Diphenyl chlorophosphonate

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  • Identifiers

    CAS number
    2524-64-3

    Molecular formula
    C12H10ClO3P

    SMILES
    C1=CC=C(C=C1)OP(=O)(OC2=CC=CC=C2)Cl

    Safety labels

    Corrosive
    Corrosive

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Green 61.23%
    Floral 61.14%
    Balsamic 52.96%
    Rose 41.39%
    Metallic 34.14%
    Honey 31.28%
    Phenolic 30.97%
    Herbal 29.96%
    Fruity 27.29%
    Geranium 26.15%

     

    Flavor
    Sweet 35.2%
    Odorless 31.46%
    Mild 30.12%
    Balsam 29.4%
    Honey 26.98%
    Phenolic 26.59%
    Sour 24.34%
    Floral 22.42%
    Balsamic 22.36%
    Bitter 21.86%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    3.5

    pKa est.
    6.71 (neutral)

    Molecular weight
    268.63 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    345°C

    Flash point

    • 175.97 ˚C est.

  • Synonyms

    • Diphenyl chlorophosphate
    • 2524-64-3
    • Diphenyl phosphorochloridate
    • diphenyl chlorophosphonate
    • Diphenylphosphoryl chloride
    • Diphenyl phosphoryl chloride
    • Phosphorochloridic acid, diphenyl ester
    • Chlorodiphenoxyphosphine oxide
    • diphenylchlorophosphate
    • O,O-Diphenyl chlorophosphate
    • Diphenoxychlorophosphine oxide
    • [chloro(phenoxy)phosphoryl]oxybenzene
    • Diphenylphosphoric acid monochloride
    • Diphenyl phosphochloridate
    • Phosphoric acid chloride diphenyl ester
    • Diphenylphosphorylchloridate
    • Phenyl phosphorochloridate ((PhO)2ClPO)
    • NSC 43771
    • 1KEE9757OT
    • DTXSID2044892
    • EINECS 219-759-6
    • NSC-43771
    • AI3-52364
    • DIPHENYL PHOSPHOROCHLORATE
    • DTXCID0024892
    • PHENYL PHOSPHOROCHLORIDITE
    • EC 219-759-6
    • DIPHENYL PHOSPHORYL CHLORIDE [MI]
    • CHLOROPHOSPHONIC ACID DIPHENYL ESTER
    • C12H10ClO3P
    • Chlorodiphenyl Phosphate
    • UNII-1KEE9757OT
    • o,o-Diphenylphosphorochloridate
    • MFCD00003030
    • DPOC
    • Diphenyichiorophosphate
    • diphenyl-chlorophosphate
    • (PhO)2POCl
    • (PhO)2POCI
    • Diphenyl chloridophosphate
    • Diphenyl chloridophosphate #
    • SCHEMBL122230
    • CHEMBL3188224
    • BHIIGRBMZRSDRI-UHFFFAOYSA-
    • Diphenyl phosphoryl chloride, 96%
    • Diphenyl phosphoryl chloride, 99%
    • NSC43771
    • Tox21_301665
    • (chloro-phenoxy-phosphoryl)oxybenzene
    • STL280429
    • AKOS000121125
    • Phosphorochloridic Acid Diphenyl Ester
    • NCGC00256112-01
    • CAS-2524-64-3
    • DB-002702
    • CS-0011542
    • D1059
    • NS00003953
    • EN300-23920
    • Q10266258
    • 219-759-6
    • InChI=1/C12H10ClO3P/c13-17(14,15-11-7-3-1-4-8-11)16-12-9-5-2-6-10-12/h1-10H

  • Applications

    Diphenyl chlorophosphonate (CAS number: 2524-64-3) is primarily used as an electrophilic phosphorylating reagent to install phosphonate or phosphate ester groups by reaction with alcohols or phenols, enabling the synthesis of organophosphorus esters. It serves as an intermediate for preparing phosphate-containing monomers, crosslinkers, and additives for industrial formulations. In coatings and inks, it is used to make phosphate esters that can improve thermal stability and flame retardancy of coatings. In polymers and plastics, it acts as a building block for flame-retardant additives and phosphate crosslinkers. In adhesives, it enables the introduction of phosphonate functionalities to improve compatibility with polymer matrices and adhesion. In electronics and specialty materials, it is used to synthesize phosphonate-containing materials for dielectric or flame-retardant applications. Use is subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 130.6
    methanol 139.19
    isopropanol 68.74
    water 0.16
    ethyl acetate 123.23
    n-propanol 95.51
    acetone 268.27
    n-butanol 84.81
    acetonitrile 149.58
    DMF 1367.93
    toluene 110.46
    isobutanol 55.7
    1,4-dioxane 283.8
    methyl acetate 151.54
    THF 892.88
    2-butanone 214.38
    n-pentanol 49.21
    sec-butanol 73.98
    n-hexane 6.25
    ethylene glycol 24.45
    NMP 697.83
    cyclohexane 24.08
    DMSO 702.49
    n-butyl acetate 96.2
    n-octanol 48.75
    chloroform 640.46
    n-propyl acetate 77.81
    acetic acid 131.34
    dichloromethane 562.04
    cyclohexanone 380.53
    propylene glycol 35.29
    isopropyl acetate 76.72
    DMAc 742.9
    2-ethoxyethanol 84.39
    isopentanol 56.14
    n-heptane 11.42
    ethyl formate 124.03
    1,2-dichloroethane 433.19
    n-hexanol 66.22
    2-methoxyethanol 273.69
    isobutyl acetate 47.13
    tetrachloromethane 25.35
    n-pentyl acetate 79.89
    transcutol 211.93
    n-heptanol 42.31
    ethylbenzene 38.97
    MIBK 80.61
    2-propoxyethanol 138.92
    tert-butanol 66.64
    MTBE 69.21
    2-butoxyethanol 84.24
    propionic acid 89.27
    o-xylene 48.2
    formic acid 50.51
    diethyl ether 114.96
    m-xylene 41.96
    p-xylene 45.89
    chlorobenzene 185.95
    dimethyl carbonate 113.58
    n-octane 6.76
    formamide 152.97
    cyclopentanone 570.81
    2-pentanone 163.83
    anisole 104.76
    cyclopentyl methyl ether 201.54
    gamma-butyrolactone 515.67
    1-methoxy-2-propanol 184.15
    pyridine 497.22
    3-pentanone 136.57
    furfural 470.58
    n-dodecane 8.01
    diethylene glycol 89.88
    diisopropyl ether 26.02
    tert-amyl alcohol 63.68
    acetylacetone 199.68
    n-hexadecane 9.0
    acetophenone 109.87
    methyl propionate 147.22
    isopentyl acetate 75.66
    trichloroethylene 730.02
    n-nonanol 46.25
    cyclohexanol 96.98
    benzyl alcohol 83.28
    2-ethylhexanol 40.02
    isooctanol 32.9
    dipropyl ether 63.67
    1,2-dichlorobenzene 146.62
    ethyl lactate 49.7
    propylene carbonate 220.61
    n-methylformamide 331.92
    2-pentanol 52.77
    n-pentane 9.26
    1-propoxy-2-propanol 97.94
    1-methoxy-2-propyl acetate 115.13
    2-(2-methoxypropoxy) propanol 88.38
    mesitylene 25.85
    ε-caprolactone 243.59
    p-cymene 31.2
    epichlorohydrin 627.26
    1,1,1-trichloroethane 173.07
    2-aminoethanol 64.89
    morpholine-4-carbaldehyde 467.29
    sulfolane 553.51
    2,2,4-trimethylpentane 5.29
    2-methyltetrahydrofuran 290.01
    n-hexyl acetate 97.07
    isooctane 3.71
    2-(2-butoxyethoxy)ethanol 113.53
    sec-butyl acetate 50.97
    tert-butyl acetate 78.02
    decalin 9.34
    glycerin 55.92
    diglyme 200.86
    acrylic acid 103.1
    isopropyl myristate 46.3
    n-butyric acid 119.49
    acetyl acetate 92.0
    di(2-ethylhexyl) phthalate 48.59
    ethyl propionate 76.16
    nitromethane 318.84
    1,2-diethoxyethane 91.96
    benzonitrile 141.89
    trioctyl phosphate 35.73
    1-bromopropane 176.07
    gamma-valerolactone 571.95
    n-decanol 36.65
    triethyl phosphate 44.9
    4-methyl-2-pentanol 28.72
    propionitrile 131.01
    vinylene carbonate 221.07
    1,1,2-trichlorotrifluoroethane 268.44
    DMS 98.28
    cumene 23.25
    2-octanol 36.32
    2-hexanone 88.36
    octyl acetate 58.6
    limonene 44.15
    1,2-dimethoxyethane 228.51
    ethyl orthosilicate 40.7
    tributyl phosphate 41.05
    diacetone alcohol 103.14
    N,N-dimethylaniline 74.09
    acrylonitrile 217.84
    aniline 125.22
    1,3-propanediol 88.86
    bromobenzene 187.92
    dibromomethane 375.5
    1,1,2,2-tetrachloroethane 564.16
    2-methyl-cyclohexyl acetate 65.56
    tetrabutyl urea 73.99
    diisobutyl methanol 26.85
    2-phenylethanol 84.45
    styrene 61.82
    dioctyl adipate 67.66
    dimethyl sulfate 181.85
    ethyl butyrate 75.85
    methyl lactate 92.92
    butyl lactate 69.54
    diethyl carbonate 56.46
    propanediol butyl ether 83.41
    triethyl orthoformate 56.51
    p-tert-butyltoluene 29.84
    methyl 4-tert-butylbenzoate 93.8
    morpholine 394.34
    tert-butylamine 41.24
    n-dodecanol 29.85
    dimethoxymethane 405.36
    ethylene carbonate 161.51
    cyrene 104.76
    2-ethoxyethyl acetate 105.03
    2-ethylhexyl acetate 65.92
    1,2,4-trichlorobenzene 172.0
    4-methylpyridine 323.4
    dibutyl ether 54.66
    2,6-dimethyl-4-heptanol 26.85
    DEF 275.1
    dimethyl isosorbide 173.09
    tetrachloroethylene 266.9
    eugenol 104.01
    triacetin 95.08
    span 80 86.69
    1,4-butanediol 25.7
    1,1-dichloroethane 245.5
    2-methyl-1-pentanol 38.97
    methyl formate 223.0
    2-methyl-1-butanol 59.72
    n-decane 10.67
    butyronitrile 130.25
    3,7-dimethyl-1-octanol 41.75
    1-chlorooctane 39.87
    1-chlorotetradecane 20.67
    n-nonane 9.24
    undecane 8.98
    tert-butylcyclohexane 7.07
    cyclooctane 6.83
    cyclopentanol 137.03
    tetrahydropyran 296.83
    tert-amyl methyl ether 70.84
    2,5,8-trioxanonane 152.75
    1-hexene 31.56
    2-isopropoxyethanol 51.67
    2,2,2-trifluoroethanol 44.28
    methyl butyrate 111.62

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction