Dipotassium Glycyrrhizinate

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  • Identifiers

    CAS number
    68797-35-3

    Molecular formula
    C42H60K2O16

    SMILES
    C[C@]12CC[C@](C[C@H]1C3=CC(=O)[C@@H]4[C@]5(CC[C@@H](C([C@@H]5CC[C@]4([C@@]3(CC2)C)C)(C)C)O[C@@H]6[C@@H]([C@H]([C@@H]([C@H](O6)C(=O)[O-])O)O)O[C@H]7[C@@H]([C@H]([C@@H]([C@H](O7)C(=O)[O-])O)O)O)C)(C)C(=O)O.[K+].[K+]

    Safety labels

  • Odor profile

    Fragrance
    Odorless 53.13%
    Woody 39.01%
    Spicy 36.64%
    Dry 26.13%
    Cooling 25.76%
    Amber 24.85%
    Balsamic 23.64%
    Cedar 22.21%
    Warm 21.06%
    Mint 20.34%

     

    Flavor
    Bitter 74.96%
    Odorless 29.2%
    Bland 26.32%
    Sweet-like 24.18%
    Cedarleaf 22.42%
    Ripe apricot 20.74%
    Red fruit 20.33%
    Parsley 20.15%
    Patchouli 19.88%
    Leaves 19.81%

     

    Odor impact est.
    Odorless

  • Properties

    pKa est.
    -0.19 (strong acid)

    Molecular weight
    899.1 g/mol

    Flash point

    • 254.28 ˚C est.

  • Synonyms

    • Dipotassium glycyrrhizinate
    • 68797-35-3
    • Glycyrrhizinate dipotassium
    • Glycyrrhizic acid dipotassium
    • CA2Y0FE3FX
    • dipotassium;(2S,3S,4S,5R,6R)-6-((2S,3R,4S,5S,6S)-2-(((3S,4aR,6aR,6bS,8aS,11S,12aR,14aR,14bS)-11-carboxy-4,4,6a,6b,8a,11,14b-heptamethyl-14-oxo-2,3,4a,5,6,7,8,9,10,12,12a,14a-dodecahydro-1H-picen-3-yl)oxy)-6-carboxylato-4,5-dihydroxyoxan-3-yl)oxy-3,4,5-trihydroxyoxane-2-carboxylate
    • dipotassium;(2S,3S,4S,5R,6R)-6-[(2S,3R,4S,5S,6S)-2-[[(3S,4aR,6aR,6bS,8aS,11S,12aR,14aR,14bS)-11-carboxy-4,4,6a,6b,8a,11,14b-heptamethyl-14-oxo-2,3,4a,5,6,7,8,9,10,12,12a,14a-dodecahydro-1H-picen-3-yl]oxy]-6-carboxylato-4,5-dihydroxyoxan-3-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylate
    • RefChem:37953
    • MELAO AFTER SHAVE COLOGNE
    • GLYCYRRHIZINATE DIPOTASSIUM 0.5%
    • alpha-D-Glucopyranosiduronic acid, (3beta,20beta)-20-carboxy-11-oxo-30-norolean-12-en-3-yl 2-O-beta-D-glucopyranuronosyl-, dipotassium salt
    • THE SKIN HOUSE EGF COLLAGEN AMPOULE
    • Hydrolyzed Collagen (GLYCYRRHIZINATE DIPOTASSIUM)
    • 272-296-1
    • alpha-D-Glucopyranosiduronic acid, (3beta,20beta)-20-carboxy-11-oxo-30-norolean-12-en-3-yl 2-O-beta-D-glucopyranuronosyl-, potassium salt (1:2)
    • Dipotassium glycyrrhizate
    • Dipotassium glycyrrhizinate (JAN)
    • C42H60K2O16
    • Neubormitin (TN)
    • Glycyrrhizin Dipotassium Salt
    • orb1301604
    • SCHEMBL2390606
    • CHEMBL1923952
    • CHEBI:79402
    • BIVBRWYINDPWKA-VLQRKCJKSA-L
    • DTXSID501015077
    • Glycyrrhizic Acid Dipotassium Salt
    • MSK40377
    • Glycyrrhizicaciddipotassiumsalt,hydrate
    • AKOS037515318
    • CCG-270565
    • .alpha.-D-Glucopyranosiduronic acid, (3.beta.,20.beta.)-20-carboxy-11-oxo-30-norolean-12-en-3-yl 2-O-.beta.-D-glucopyranuronosyl-, dipotassium salt
    • 18beta-Glycyrrhizic acid dipotassium salt
    • FD166891
    • G0270
    • D02264
    • F17684
    • Q11300469
    • .alpha.-D-Glucopyranosiduronicacid,(3.beta.,20.beta.),20-carboxy-11-oxo-30-norlean
    • Dipotassium (3beta,20beta)-20-carboxy-11-oxo-30-norlean-12-en-3-yl-2-O-beta-D-gucopyranuronosyl-alpha-D-glucopyranosiduronate
    • dipotassium;(2S,3S,4S,5R,6R)-6-[(2S,3R,4S,5S,6S)-2-[[(3S,4aR,6aR,6bS,8aS,11S,12aR,14aR,14bS)-11-carboxy-4,4,6a,6b,8a,11,14b-heptamethyl-14-oxo-2,3,4a,5,6,7,8,9,10,12,12a,14a-dodecahydro-1H-picen-3-yl]oxy]-6-carboxylato-4,5-dihydroxy-tetrahydropyran-3-yl]oxy-3,4,5-trihydroxy-tetrahydropyran-2-carboxylate
    • potassium (2S,3S,4S,5R,6S)-6-(((3S,4aR,6aR,6bS,8aS,11S,12aR,14aR,14bS)-11-carboxy-4,4,6a,6b,8a,11,14b-heptamethyl-14-oxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,14,14a,14b-icosahydropicen-3-yl)oxy)-5-(((2R,3R,4S,5S,6S)-6-carboxylato-3,4,5-trihydroxytet
    • 68797-35-3

  • Applications

    Dipotassium Glycyrrhizinate is commonly used in cosmetics and personal care as a soothing, anti-irritant skin conditioning agent; in topical pharmaceutical formulations it may serve as an excipient or active ingredient with soothing properties; in the food and flavor industry it may be utilized as a water-soluble licorice flavoring and/or sweetener, depending on formulation and regulatory considerations.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 3.17
    methanol 21.74
    isopropanol 1.11
    water 0.06
    ethyl acetate 2.39
    n-propanol 1.71
    acetone 9.34
    n-butanol 0.6
    acetonitrile 2.33
    DMF 89.11
    toluene 0.84
    isobutanol 0.62
    1,4-dioxane 12.81
    methyl acetate 4.23
    THF 27.01
    2-butanone 3.72
    n-pentanol 0.59
    sec-butanol 0.52
    n-hexane 0.03
    ethylene glycol 6.81
    NMP 61.58
    cyclohexane 0.05
    DMSO 72.8
    n-butyl acetate 0.82
    n-octanol 0.48
    chloroform 4.56
    n-propyl acetate 1.25
    acetic acid 35.41
    dichloromethane 4.6
    cyclohexanone 3.79
    propylene glycol 5.92
    isopropyl acetate 1.36
    DMAc 53.99
    2-ethoxyethanol 9.49
    isopentanol 0.33
    n-heptane 0.03
    ethyl formate 2.59
    1,2-dichloroethane 2.35
    n-hexanol 0.42
    2-methoxyethanol 23.78
    isobutyl acetate 0.57
    tetrachloromethane 0.49
    n-pentyl acetate 1.23
    transcutol 14.21
    n-heptanol 0.53
    ethylbenzene 0.26
    MIBK 1.1
    2-propoxyethanol 9.68
    tert-butanol 0.76
    MTBE 0.63
    2-butoxyethanol 4.51
    propionic acid 3.9
    o-xylene 0.49
    formic acid 36.19
    diethyl ether 1.11
    m-xylene 0.51
    p-xylene 0.37
    chlorobenzene 0.8
    dimethyl carbonate 9.55
    n-octane 0.02
    formamide 31.37
    cyclopentanone 14.41
    2-pentanone 2.12
    anisole 1.54
    cyclopentyl methyl ether 2.98
    gamma-butyrolactone 23.58
    1-methoxy-2-propanol 12.96
    pyridine 7.34
    3-pentanone 1.96
    furfural 19.41
    n-dodecane 0.01
    diethylene glycol 15.51
    diisopropyl ether 0.19
    tert-amyl alcohol 0.47
    acetylacetone 9.52
    n-hexadecane 0.02
    acetophenone 2.4
    methyl propionate 4.82
    isopentyl acetate 0.57
    trichloroethylene 8.39
    n-nonanol 0.48
    cyclohexanol 0.46
    benzyl alcohol 1.9
    2-ethylhexanol 0.17
    isooctanol 0.33
    dipropyl ether 0.71
    1,2-dichlorobenzene 0.85
    ethyl lactate 2.17
    propylene carbonate 5.51
    n-methylformamide 29.33
    2-pentanol 0.28
    n-pentane 0.03
    1-propoxy-2-propanol 4.33
    1-methoxy-2-propyl acetate 4.01
    2-(2-methoxypropoxy) propanol 3.51
    mesitylene 0.26
    ε-caprolactone 4.13
    p-cymene 0.16
    epichlorohydrin 17.96
    1,1,1-trichloroethane 1.33
    2-aminoethanol 6.26
    morpholine-4-carbaldehyde 53.13
    sulfolane 46.46
    2,2,4-trimethylpentane 0.01
    2-methyltetrahydrofuran 3.39
    n-hexyl acetate 1.3
    isooctane 0.01
    2-(2-butoxyethoxy)ethanol 5.49
    sec-butyl acetate 0.56
    tert-butyl acetate 1.59
    decalin 0.02
    glycerin 17.04
    diglyme 12.42
    acrylic acid 9.9
    isopropyl myristate 0.3
    n-butyric acid 2.26
    acetyl acetate 3.61
    di(2-ethylhexyl) phthalate 0.69
    ethyl propionate 1.25
    nitromethane 59.13
    1,2-diethoxyethane 2.29
    benzonitrile 1.21
    trioctyl phosphate 0.41
    1-bromopropane 0.47
    gamma-valerolactone 34.21
    n-decanol 0.28
    triethyl phosphate 0.52
    4-methyl-2-pentanol 0.18
    propionitrile 1.18
    vinylene carbonate 6.7
    1,1,2-trichlorotrifluoroethane 29.4
    DMS 3.0
    cumene 0.16
    2-octanol 0.27
    2-hexanone 1.14
    octyl acetate 0.63
    limonene 0.19
    1,2-dimethoxyethane 11.52
    ethyl orthosilicate 0.46
    tributyl phosphate 0.37
    diacetone alcohol 4.0
    N,N-dimethylaniline 1.4
    acrylonitrile 3.61
    aniline 1.41
    1,3-propanediol 4.46
    bromobenzene 0.73
    dibromomethane 1.65
    1,1,2,2-tetrachloroethane 5.6
    2-methyl-cyclohexyl acetate 0.66
    tetrabutyl urea 0.86
    diisobutyl methanol 0.12
    2-phenylethanol 1.42
    styrene 0.35
    dioctyl adipate 0.83
    dimethyl sulfate 23.33
    ethyl butyrate 0.76
    methyl lactate 8.79
    butyl lactate 1.8
    diethyl carbonate 0.52
    propanediol butyl ether 5.78
    triethyl orthoformate 0.84
    p-tert-butyltoluene 0.18
    methyl 4-tert-butylbenzoate 2.97
    morpholine 12.91
    tert-butylamine 0.2
    n-dodecanol 0.16
    dimethoxymethane 35.23
    ethylene carbonate 3.6
    cyrene 10.58
    2-ethoxyethyl acetate 3.99
    2-ethylhexyl acetate 0.39
    1,2,4-trichlorobenzene 1.48
    4-methylpyridine 3.31
    dibutyl ether 0.33
    2,6-dimethyl-4-heptanol 0.12
    DEF 4.64
    dimethyl isosorbide 8.81
    tetrachloroethylene 4.0
    eugenol 3.16
    triacetin 3.91
    span 80 3.52
    1,4-butanediol 2.08
    1,1-dichloroethane 1.32
    2-methyl-1-pentanol 0.28
    methyl formate 28.42
    2-methyl-1-butanol 0.33
    n-decane 0.03
    butyronitrile 0.58
    3,7-dimethyl-1-octanol 0.24
    1-chlorooctane 0.16
    1-chlorotetradecane 0.05
    n-nonane 0.03
    undecane 0.02
    tert-butylcyclohexane 0.02
    cyclooctane 0.03
    cyclopentanol 1.45
    tetrahydropyran 2.51
    tert-amyl methyl ether 0.53
    2,5,8-trioxanonane 7.35
    1-hexene 0.11
    2-isopropoxyethanol 3.75
    2,2,2-trifluoroethanol 11.1
    methyl butyrate 1.57

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction