Dinitolmide

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  • Identifiers

    CAS number
    148-01-6

    Molecular formula
    C8H7N3O5

    SMILES
    CC1=C(C=C(C=C1[N+](=O)[O-])[N+](=O)[O-])C(=O)N

    Safety labels

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Sweet 49.86%
    Odorless 48.24%
    Fatty 33.48%
    Powdery 29.54%
    Musk 28.65%
    Creamy 25.68%
    Milky 25.38%
    Dry 24.97%
    Bitter 22.26%
    Floral 22.0%

     

    Flavor
    Bitter 60.29%
    Odorless 53.3%
    Mild 26.95%
    Very mild 25.61%
    Bland 22.2%
    Nutty 20.85%
    Nitrile 20.8%
    Bread crust 20.64%
    Sweet-like 20.31%
    Yeast 20.23%

     

    Odor impact est.
    Odorless

  • Properties

    XLogP3-AA
    0.7

    pKa est.
    6.14 (neutral)

    Molecular weight
    225.16 g/mol

    Melting point expt.

    • 351 °F (NIOSH, 2024)
    • 181 °C
    • 351 °F

    Flash point

    • 183.43 ˚C est.

    Solubility expt.

    • Slight (NIOSH, 2024)
    • Very slightly soluble in water; soluble in acetone, acetonitrile, and dimethyl formamide
    • Soluble in dioxane
    • 1 mg/mL
    • Solubility in water: poor
    • Slight

  • Synonyms

    • dinitolmide
    • 2-Methyl-3,5-dinitrobenzamide
    • 148-01-6
    • Zoalene
    • 3,5-Dinitro-o-toluamide
    • Zoamix
    • Coccidot
    • Benzamide, 2-methyl-3,5-dinitro-
    • Coccidine A
    • Dinitolmida
    • Dinitrotoluamide
    • Salcostat
    • Zoalene [ANSI]
    • Methyldinitrobenzamide
    • Dinitolmide [INN:BAN]
    • Dinitolmidum
    • Zoalele
    • Caswell No. 932
    • Dinitolmidum [INN-Latin]
    • Dinitolmida [INN-Spanish]
    • o-Toluamide, 3,5-dinitro-
    • HSDB 7192
    • UNII-AOX68RY4TV
    • EINECS 205-706-4
    • Dinitolmide (INN)
    • EPA Pesticide Chemical Code 037510
    • NSC-758213
    • BRN 1990738
    • DTXSID6042521
    • DINITOLMIDE [MI]
    • DINITOLMIDE [INN]
    • AOX68RY4TV
    • DINITOLMIDE [HSDB]
    • DINITOLMIDE [MART.]
    • 3,5-Dinitro-ortho-toluamide
    • ZOALENE [GREEN BOOK]
    • D.O.T.
    • DTXCID4022521
    • 3-09-00-02316 (Beilstein Handbook Reference)
    • Zoalene (ANSI)
    • NSC 758213
    • NCGC00094985-01
    • Dinitolmidum (INN-Latin)
    • Dinitolmida (INN-Spanish)
    • DINITOLMIDE (MART.)
    • C8H7N3O5
    • Coccidin
    • 3,5-Dinitro Toluamide
    • Zoalene (500 ug/mL in Methanol)
    • CAS-148-01-6
    • SR-01000872611
    • Abilene
    • Coccidine
    • Zamix
    • 3,5-Dinitro-2-methylbenzamide
    • Whitsyn T
    • 2-methyl-3,5-dinitro-benzamide
    • ZoaShield 25%
    • MFCD00072065
    • 3,5Dinitrootoluamide
    • Dinitolmide (ACGIH)
    • Dinitolmide (Zoalene)
    • Spectrum_001272
    • Dinitolmide, BAN, INN
    • Spectrum2_000677
    • Spectrum3_001545
    • Spectrum4_000732
    • Spectrum5_001231
    • 2Methyl3,5dinitrobenzamide
    • SCHEMBL43712
    • BSPBio_002990
    • KBioGR_001024
    • KBioSS_001752
    • MLS002695903
    • Benzamide, 2methyl3,5dinitro
    • DivK1c_000214
    • SPECTRUM1503036
    • SPBio_000773
    • CHEMBL472565
    • Zoamix Type A Medicated Article
    • D.O.T. (TN)
    • HMS500K16
    • KBio1_000214
    • KBio2_001752
    • KBio2_004320
    • KBio2_006888
    • KBio3_002490
    • 3,5-Dinitro-o-toluamide, 98%
    • CHEBI:174162
    • NINDS_000214
    • HMS1922A07
    • HMS3089A22
    • HMS3652K20
    • Pharmakon1600-01503036
    • Zoalene 90 Medicated Coccidiostat
    • HY-B1004
    • Tox21_111374
    • Tox21_301320
    • BBL003876
    • CCG-40029
    • NSC758213
    • s4141
    • STK395739
    • 2-Methyl-3,5-dinitrobenzamide, 9CI
    • AKOS003282656
    • Tox21_111374_1
    • CS-4501
    • DB11480
    • IDI1_000214
    • USEPA/OPP Pesticide Code: 037510
    • NCGC00094985-02
    • NCGC00094985-03
    • NCGC00094985-05
    • NCGC00255914-01
    • AC-20062
    • SMR001253784
    • VS-01441
    • SBI-0051752.P002
    • DB-021326
    • NS00021673
    • SW219233-1
    • D07857
    • E77947
    • EN300-199771
    • AB00052301_04
    • Dinitolmide, VETRANAL(TM), analytical standard
    • Q4024614
    • SR-01000872611-2

  • Applications

    Dinitolmide is commonly used as a coccidiostat in poultry and other livestock feeds to help control coccidiosis; it also serves as an intermediate in organic synthesis, enabling the preparation of other fine chemicals; in research and development contexts it can be used as a reagent or precursor for related compounds, and it may be evaluated for inclusion in veterinary pharmaceutical formulations; and its use is subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 12.54
    methanol 24.16
    isopropanol 5.91
    water 0.55
    ethyl acetate 23.21
    n-propanol 8.05
    acetone 106.21
    n-butanol 3.92
    acetonitrile 44.75
    DMF 283.6
    toluene 4.2
    isobutanol 3.65
    1,4-dioxane 132.09
    methyl acetate 60.99
    THF 179.24
    2-butanone 59.52
    n-pentanol 4.47
    sec-butanol 4.76
    n-hexane 0.13
    ethylene glycol 15.72
    NMP 439.93
    cyclohexane 0.04
    DMSO 730.8
    n-butyl acetate 16.05
    n-octanol 2.92
    chloroform 3.53
    n-propyl acetate 20.4
    acetic acid 37.18
    dichloromethane 14.38
    cyclohexanone 40.18
    propylene glycol 9.65
    isopropyl acetate 10.59
    DMAc 242.7
    2-ethoxyethanol 42.84
    isopentanol 3.03
    n-heptane 0.22
    ethyl formate 20.02
    1,2-dichloroethane 16.2
    n-hexanol 4.43
    2-methoxyethanol 74.53
    isobutyl acetate 6.95
    tetrachloromethane 0.41
    n-pentyl acetate 10.52
    transcutol 75.94
    n-heptanol 3.63
    ethylbenzene 2.33
    MIBK 9.34
    2-propoxyethanol 41.59
    tert-butanol 6.52
    MTBE 7.53
    2-butoxyethanol 19.11
    propionic acid 21.3
    o-xylene 3.23
    formic acid 48.95
    diethyl ether 11.62
    m-xylene 2.49
    p-xylene 3.64
    chlorobenzene 5.74
    dimethyl carbonate 38.05
    n-octane 0.11
    formamide 116.14
    cyclopentanone 129.9
    2-pentanone 22.69
    anisole 25.2
    cyclopentyl methyl ether 21.36
    gamma-butyrolactone 196.08
    1-methoxy-2-propanol 36.34
    pyridine 83.56
    3-pentanone 22.4
    furfural 170.31
    n-dodecane 0.12
    diethylene glycol 45.74
    diisopropyl ether 1.65
    tert-amyl alcohol 5.46
    acetylacetone 50.19
    n-hexadecane 0.14
    acetophenone 33.51
    methyl propionate 38.77
    isopentyl acetate 12.02
    trichloroethylene 28.99
    n-nonanol 3.33
    cyclohexanol 3.3
    benzyl alcohol 15.55
    2-ethylhexanol 3.2
    isooctanol 2.53
    dipropyl ether 7.46
    1,2-dichlorobenzene 6.14
    ethyl lactate 15.71
    propylene carbonate 40.89
    n-methylformamide 103.19
    2-pentanol 2.41
    n-pentane 0.09
    1-propoxy-2-propanol 21.59
    1-methoxy-2-propyl acetate 31.56
    2-(2-methoxypropoxy) propanol 25.72
    mesitylene 1.2
    ε-caprolactone 50.03
    p-cymene 2.13
    epichlorohydrin 164.78
    1,1,1-trichloroethane 3.52
    2-aminoethanol 14.59
    morpholine-4-carbaldehyde 306.69
    sulfolane 271.68
    2,2,4-trimethylpentane 0.09
    2-methyltetrahydrofuran 53.61
    n-hexyl acetate 12.39
    isooctane 0.05
    2-(2-butoxyethoxy)ethanol 30.34
    sec-butyl acetate 8.98
    tert-butyl acetate 13.27
    decalin 0.15
    glycerin 26.41
    diglyme 67.35
    acrylic acid 35.25
    isopropyl myristate 4.79
    n-butyric acid 11.07
    acetyl acetate 15.46
    di(2-ethylhexyl) phthalate 7.88
    ethyl propionate 18.22
    nitromethane 250.88
    1,2-diethoxyethane 24.11
    benzonitrile 15.63
    trioctyl phosphate 4.72
    1-bromopropane 2.82
    gamma-valerolactone 242.79
    n-decanol 2.51
    triethyl phosphate 10.11
    4-methyl-2-pentanol 1.41
    propionitrile 13.56
    vinylene carbonate 41.68
    1,1,2-trichlorotrifluoroethane 64.03
    DMS 34.31
    cumene 1.67
    2-octanol 2.01
    2-hexanone 19.82
    octyl acetate 7.74
    limonene 2.62
    1,2-dimethoxyethane 84.89
    ethyl orthosilicate 7.81
    tributyl phosphate 5.86
    diacetone alcohol 22.44
    N,N-dimethylaniline 13.4
    acrylonitrile 36.33
    aniline 11.44
    1,3-propanediol 15.44
    bromobenzene 3.91
    dibromomethane 4.54
    1,1,2,2-tetrachloroethane 13.54
    2-methyl-cyclohexyl acetate 12.78
    tetrabutyl urea 10.51
    diisobutyl methanol 1.77
    2-phenylethanol 14.56
    styrene 3.36
    dioctyl adipate 11.74
    dimethyl sulfate 105.77
    ethyl butyrate 13.81
    methyl lactate 29.35
    butyl lactate 10.82
    diethyl carbonate 11.16
    propanediol butyl ether 15.26
    triethyl orthoformate 11.07
    p-tert-butyltoluene 1.91
    methyl 4-tert-butylbenzoate 21.43
    morpholine 114.4
    tert-butylamine 2.02
    n-dodecanol 1.76
    dimethoxymethane 105.1
    ethylene carbonate 25.75
    cyrene 52.6
    2-ethoxyethyl acetate 31.59
    2-ethylhexyl acetate 9.52
    1,2,4-trichlorobenzene 11.85
    4-methylpyridine 46.08
    dibutyl ether 4.34
    2,6-dimethyl-4-heptanol 1.77
    DEF 43.68
    dimethyl isosorbide 64.12
    tetrachloroethylene 8.05
    eugenol 23.23
    triacetin 29.29
    span 80 15.26
    1,4-butanediol 8.13
    1,1-dichloroethane 4.9
    2-methyl-1-pentanol 3.37
    methyl formate 102.31
    2-methyl-1-butanol 3.16
    n-decane 0.19
    butyronitrile 7.11
    3,7-dimethyl-1-octanol 2.38
    1-chlorooctane 1.23
    1-chlorotetradecane 0.57
    n-nonane 0.15
    undecane 0.15
    tert-butylcyclohexane 0.15
    cyclooctane 0.04
    cyclopentanol 9.08
    tetrahydropyran 22.19
    tert-amyl methyl ether 7.17
    2,5,8-trioxanonane 48.75
    1-hexene 0.8
    2-isopropoxyethanol 22.74
    2,2,2-trifluoroethanol 22.99
    methyl butyrate 22.9

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction