Disodium 5'-guanylate

Overview IFRA Request a quote

  • Identifiers

    CAS number
    5550-12-9

    Molecular formula
    C10H12N5Na2O8P

    SMILES
    C1=NC2=C(N1[C@H]3[C@@H]([C@@H]([C@H](O3)COP(=O)([O-])[O-])O)O)N=C(NC2=O)N.[Na+].[Na+]

  • Odor profile

    Fragrance
    Odorless 90.86%
    Savory 18.51%
    Bitter 16.98%
    Milky 14.96%
    Cooling 14.63%
    Cooked 14.35%
    Clean 12.5%
    Sweet 11.67%
    Meaty 10.09%
    Dairy 9.85%

     

    Flavor
    Bitter 60.17%
    Odorless 59.38%
    Bland 31.71%
    Very mild 25.39%
    Mild 25.27%
    Sweet-like 23.49%
    Yeast 19.87%
    Nitrile 19.04%
    Bread crust 18.71%
    Scallion 18.56%

     

    Odor impact est.
    Low

  • Properties

    pKa est.
    5.26 (weak acid)

    Molecular weight
    407.18 g/mol

    Flash point

    • 390.92 ˚C est.

    Solubility expt.

    • Soluble in water, sparingly soluble in ethanol, practically insoluble in ether

  • Synonyms

    • Guanosine 5'-monophosphate disodium salt
    • 5550-12-9
    • Disodium guanylate
    • DISODIUM 5'-GUANYLATE
    • 5'-Guanylic acid disodium salt
    • Sodium guanylate
    • 5'-Guanylic acid, disodium salt
    • Disodium GMP
    • Disodium 5'-gmp
    • GMP disodium salt
    • Disodium guanosine-5'-monophosphate
    • Sodium 5'-guanylate
    • 5'-Gmp disodium salt
    • Disodium guanosine 5'-monophosphate
    • 5-Guanylic acid disodium salt
    • FEMA No. 3668
    • Sodium guanosine 5'-monophosphate
    • Guanosine 5'-phosphate disodium salt
    • 5'-GMP-Na2
    • GUANYLIC ACID DISODIUM
    • INS NO.627
    • DISODIUM GUANYLATE [FCC]
    • DTXSID9044245
    • CHEBI:132932
    • INS-627
    • ANHYDROUS DISODIUM GUANYLATE
    • B768T44Q8V
    • disodium 5'-O-phosphonatoguanosine
    • DISODIUM GUANYLATE [MART.]
    • DISODIUM GUANYLATE [USP-RS]
    • DISODIUM GUANYLATE [WHO-DD]
    • Guanosine 5'-monophosphate, disodium salt
    • NSC-20265
    • DISODIUM 5'-GUANYLATE [FHFI]
    • Sodium ((2R,3S,4R,5R)-5-(2-amino-6-oxo-1H-purin-9(6H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl phosphate
    • 5'-Guanylic acid, sodium salt (1:2)
    • Guanosine-5'-monophosphate disodium salt
    • E627
    • GMP sodium salt
    • Guanosine 5'-monophosphate disodium salt hydrate
    • Sodium GMP
    • E 627
    • E-627
    • Guanylic acid sodium salt
    • DISODIUM GUANYLATE (MART.)
    • DISODIUM GUANYLATE (USP-RS)
    • Guanosine 5'MP, disodium salt
    • disodium;[(2R,3S,4R,5R)-5-(2-amino-6-oxo-1H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl phosphate
    • disodium;[(2R,3S,4R,5R)-5-(2-amino-6-oxo-3H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl phosphate
    • Disodium 5'-guanylate (VAN)
    • CCRIS 6561
    • MFCD00070575
    • EINECS 226-914-1
    • NSC 20265
    • disodium 5'--guanylate
    • GMP sodium salt hydrate
    • 5'-GMP 2Na hydrate
    • GMP disodium salt hydrate
    • 5'-GMP 2Na
    • Disodium 5'-guanylate hydrate
    • UNII-B768T44Q8V
    • SCHEMBL1072983
    • DTXCID7024245
    • SCHEMBL20266271
    • DISODIUM GUANYLATE [INCI]
    • PVBRXXAAPNGWGE-LGVAUZIVSA-L
    • Guanosine-5'phosphate disodium salt
    • Sodium guanylateSodium 5'-guanylate
    • HG1319
    • MFCD00151239
    • AKOS015896908
    • AKOS024282560
    • 5'-Guanylic acid disodium salt hydrate
    • Guanosine-5'-monophosphate sodium salt
    • [(3S,2R,4R,5R)-5-(2-amino-6-oxohydropurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methy l dihydrogen phosphate, sodium salt, sodium salt
    • AS-13243
    • G0172
    • NS00074168
    • GUANOSINE-5'-MONOPHOSPHATE, DISODIUM SALT
    • Q905776
    • Guanosine 5 inverted exclamation marka-monophosphate disodium salt hydrate
    • 226-914-1

  • Applications

    Disodium 5'-guanylate is commonly used as a flavor enhancer (umami) in processed foods and seasoning blends; typical applications include addition to processed meat and poultry products, soups and sauces, ready-to-eat meals and snack formulations, and base broths or bouillon and seasoning powders; it is often used in combination with monosodium glutamate (MSG) or disodium inosinate to optimize umami at lower levels.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 0.2
    methanol 0.56
    isopropanol 0.14
    water 3.43
    ethyl acetate 0.02
    n-propanol 0.22
    acetone 0.05
    n-butanol 0.15
    acetonitrile 0.09
    DMF 3.69
    toluene 0.01
    isobutanol 0.1
    1,4-dioxane 0.11
    methyl acetate 0.06
    THF 0.25
    2-butanone 0.12
    n-pentanol 0.07
    sec-butanol 0.16
    n-hexane 0.0
    ethylene glycol 2.29
    NMP 11.63
    cyclohexane 0.01
    DMSO 8.53
    n-butyl acetate 0.07
    n-octanol 0.07
    chloroform 0.01
    n-propyl acetate 0.03
    acetic acid 0.95
    dichloromethane 0.02
    cyclohexanone 0.23
    propylene glycol 2.01
    isopropyl acetate 0.01
    DMAc 4.67
    2-ethoxyethanol 0.95
    isopentanol 0.08
    n-heptane 0.02
    ethyl formate 0.1
    1,2-dichloroethane 0.02
    n-hexanol 0.09
    2-methoxyethanol 3.54
    isobutyl acetate 0.01
    tetrachloromethane 0.01
    n-pentyl acetate 0.05
    transcutol 0.84
    n-heptanol 0.13
    ethylbenzene 0.0
    MIBK 0.02
    2-propoxyethanol 1.05
    tert-butanol 0.09
    MTBE 0.01
    2-butoxyethanol 0.84
    propionic acid 0.44
    o-xylene 0.01
    formic acid 12.82
    diethyl ether 0.03
    m-xylene 0.0
    p-xylene 0.01
    chlorobenzene 0.0
    dimethyl carbonate 0.13
    n-octane 0.01
    formamide 11.86
    cyclopentanone 0.4
    2-pentanone 0.05
    anisole 0.01
    cyclopentyl methyl ether 0.07
    gamma-butyrolactone 0.56
    1-methoxy-2-propanol 1.5
    pyridine 0.13
    3-pentanone 0.07
    furfural 1.04
    n-dodecane 0.0
    diethylene glycol 3.13
    diisopropyl ether 0.01
    tert-amyl alcohol 0.11
    acetylacetone 0.04
    n-hexadecane 0.0
    acetophenone 0.04
    methyl propionate 0.08
    isopentyl acetate 0.04
    trichloroethylene 0.02
    n-nonanol 0.07
    cyclohexanol 0.12
    benzyl alcohol 0.04
    2-ethylhexanol 0.05
    isooctanol 0.06
    dipropyl ether 0.09
    1,2-dichlorobenzene 0.0
    ethyl lactate 0.26
    propylene carbonate 0.16
    n-methylformamide 2.2
    2-pentanol 0.07
    n-pentane 0.01
    1-propoxy-2-propanol 0.65
    1-methoxy-2-propyl acetate 0.11
    2-(2-methoxypropoxy) propanol 0.56
    mesitylene 0.0
    ε-caprolactone 0.21
    p-cymene 0.01
    epichlorohydrin 0.14
    1,1,1-trichloroethane 0.0
    2-aminoethanol 1.86
    morpholine-4-carbaldehyde 3.3
    sulfolane 3.75
    2,2,4-trimethylpentane 0.0
    2-methyltetrahydrofuran 0.1
    n-hexyl acetate 0.04
    isooctane 0.0
    2-(2-butoxyethoxy)ethanol 0.79
    sec-butyl acetate 0.01
    tert-butyl acetate 0.01
    decalin 0.0
    glycerin 11.23
    diglyme 1.26
    acrylic acid 0.9
    isopropyl myristate 0.02
    n-butyric acid 0.2
    acetyl acetate 0.01
    di(2-ethylhexyl) phthalate 0.05
    ethyl propionate 0.03
    nitromethane 1.19
    1,2-diethoxyethane 0.07
    benzonitrile 0.03
    trioctyl phosphate 0.06
    1-bromopropane 0.01
    gamma-valerolactone 1.26
    n-decanol 0.05
    triethyl phosphate 0.09
    4-methyl-2-pentanol 0.02
    propionitrile 0.09
    vinylene carbonate 0.14
    1,1,2-trichlorotrifluoroethane 1.66
    DMS 0.05
    cumene 0.0
    2-octanol 0.06
    2-hexanone 0.05
    octyl acetate 0.04
    limonene 0.02
    1,2-dimethoxyethane 0.66
    ethyl orthosilicate 0.07
    tributyl phosphate 0.05
    diacetone alcohol 0.18
    N,N-dimethylaniline 0.02
    acrylonitrile 0.17
    aniline 0.03
    1,3-propanediol 1.5
    bromobenzene 0.0
    dibromomethane 0.01
    1,1,2,2-tetrachloroethane 0.03
    2-methyl-cyclohexyl acetate 0.05
    tetrabutyl urea 0.18
    diisobutyl methanol 0.02
    2-phenylethanol 0.06
    styrene 0.0
    dioctyl adipate 0.04
    dimethyl sulfate 0.55
    ethyl butyrate 0.06
    methyl lactate 0.84
    butyl lactate 0.3
    diethyl carbonate 0.05
    propanediol butyl ether 0.88
    triethyl orthoformate 0.1
    p-tert-butyltoluene 0.01
    methyl 4-tert-butylbenzoate 0.13
    morpholine 0.31
    tert-butylamine 0.03
    n-dodecanol 0.04
    dimethoxymethane 0.49
    ethylene carbonate 0.09
    cyrene 1.17
    2-ethoxyethyl acetate 0.08
    2-ethylhexyl acetate 0.04
    1,2,4-trichlorobenzene 0.01
    4-methylpyridine 0.05
    dibutyl ether 0.04
    2,6-dimethyl-4-heptanol 0.02
    DEF 0.32
    dimethyl isosorbide 0.7
    tetrachloroethylene 0.03
    eugenol 0.28
    triacetin 0.08
    span 80 0.37
    1,4-butanediol 0.52
    1,1-dichloroethane 0.01
    2-methyl-1-pentanol 0.04
    methyl formate 0.83
    2-methyl-1-butanol 0.11
    n-decane 0.01
    butyronitrile 0.05
    3,7-dimethyl-1-octanol 0.03
    1-chlorooctane 0.01
    1-chlorotetradecane 0.01
    n-nonane 0.01
    undecane 0.01
    tert-butylcyclohexane 0.0
    cyclooctane 0.0
    cyclopentanol 0.27
    tetrahydropyran 0.07
    tert-amyl methyl ether 0.03
    2,5,8-trioxanonane 0.96
    1-hexene 0.01
    2-isopropoxyethanol 0.25
    2,2,2-trifluoroethanol 1.25
    methyl butyrate 0.07

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction