Diphacinone

Overview IFRA Request a quote

  • Identifiers

    CAS number
    82-66-6

    Molecular formula
    C23H16O3

    SMILES
    C1=CC=C(C=C1)C(C2=CC=CC=C2)C(=O)C3C(=O)C4=CC=CC=C4C3=O

    Safety labels

    Acute Toxic
    Acute Toxic

    Health Hazard
    Health

  • Odor profile

    Fragrance
    Fruity 63.9%
    Floral 49.03%
    Balsamic 48.4%
    Sweet 45.69%
    Honey 42.03%
    Spicy 37.02%
    Berry 33.53%
    Powdery 32.19%
    Green 30.6%
    Bitter 29.34%

     

    Flavor
    Bitter 83.19%
    Odorless 22.9%
    Nitrile 19.26%
    Lovage 18.01%
    Cedarleaf 17.99%
    Broom 17.79%
    Heather 17.78%
    Genet 17.71%
    Oriental 17.47%
    Moth ball 17.32%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    3.7

    pKa est.
    6.57 (neutral)

    Molecular weight
    340.4 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    598°C

    Melting point expt.

    • 295 to 297 °F (EPA, 1998)
    • 141-145 °C
    • 147 °C

    Flash point

    • 205.73 ˚C est.

    Solubility expt.

    • In water, 0.3 mg/L, temp not specified
    • Soluble in methyl cyanide, cyclohexane
    • SOL IN ETHER, GLACIAL ACETIC ACID
    • Soluble in acetic acid
    • For more Solubility (Complete) data for Diphacinone (6 total), please visit the HSDB record page.
    • Solubility in water: very poor

  • Synonyms

    • Diphacinone
    • DIPHENADIONE
    • 82-66-6
    • Diphenandione
    • Didandin
    • Diphenacin
    • Promar
    • Diphenadion
    • Dipaxin
    • Diphacin
    • Oragulant
    • Ratindan
    • Didion
    • Diphac
    • Ramik
    • Solvan
    • Ratindan 1
    • 2-(Diphenylacetyl)-1H-indene-1,3(2H)-dione
    • Difenadione
    • 2-(Diphenylacetyl)-1,3-indandione
    • Gold Crest
    • Diphacin [Turkey]
    • Difenadiona
    • Kill-Ko Rat Killer
    • Caswell No. 394
    • URI 788
    • Difenadiona [INN-Spanish]
    • Diphacinone [ISO]
    • Diphenadionum [INN-Latin]
    • Diphenylacetylindandione
    • Diphacinone [ANSI:BSI:ISO]
    • U-1363
    • HSDB 2788
    • 2-Diphenylacetyl-1,3-indandione
    • NSC 9138
    • NSC-9138
    • 1,3-Indandione, 2-diphenylacetyl-
    • EINECS 201-434-5
    • UNII-54CA01C6JX
    • 2-Diphenylacetyl-1,3-diketohydrindene
    • U 1363
    • 1,3-Indandione, 2-(diphenylacetyl)-
    • EPA Pesticide Chemical Code 067701
    • Diphenadione [USP:INN:BAN]
    • BRN 2060511
    • Diphenadione (INN)
    • 1H-Indene-1,3(2H)-dione, 2-(diphenylacetyl)-
    • DTXSID4032378
    • 2-Diphenyl-acetyl-indan-1,3-dion
    • NCI-9138
    • DIPHACINONE [MI]
    • 2-(Diphenylacetyl)indan-1,3-dione
    • DIPHENADIONE [INN]
    • DIPHENADIONE [HSDB]
    • 1H-Indene-1,3-(2H)-dione, 2-(diphenylacetyl)-
    • DIPHENADIONE [MART.]
    • DIPHENADIONE [WHO-DD]
    • 2-(2,2-diphenylacetyl)indene-1,3-dione
    • 54CA01C6JX
    • difenadion
    • diphacine
    • DTXCID2012378
    • CHEBI:81896
    • 2-(Diphenylacetyl)-1H-indene-1,3-(2H)-dione
    • 4-07-00-02838 (Beilstein Handbook Reference)
    • Diphacin (Turkey)
    • diphacinon
    • NCGC00160553-01
    • 2-(2,2-diphenylacetyl)-2,3-dihydro-1H-indene-1,3-dione
    • 2-(Diphenylacetyl)-1,3-diketohydrindene
    • Diphacins
    • Parakakes
    • Rodent Cake
    • Contrax-D
    • Difenadiona (INN-Spanish)
    • Diphenadionum (INN-Latin)
    • Promar PCQ
    • DIPHENADIONE (MART.)
    • Diphenadione (USP:INN:BAN)
    • Diphacinone (ANSI:BSI:ISO)
    • Difenadione [DCIT]
    • Diphenadionum
    • CAS-82-66-6
    • ContraxD
    • P.C.Q.
    • 2-Diphenyl-acetyl-indan-1,3-dion [German]
    • KillKo Rat Killer
    • DIANDIN
    • DIFACIONE
    • 1, 2-(diphenylacetyl)-
    • 2Diphenylacetylindan1,3dion
    • Oprea1_049194
    • SCHEMBL43891
    • CBDivE_000266
    • MLS004774071
    • 2(Diphenylacetyl)1,3indandione
    • CHEMBL1413199
    • 2-diphenylacetylindan-1,3-dione
    • NSC9138
    • 1,3Indandione, 2(diphenylacetyl)
    • 2Diphenylacetyl1,3diketohydrindene
    • 2-Diphenyl acetyl-1,3-indanedione
    • Tox21_111893
    • 1H-Indene-1, 2-(diphenylacetyl)-
    • BBL004126
    • STK396707
    • WLN: L56 BV DV CHJ CVYR&R
    • AKOS003597405
    • Tox21_111893_1
    • DB13347
    • USEPA/OPP Pesticide Code: 067701
    • 2(Diphenylacetyl)1Hindene1,3(2H)dione
    • NCGC00160553-02
    • NCGC00160553-03
    • 2-DIPHENYLACETYL-1,3-INDANEDIONE
    • SMR002049143
    • VS-01515
    • 1,3Indandione, 2(diphenylacetyl) (8CI)
    • 2-(2,2-Diphenylacetyl)indane-1,3-dione
    • Diphacinone 100 microg/mL in Acetonitrile
    • 1HIndene1,3(2H)dione, 2(diphenylacetyl)
    • DB-056645
    • NS00007899
    • U1363
    • 2-(Diphenylacetyl)-1H-indene-2,3(2H)dione
    • C18698
    • D07136
    • 1HIndene1,3(2H)dione, 2(diphenylacetyl) (9CI)

  • Applications

    Diphacinone (CAS 82-66-6) is primarily used as an active ingredient in anticoagulant rodenticide baits, functioning by inhibiting vitamin K epoxide reductase and causing anticoagulation and death in rodents. Real-world applications include rodent control in agricultural settings and stored product protection, urban and industrial pest management in buildings and warehouses, infrastructure facility management such as ports and processing plants, and its use as a component in ready-to-use bait formulations, with practice governed by local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 6.5
    methanol 9.04
    isopropanol 3.78
    water 0.05
    ethyl acetate 31.79
    n-propanol 7.24
    acetone 72.71
    n-butanol 5.91
    acetonitrile 34.86
    DMF 268.52
    toluene 32.82
    isobutanol 5.53
    1,4-dioxane 72.25
    methyl acetate 53.13
    THF 271.79
    2-butanone 65.23
    n-pentanol 6.03
    sec-butanol 4.77
    n-hexane 0.45
    ethylene glycol 5.61
    NMP 316.39
    cyclohexane 0.95
    DMSO 166.22
    n-butyl acetate 26.37
    n-octanol 3.75
    chloroform 172.99
    n-propyl acetate 24.12
    acetic acid 30.17
    dichloromethane 181.33
    cyclohexanone 124.84
    propylene glycol 6.1
    isopropyl acetate 23.96
    DMAc 313.32
    2-ethoxyethanol 19.37
    isopentanol 7.01
    n-heptane 0.64
    ethyl formate 24.52
    1,2-dichloroethane 146.25
    n-hexanol 7.1
    2-methoxyethanol 38.22
    isobutyl acetate 18.12
    tetrachloromethane 8.28
    n-pentyl acetate 16.14
    transcutol 46.63
    n-heptanol 5.31
    ethylbenzene 15.19
    MIBK 28.12
    2-propoxyethanol 30.7
    tert-butanol 5.86
    MTBE 7.75
    2-butoxyethanol 18.07
    propionic acid 25.82
    o-xylene 16.95
    formic acid 14.6
    diethyl ether 11.62
    m-xylene 16.29
    p-xylene 18.55
    chlorobenzene 55.11
    dimethyl carbonate 71.93
    n-octane 0.36
    formamide 42.07
    cyclopentanone 263.68
    2-pentanone 42.2
    anisole 38.03
    cyclopentyl methyl ether 61.31
    gamma-butyrolactone 256.69
    1-methoxy-2-propanol 29.98
    pyridine 121.13
    3-pentanone 45.95
    furfural 152.19
    n-dodecane 0.51
    diethylene glycol 26.1
    diisopropyl ether 4.22
    tert-amyl alcohol 6.32
    acetylacetone 89.21
    n-hexadecane 0.62
    acetophenone 50.31
    methyl propionate 57.17
    isopentyl acetate 25.95
    trichloroethylene 319.33
    n-nonanol 4.5
    cyclohexanol 12.04
    benzyl alcohol 28.17
    2-ethylhexanol 8.05
    isooctanol 5.42
    dipropyl ether 12.99
    1,2-dichlorobenzene 57.29
    ethyl lactate 22.17
    propylene carbonate 93.88
    n-methylformamide 69.85
    2-pentanol 4.12
    n-pentane 0.27
    1-propoxy-2-propanol 22.06
    1-methoxy-2-propyl acetate 47.59
    2-(2-methoxypropoxy) propanol 25.93
    mesitylene 8.27
    ε-caprolactone 85.11
    p-cymene 9.48
    epichlorohydrin 274.12
    1,1,1-trichloroethane 66.4
    2-aminoethanol 8.89
    morpholine-4-carbaldehyde 156.75
    sulfolane 304.87
    2,2,4-trimethylpentane 0.55
    2-methyltetrahydrofuran 84.79
    n-hexyl acetate 17.31
    isooctane 0.38
    2-(2-butoxyethoxy)ethanol 23.17
    sec-butyl acetate 19.07
    tert-butyl acetate 26.66
    decalin 1.68
    glycerin 17.83
    diglyme 61.39
    acrylic acid 36.21
    isopropyl myristate 10.01
    n-butyric acid 26.25
    acetyl acetate 37.87
    di(2-ethylhexyl) phthalate 13.75
    ethyl propionate 28.57
    nitromethane 120.31
    1,2-diethoxyethane 20.19
    benzonitrile 43.82
    trioctyl phosphate 8.34
    1-bromopropane 28.9
    gamma-valerolactone 217.11
    n-decanol 3.67
    triethyl phosphate 19.88
    4-methyl-2-pentanol 4.76
    propionitrile 28.32
    vinylene carbonate 89.58
    1,1,2-trichlorotrifluoroethane 122.57
    DMS 48.84
    cumene 9.31
    2-octanol 3.36
    2-hexanone 28.56
    octyl acetate 11.49
    limonene 11.54
    1,2-dimethoxyethane 52.99
    ethyl orthosilicate 15.94
    tributyl phosphate 10.88
    diacetone alcohol 35.04
    N,N-dimethylaniline 26.45
    acrylonitrile 60.33
    aniline 38.45
    1,3-propanediol 11.19
    bromobenzene 58.91
    dibromomethane 90.38
    1,1,2,2-tetrachloroethane 202.7
    2-methyl-cyclohexyl acetate 26.62
    tetrabutyl urea 17.95
    diisobutyl methanol 6.43
    2-phenylethanol 26.34
    styrene 19.45
    dioctyl adipate 19.23
    dimethyl sulfate 146.81
    ethyl butyrate 23.26
    methyl lactate 43.25
    butyl lactate 18.21
    diethyl carbonate 20.33
    propanediol butyl ether 12.03
    triethyl orthoformate 19.14
    p-tert-butyltoluene 8.22
    methyl 4-tert-butylbenzoate 34.39
    morpholine 78.92
    tert-butylamine 3.17
    n-dodecanol 3.13
    dimethoxymethane 96.53
    ethylene carbonate 64.74
    cyrene 51.0
    2-ethoxyethyl acetate 29.18
    2-ethylhexyl acetate 21.71
    1,2,4-trichlorobenzene 74.86
    4-methylpyridine 91.47
    dibutyl ether 7.73
    2,6-dimethyl-4-heptanol 6.43
    DEF 72.5
    dimethyl isosorbide 72.38
    tetrachloroethylene 101.94
    eugenol 31.0
    triacetin 33.48
    span 80 18.86
    1,4-butanediol 5.37
    1,1-dichloroethane 68.59
    2-methyl-1-pentanol 7.82
    methyl formate 63.22
    2-methyl-1-butanol 7.06
    n-decane 0.74
    butyronitrile 19.21
    3,7-dimethyl-1-octanol 5.61
    1-chlorooctane 4.29
    1-chlorotetradecane 2.38
    n-nonane 0.55
    undecane 0.6
    tert-butylcyclohexane 1.15
    cyclooctane 0.39
    cyclopentanol 24.48
    tetrahydropyran 50.29
    tert-amyl methyl ether 9.75
    2,5,8-trioxanonane 46.64
    1-hexene 3.45
    2-isopropoxyethanol 15.31
    2,2,2-trifluoroethanol 23.86
    methyl butyrate 35.15

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction