Dipalmitoyl hydroxyproline

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  • Identifiers

    CAS number
    41672-81-5

    Molecular formula
    C37H69NO5

    SMILES
    CCCCCCCCCCCCCCCC(=O)N1C[C@@H](C[C@H]1C(=O)O)OC(=O)CCCCCCCCCCCCCCC

    Safety labels

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Waxy 57.19%
    Fatty 46.28%
    Odorless 38.33%
    Oily 36.31%
    Milky 24.95%
    Savory 22.71%
    Woody 22.64%
    Lactonic 20.91%
    Animal 20.5%
    Creamy 20.27%

     

    Flavor
    Bland 39.32%
    Fatty 35.66%
    Mild 35.25%
    Odorless 33.84%
    Waxy 32.63%
    Faint 28.83%
    Oily 26.91%
    Slightly waxy 23.4%
    Bay oil 21.9%
    Beer 20.86%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    14.1

    pKa est.
    7.38 (neutral)

    Molecular weight
    607.9 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    627°C

    Flash point

    • 276.41 ˚C est.

  • Synonyms

    • Dipalmitoyl hydroxyproline
    • Dipalmitoylhydroxyproline
    • Dipamitoylhydroxyproline
    • trans-O, N-Dipalmitoylhydroxyproline
    • E6AHA53N1H
    • LIPACIDE DPHP
    • SEPILIFT DPHP
    • RONACARE ASC III
    • EINECS 255-490-0
    • DTXSID60885734
    • EC 255-490-0
    • O,N-DIPALMITOYLHYDROXYPROLINE
    • trans-1-(1-Oxohexadecyl)-4-((1-oxohexadecyl)oxy)-L-proline
    • Trans-1-(1-oxohexadecyl)-4-[(1-oxohexadecyl)oxy]-L-proline
    • L-Proline, 1-(1-oxohexadecyl)-4-((1-oxohexadecyl)oxy)-, (4R)-
    • L-Proline, 1-(1-oxohexadecyl)-4-((1-oxohexadecyl)oxy)-, trans-
    • L-Proline, 1-(1-oxohexadecyl)-4-[(1-oxohexadecyl)oxy]-, (4R)-
    • RefChem:588778
    • DTXCID001025097
    • DIPALMITOYL HYDROXYPROLINE [INCI]
    • L-Proline, 1-(1-oxohexadecyl)-4-(1-oxohexadecyl)oxy-, (4R)-
    • 41672-81-5
    • (2S,4R)-1-hexadecanoyl-4-hexadecanoyloxypyrrolidine-2-carboxylic acid
    • UNII-E6AHA53N1H
    • SCHEMBL4403605
    • QZLXCFQVOCEKSX-NOCHOARKSA-N
    • NS00008530
    • 672D815
    • (4R)-1-hexadecanoyl-4-(hexadecanoyloxy)-L-proline
    • Q27276932
    • 41672-81-5

  • Applications

    Dipalmitoyl hydroxyproline (CAS 41672-81-5) is a lipophilic, palmitoyl-derivatized amino acid derivative used primarily as a skin-conditioning agent in cosmetics and personal care, providing emollience and potential film-forming properties; it can serve as a lipid-compatible building block or intermediate in formulations of lipid-based actives and delivery systems; in topical pharmaceutical formulations, it may act as an excipient or carrier for active ingredients; in polymers, coatings, and adhesive formulations, it can be used to adjust hydrophobicity and compatibility of lipid-like components; it may also be evaluated as a plasticizer or texture-modifying additive in certain polymer and coating materials.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 20.29
    methanol 23.09
    isopropanol 20.22
    water 0.61
    ethyl acetate 131.89
    n-propanol 32.0
    acetone 102.73
    n-butanol 29.08
    acetonitrile 41.63
    DMF 209.12
    toluene 48.97
    isobutanol 25.61
    1,4-dioxane 104.9
    methyl acetate 121.2
    THF 266.99
    2-butanone 154.62
    n-pentanol 32.54
    sec-butanol 39.85
    n-hexane 7.05
    ethylene glycol 3.68
    NMP 632.91
    cyclohexane 15.5
    DMSO 205.65
    n-butyl acetate 102.46
    n-octanol 27.56
    chloroform 333.7
    n-propyl acetate 118.42
    acetic acid 112.55
    dichloromethane 346.51
    cyclohexanone 308.03
    propylene glycol 9.34
    isopropyl acetate 109.47
    DMAc 579.74
    2-ethoxyethanol 75.53
    isopentanol 28.95
    n-heptane 4.24
    ethyl formate 80.28
    1,2-dichloroethane 198.69
    n-hexanol 21.96
    2-methoxyethanol 66.66
    isobutyl acetate 65.52
    tetrachloromethane 75.13
    n-pentyl acetate 158.91
    transcutol 248.94
    n-heptanol 27.25
    ethylbenzene 32.87
    MIBK 73.1
    2-propoxyethanol 68.7
    tert-butanol 26.46
    MTBE 59.46
    2-butoxyethanol 89.78
    propionic acid 83.32
    o-xylene 46.17
    formic acid 33.37
    diethyl ether 49.34
    m-xylene 31.74
    p-xylene 47.32
    chlorobenzene 109.36
    dimethyl carbonate 75.35
    n-octane 3.16
    formamide 58.14
    cyclopentanone 352.6
    2-pentanone 115.78
    anisole 69.71
    cyclopentyl methyl ether 122.77
    gamma-butyrolactone 431.13
    1-methoxy-2-propanol 67.98
    pyridine 166.24
    3-pentanone 124.1
    furfural 300.68
    n-dodecane 1.96
    diethylene glycol 27.82
    diisopropyl ether 19.73
    tert-amyl alcohol 51.66
    acetylacetone 181.34
    n-hexadecane 2.31
    acetophenone 125.82
    methyl propionate 131.19
    isopentyl acetate 97.2
    trichloroethylene 424.08
    n-nonanol 29.26
    cyclohexanol 56.08
    benzyl alcohol 51.77
    2-ethylhexanol 21.74
    isooctanol 25.49
    dipropyl ether 37.77
    1,2-dichlorobenzene 134.76
    ethyl lactate 64.85
    propylene carbonate 270.1
    n-methylformamide 87.94
    2-pentanol 27.75
    n-pentane 5.15
    1-propoxy-2-propanol 65.03
    1-methoxy-2-propyl acetate 124.0
    2-(2-methoxypropoxy) propanol 91.62
    mesitylene 19.8
    ε-caprolactone 368.29
    p-cymene 21.39
    epichlorohydrin 346.58
    1,1,1-trichloroethane 240.29
    2-aminoethanol 13.25
    morpholine-4-carbaldehyde 311.84
    sulfolane 626.47
    2,2,4-trimethylpentane 6.2
    2-methyltetrahydrofuran 209.33
    n-hexyl acetate 140.73
    isooctane 2.06
    2-(2-butoxyethoxy)ethanol 106.17
    sec-butyl acetate 92.88
    tert-butyl acetate 115.77
    decalin 9.04
    glycerin 18.16
    diglyme 237.31
    acrylic acid 73.36
    isopropyl myristate 38.32
    n-butyric acid 133.97
    acetyl acetate 123.04
    di(2-ethylhexyl) phthalate 47.68
    ethyl propionate 118.78
    nitromethane 230.4
    1,2-diethoxyethane 101.98
    benzonitrile 68.9
    trioctyl phosphate 31.55
    1-bromopropane 99.01
    gamma-valerolactone 470.42
    n-decanol 17.52
    triethyl phosphate 75.02
    4-methyl-2-pentanol 17.31
    propionitrile 46.33
    vinylene carbonate 223.46
    1,1,2-trichlorotrifluoroethane 267.74
    DMS 119.56
    cumene 23.08
    2-octanol 24.05
    2-hexanone 106.92
    octyl acetate 57.29
    limonene 33.77
    1,2-dimethoxyethane 136.64
    ethyl orthosilicate 66.04
    tributyl phosphate 46.05
    diacetone alcohol 103.18
    N,N-dimethylaniline 56.54
    acrylonitrile 58.24
    aniline 57.0
    1,3-propanediol 23.6
    bromobenzene 120.31
    dibromomethane 193.0
    1,1,2,2-tetrachloroethane 374.5
    2-methyl-cyclohexyl acetate 88.85
    tetrabutyl urea 68.49
    diisobutyl methanol 13.23
    2-phenylethanol 41.14
    styrene 39.07
    dioctyl adipate 78.82
    dimethyl sulfate 202.36
    ethyl butyrate 100.23
    methyl lactate 71.01
    butyl lactate 112.73
    diethyl carbonate 69.84
    propanediol butyl ether 63.57
    triethyl orthoformate 83.07
    p-tert-butyltoluene 18.62
    methyl 4-tert-butylbenzoate 133.5
    morpholine 156.84
    tert-butylamine 16.56
    n-dodecanol 11.42
    dimethoxymethane 102.07
    ethylene carbonate 187.01
    cyrene 120.91
    2-ethoxyethyl acetate 204.41
    2-ethylhexyl acetate 85.22
    1,2,4-trichlorobenzene 183.13
    4-methylpyridine 162.7
    dibutyl ether 48.71
    2,6-dimethyl-4-heptanol 13.23
    DEF 185.5
    dimethyl isosorbide 186.16
    tetrachloroethylene 225.1
    eugenol 102.75
    triacetin 195.65
    span 80 73.37
    1,4-butanediol 14.38
    1,1-dichloroethane 175.86
    2-methyl-1-pentanol 38.96
    methyl formate 72.97
    2-methyl-1-butanol 36.59
    n-decane 4.63
    butyronitrile 47.01
    3,7-dimethyl-1-octanol 25.14
    1-chlorooctane 28.21
    1-chlorotetradecane 8.12
    n-nonane 4.26
    undecane 2.8
    tert-butylcyclohexane 6.06
    cyclooctane 4.96
    cyclopentanol 68.07
    tetrahydropyran 138.35
    tert-amyl methyl ether 70.99
    2,5,8-trioxanonane 134.56
    1-hexene 23.84
    2-isopropoxyethanol 60.14
    2,2,2-trifluoroethanol 83.41
    methyl butyrate 166.51

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction