Dipalmitoyl glutathione

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  • Identifiers

    CAS number
    37491-53-5

    Molecular formula
    C42H77N3O8S

    SMILES
    CCCCCCCCCCCCCCCC(=O)N[C@@H](CCC(=O)N[C@@H](CSC(=O)CCCCCCCCCCCCCCC)C(=O)NCC(=O)O)C(=O)O

    Safety labels

  • Odor profile

    Fragrance
    Savory 41.18%
    Odorless 40.52%
    Meaty 36.6%
    Fatty 29.19%
    Waxy 25.96%
    Cooling 25.85%
    Oily 23.62%
    Milky 21.41%
    Herbal 20.38%
    Fishy 19.36%

     

    Flavor
    Odorless 44.41%
    Bland 41.77%
    Mild 30.24%
    Bitter 28.8%
    Faint 23.41%
    Slightly waxy 20.35%
    Sweet-like 19.84%
    Bay oil 19.74%
    Cedarleaf 19.39%
    Delicate 18.88%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    12.8

    pKa est.
    8.17 (weak base)

    Molecular weight
    784.1 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    1052°C

    Flash point

    • 327.25 ˚C est.

  • Synonyms

    • Dipalmitoyl glutathione
    • N,S-Dipalmitoylglutathione
    • UNII-MKJ7AEO92J
    • MKJ7AEO92J
    • Dipalmitoyl glutathione [INCI]
    • 37491-53-5
    • Glycine, N-(1-oxohexadecyl)-L-gamma-glutamyl-S-(1-oxohexadecyl)-L-cysteinyl-
    • GLYCINE, N-(1-OXOHEXADECYL)-L-.GAMMA.-GLUTAMYL-S-(1-OXOHEXADECYL)-L-CYSTEINYL-
    • RefChem:200641
    • SCHEMBL30565118
    • PNQGEMVOEPSFES-ZPGRZCPFSA-N
    • Q27284084
    • 37491-53-5

  • Applications

    Dipalmitoyl glutathione (CAS 37491-53-5) is commonly used in cosmetics and personal care as a lipophilic antioxidant and skin-conditioning agent, helping to stabilize lipid-rich formulations and improve emollience; it is also explored as a lipid-compatible excipient or stabilizer in pharmaceutical formulations, particularly in lipid-based delivery systems; in polymer and coatings sectors it can act as a processing aid or stabilizer to enhance compatibility with lipophilic components; and it may be used as an intermediate or additive in specialty coatings where long-chain fatty acyl groups influence film properties.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 1.84
    methanol 4.27
    isopropanol 1.24
    water 0.2
    ethyl acetate 2.85
    n-propanol 2.22
    acetone 4.28
    n-butanol 1.51
    acetonitrile 1.12
    DMF 36.8
    toluene 1.08
    isobutanol 1.29
    1,4-dioxane 4.97
    methyl acetate 3.92
    THF 12.52
    2-butanone 5.34
    n-pentanol 1.75
    sec-butanol 1.89
    n-hexane 0.17
    ethylene glycol 1.19
    NMP 86.7
    cyclohexane 0.2
    DMSO 23.16
    n-butyl acetate 2.13
    n-octanol 1.39
    chloroform 4.8
    n-propyl acetate 3.1
    acetic acid 9.9
    dichloromethane 4.67
    cyclohexanone 10.59
    propylene glycol 2.72
    isopropyl acetate 2.37
    DMAc 79.29
    2-ethoxyethanol 7.44
    isopentanol 1.07
    n-heptane 0.12
    ethyl formate 3.27
    1,2-dichloroethane 2.9
    n-hexanol 0.79
    2-methoxyethanol 9.16
    isobutyl acetate 1.58
    tetrachloromethane 1.12
    n-pentyl acetate 3.91
    transcutol 23.4
    n-heptanol 1.26
    ethylbenzene 0.9
    MIBK 1.85
    2-propoxyethanol 5.25
    tert-butanol 1.27
    MTBE 1.63
    2-butoxyethanol 6.67
    propionic acid 5.69
    o-xylene 1.23
    formic acid 7.85
    diethyl ether 1.23
    m-xylene 0.84
    p-xylene 1.19
    chlorobenzene 1.31
    dimethyl carbonate 4.72
    n-octane 0.1
    formamide 10.91
    cyclopentanone 16.38
    2-pentanone 3.53
    anisole 2.42
    cyclopentyl methyl ether 4.43
    gamma-butyrolactone 20.92
    1-methoxy-2-propanol 8.26
    pyridine 5.48
    3-pentanone 3.96
    furfural 18.34
    n-dodecane 0.06
    diethylene glycol 3.78
    diisopropyl ether 0.4
    tert-amyl alcohol 2.27
    acetylacetone 6.77
    n-hexadecane 0.07
    acetophenone 4.9
    methyl propionate 4.83
    isopentyl acetate 1.84
    trichloroethylene 7.62
    n-nonanol 1.43
    cyclohexanol 2.16
    benzyl alcohol 2.97
    2-ethylhexanol 0.63
    isooctanol 0.96
    dipropyl ether 1.26
    1,2-dichlorobenzene 1.87
    ethyl lactate 4.52
    propylene carbonate 10.48
    n-methylformamide 11.45
    2-pentanol 1.03
    n-pentane 0.11
    1-propoxy-2-propanol 4.47
    1-methoxy-2-propyl acetate 4.83
    2-(2-methoxypropoxy) propanol 7.71
    mesitylene 0.51
    ε-caprolactone 12.79
    p-cymene 0.51
    epichlorohydrin 12.08
    1,1,1-trichloroethane 2.73
    2-aminoethanol 2.83
    morpholine-4-carbaldehyde 37.82
    sulfolane 53.9
    2,2,4-trimethylpentane 0.12
    2-methyltetrahydrofuran 6.18
    n-hexyl acetate 3.84
    isooctane 0.04
    2-(2-butoxyethoxy)ethanol 8.52
    sec-butyl acetate 2.31
    tert-butyl acetate 2.99
    decalin 0.17
    glycerin 6.33
    diglyme 17.61
    acrylic acid 6.96
    isopropyl myristate 1.03
    n-butyric acid 5.56
    acetyl acetate 3.02
    di(2-ethylhexyl) phthalate 1.89
    ethyl propionate 3.18
    nitromethane 15.27
    1,2-diethoxyethane 3.98
    benzonitrile 1.98
    trioctyl phosphate 1.32
    1-bromopropane 1.21
    gamma-valerolactone 31.31
    n-decanol 0.86
    triethyl phosphate 2.61
    4-methyl-2-pentanol 0.56
    propionitrile 1.31
    vinylene carbonate 9.1
    1,1,2-trichlorotrifluoroethane 21.23
    DMS 5.01
    cumene 0.67
    2-octanol 0.99
    2-hexanone 3.62
    octyl acetate 1.72
    limonene 0.74
    1,2-dimethoxyethane 10.1
    ethyl orthosilicate 2.31
    tributyl phosphate 1.78
    diacetone alcohol 5.83
    N,N-dimethylaniline 3.0
    acrylonitrile 2.24
    aniline 2.16
    1,3-propanediol 3.28
    bromobenzene 1.19
    dibromomethane 2.26
    1,1,2,2-tetrachloroethane 8.18
    2-methyl-cyclohexyl acetate 2.51
    tetrabutyl urea 3.61
    diisobutyl methanol 0.38
    2-phenylethanol 1.78
    styrene 0.92
    dioctyl adipate 2.57
    dimethyl sulfate 17.64
    ethyl butyrate 2.46
    methyl lactate 7.71
    butyl lactate 6.26
    diethyl carbonate 1.68
    propanediol butyl ether 7.83
    triethyl orthoformate 3.09
    p-tert-butyltoluene 0.51
    methyl 4-tert-butylbenzoate 7.45
    morpholine 8.5
    tert-butylamine 0.58
    n-dodecanol 0.54
    dimethoxymethane 8.51
    ethylene carbonate 6.36
    cyrene 13.66
    2-ethoxyethyl acetate 7.49
    2-ethylhexyl acetate 1.6
    1,2,4-trichlorobenzene 3.25
    4-methylpyridine 4.75
    dibutyl ether 1.48
    2,6-dimethyl-4-heptanol 0.38
    DEF 9.98
    dimethyl isosorbide 11.89
    tetrachloroethylene 5.08
    eugenol 6.59
    triacetin 10.05
    span 80 5.89
    1,4-butanediol 2.04
    1,1-dichloroethane 2.14
    2-methyl-1-pentanol 1.48
    methyl formate 7.86
    2-methyl-1-butanol 1.54
    n-decane 0.14
    butyronitrile 1.14
    3,7-dimethyl-1-octanol 0.8
    1-chlorooctane 0.71
    1-chlorotetradecane 0.22
    n-nonane 0.13
    undecane 0.09
    tert-butylcyclohexane 0.13
    cyclooctane 0.09
    cyclopentanol 3.68
    tetrahydropyran 3.56
    tert-amyl methyl ether 2.24
    2,5,8-trioxanonane 10.94
    1-hexene 0.59
    2-isopropoxyethanol 4.64
    2,2,2-trifluoroethanol 7.55
    methyl butyrate 4.91

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction