Diosmetin

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  • Identifiers

    CAS number
    520-34-3

    Molecular formula
    C16H12O6

    SMILES
    COC1=C(C=C(C=C1)C2=CC(=O)C3=C(C=C(C=C3O2)O)O)O

    Safety labels

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Phenolic 59.95%
    Odorless 46.55%
    Burnt 35.33%
    Vanilla 31.48%
    Smoky 28.49%
    Spicy 27.58%
    Medicinal 26.2%
    Balsamic 25.5%
    Sweet 23.78%
    Creamy 23.02%

     

    Flavor
    Bitter 91.72%
    Odorless 22.75%
    Sweet-like 21.08%
    Parsley 20.91%
    Eugenol 20.85%
    Cedarleaf 20.69%
    Bland 20.31%
    Very strong 20.18%
    Lovage 20.13%
    Indole 20.11%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    1.7

    pKa est.
    9.86 (weak base)

    Molecular weight
    300.26 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    700°C

    Melting point expt.

    • 256-258 °C
    • 228 - 230 °C

    Flash point

    • 225.43 ˚C est.

    Solubility expt.

    • Soluble in chloroform, dichloromethane, DMSO, acetone

  • Synonyms

    • Diosmetin
    • 520-34-3
    • Luteolin 4'-methyl ether
    • Salinigricoflavonol
    • 4'-Methylluteolin
    • Diosmetine
    • 3',5,7-trihydroxy-4'-methoxyflavone
    • 5,7,3'-Trihydroxy-4'-methoxyflavone
    • 5,7-Dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-4H-1-benzopyran-4-one
    • 5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)chromen-4-one
    • 5,7-Dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-4-benzopyrone
    • 4H-1-Benzopyran-4-one, 5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-
    • TWZ37241OT
    • DTXSID80199966
    • Flavone, 3',5,7-trihydroxy-4'-methoxy-
    • CHEBI:4630
    • RefChem:34944
    • DTXCID40122457
    • GONGJINHYANG SEOL WHITENING
    • Whoo Gongjinhyang Seol Whitening Jin Essence
    • ISAKNOX X202 WHITENING SECRET ESSENCE
    • ISA KNOX WXII PLUS WHITENING REVOLUTION SERUM
    • 208-291-8
    • 5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-4H-chromen-4-one
    • Luteolin 4-methyl ether
    • MFCD00017425
    • 5,7-dihydroxy-2-(3-hydroxy-4-methoxy-phenyl)chromen-4-one
    • Diosmin EP Impurity F
    • Pillon
    • DIOSMETOL
    • SR-05000002196
    • disometin
    • UNII-TWZ37241OT
    • HSDB 8101
    • 5,7-Dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-4H-1-benzopyran-4-one (Diosmetin)
    • EINECS 208-291-8
    • Diosmetin (Standard)
    • 3',5,7-trihydroxy-4'-methoxy flavone
    • 4'-O-methyl-luteolin
    • Spectrum_001505
    • SpecPlus_000435
    • DIOSMETIN [MI]
    • Spectrum2_001638
    • Spectrum3_000987
    • Spectrum4_001113
    • Spectrum5_001707
    • DIOSMETIN [WHO-DD]
    • BSPBio_002653
    • KBioGR_001586
    • KBioSS_001985
    • MLS006011843
    • CHEMBL90568
    • Diosmetin, analytical standard
    • DivK1c_006531
    • SCHEMBL289337
    • Salinigricoflavonol; Vitamin P
    • SPBio_001735
    • orb1307680
    • SCHEMBL29363916
    • SCHEMBL29453246
    • SCHEMBL30541886
    • BDBM23414
    • GTPL13861
    • HY-N0125R
    • KBio1_001475
    • KBio2_001985
    • KBio2_004553
    • KBio2_007121
    • KBio3_001873
    • LUTEOLIN-4'-METHYL ETHER
    • Diosmetin; Diosmin EP Impurity F
    • HMS3656G13
    • HMS3753G11
    • HMS5080B20
    • BB_NC-02600
    • HY-N0125
    • BBL027839
    • CCG-38758
    • Diosmetin (Luteolin 4-methyl ether)
    • LMPK12110824
    • s2380
    • SBB066130
    • STL146390
    • AKOS005720974
    • 4'-Methoxy-5,7,3'-Trihydroxyflavone
    • CS-5455
    • DB11259
    • EBC-436043
    • FD22465
    • SDCCGMLS-0066783.P001
    • NCGC00163540-01
    • NCGC00163540-02
    • NCGC00163540-03
    • NCGC00178549-01
    • AC-34868
    • BS-17174
    • SMR002044787
    • SY066981
    • CYANIDENON-4'-METHYL ETHER 1479
    • DB-050154
    • D4441
    • NS00014641
    • ST50331610
    • SW219332-1
    • C10038
    • 520D343
    • A828902
    • AN-668/21246025
    • F239117
    • Q1649664
    • SR-05000002196-2
    • SR-05000002196-3
    • BRD-K26862302-001-02-9
    • BRD-K26862302-001-03-7
    • BRD-K26862302-001-05-2
    • 2-(4-methoxy-3-oxidanyl-phenyl)-5,7-bis(oxidanyl)chromen-4-one
    • 5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-1-benzopyran-4-one
    • 5,7-Dihydroxy-2-(3-hydroxy-4-methoxyphenyl);-4H-chromen-4-one
    • J8D
    • 520-34-3

  • Applications

    Diosmetin is a natural flavone that is commonly regarded as an antioxidant ingredient for cosmetics and personal care products, helping stabilize formulations and protect product integrity. It is also used as an intermediate in the synthesis of flavonoid derivatives for pharmaceutical research. In industrial materials, it shows potential as a natural antioxidant additive for polymers and coatings to enhance material durability and chemical stability. Additionally, it is evaluated in functional foods and agriculture as a natural polyphenol source, though use is subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 0.49
    methanol 0.55
    isopropanol 0.76
    water 0.0
    ethyl acetate 1.1
    n-propanol 1.13
    acetone 0.54
    n-butanol 1.25
    acetonitrile 0.33
    DMF 20.35
    toluene 0.03
    isobutanol 0.73
    1,4-dioxane 2.02
    methyl acetate 1.32
    THF 18.57
    2-butanone 2.74
    n-pentanol 0.63
    sec-butanol 1.57
    n-hexane 0.0
    ethylene glycol 1.78
    NMP 23.12
    cyclohexane 0.0
    DMSO 216.86
    n-butyl acetate 1.08
    n-octanol 0.26
    chloroform 0.03
    n-propyl acetate 1.01
    acetic acid 1.89
    dichloromethane 0.04
    cyclohexanone 2.99
    propylene glycol 3.09
    isopropyl acetate 0.82
    DMAc 33.7
    2-ethoxyethanol 9.98
    isopentanol 1.2
    n-heptane 0.01
    ethyl formate 0.71
    1,2-dichloroethane 0.1
    n-hexanol 0.34
    2-methoxyethanol 28.39
    isobutyl acetate 0.46
    tetrachloromethane 0.01
    n-pentyl acetate 0.63
    transcutol 44.51
    n-heptanol 0.36
    ethylbenzene 0.03
    MIBK 1.07
    2-propoxyethanol 10.99
    tert-butanol 1.32
    MTBE 0.65
    2-butoxyethanol 3.79
    propionic acid 1.93
    o-xylene 0.05
    formic acid 1.81
    diethyl ether 0.33
    m-xylene 0.04
    p-xylene 0.04
    chlorobenzene 0.03
    dimethyl carbonate 1.65
    n-octane 0.0
    formamide 4.86
    cyclopentanone 7.92
    2-pentanone 1.63
    anisole 0.5
    cyclopentyl methyl ether 1.6
    gamma-butyrolactone 10.56
    1-methoxy-2-propanol 22.69
    pyridine 0.92
    3-pentanone 1.04
    furfural 7.6
    n-dodecane 0.01
    diethylene glycol 13.93
    diisopropyl ether 0.09
    tert-amyl alcohol 1.8
    acetylacetone 3.13
    n-hexadecane 0.01
    acetophenone 0.87
    methyl propionate 2.38
    isopentyl acetate 1.21
    trichloroethylene 0.25
    n-nonanol 0.34
    cyclohexanol 0.85
    benzyl alcohol 0.72
    2-ethylhexanol 0.35
    isooctanol 0.4
    dipropyl ether 0.67
    1,2-dichlorobenzene 0.06
    ethyl lactate 2.6
    propylene carbonate 2.19
    n-methylformamide 5.15
    2-pentanol 0.81
    n-pentane 0.0
    1-propoxy-2-propanol 8.4
    1-methoxy-2-propyl acetate 5.17
    2-(2-methoxypropoxy) propanol 8.34
    mesitylene 0.03
    ε-caprolactone 3.78
    p-cymene 0.08
    epichlorohydrin 10.96
    1,1,1-trichloroethane 0.04
    2-aminoethanol 3.14
    morpholine-4-carbaldehyde 23.21
    sulfolane 44.21
    2,2,4-trimethylpentane 0.01
    2-methyltetrahydrofuran 3.67
    n-hexyl acetate 0.92
    isooctane 0.0
    2-(2-butoxyethoxy)ethanol 9.38
    sec-butyl acetate 0.69
    tert-butyl acetate 1.43
    decalin 0.01
    glycerin 15.49
    diglyme 21.88
    acrylic acid 2.23
    isopropyl myristate 0.46
    n-butyric acid 1.99
    acetyl acetate 0.6
    di(2-ethylhexyl) phthalate 0.83
    ethyl propionate 1.3
    nitromethane 6.74
    1,2-diethoxyethane 3.06
    benzonitrile 0.32
    trioctyl phosphate 0.55
    1-bromopropane 0.06
    gamma-valerolactone 22.17
    n-decanol 0.26
    triethyl phosphate 1.33
    4-methyl-2-pentanol 0.46
    propionitrile 0.58
    vinylene carbonate 1.44
    1,1,2-trichlorotrifluoroethane 12.71
    DMS 1.72
    cumene 0.03
    2-octanol 0.21
    2-hexanone 1.24
    octyl acetate 0.61
    limonene 0.14
    1,2-dimethoxyethane 14.27
    ethyl orthosilicate 1.11
    tributyl phosphate 0.78
    diacetone alcohol 7.17
    N,N-dimethylaniline 0.44
    acrylonitrile 1.17
    aniline 0.33
    1,3-propanediol 6.51
    bromobenzene 0.02
    dibromomethane 0.02
    1,1,2,2-tetrachloroethane 0.34
    2-methyl-cyclohexyl acetate 1.15
    tetrabutyl urea 1.38
    diisobutyl methanol 0.36
    2-phenylethanol 0.71
    styrene 0.03
    dioctyl adipate 1.38
    dimethyl sulfate 7.5
    ethyl butyrate 1.38
    methyl lactate 6.87
    butyl lactate 1.94
    diethyl carbonate 0.96
    propanediol butyl ether 3.94
    triethyl orthoformate 1.79
    p-tert-butyltoluene 0.09
    methyl 4-tert-butylbenzoate 2.35
    morpholine 7.2
    tert-butylamine 0.25
    n-dodecanol 0.19
    dimethoxymethane 9.24
    ethylene carbonate 1.03
    cyrene 8.58
    2-ethoxyethyl acetate 2.21
    2-ethylhexyl acetate 0.8
    1,2,4-trichlorobenzene 0.15
    4-methylpyridine 0.69
    dibutyl ether 0.48
    2,6-dimethyl-4-heptanol 0.36
    DEF 4.37
    dimethyl isosorbide 15.74
    tetrachloroethylene 0.12
    eugenol 3.05
    triacetin 2.77
    span 80 3.76
    1,4-butanediol 1.23
    1,1-dichloroethane 0.04
    2-methyl-1-pentanol 0.77
    methyl formate 2.4
    2-methyl-1-butanol 1.22
    n-decane 0.01
    butyronitrile 0.5
    3,7-dimethyl-1-octanol 0.43
    1-chlorooctane 0.06
    1-chlorotetradecane 0.03
    n-nonane 0.01
    undecane 0.01
    tert-butylcyclohexane 0.01
    cyclooctane 0.0
    cyclopentanol 1.55
    tetrahydropyran 0.89
    tert-amyl methyl ether 1.02
    2,5,8-trioxanonane 15.87
    1-hexene 0.03
    2-isopropoxyethanol 4.69
    2,2,2-trifluoroethanol 0.87
    methyl butyrate 1.89

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction