
    isooctanol 0.36
    dipropyl ether 0.77
    1,2-dichlorobenzene 1.0
    ethyl lactate 2.39
    propylene carbonate 6.33
    n-methylformamide 32.26
    2-pentanol 0.31
    n-pentane 0.03
    1-propoxy-2-propanol 4.61
    1-methoxy-2-propyl acetate 4.41
    2-(2-methoxypropoxy) propanol 3.75
    mesitylene 0.29
    ε-caprolactone 4.65
    p-cymene 0.18
    epichlorohydrin 19.92
    1,1,1-trichloroethane 1.56
    2-aminoethanol 6.74
    morpholine-4-carbaldehyde 57.59
    sulfolane 51.25
    2,2,4-trimethylpentane 0.01
    2-methyltetrahydrofuran 3.67
    n-hexyl acetate 1.44
    isooctane 0.01
    2-(2-butoxyethoxy)ethanol 5.84
    sec-butyl acetate 0.62
    tert-butyl acetate 1.75
    decalin 0.03
    glycerin 18.1
    diglyme 13.16
    acrylic acid 11.26
    isopropyl myristate 0.34
    n-butyric acid 2.55
    acetyl acetate 4.16
    di(2-ethylhexyl) phthalate 0.78
    ethyl propionate 1.37
    nitromethane 65.25
    1,2-diethoxyethane 2.5
    benzonitrile 1.4
    trioctyl phosphate 0.46
    1-bromopropane 0.54
    gamma-valerolactone 37.58
    n-decanol 0.3
    triethyl phosphate 0.59
    4-methyl-2-pentanol 0.19
    propionitrile 1.33
    vinylene carbonate 7.75
    1,1,2-trichlorotrifluoroethane 32.32
    DMS 3.37
    cumene 0.18
    2-octanol 0.29
    2-hexanone 1.24
    octyl acetate 0.69
    limonene 0.21
    1,2-dimethoxyethane 12.19
    ethyl orthosilicate 0.52
    tributyl phosphate 0.41
    diacetone alcohol 4.35
    N,N-dimethylaniline 1.55
    acrylonitrile 4.09
    aniline 1.58
    1,3-propanediol 4.88
    bromobenzene 0.88
    dibromomethane 1.97
    1,1,2,2-tetrachloroethane 6.44
    2-methyl-cyclohexyl acetate 0.75
    tetrabutyl urea 0.95
    diisobutyl methanol 0.13
    2-phenylethanol 1.59
    styrene 0.4
    dioctyl adipate 0.92
    dimethyl sulfate 25.96
    ethyl butyrate 0.84
    methyl lactate 9.67
    butyl lactate 1.98
    diethyl carbonate 0.59
    propanediol butyl ether 6.1
    triethyl orthoformate 0.93
    p-tert-butyltoluene 0.21
    methyl 4-tert-butylbenzoate 3.3
    morpholine 13.87
    tert-butylamine 0.21
    n-dodecanol 0.18
    dimethoxymethane 37.43
    ethylene carbonate 4.18
    cyrene 11.52
    2-ethoxyethyl acetate 4.38
    2-ethylhexyl acetate 0.44
    1,2,4-trichlorobenzene 1.77
    4-methylpyridine 3.74
    dibutyl ether 0.35
    2,6-dimethyl-4-heptanol 0.13
    DEF 5.13
    dimethyl isosorbide 9.66
    tetrachloroethylene 4.62
    eugenol 3.45
    triacetin 4.35
    span 80 3.84
    1,4-butanediol 2.26
    1,1-dichloroethane 1.54
    2-methyl-1-pentanol 0.31
    methyl formate 31.06
    2-methyl-1-butanol 0.36
    n-decane 0.03
    butyronitrile 0.65
    3,7-dimethyl-1-octanol 0.27
    1-chlorooctane 0.17
    1-chlorotetradecane 0.05
    n-nonane 0.03
    undecane 0.02
    tert-butylcyclohexane 0.02
    cyclooctane 0.03
    cyclopentanol 1.58
    tetrahydropyran 2.74
    tert-amyl methyl ether 0.58
    2,5,8-trioxanonane 7.83
    1-hexene 0.12
    2-isopropoxyethanol 4.05
    2,2,2-trifluoroethanol 12.72
    methyl butyrate 1.71

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction