Dipotassium 5'-guanylate

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  • Identifiers

    CAS number
    3254-39-5

    Molecular formula
    C10H12K2N5O8P

    SMILES
    C1=NC2=C(N1[C@H]3[C@@H]([C@@H]([C@H](O3)COP(=O)([O-])[O-])O)O)N=C(NC2=O)N.[K+].[K+]

  • Odor profile

    Fragrance
    Odorless 90.86%
    Savory 18.51%
    Bitter 16.98%
    Milky 14.96%
    Cooling 14.63%
    Cooked 14.35%
    Clean 12.5%
    Sweet 11.67%
    Meaty 10.09%
    Dairy 9.85%

     

    Flavor
    Bitter 60.17%
    Odorless 59.38%
    Bland 31.71%
    Very mild 25.39%
    Mild 25.27%
    Sweet-like 23.49%
    Yeast 19.87%
    Nitrile 19.04%
    Bread crust 18.71%
    Scallion 18.56%

     

    Odor impact est.
    Low

  • Properties

    pKa est.
    5.26 (weak acid)

    Molecular weight
    439.4 g/mol

    Flash point

    • 390.92 ˚C est.

    Solubility expt.

    • Freely soluble in water, practically insoluble in ethanol

  • Synonyms

    • Dipotassium 5'-guanylate
    • 3254-39-5
    • Dipotassium guanylate
    • 5'-Guanylic acid, dipotassium salt
    • UNII-R87C8160YV
    • R87C8160YV
    • potassium guanylate
    • EINECS 221-849-5
    • POTASSIUM 5'-GUANYLATE
    • INS NO.628
    • INS NO. 628
    • INS-628
    • E-628
    • DIPOTASSIUM GUANOSINE-5'-MONOPHOSPHATE
    • GUANOSINE 5'-MONOPHOSPHATE DIPOTASSIUM SALT
    • dipotassium;[(2R,3S,4R,5R)-5-(2-amino-6-oxo-1H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl phosphate
    • E628
    • SCHEMBL3802708
    • DTXSID80954279
    • 5'-Guanylic acid,dipotassium salt
    • Potassium guanylatePotassium 5'-guanylate
    • 5'-GUANYLIC ACID, POTASSIUM SALT (1:2)
    • Q5280047
    • 221-849-5

  • Applications

    Dipotassium 5'-guanylate (CAS 3254-39-5) is primarily used as a flavor enhancer in processed foods, notably in soups, sauces, snacks, and meat products, to boost umami and is commonly formulated with monosodium glutamate (MSG) to enhance savory taste; it may also be added to pet-food formulations to improve palatability in specialized nutrition for animals; in biotechnology and pharmaceutical development, it can serve as a nucleotide salt or reagent in nucleotide synthesis and as a component of buffering or culture-media formulations.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 0.2
    methanol 0.56
    isopropanol 0.14
    water 3.43
    ethyl acetate 0.02
    n-propanol 0.22
    acetone 0.05
    n-butanol 0.15
    acetonitrile 0.09
    DMF 3.69
    toluene 0.01
    isobutanol 0.1
    1,4-dioxane 0.11
    methyl acetate 0.06
    THF 0.25
    2-butanone 0.12
    n-pentanol 0.07
    sec-butanol 0.16
    n-hexane 0.0
    ethylene glycol 2.29
    NMP 11.63
    cyclohexane 0.01
    DMSO 8.53
    n-butyl acetate 0.07
    n-octanol 0.07
    chloroform 0.01
    n-propyl acetate 0.03
    acetic acid 0.95
    dichloromethane 0.02
    cyclohexanone 0.23
    propylene glycol 2.01
    isopropyl acetate 0.01
    DMAc 4.67
    2-ethoxyethanol 0.95
    isopentanol 0.08
    n-heptane 0.02
    ethyl formate 0.1
    1,2-dichloroethane 0.02
    n-hexanol 0.09
    2-methoxyethanol 3.54
    isobutyl acetate 0.01
    tetrachloromethane 0.01
    n-pentyl acetate 0.05
    transcutol 0.84
    n-heptanol 0.13
    ethylbenzene 0.0
    MIBK 0.02
    2-propoxyethanol 1.05
    tert-butanol 0.09
    MTBE 0.01
    2-butoxyethanol 0.84
    propionic acid 0.44
    o-xylene 0.01
    formic acid 12.82
    diethyl ether 0.03
    m-xylene 0.0
    p-xylene 0.01
    chlorobenzene 0.0
    dimethyl carbonate 0.13
    n-octane 0.01
    formamide 11.86
    cyclopentanone 0.4
    2-pentanone 0.05
    anisole 0.01
    cyclopentyl methyl ether 0.07
    gamma-butyrolactone 0.56
    1-methoxy-2-propanol 1.5
    pyridine 0.13
    3-pentanone 0.07
    furfural 1.04
    n-dodecane 0.0
    diethylene glycol 3.13
    diisopropyl ether 0.01
    tert-amyl alcohol 0.11
    acetylacetone 0.04
    n-hexadecane 0.0
    acetophenone 0.04
    methyl propionate 0.08
    isopentyl acetate 0.04
    trichloroethylene 0.02
    n-nonanol 0.07
    cyclohexanol 0.12
    benzyl alcohol 0.04
    2-ethylhexanol 0.05
    isooctanol 0.06
    dipropyl ether 0.09
    1,2-dichlorobenzene 0.0
    ethyl lactate 0.26
    propylene carbonate 0.16
    n-methylformamide 2.2
    2-pentanol 0.07
    n-pentane 0.01
    1-propoxy-2-propanol 0.65
    1-methoxy-2-propyl acetate 0.11
    2-(2-methoxypropoxy) propanol 0.56
    mesitylene 0.0
    ε-caprolactone 0.21
    p-cymene 0.01
    epichlorohydrin 0.14
    1,1,1-trichloroethane 0.0
    2-aminoethanol 1.86
    morpholine-4-carbaldehyde 3.3
    sulfolane 3.75
    2,2,4-trimethylpentane 0.0
    2-methyltetrahydrofuran 0.1
    n-hexyl acetate 0.04
    isooctane 0.0
    2-(2-butoxyethoxy)ethanol 0.79
    sec-butyl acetate 0.01
    tert-butyl acetate 0.01
    decalin 0.0
    glycerin 11.23
    diglyme 1.26
    acrylic acid 0.9
    isopropyl myristate 0.02
    n-butyric acid 0.2
    acetyl acetate 0.01
    di(2-ethylhexyl) phthalate 0.05
    ethyl propionate 0.03
    nitromethane 1.19
    1,2-diethoxyethane 0.07
    benzonitrile 0.03
    trioctyl phosphate 0.06
    1-bromopropane 0.01
    gamma-valerolactone 1.26
    n-decanol 0.05
    triethyl phosphate 0.09
    4-methyl-2-pentanol 0.02
    propionitrile 0.09
    vinylene carbonate 0.14
    1,1,2-trichlorotrifluoroethane 1.66
    DMS 0.05
    cumene 0.0
    2-octanol 0.06
    2-hexanone 0.05
    octyl acetate 0.04
    limonene 0.02
    1,2-dimethoxyethane 0.66
    ethyl orthosilicate 0.07
    tributyl phosphate 0.05
    diacetone alcohol 0.18
    N,N-dimethylaniline 0.02
    acrylonitrile 0.17
    aniline 0.03
    1,3-propanediol 1.5
    bromobenzene 0.0
    dibromomethane 0.01
    1,1,2,2-tetrachloroethane 0.03
    2-methyl-cyclohexyl acetate 0.05
    tetrabutyl urea 0.18
    diisobutyl methanol 0.02
    2-phenylethanol 0.06
    styrene 0.0
    dioctyl adipate 0.04
    dimethyl sulfate 0.55
    ethyl butyrate 0.06
    methyl lactate 0.84
    butyl lactate 0.3
    diethyl carbonate 0.05
    propanediol butyl ether 0.88
    triethyl orthoformate 0.1
    p-tert-butyltoluene 0.01
    methyl 4-tert-butylbenzoate 0.13
    morpholine 0.31
    tert-butylamine 0.03
    n-dodecanol 0.04
    dimethoxymethane 0.49
    ethylene carbonate 0.09
    cyrene 1.17
    2-ethoxyethyl acetate 0.08
    2-ethylhexyl acetate 0.04
    1,2,4-trichlorobenzene 0.01
    4-methylpyridine 0.05
    dibutyl ether 0.04
    2,6-dimethyl-4-heptanol 0.02
    DEF 0.32
    dimethyl isosorbide 0.7
    tetrachloroethylene 0.03
    eugenol 0.28
    triacetin 0.08
    span 80 0.37
    1,4-butanediol 0.52
    1,1-dichloroethane 0.01
    2-methyl-1-pentanol 0.04
    methyl formate 0.83
    2-methyl-1-butanol 0.11
    n-decane 0.01
    butyronitrile 0.05
    3,7-dimethyl-1-octanol 0.03
    1-chlorooctane 0.01
    1-chlorotetradecane 0.01
    n-nonane 0.01
    undecane 0.01
    tert-butylcyclohexane 0.0
    cyclooctane 0.0
    cyclopentanol 0.27
    tetrahydropyran 0.07
    tert-amyl methyl ether 0.03
    2,5,8-trioxanonane 0.96
    1-hexene 0.01
    2-isopropoxyethanol 0.25
    2,2,2-trifluoroethanol 1.25
    methyl butyrate 0.07

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction